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Kaur Berneet B Alzheimer's Disease Center, University of California-Davis Medical Center, Sacramento, CA 95814, USA. - - 2013
Alzheimer disease (AD) and dementia with Lewy bodies (DLB) are common etiologies of dementia with overlapping clinical features. Our objective was to determine which extrapyramidal signs (EPSs) are most helpful in identifying DLB. We analyzed data from the National Alzheimer's Coordinating Center, including demographics, Unified Parkinson's Disease Rating Scale (UPDRS) ...
Stimpfel Amy Witkoski AW Center for Health Outcomes and Policy Research, University of Pennsylvania School of Nursing, Philadelphia, PA 19104, USA. - - 2013
The objective of this study was to analyze hospital staff nurses' shift length, scheduling characteristics, and nurse reported safety and quality. A secondary analysis of a large nurse survey linked with hospital administrative data was conducted. More than 22 000 registered nurses' reports of shift length and scheduling characteristics were ...
McMonnies Charles W CW School of Optometry and Vision Science, University of New South Wales, Kensington, Australia. - - 2013
To examine the validity of the observations made by specialist corneal surgeons that there seems to be an absence or loss of older patients with keratoconus (KC). Using a PubMed search and key words such as KC, epidemiology, mortality, mitral valve prolapse, atopy, and asthma, the literature related to this ...
Moreira Carlos A CA - - 2013
To evaluate the long-term results of retinal pigment epithelium tears in eyes treated with repeated anti-vascular endothelial growth factor (VEGF) therapy. Five patients with retinal pigment epithelial tears (without foveal center involvement) after anti-VEGF injection were studied retrospectively. Mean follow-up time was 52 months, with measurements of visual acuity and ...
Petersen Bibi B Department of Dermatological Research, Bispebjerg Hospital, Bispebjerg Bakke 23, Copenhagen 2400, Denmark. - - 2013
With this observation study we aimed to determine how and when sunscreen was used. 20 sun seekers were observed during a one-week sun holiday in Hurghada, Egypt. The sunscreen application thickness was related to part of body, time outdoors, exposure to ultraviolet radiation and to sunburning. Skin sites with sunscreen ...
Weatherhead Sophie C SC Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK. - - 2013
Ultraviolet B (UVB) is a highly effective, relatively safe, affordable and widely used therapeutic option for moderate psoriasis. Several types of UVB lamp are available to treat psoriasis, both broadband and narrowband, allowing a choice of spectral emission. However despite years of clinical use, the mechanism of action of UVB ...
Willemink Martin J - - 2012
A prospective single-arm trial. To investigate whether dynamic isolated resistance training of global lumbar extensor muscles leads to changes in lumbar multifidus (LM) morphology in terms of cross-sectional muscle, and, if so, whether these changes are associated with observed changes in self-experienced functional status of chronic nonspecific low back pain ...
Kim David J DJ University of Alabama School of Medicine, Birmingham, AL 35294-2050, - - 2012
Increases in multimorbidity and obesity have been noted in HIV-infected populations in the current treatment era. Patterns of multimorbid disease clustering and the impact of obesity on multimorbidity are understudied in this population. We examined obesity and multimorbidity patterns among 1844 HIV-infected patients in the UAB 1917 Clinic. Exploratory factor ...
Shlipak Michael G MG Department of Medicine, San Francisco VA Medical Center, San Francisco, CA 94121, USA. - - 2012
HIV-infected persons have substantially higher risk of kidney failure than persons without HIV, but serum creatinine levels are insensitive for detecting declining kidney function. We hypothesized that urine markers of kidney injury would be associated with declining kidney function among HIV-infected women. In the Women's Interagency HIV Study, we measured ...
Södersten Fredrik - - 2013
This is a descriptive study of tendon pathology with different structural appearances of repair tissue correlated to immunolocalization of cartilage oligomeric matrix protein (COMP) and type I and III collagens and expression of COMP mRNA. The material consists of nine tendons from seven horses (5-25 years old; mean age of ...
