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Lindeman Neal - - 2012
The past 9 years have seen a remarkable shift in the diagnostic and therapeutic approach to lung carcinomas, beginning with the discovery of EGFR mutations and their role in directing management with targeted tyrosine kinase inhibitors. This special review recounts the experiences at one molecular diagnostic testing center, the Brigham ...
Karnis Megan Freebury - - 2012
Turner syndrome results in infertility in most cases. Fertility preservation through the cryopreservation of oocytes or ovarian tissue may be an option for some girls with Turner syndrome. Oocyte donation results in high pregnancy rates (PR). Those women who plan to pursue pregnancy need comprehensive screening and counseling before and ...
Barnett Michael L - - 2012
BACKGROUND: and Overview Randomized controlled clinical trials are considered to provide the highest level of evidence for clinical practice, public health policy and evidence-based systematic reviews. Although all randomized controlled clinical trials share basic design characteristics, to assess the outcome of a particular trial one must carefully evaluate specific details ...
Chaianunporn T - - 2012
Theoretical studies on the evolution of dispersal in metacommunities are rare despite empirical evidence suggesting that interspecific interactions can modify dispersal behaviour of organisms. To understand the role of species interactions for dispersal evolution, we utilize an individual-based model of a metacommunity where local population dynamics follows a stochastic version ...
Demirci Jill Radtke - - 2012
Poor breastfeeding outcomes among late preterm infants (LPIs) have been attributed to inadequate breast milk transfer stemming from physiological immaturities. However, breastfeeding is more than a biological phenomenon, and it is unclear how mothers of LPIs manage other factors that may also impact the breastfeeding course. Using grounded theory methods ...
Hashemzadeh Segherloo I - - 2012
The phylogenetic relationship between two sympatric morphotypes of the Iran cave barb Iranocypris typhlops, and Garra rufa, was investigated by sequencing the cytochrome c oxidase I (coI) region (788 bp) providing the first molecular evidence of their phylogeny. Consistent with their morphological differences, the mean genetic distance between the two ...
Dwivedi Pankaj - - 2012
The present study was focused on the development of surface modified gelatin nanoparticles (SGNPs) using novel ligand 4-sulfated N-acetyl galactosamine (4-SO(4)GalNAc) for specific targeting to macrophages. The gelatin has been modified with the potential targeting moiety 4-SO(4)GalNAc, which was further used for the preparation of modified nanoparticles. The nanoparticles have ...
Borghol-Kassar R - - 2012
OBJECTIVE: To evaluate the effectiveness of various surgical procedures in the management of posterior capsule and anterior vitreous on the prevention of visual axis opacification. SUBJECTS, MATERIAL AND METHODS: We retrospectively reviewed 120 eyes operated for unilateral congenital cataracts, with a median age at the time of cataract surgery of ...
Pogorzelska Monika - - 2012
We performed a survey of National Healthcare Safety Network hospitals in 2008 to describe adoption of screening and infection control policies aimed at multidrug-resistant organisms (MDRO) in intensive care units (ICUs) and identify predictors of their presence, monitoring, and implementation. Four hundred forty-one infection control directors were surveyed using a ...
Baeesa Saleh S - - 2012
To describe the prevalence and morphologic characteristics of the foramen arcuale of the atlas vertebra in the Saudi population and propose a simplified classification system. A cross-sectional hospital-based study was conducted at King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia from September 2010 to February 2011. During the 6-month ...
Ohta Morio - - 2012
The use of single-incision laparoscopic surgery is spreading widely, even in Japan, however, in the field of thoracic surgery, there exist no previous reports on the use of the Wound retractor system in single-incision thoracoscopic surgery (SITS) for mediastinal disease. We herein describe the 1st cases of video-assisted SITS of ...
Al-Awadhi Anwar M - - 2012
While von Willebrand factor (vWF) has been reported to be elevated in smokers, there are no reports on the effects of smoking on its cleaving protease ADAMTS-13, particularly in subjects of Arab ethnicity. This study was conducted to determine the effects of smoking on vWF and ADAMTS-13 antigen and activity ...
