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Hu Qiong-Zheng - - 2012
In this study, we demonstrate a new strategy to image biomolecular events through interactions between liquid crystals (LCs) and oil-in-water emulsions. The optical response had a dark appearance when a nematic LC, 4-cyano-4'-pentylbiphenyl (5CB), is in contact with emulsion droplets of glyceryl trioleate (GT). In contrast, the optical response had ...
Manganoni A M - - 2012
Background.  The risk of a subsequent cancer is an important issue for patients with melanoma. The development of a second primary cancer in patients with a solitary melanoma has been discussed in several studies. However, to our knowledge, the incidence of second primary cancer (SPC) in patients with multiple primary ...
Nixon N L - - 2012
BACKGROUND: Recent models of major depressive disorder (MDD) have proposed the rostral anterior cingulate (rACC) and dorsomedial prefrontal cortex (dmPFC) as nexus sites in the dysfunctional regulation of cognitive-affective state. Limited evidence from remitted-state MDD supports these theories by suggesting that aberrant neural activity proximal to the rACC and the ...
Bunner Christina - - 2012
Because peer review is central to the publication of rigorous research, periodic assessment of the process's effectiveness is clearly warranted. Two online surveys, one for authors (n = 102) and the other for Editorial Board members (n = 20), were conducted to assess their perspectives on the quality and timeliness of peer review. ...
Mayer Deborah K - - 2012
October has become synonymous with pink ribbons and breast cancer. You can't miss the numerous events and products that raise awareness of breast cancer and funds for research. Today's public discussion and media presence regarding breast cancer has dramatically changed in the past 40 years. In the 1970s, Betty Ford ...
Nakamura Ken - - 2012
We describe a case of replacement with a cryopreserved homograft for graft infection. A 48-year-old man had been performed ascending aorta replacement using woven dacron graft for type A aortic dissection. Two months ago, methicillin-resistant Staphylococcus aureus infection was suspected because of high-grade fever. Computed tomography (CT) scan revealed abcess ...
Carr Rachel - - 2012
Reversible and selective binding of a dynamically racemic europium(iii) complex to α(1)-acid glycoprotein and α(1)-antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into ...
Wang Changshan - - 2012
Abstract Purpose: Precise understanding of radiation effects is critical to development of new modalities for the prevention and treatment of radiation-induced damage. In this study, we evaluated the effects of non-lethal doses of X-ray irradiation on human hematopoietic stem and progenitor cells (HSPCs) reconstituted in NOD/Shi-scid, IL2Rγ(null) (NOG) immunodeficient mice. ...
Mabry Ella - - 2012
I wanted to personally write you to share the positive feedback I have received on your article, "Interventions to Manage Compassion Fatigue in Oncology Nursing" by Nancy Aycock, RN, BSN, OCN®, CHPN®, and Deborah Boyle, RN, MSN, AOCN®, FAAN. I work on a 12-bed medical research oncology unit at the ...
Hirooka Shigeki - - 2012
Sinus venosus atrial septal defect( SVD) represent 5~10% of atrial septal defect( ASD). In contrast to the more common superior type in which the superior vena cava overrides the pathological interatrial communication, the inferior type with overriding inferior vena cava is extremely rare. We describe a case of residual inferior ...
Smith Jessica W - - 2012
The relationship between systemic inflammatory processes to total knee arthroplasty (TKA) outcomes remains unclear. This study investigates the relationship between serum high-sensitivity C-reactive protein (hs-CRP) and functional outcomes post-TKA. A total of 31 patients with osteoarthritis (OA) who underwent TKA were enrolled in the study; 15 with hs-CRP ≤1.0 mg/l ...
McGarry Conor K - - 2012
The aim of this work is to determine the out-of-field survival of cells irradiated with either the primary field or scattered radiation in the presence and absence of intercellular communication following delivery of conformal, IMRT and VMAT treatment plans. Single beam, conformal, IMRT and VMAT plans were created to deliver ...
Deubzer Hedwig E - - 2012
Inhibition of histone deacetylase (HDAC) activity as stand-alone or combination therapy represents a promising therapeutic approach in oncology. The pan- or class I HDAC-inhibitors (HDACi) currently approved or in clinical studies for oncology give rise to dose-limiting toxicities, presumably due to the inhibition of several HDACs. This could potentially be ...