Kappel Kalli K Bioengineering Department, University of California, San Diego, La Jolla, California 92093, - - 2012
Sortase enzymes are vitally important for the virulence of gram-positive bacteria as they play a key role in the attachment of surface proteins to the cell wall. These enzymes recognize a specific sorting sequence in proteins destined to be displayed on the surface of the bacteria and catalyze the transpeptidation ...
Zhang Yuqing Y Boston University, Boston, MA 02118, USA. - - 2012
To study the relationship between cherry intake and the risk of recurrent gout attacks among individuals with gout. We conducted a case-crossover study to examine the associations of a set of putative risk factors with recurrent gout attacks. Individuals with gout were prospectively recruited and followed up online for 1 ...
Liu Fang F Department of Dermatology, Boston University School of Medicine, Boston, MA, - - 2013
The paired box homeotic gene 3 (PAX3) is a crucial regulator for the maintenance of melanocytic progenitor cells and has a poorly defined role in melanoma. To understand how PAX3 affects melanocyte and melanoma proliferation, we identified potential PAX3 downstream targets through gene expression profiling. Here, we identify T-box 2 ...
Funamoto Kenichi K Institute of Fluid Science, Tohoku University, Sendai 980-8577, Japan. - - 2012
Low oxygen tensions experienced in various pathological and physiological conditions are a major stimulus for angiogenesis. Hypoxic conditions play a critical role in regulating cellular behaviour including migration, proliferation and differentiation. This study introduces the use of a microfluidic device that allows for the control of oxygen tension for the ...
Lin Yu Hsien YH - - 2012
β-Glycosyl imidinium triflate is generated from participating thioglycoside donors for disarmed-armed iterative glycosylations and one-pot oligosaccharide synthesis.
Gruppi Francesca - - 2012
Due to the importance of Mn(2+) ions in biological processes, it is of growing interest to develop protocols for analysis of Mn(2+) uptake and distribution in cells. A supramolecular metal displacement assay can provide ratiometric fluorescence detection of Mn(2+), allowing for quantitative and longitudinal analysis of Mn(2+) uptake in living ...
Rana Poonam P NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), - - 2013
Abstract Purpose: In the classical description of acute radiation syndrome, the role of central nervous system (CNS) is underestimated. It is now well recognised that ionising radiation-induced oxidative stress may bring about functional changes in the brain. In this study, we prospectively evaluated metabolic changes in the brain after whole ...
Qin Yong Y Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, - - 2013
CDDO-Me has been shown to exert potent anti-inflammatory activity for chronic kidney disease and antitumor activity for several tumors, including melanoma, in early clinical trials. To improve CDDO-Me response in melanoma, we utilized a large-scale synthetic lethal RNAi screen targeting 6000 human druggable genes to identify targets that would sensitize ...
Mitchell Caroline C Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, - - 2013
Bacterial vaginosis has been associated with genital HIV-1 shedding; however, the effect of specific vaginal bacterial species has not been assessed. We tested cervicovaginal lavage from HIV-1-seropositive women for common Lactobacillus species: L. crispatus, L. jensenii, and seven BV-associated species: BVAB1, BVAB2, BVAB3, Leptotrichia, Sneathia, Megasphaera, and Atopobium spp. using ...
Shah Gulzar H - - 2012
: To examine the level of involvement by local health departments (LHDs) in practice-based research (PBR) activities, and determine factors associated with variation in such involvement. : A total of 625 LHDs in a nationally representative stratified random sample of LHDs were administered questions about their participation in PBR activities ...
Bevc Christine A - - 2012
: The North Carolina Division of Public Health established an innovative program in 2003 that placed public health epidemiologists (PHEs) in hospitals around the state to improve communication between hospitals and local public health departments (LHDs) and bolster public health surveillance and response. : To use social network analysis to ...
Meyer Anne-Marie - - 2012
More than a decade has passed since a conceptual framework was introduced to guide public health services and systems research (PHSSR) and elucidate the relationships associated with system performance. Since then, research has primarily focused on performance, standards, and key processes, with less emphasis on identification of measures or methods. ...
Riley William - - 2012
: Quality improvement (QI) methods have been used for almost a decade in public health departments to increase effectiveness and efficiency. Although results are rapidly accumulating, the evidence for the science of improvement is shallow and limited. To advance the use and effectiveness of QI in public health, it is ...
