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Primozic J - - 2012
Primozic J., Perinetti G., Zhurov A., Richmond S., Ovsenik M. Assessment of facial asymmetry in growing subjects with a three-dimensional laser scanning system Orthod Craniofac Res 2012;15:237-244. © 2012 John Wiley & Sons A/S STRUCTURED ABSTRACT: Authors -  Primozic J, Perinetti G, Zhurov A, Richmond S, Ovsenik M Objectives -  To evaluate ...
Riley William - - 2012
: Quality improvement (QI) methods have been used for almost a decade in public health departments to increase effectiveness and efficiency. Although results are rapidly accumulating, the evidence for the science of improvement is shallow and limited. To advance the use and effectiveness of QI in public health, it is ...
Chen Li-Wu - - 2012
: This study assessed the workforce capacity of Nebraska Local Health Departments (LHDs) from the perspective of public health programmatic areas. DESIGN AND OUTCOMES MEASURES:: We conducted a mail survey of 21 LHD directors in Nebraska and collected the information on LHD workforce capacity, training, and competency by public health ...
Russo Sarah Brice - - 2012
Diabetic cardiomyopathy (DbCM), which consists of cardiac hypertrophy and failure in the absence of traditional risk factors, is a major contributor to increased heart failure risk in type 2 diabetes patients. In rodent models of DbCM, cardiac hypertrophy and dysfunction have been shown to depend upon saturated fatty acid (SFA) ...
Gearin Kimberly J Miner - - 2012
: Studies have reported a relationship between the organization of public health services and variability in public health practice at the local and state levels. A national research agenda has prioritized practice-based research to understand pathways that lead to this variation and examine the impact of these differences on outcomes. ...
Kang Y H - - 2012
Kang Y. H., Kim B. C., Park K. R., Yon J. Y., Kim H. J., Tak H. J., Piao Z., Kim M. K., Lee S. H. Visual pathway-related horizontal reference plane for three-dimensional craniofacial analysis Orthod Craniofac Res 2012;15:245-254. © 2012 John Wiley & Sons A/S STRUCTURED ABSTRACT: Authors -  Kang ...
Hong Peng P Department of Cell Biology, State University of New York Downstate Medical Center,New York, New York, - - 2012
The native capacity of adult skeletal muscles to regenerate is vital to the recovery from physical injuries and dystrophic diseases. Currently, the development of therapeutic interventions has been hindered by the complex regulatory network underlying the process of muscle regeneration. Using a mouse model of skeletal muscle regeneration after injury, ...
Dong Fei F Department of Anesthesiology, Pain Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, - - 2012
Inflammation of the dorsal root ganglia (DRG) may contribute to low back pain, postherpetic neuralgia, and neuropathic pain. The mineralocorticoid receptor (MR) plays a proinflammatory role in many nonrenal tissues, but its role in peripheral pain at the DRG level is not well studied. Local inflammation of the L5 DRG ...
Zhang Jianning J Department of Neurosurgery, Tianjin Medical University and Tianjin Neurology Institute, Tianjin, - - 2012
Traumatic injury is a common cause of coagulopathy, primarily due to blood loss and hemodilution secondary to fluid resuscitation. Traumatic injury-associated coagulopathy often follows a course of transition from hyper- to hypocoagulable state exemplified in disseminated intravascular coagulation. The incidence of coagulopathy is significantly higher in patients with traumatic brain ...
Xiao Longxi - - 2012
Block copolymer micelles (BCMs) were prepared from amphiphilic diblock copolymers of poly(n-butyl acrylate) and poly(acrylic acid) partially modified with 2-hydroxyethyl acrylate. Radical polymerization of acrylamide in the presence of micellar crosslinkers gave rise to elastomeric hydrogels (BCM-PAAm) whose mechanical properties can be tuned by varying the BCM composition. Transmission electron ...
Marcu Delia D Faculty of Environmental Sciences and Engineering, BabeĊŸ-Bolyai University, Cluj-Napoca, - - 2013
Abstract Purpose: The objectives of this study were to determine the effects of gamma radiation on lettuce growth and development, as well as on the content of photosynthetic pigments in 28 days lettuce leaf. Lettuce dry seeds were exposed to a (60)Co [Cobalt-60] gamma source at doses ranging from 2-70 ...
Choi Yun-Sik YS Department of Pharmaceutical Science & Technology, Catholic University of Daegu, Gyeongbuk, Rep. of - - 2012
The neurogenic niche within the subgranular zone (SGZ) of the dentate gyrus is a source of new neurons throughout life. Interestingly, SGZ proliferative capacity is regulated by both physiological and pathophysiological conditions. One outstanding question involves the molecular mechanisms that regulate both basal and inducible adult neurogenesis. Here, we examined ...