Bousse Alexandre - - 2012
In this paper we propose a segmented magnetic resonance imaging (MRI) prior-based maximum penalized likelihood deconvolution technique for positron emission tomography (PET) images. The model assumes the existence of activity classes that behave like a hidden Markov random field (MRF) driven by the segmented MRI. We utilize a mean field ...
Pilliod Rachel A - - 2012
We sought to evaluate the risk of intrauterine fetal death (IUFD) in small-for-gestational-age (SGA) fetuses. We analyzed a retrospective cohort of all births in the United States in 2005, as recorded in a national database. We calculated the risk of IUFD within 3 sets of SGA threshold categories as well ...
Raz Sabina Rebe - - 2012
We present a novel approach to tackle the most common drawback of using surface plasmon resonance for analyte screening in complex biological matrices - the nonspecific binding to the sensor chip surface. By using a perforated membrane supported by a polymeric gel structure at the evanescent wave penetration depth, we ...
Bourillon Agnes - - 2012
As loss of KIT frequently occurs in melanoma progression, we hypothesized that KIT is implicated in predisposition to melanoma (MM). Thus, we sequenced the KIT coding region in 112 familial MM cases and 143 matched controls and genotyped Tag SNPs in 2 cohorts of melanoma patients and matched controls. Five ...
Kiss F - - 2012
Photosensitivity to UVB is a prominent feature of a small number of congenital skin disorders. In addition UVB may also contribute to the action spectrum of a number of acquired photosensitivity syndromes. The gene mutations underlying the genetically inherited disorders have largely been identified and have provided insights into DNA ...
Libon F - - 2012
Summary Ipilimumab blocks cytotoxic T-lymphocyte-associated antigen (CTLA)-4, potentiating the antimelanoma T-cell host response. Ipilimumab has been shown to improve overall survival in patients with previously treated metastatic melanoma. CTLA-4 antibodies generate immune responses to the melanoma-associated antigens Melan-A, NY-ESO-1 and glycoprotein (gp)100 in metastatic melanoma. Digital epiluminescence microscopy (DELM) is ...
Bang Yung-Jue - - 2012
Crizotinib (Xalkori), the first inhibitor of both anaplastic lymphoma kinase (ALK) and c-Met receptor kinases, has been approved in the United States, Korea, and other countries for the treatment of ALK-positive non-small cell lung cancer (NSCLC). This approval came within just 4 years of the discovery of rearrangements in the ...
Casolo Giancarlo - - 2012
Cardiovascular magnetic resonance (CMR) is a unique diagnostic imaging tool for the assessment of cardiomyopathies, allowing a non-invasive detection of the most common diseases of the heart muscle. In the real world, patients with suspected cardiomyopathies who show signs and symptoms of heart failure should undergo a thorough diagnostic evaluation. ...
Wasserman David - - 2012
This article discusses the ethical issues raised by the medical responses to Turner syndrome (TS). It explores the issues and challenges faced by women with Turner, and by prospective parents of a child with Turner. It focuses on four issues: the use of GH to increase height; the use of ...
Brar Bhupinder S - - 2012
/st> Ayurveda, an ancient medical science originating in India, also is practiced in the United States. The authors conducted a study primarily to explore the involvement of ayurvedic practitioners in treating oral diseases. /st> Eighty-five practitioners participated in this cross-sectional survey. The authors obtained self-reported data on demographics of the ...
Hermans Michel P - - 2012
Abstract Objective: The PROMPT study compared efficacy and tolerability of two treatment intensification strategies: adding saxagliptin or uptitrating metformin monotherapy, in patients with type 2 diabetes (T2D) and inadequate glycaemic control on a sub-maximal metformin dose. Research design and methods: In this double-blind, 24-week study, metformin-tolerant patients with T2D on ...
Kaae Susanne - - 2012
BACKGROUND: Despite pharmacists' extensive knowledge in the optimization of patients' medical treatments, community pharmacies are still fighting to earn patients' trust with respect to medicinal counselling at the counter. OBJECTIVE: The aim was to investigate how patients perceive pharmacy counselling at the present time, in order to develop the patient-pharmacy ...