Thiede Hanne - - 2012
: To assess variability in investigation, prevention, and control of communicable diseases of public health significance among Washington State local health jurisdictions. : Online survey conducted from December 2010 to January 2011. : Washington State local health jurisdictions. : Local health officers in the 35 local health jurisdictions in Washington ...
Livingood William - - 2012
: Local health departments are increasingly challenged to meet emerging health problems at the same time that they are being challenged with dwindling resources and the demands of accreditation. : To assess the capacity of Multicounty health districts to serve as "Quality Improvement Collaboratives" and support local health departments to ...
Yao Y - - 2012
Distinct human leukocyte antigen (HLA) allele and haplotype distributions occur in the northern and southern Han populations of China. However, different ethnic groups in China show limited regional distributions for many HLA alleles and haplotypes. Therefore, it is necessary and meaningful to study the differences in HLA allele and haplotype ...
Ingram Richard C - - 2012
There is a growing recognition that the US public health system should strive for efficiency-that it should determine the optimal ways to utilize limited resources to improve and protect public health. The field of public health finance research is a critical part of efforts to understand the most efficient ways ...
Harris James M - - 2012
The objectives of this study were to examine the feasibility of using glucose oxidase (GOx) dispersed in a silica matrix for glucose monitoring in whole blood, and then to assess whether the flexibility of silica sol-gel chemistry could be exploited to enhance glucose sensor performance and stability. Silica-dispersed GOx was ...
Vest Joshua R - - 2012
: Resource sharing, arrangements between local health departments (LHDs) for joint programs or to share staff, is a growing occurrence. The post-9/11 influx of federal funding and new public health preparedness responsibilities dramatically increased the occurrence of these inter-LHD relationships, and several states have pursed more intrastate collaboration. This article ...
Jones Jeff A - - 2012
: To describe the composition and duties of local boards of health (LBOHs). : An online and written survey was utilized for data collection. The survey included demographics, roles and responsibilities, orientation and training, and concerns and needs of LBOHs. : This article seeks to expand what limited information we ...
Hyde Justeen - - 2012
: This study examined jurisdictional, organizational, and structural characteristics associated with capacity to deliver 10 essential public health services (EPHS) in Massachusetts, a state where a majority of local public health departments serve small municipalities. : A survey was administered to local health directors or board of health chairs. : ...
O'May Che - - 2012
Surface-associated swarming motility is implicated in enhanced bacterial spreading and virulence, hence it follows that anti-swarming effectors could have clinical benefits. When investigating potential applications of anti-swarming materials it is important to consider whether the lack of swarming corresponds with an enhanced sessile biofilm lifestyle and resistance to antibiotics. In ...
Merrill Jacqueline - - 2012
: To determine how a health officials' advice network might contribute to a high-performing public health systems by facilitating diffusion of innovation and best practices. : A secondary analysis of cross-sectional data obtained from the National Association of County and City Health Officials 2010 Profile of local health departments (LHDs) ...
Primozic J - - 2012
Primozic J., Perinetti G., Zhurov A., Richmond S., Ovsenik M. Assessment of facial asymmetry in growing subjects with a three-dimensional laser scanning system Orthod Craniofac Res 2012;15:237-244. © 2012 John Wiley & Sons A/S STRUCTURED ABSTRACT: Authors -  Primozic J, Perinetti G, Zhurov A, Richmond S, Ovsenik M Objectives -  To evaluate ...
Gearin Kimberly J Miner - - 2012
: Studies have reported a relationship between the organization of public health services and variability in public health practice at the local and state levels. A national research agenda has prioritized practice-based research to understand pathways that lead to this variation and examine the impact of these differences on outcomes. ...
Kang Y H - - 2012
Kang Y. H., Kim B. C., Park K. R., Yon J. Y., Kim H. J., Tak H. J., Piao Z., Kim M. K., Lee S. H. Visual pathway-related horizontal reference plane for three-dimensional craniofacial analysis Orthod Craniofac Res 2012;15:245-254. © 2012 John Wiley & Sons A/S STRUCTURED ABSTRACT: Authors -  Kang ...