Zuccolo Luisa L MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom. - - 2013
Alcohol is an established carcinogen but not an established risk factor for prostate cancer, despite some recent prospective studies suggesting increased risk among heavy drinkers. The aim of this study was to investigate the role of alcohol on prostate-specific antigen (PSA) levels and prostate cancer risk. Two thousand four hundred ...
Rogers Nicole H NH Department of Metabolism and Aging, Scripps Research Institute Florida, Jupiter, FL 33458, - - 2012
Insulin sensitivity deteriorates with age, but mechanisms remain unclear. Age-related changes in the function of subcutaneous white adipose tissue (sWAT) are less characterized than those in visceral WAT. We hypothesized that metabolic alterations in sWAT, which in contrast to epididymal WAT, harbors a subpopulation of energy-dissipating UCP1+ brown adipocytes, promote ...
Morozov Alexander N - - 2012
Chloroperoxidase, the most versatile heme protein, has a hybrid active site pocket that shares structural features with peroxidases and cytochrome P450s. The simulation studies presented here show that the enzyme possesses a remarkable ability to efficiently utilize its hybrid structure, assuming structurally different peroxidase-like and P450-like distal pocket faces and ...
Aktas Savas S Department of Histology & Embryology, Faculty of Medicine, Mersin University, Mersin, Turkey. - - 2013
Abstract Purpose: The aim of the present study was to evaluate the electrophysiological, biochemical and ultrastructural changes on the rat sciatic nerve after radiotherapy. Thirty male Wistar albino rats were divided into three groups as: Control group (n = 10), Group I: 3 months after radiotherapy (n = 10), and ...
Mu Xiaojia - - 2012
We have investigated the self-assembly of fluorenylmethoxycarbonyl-conjugated dialanine (Fmoc-AA) molecules using combined computational and experimental approaches. Fmoc-AA gels were characterized using transmission electron microscopy (TEM), circular dichroism (CD), Fourier transform infrared (FTIR), and wide-angle X-ray scattering (WAXS). Computationally, we simulated the assembly of Fmoc-AA using molecular dynamics techniques. All simulations ...
Oslund Rob C - - 2012
We explored the inhibition mode of group IIA secreted phospholipase A(2) (GIIA sPLA(2)) selective inhibitors and tested their ability to inhibit GIIA sPLA(2) activity as chemical conjugates with hyaluronic acid (HA). Analogues of a benzo-fused indole sPLA(2) inhibitor were developed in which the carboxylate group on the inhibitor scaffold, which ...
Yan Lin L Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA. - - 2012
Adenylyl cyclase type 5 knockout mice (AC5 KO) live longer and are stress resistant, similar to calorie restriction (CR). AC5 KO mice eat more, but actually weigh less and accumulate less fat compared with WT mice. CR applied to AC5 KO results in rapid decrease in body weight, metabolic deterioration, ...
Zhao Huaying H Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institutes of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, - - 2012
Cooperativity, multisite, and multicomponent interactions are hallmarks of biological systems of interacting macromolecules. Their thermodynamic characterization is often very challenging due to the notoriously low information content of binding isotherms. We introduce a strategy for the global multimethod analysis of data from multiple techniques (GMMA) that exploits enhanced information content ...
Yamamoto Masanori - - 2012
In a fraction of patients aged ≥90 years, less-invasive transcatheter aortic valve implantation (TAVI) has been considered a therapeutic option for aortic stenosis under careful clinical screening. However, the safety and effectiveness using TAVI in such a population has not been fully elucidated. The aim of the present study was ...
Matrone Carmela C CNR--National Research Council, Cell Biology and Neurobiology Institute, Rome, 00143, Italy. - - 2012
Processing of Aβ-precursor protein (APP) plays an important role in Alzheimer's disease (AD) pathogenesis. The APP intracellular domain contains residues important in regulating APP function and processing, in particular the 682YENPTY687 motif. To dissect the functions of this sequence in vivo, we created an APP knock-in allele mutating Y682 to ...
Benoit Danielle S W DS Department of Biomedical Engineering, University of Rochester Medical Center, University of Rochester, Rochester, NY 14627, USA. - - 2012
siRNA treatment has great promise to specifically control gene expression and select cell behaviors but has delivery challenges limiting its use. Particularly for applications in regenerative medicine, uniform and consistent delivery of siRNA to control gene expression and subsequent stem cell functions, such as differentiation, is paramount. Therefore, a diblock ...