Sakama M - - 2012
Spread-out Bragg peaks made by ridge filters or wheel range modulators are used in charged particle therapy with passive methods to achieve uniform biological responses in irradiated tumors. Following the biological responses needed to design the ridge filters, which were developed at the National Institute of Radiological Sciences in Japan, ...
Neumann Ingmar - - 2012
Spin injection and detection is achieved in freely suspended graphene using cobalt electrodes and a nonlocal spin-valve geometry. The devices are fabricated with a single electron-beam-resist poly(methyl methacrylate) process that minimizes both the fabrication steps and the number of (aggressive) chemicals used, greatly reducing contamination and increasing the yield of ...
Xu Zheng - - 2012
A new ratiometric fluorescence probe based on an excited-state intramolecular proton transfer (ESIPT) mechanism for detection of hydrogen sulfide (H(2)S) is reported. responds to H(2)S quickly and showed a 30-fold fluorescence enhancement in 2 minutes. Moreover, can detect H(2)S quantitatively with a detection limit as low as 0.12 μM in ...
Capalbo D - - 2012
Growth hormone (GH), in addition to promote linear growth during childhood, exerts a key role in several processes of substrate metabolism. Adults with untreated GH deficiency and adolescents who discontinued GH therapy at completion of growth, exhibit a cluster of cardiovascular risk factors such as impaired cardiac performance, alteration in ...
Tanaka Hisae - - 2012
Phosphate homeostasis is maintained by intestine, bone, and kidney, which is regulated by many hormones. In addition to classical hormones such as parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D [1,25 (OH) (2)D] , fibroblast growth factor 23 (FGF23) and Klotho have been discovered as novel factors for phosphate metabolism. FGF23 is ...
Hammonds Linda Sue - - 2012
Distress remains a pervasive experience of patients with cancer. As a result, a quality improvement project was conducted in the breast cancer clinic of a university cancer center in the midwestern United States. Nurses identified a need to increase identification of distress over a six-month period when they made only ...
Károlyi Zoltán - - 2012
The author summarizes the factors which play a role in the development of polycystic ovary syndrome highlighting the impact of intrauterine genetic programming and the importance of the maternal steroid environment. Environmental effects, steroid receptor modulators, endocrine disruptor compounds, and the role of obesity in the development of polycystic ovary ...
Santo S - - 2012
The aim of this review is to provide up-to-date and evidence based answers to common questions regarding the diagnosis and prognosis of prenatally detected absence of the corpus callosum (ACC). A systematic literature search was performed to identify all reports of ACC and reference lists of articles were identified. ACC ...
Jella K Kumar - - 2012
Abstract Purpose: The aim of this study was to compare levels of apoptosis, necrosis, mitotic cell death and senescence after treatment with both direct radiation and irradiated cell conditioned medium. Materials and methods: Human keratinocytes (HaCaT cell line) were irradiated (0.005, 0.05 and 0.5 Gy) using a cobalt 60 teletherapy ...
Knottenbelt C M - - 2012
OBJECTIVES: To investigate the association between dog hair nicotine concentration and owner-reported exposure to environmental tobacco smoke to establish whether dogs are exposed to significant, detectable amounts of environmental tobacco smoke in the home. METHODS: Hair was collected from 23 dogs exposed to environmental tobacco smoke and from 15 dogs ...
Wang Shangli - - 2012
A strategy to prepare stable monodispersed fluorescent microspheres is developed by modifying the Wessling method to synthesize poly(p-phenylenevinylene) (PPV) on the surface of a highly crosslinked polymer core. The positively charged PPV polymer precursors (pre-PPV) are adsorbed onto the core with negative charges on the surface and then the insoluble ...
Boschloo L - - 2012
BACKGROUND: Much is still unclear about the role of personality in the structure of common psychiatric disorders such as depressive/anxiety disorders and alcohol dependence. This study will therefore examine whether various traits of negative emotionality and impulsivity showed shared or specific associations with these disorders. Method Cross-sectional data were used ...
Körner Robert W - - 2012
Premature infants constitute a risk group for thiamin deficiency but only little is known about their thiamin status. The aim of the present study was to investigate the thiamin status of premature infants by determination of thiamin diphosphate (TDP) and to identify risk factors for low TDP concentrations. In a ...