Ibrahim Jennifer K - - 2012
The importance of law in the organization and operation of public health systems has long been a matter of interest to public health lawyers and practitioners, but empirical research on law as a factor in health system performance has been limited in quantity and sophistication. The emergence of Public Health ...
van Rijn Anne F - - 2012
Although all international guidelines state that there is no indication to perform a faecal occult blood test (FOBT) in symptomatic patients, we believe the test is frequently used as a diagnostic test. The objective of this study was to investigate whether the current guidelines for FOBT use are being followed ...
Meit Michael - - 2012
: Public health practitioners and researchers often refer to state public health systems as being centralized, decentralized, shared, or mixed. These categories refer to governance of the local public health units within the state and whether they operate under the authority of the state government, local government, shared state and ...
Cilenti Dorothy - - 2012
The objective of this article was to describe factors that contribute to successful translation of science into evidence-based practices and their implementation in public health practice agencies, based on a review of the literature and evidence from a series of case studies. The case studies involved structured interviews with key ...
Kim Hyoung-Nam - - 2012
Future generations of upper limb prosthesis will have dexterous hand with individual fingers and will be controlled directly by neural signals. Neurons from the primary motor (M1) cortex code for finger movements and provide the source for neural control of dexterous prosthesis. Each neuron's activation can be quantified by the ...
Chen Li-Wu - - 2012
: This study assessed the workforce capacity of Nebraska Local Health Departments (LHDs) from the perspective of public health programmatic areas. DESIGN AND OUTCOMES MEASURES:: We conducted a mail survey of 21 LHD directors in Nebraska and collected the information on LHD workforce capacity, training, and competency by public health ...
Huang C-Y - - 2012
Hashimoto disease (HD) is an autoimmune thyroid disease resulting from complex interactions between genetic and environmental factors. The human leukocyte antigen (HLA) gene has been established to be involved in the susceptibility to HD. We aim to investigate the associations between HLA-B alleles and Han Chinese children with HD by ...
Sekiya Sayaka - - 2012
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary malignancy in the liver. ICC has been classified as a malignant tumor arising from cholangiocytes; however, the co-occurrence of ICC and viral hepatitis suggests that ICC originates in hepatocytes. In order to determine the cellular origin of ICC, we used a ...
Wang Xiaoli - - 2012
Cancer stem cell behavior is thought to be largely determined by intrinsic properties and by regulatory signals provided by the microenvironment. Myelofibrosis (MF) is characterized by hematopoiesis occurring not only in the marrow but also in extramedullary sites such as the spleen. In order to study the effects of these ...
Russo Sarah Brice - - 2012
Diabetic cardiomyopathy (DbCM), which consists of cardiac hypertrophy and failure in the absence of traditional risk factors, is a major contributor to increased heart failure risk in type 2 diabetes patients. In rodent models of DbCM, cardiac hypertrophy and dysfunction have been shown to depend upon saturated fatty acid (SFA) ...
Li John Zhong - - 2012
A genetic variant in PNPLA3 (PNPLA3(I148M)), a triacylglycerol (TAG) hydrolase, is a major risk factor for nonalcoholic fatty liver disease (NAFLD); however, the mechanism underlying this association is not known. To develop an animal model of PNPLA3-induced fatty liver disease, we generated transgenic mice that overexpress similar amounts of wild-type ...
Cadigan Ken M - - 2012
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are multifunctional proteins that use their sequence-specific DNA-binding and context-dependent interactions to specify which genes will be regulated by Wnts. Much of the work to define their actions has focused on ...
Tiozzo Caterina - - 2012
Alveolar capillary dysplasia (ACD) is a congenital, lethal disorder of the pulmonary vasculature. Phosphatase and tensin homologue deleted from chromosome 10 (Pten) encodes a lipid phosphatase controlling key cellular functions, including stem/progenitor cell proliferation and differentiation; however, the role of PTEN in mesodermal lung cell lineage formation remains unexamined. To ...
Bekemeier Betty - - 2012
As a part of the Public Health Activities and Service Tracking study and in collaboration with partners in 2 Public Health Practice-Based Research Network states, we examined relationships between local health department (LHD) maternal and child health (MCH) expenditures and local needs. We used a multivariate pooled time-series design to ...
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