Day J L - - 2012
A two-year-old spayed female shih-tzu was referred with a 10-month history of lethargy, chronic diarrhoea and weight loss. On presentation, a partial response to antibiotics was noted. Physical examination revealed an abdominal mass, and serum biochemistry and haematology revealed a mature neutrophilia, hypoalbuminaemia and a non-regenerative anaemia. Contrast radiography and ...
Ho E K H - - 2012
Deleterious alleles are constantly introduced into populations due to mutation. In subdivided populations, the impact of these mutations depends on the strength of selection as well as the softness of selection, that is, the extent to which fitness is governed by local rather than global competition. It is widely appreciated ...
Zhao Ying-Yong - - 2012
Chronic renal failure (CRF) is a major challenge for the public healthcare problem. A novel UPLC Q-TOF/MS method with MS(E) data collection mode was developed as a very effective biochemical analytical tool for precise identification of important biomarkers in the adenine-induced CRF rats. Nine endogenous metabolites were identified by using ...
Qu Changhai - - 2012
Context: Cerebral ischemia-reperfusion (I/R) injury is a secondary injury caused by oxidative stresses and inflammatory responses after recovery from cerebral ischemia. Brain protective drugs were used to reduce the injury. In order to improve the distribution in brain and enhance the brain-protective efficacy, some pharmaceutical technologies were used to achieve ...
Martínez-Amorós Erika - - 2012
Patients with major depressive disorder (MDD) who require an acute course of electroconvulsive therapy (ECT) have high relapse rates. Therefore, an effective maintenance treatment strategy needs to be established. Continuation and maintenance ECT (C/M-ECT) could be an adequate treatment option, although the lack of controlled studies has led to its ...
Blair Ellen W - - 2012
Clinical depression often is overlooked by healthcare providers when treating patients with cancer. Oncology nurses are in a pivotal position to assess for depression, communicate any changes in emotional status to the oncology treatment team, and offer support and education to patients and families. This article discusses the symptoms of ...
Baingana Rhona - - 2012
OBJECTIVE: To improve estimates of vitamin A deficiency in children of pre-school age in the 2006 Uganda Demographic and Health Survey (UDHS 2006). DESIGN: A cross-sectional study in which dried blood spot samples were analysed for C-reactive protein (CRP). Retinol-binding protein (RBP) had previously been analysed using a commercial enzyme ...
Borer Elizabeth T - - 2012
Understanding the linkages among species diversity, biomass production and stability underlies effective predictions for conservation, agriculture and fisheries. Although these relationships have been well studied for plants and, to a lesser extent, consumers, relationships among plant and consumer diversity, productivity, and temporal stability remain relatively unexplored. We used structural equation ...
Kanazawa Arihiro - - 2012
Fe(3)O(4) synthesized by magnetotactic bacteria and α-Fe(2)O(3) synthesized via a microbial-mineralization-inspired process functioned as catalysts for the controlled cationic polymerization of a vinyl ether.
Segawa Hiroko - - 2012
Inorganic phosphate (Pi) is an essential nutrient for several biological functions, including intracellular signal transduction, the production and function of cell membranes, and energy exchange. To achieve these functions, a transport system is required to transfer Pi across hydrophobic cell membranes. Pi (re) absorption in the small intestine and renal ...
Kerr Keith M - - 2012
Clinical need and developments in pathology and molecular biology require our cancer classifications to be constantly updated to keep them relevant and useful. A review of lung cancer classification is due and has been initiated with new proposals on classification of lung adenocarcinoma. Other major lung cancer types also deserve ...
Noma Noboru - - 2012
/st> There are nonodontogenic headache disorders that mimic dental pain. One such headache disorder is hemicrania continua (HC). HC is a primary headache syndrome characterized by a continuous, unilateral headache that is completely responsive to indomethacin. Patients may have signs and symptoms that the dentist should differentiate from odontogenic pain ...
Nelson Matthew T - - 2012
The objective was to develop a preoperative mortality risk stratification tool for patients facing major amputation. Patients who underwent above-knee (AKA) or below-knee amputation (BKA) from 2005 to 2010 were identified from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database. Univariate and multivariate analyses were ...