McCann Sue - - 2012
Cutaneous T-cell lymphoma (CTCL) is a rare non-Hodgkin lymphoma with predominant skin manifestations and a relatively indolent course at early stages, but it can be fatal in advanced settings. In the absence of cure, the goal of therapy for CTCL is to induce long-term remissions without further compromising a patient's ...
Dana Caroline - - 2012
Centralization and radialization are the most widely reported surgical treatments for Bayne and Klug Type III and IV radial longitudinal deficiency. Prior soft tissue distraction has been introduced to improve reducibility of the deformity without skeletal resection. Satisfying long-term effects have been reported with centralization but are still unclear with ...
Xing Yan - - 2012
The active metabolite in the post-harvested biomass of zinc (Zn) and cadmium (Cd) hyperaccumulator Sedum alfredii Hance from phytoextraction is of great interest in China. The current study demonstrates that a salidroside-type metabolite can be yielded from the Zn/Cd hyperaccumulator S. alfredii biomass by means of sonication/ethanol extraction and macroporous ...
Vanini Giancarlo G Department of Anesthesiology, University of Michigan, Ann Arbor, MI, - - 2012
GABAergic and cholinergic transmission within the basal forebrain and cerebral cortex contribute to the regulation of sleep and wakefulness. In contrast to levels of acetylcholine (ACh), levels of endogenous GABA in basal forebrain and cortex during sleep and wakefulness have not previously been quantified. This study (1) tested the hypothesis ...
Masojć Piotr - - 2012
Qualitative and quantitative differences were found between two-dimensional electrophoretic spectra of 546 proteins from two bulked samples of mature rye grain representing: (1) 20 recombinant inbred lines extremely resistant to preharvest sprouting and (2) 20 recombinant inbred lines extremely susceptible to preharvest sprouting. Mass spectrometry of resolved proteins showed that ...
Tongsiri Sirinart - - 2012
Purpose: This study aims to determine functioning information, rehabilitation needs, and environmental barriers of persons with disabilities (PWDs) using a developed ICF-based questionnaire with community survey approach in Thailand. Method: A systematic review of the use of ICF and disability surveys from January 2000- June 2010 was undertaken. A questionnaire ...
Bohrer Rc - - 2012
The growth factor receptor-bound protein 14 (Grb14) is a cellular adapter protein belonging to the Grb7 family of proteins. Studies with human and rodent cells have demonstrated that Grb14 acts as a negative regulator of tyrosine kinase receptor signalling through the MAPK and PI3K pathways. In cattle, tyrosine kinase receptors ...
Zhu Peining - - 2012
Mesoporous SnO(2) agglomerates with hierarchical structures and a high surface area were fabricated through a molten salt method. The SnO(2) demonstrated high photoelectric conversion efficiencies of 3.05% and 6.23% (with TiCl(4) treatment) in dye-sensitized solar cells, which are attributed to its dual functionality of providing high dye-loading and efficient light ...
Langerhans R B - - 2012
Gambusia quadruncus n. sp., the llanos mosquitofish, is described from east-central México. The region inhabited by the species represents a hotspot of diversity of Gambusia, and G. quadruncus sometimes coexists with at least three congeners. The species differs from its closest relative, Gambusia affinis, in several characteristics with plausible effects ...
Czaplicki Kathy L - - 2012
The incidence of concurrent breast cancer and pregnancy (also known as pregnancy-associated breast cancer [PABC]) may increase as women delay child bearing. Because of the physiologic changes associated with pregnancy, diagnosis often is delayed, lending to poorer prognostic factors on presentation. Therefore, the clinical challenge in managing PABC involves controlling ...
Bauer Rebecca N RN Curriculum in Toxicology, Gillings School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, - - 2012
The leading cause of asthma exacerbation is respiratory viral infection. Innate antiviral defense pathways are altered in the asthmatic epithelium, yet involvement of inflammasome signaling in virus-induced asthma exacerbation is not known. This study compared influenza-induced activation of inflammasome and innate immune signaling in human bronchial epithelial cells from volunteers ...
Barbour John - - 2012
Functional motor recovery after peripheral nerve injury is predominantly determined by the time to motor end plate reinnervation and the absolute number of regenerated motor axons that reach target. Experimental models have shown that axonal regeneration occurs across a supercharged end-to-side (SETS) nerve coaptation. In patients with a recovering proximal ...
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