Zhao Ling L Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, 5 Yiheyuan Road, Beijing, 100871, - - 2012
β-adrenoceptors are the common pharmacological targets for the treatment of cardiovascular diseases and asthma. Genetic modifications of β-adrenergic system in engineered mice affect their lifespan. Here, we tested whether genes encoding for key components of the β-adrenergic signaling pathway are associated with human longevity. We performed a 10-year follow-up study ...
Czigány Zoltán Z Semmelweis Egyetem, Általános Orvostudományi Kar I. Sebészeti Klinika - - 2012
Several techniques have been developed to reduce ischemic-reperfusion injury. A novel method is the remote ischemic perconditioning, applied parallel with target organ ischemia. The aim of the study was to determine the extent of liver ischemic-reperfusion injury via the application of this novel method. Male Wistar rats (n = 30, ...
Stout Molly J MJ Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA. - - 2013
To evaluate urine protein-to-creatinine ratio (UPC) alone and with uric acid and clinical factors to predict or exclude significant proteinuria in preeclampsia evaluations. Retrospective cohort study patients undergoing evaluation for preeclampsia. Greater than 300 mg of protein in a 24-h collection was the gold standard defining proteinuria against which UPC performance ...
Pattanayek Rekha - - 2012
KaiA protein that stimulates KaiC phosphorylation in the cyanobacterial circadian clock was recently shown to be destabilized by dibromothymoquinone (DBMIB), thus revealing KaiA as a sensor of the plastoquinone (PQ) redox state and suggesting an indirect control of the clock by light through PQ redox changes. Here we show using ...
Salek Mogjiborahman - - 2012
Recent advances in peptide-based (bottom-up) quantitative proteomics and bioinformatics have opened unprecedented opportunities for extensive investigation of cellular proteomes and their dynamics. Here we discuss two approaches currently used to investigate the global dynamics of phosphorylation based on the isolation of phosphorylated proteins or peptides. We evaluate the accuracy of ...
Tehrani Omid S - - 2012
A case of a 31-year-old woman with sudden respiratory distress is presented. Preliminary evaluations and imaging studies did not reveal the underlying cause. Workup during hospital stay showed advanced metastatic cancer of unknown primary origin. This is an unusual presentation of cancer of an unknown primary involving the thyroid with ...
Röhner Eric - - 2012
ABSTRACT In septic joint surgery, treatment with antiseptics is a standard procedure. Postinfectious degeneration of cartilage often results in early arthritis that necessitates joint replacement, even in young patients. It is still unclear whether antiseptics have only a toxic effect on chondrocytes or also induce late cell death through apoptosis. ...
Kurai Makoto - - 2012
We performed thoracoscopic thymectomy using a method in which the anterior chest wall was lifted by Kirschner wire passed through the subcutaneous tissue. Between April 2011 and May 2012, 5 cases underwent thoracoscopic thymectomy using this method. Postoperative complications, especially subcutaneous hematoma and pain in the anterior chest wall through ...
Avital Itzhak - - 2012
Upwards of 40% of patient with colorectal cancer develop peritoneal carcinomatosis (CRCPC). Of the 2500 patients reported in the literature, 1000 underwent cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC), resulting in median survival of 22 to 63 months. However, level I data from prospective randomized trials are limited. Further ...
Foster John G - - 2012
The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B (PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide variety of cells including leukocytes. Perturbation of this signaling cascade is implicated in inflammatory and autoimmune disorders as well as hematological malignancies. Proteins within the PI3K/mTOR/Akt pathway therefore ...
Ebokaiwe Azubike P - - 2012
Biometal accumulation may contribute to organ toxicity in individuals using the Nigerian bonny light crude oil (BLCO) for ailment management. We assessed the levels of biometals, antioxidant status, along with histomorphometric analysis to investigate the effect of BLCO, commonly use in folklore medicine, on the brain. Adult male Wistar rats ...
Johnson Eric S - - 2012
Comparative effectiveness research includes cohort studies and registries of interventions. When investigators design such studies, how important is it to follow patients from the day they initiated treatment with the study interventions? Our article considers this question and related issues to start a dialogue on the value of the incident ...
Rana Utpal - - 2012
The formation of unique polyaniline nanotubes has been reported in presence of graphene oxide (GO) which plays crucial dual role as dopant and soft template, simultaneously. GO in nanotubes is in situ reduced to reduced GO with restoration of electrical conductivities and enhanced thermal stabilities.