Barrionuevo J Sebastián - - 2012
The osteological diversity among species of Telmatobius has been considered conservative. Nonetheless, the degree of ossification of several features varies both intraspecifically and interspecifically. Herein, intraspecific osteological variation and postmetamorphic ontogenetic changes in osteological features are described in Telmatobius oxycephalus. These data are compared with published descriptions of congeners. There ...
Al-Rumayyan Ahmed R - - 2012
To estimate the prevalence of abnormal neuroimaging in children presenting to the emergency department (ED) with a new-onset seizure, and to identify the significant clinical predictors for an abnormal CT scan. In this cross-sectional study, all children age 12 or younger, admitted to the ED at King Abdulaziz Medical City ...
Vichera G - - 2012
Summary This study was designed to evaluate the quality and viability of bovine embryos produced by in vitro fertilization (IVF), after intracytoplasmic injection of pCX-EGFP-liposome complexes or pBCKIP2.8-liposome complexes (plasmids that codify the human insulin gene). Cleavage, blastocysts and expanded blastocysts rates of these both groups were not different from ...
Macpherson Catherine Fiona - - 2012
Julia was a six-year-old girl with stage IV neuroblastoma for which she had received two years of aggressive multimodal therapy. She lived in a small town about three hours away from the children's hospital where she was treated. Her parents were both teachers and she had two younger sisters, Jessica, ...
Drum Charles E - - 2012
The Americans with Disabilities Act (ADA) requires health care facilities to provide equal access to patents with disabilities. Yet, people with disabilities experience many access barriers. To develop a valid, reliable, and user-friendly tool that measures the physical and environmental features of outpatient health care facilities. Instead of addressing full ...
Kitay Alison - - 2012
Injuries to the scapholunate joint are the most frequent cause of carpal instability and account for a considerable degree of wrist dysfunction, lost time from work, and interference with activities. Although it is insufficient to cause abnormal carpal posture or collapse on static radiographs, an isolated injury to the scapholunate ...
Sadigh-Eteghad Saeed - - 2012
To obtain a better insight into the effect of the epsilon (e) 4 allele of the apolipoprotein E gene (APOE) on the risk of late onset Alzheimer`s disease (LOAD), and assess its heterogeneity in geographic regions. We performed a systemic review and meta-analysis of available studies. An electronic and manual ...
Matsumoto Keitaro - - 2012
This study describes minimally invasive surgery using video-assisted thoracic surgery (VATS) for thymic diseases. Our procedure has been changed in the last decade from sternum-lifting thoracoscopic surgery with mini-thoracotomy to complete thoracoscopic surgery. Indications for this method include benign thymic disease, non-invasive thymoma or myasthenia gravis (MG). We performed these ...
Joëls Marian - - 2012
Brain cells are continuously exposed to corticosteroid hormones, although the levels vary (e.g., after stress). Corticosteroids alter neural activity via two receptor types, mineralocorticoid (MR) and glucocorticoid receptors (GR). These receptors regulate gene transcription but also, as we now know, act nongenomically. Via nongenomic pathways, MRs enhance and GRs suppress ...
Augustin Matthias - - 2012
Leg ulcer management is complex, time consuming and of high socioeconomic importance. Data on cost-of-illness in leg ulcer care are sparse. The objective of this study was to evaluate the cost-of-illness in leg ulcer treatment in the metropolitan area of Hamburg. About 147 institutions involved in wound care participated in ...
Mpofu Elias - - 2012
Purpose: Rehabilitation assessment data influence decisions for the design of preferred lifestyles with a chronic illness or disability (CID). As a result, careful consideration of the source, type and scope of these data is needed in selecting appropriate procedures for their collection and use. This article proposes three essential qualities ...
Mizoshita Norihiro - - 2012
Mixtures of an amphiphilic perylene bisimide derivative and tetramethoxysilane in the absence of solvents have been found to exhibit stable columnar liquid-crystalline phases which transform into macroscopically oriented nanoporous silica films as a result of simple mechanical shearing.