Kouzoupis Anastasios V - - 2012
Evidence suggests that gender differences appear in a variety of biological and psychological responses to stress and perhaps in coping with acute and chronic illness as well. Dysfunctional parenting is also thought to be involved in the process of coping with stress and illness; hence, the present study aimed to ...
Maruyoshi Keisuke - - 2012
Two-dimensional (1)H double-quantum and (14)N-(1)H & (1)H-(13)C heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOHN(arom) and CH(arom)O[double bond, length as m-dash]C hydrogen-bonding interactions in the solid-state structure of an indomethacin-nicotinamide cocrystal, thus additionally proving cocrystal formation.
Yokoyama Keitaro - - 2012
α-Klotho was first identified as an aging gene and was later shown to be a regulator of mineral metabolism. Then, α-Klotho was reported to function as an obligate coreceptor for fibroblast growth factor 23 (FGF23). Phosphrus regulation of FGF23/Klotho axis is slow. On the other hand, α-Klotho is a key ...
Dendaas Nancy - - 2012
Dermatitis is a distressing symptom of radiation therapy, and current care guidelines often lack evidence. Using an evidence-based practice (EBP) model, a multidisciplinary group in an academic medical center reviewed the literature to create departmental patient education materials related to skin care that were grounded in evidence. Recommendations not supported ...
Shahraz Saeid - - 2012
Quantifying the quality of care in high-cost and fatal conditions such as acute myocardial infarction (AMI) is a crucial step toward improving clinical outcomes in these patients. The main objective of this pilot study is to show whether abstraction of medical charts would be a useful method to systematically assess ...
Macconaill Laura E - - 2012
Although improvements in genomic technologies during the past decade have greatly advanced our understanding of the genomic alterations that contribute to lung cancer, and the disease has (to a degree) become a paradigm for individualized cancer treatment in solid tumors, additional challenges must be addressed before the goal of personalized ...
Imazio Massimo - - 2012
Colchicine has been recently demonstrated to be efficacious and safe for the prevention of several postoperative complications including the postpericardiotomy syndrome (PPS), postoperative pericardial and pleural effusions, and postoperative atrial fibrillation according to the results of the COPPS trial. The aim of the present paper is to critically review the ...
Papaioannou D - - 2012
Follicular lymphoma (FL) is a non-Hodgkin's lymphoma which typically presents when the disease is at an advanced stage. The majority of patients receive first-line therapy of rituximab in combination with chemotherapy, with two-thirds receiving cyclophosphamide, vincristine and prednisolone. The clinical and cost-effectiveness of other chemotherapies in combination with rituximab in ...
Van Vlierberghe Pieter - - 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular ...
Chen Shi-chao - - 2012
Total dissolved gas (TDG) supersaturation caused by dam sluicing can result in gas bubble trauma (GBT) in fish and threaten their survival. In the present study, Chinese suckers (Myxocyprinus asiaticus Bleeker) were exposed to TDG supersaturated water at levels ranging from 120% to 145% for 48 h. The median lethal ...
De Luca Michele - - 2012
Amiloride photostability at different pH values was studied in depth by applying Multivariate Curve Resolution Alternating Least Squares (MCR-ALS) to the UV spectrophotometric data from drug solutions exposed to stressing irradiation. Resolution of all degradation photoproducts was possible by simultaneous spectrophotometric analysis of kinetic photodegradation and acid-base titration experiments. Amiloride ...
Li Lu-Lin - - 2012
Nature has chosen chlorophylls in plants as antennae to harvest light for the conversion of solar energy in complicated photosynthetic processes. Inspired by natural photosynthesis, scientists utilized artificial chlorophylls - the porphyrins - as efficient centres to harvest light for solar cells sensitized with a porphyrin (PSSC). After the first ...
Ahles Tim A - - 2012
Chemotherapy-induced cognitive changes have been an increasing concern among cancer survivors. By using adjuvant treatment for breast cancer as the prototype, this manuscript reviews research from neuropsychological, imaging, genetic, and animal model studies that have examined the clinical presentation and potential mechanisms for cognitive changes associated with exposure to chemotherapy. ...
Merchán-Naranjo Jessica - - 2012
INTRODUCTION: The prescribing of anti-psychotic drugs has become a normal clinical practice. METHODS: This article presents a longitudinal, multicentre study of 12 months conducted on 266 children and adolescents who were prescribed a first or second generation antipsychotic drug for the first time, and the baseline results of the study. ...
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