Obi Yoshitsugu - - 2012
Phosphate is a macronutrient essential for the survival of living organisms, and phosphate depletion impairs cellular functions in various organ systems. However, epidemiological studies have shown that high phosphate level, even within normal range, is a risk factor for cardiovascular disease and all-cause mortality. This association is partly explained by ...
Roghi Alberto - - 2012
Magnetic resonance imaging provides excellent spatial resolution and tissue characterization analysis while not exposing patients to ionizing radiation or potentially nephrotoxic iodinate contrast agents. Magnetic resonance imaging has developed into an extensively applied diagnostic tool for all fields of medicine, whilst at the same time an increasing number of patients ...
Cleveland Jennifer L - - 2012
and Overview The authors set out to identify factors associated with implementation by U.S. dentists of four practices first recommended in the Centers for Disease Control and Prevention's Guidelines for Infection Control in Dental Health-Care Settings-2003. /st> In 2008, the authors surveyed a stratified random sample of 6,825 U.S. dentists. ...
Salameh P - - 2012
Although Lebanon is a highly polluted country, so far no study has specifically been designed to assess the association between outdoor air pollution and chronic bronchitis in this country. To assess the association between exposure to outdoor air pollution and chronic bronchitis in Lebanon. A pilot case-control study was conducted ...
Bleijerveld Onno B - - 2012
Coronary atherosclerosis represents the major cause of death in Western societies. As atherosclerosis typically progresses over years without giving rise to clinical symptoms, biomarkers are urgently needed to identify patients at risk. Over the last decade, evidence has accumulated suggesting cross-talk between the diseased vasculature and cells of the innate ...
Gammon Brian T - - 2012
Obstructive sleep apnea (OSA) can present significant challenges in providing postoperative care. OSA policies have been developed and are in place within many facilities; however, a standard OSA protocol ensuring the safe delivery of postoperative care has not been universally accepted into practice. A synthesis of current OSA literature led ...
Yang Yunfeng - - 2012
Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is clinically effective at treating acute ischemic stroke. However, the use of thrombolytic therapy is associated with an increased risk of symptomatic intracerebral hemorrhage (sICH). Whether unacceptable surgical hemorrhage occurs after emergent decompressive craniotomy during the first hours for sICH remains unknown. We ...
Rinewalt Daniel - - 2012
Simulation training may be an invaluable tool in training and assessing surgeons. Questions remain regarding its true impact on acquisition of laparoscopic skills and their transferability to the operating room. Twenty general surgery residents completed 5 exercises: bean drop/rope drill, foam cutting/endoloop, checkerboard, endostitch, and suturing/intracorporeal knot. After baseline scoring, ...
He Yabing - - 2012
A novel robust three-dimensional lanthanide organic framework with high thermal stability has been demonstrated to exhibit the potential for purification of natural gas in nearly pure form from an 8-component gas mixture at room temperature.
Saha Priyanka - - 2012
Abstract Purpose : The effect of gamma rays on Metallothionein (MT) expression was studied using the medicinal plant Plantago ovata as the test system. Materials and Methods : Western blotting and Matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) have been used for this purpose. Results: Western blot ...
Groth E - - 2012
OBJECTIVE: To determine whether or not dogs develop a deficiency of ascorbic acid during hospitalisation in an intensive care unit. METHODS: Blood samples were collected daily for up to three days from dogs hospitalised in an intensive care unit for 36 to 72 hours (n = 16) or ê72 hours (n = 20) and from ...
Bangert Mark - - 2012
The beam angle selection (BAS) problem in intensity-modulated radiation therapy is often interpreted as a combinatorial optimization problem, i.e. finding the best combination of η beams in a discrete set of candidate beams. It is well established that the combinatorial BAS problem may be solved efficiently with metaheuristics such as ...
Martínez Rubio M - - 2012
OBJECTIVE: The purification of commercially prepared triamcinolone acetonide is important in order to avoid the potential toxic side-effects of the solvent benzyl alcohol. We present a new technique for preparation of pure triamcinolone acetonide by dissolving the powder in sterile distilled water with no additional solvents. As the triamcinolone powder ...
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