Search Results
Results 701 - 750 of 4409
< 10 11 12 13 14 15 16 17 18 19 20 >
Flaherty Keith T KT Massachusetts General Hospital Cancer Center, Boston, - - 2012
Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with dabrafenib, a selective BRAF inhibitor, and trametinib, a selective MAPK kinase (MEK) inhibitor. In this open-label ...
Tao Guohua - - 2012
An efficient time-dependent (TD) Monte Carlo (MC) importance sampling method has recently been developed [G. Tao and W. H. Miller, J. Chem. Phys. 135, 024104 (2011)] for the evaluation of time correlation functions using the semiclassical (SC) initial value representation (IVR) methodology. In this TD-SC-IVR method, the MC sampling uses ...
Klüpfel Simon - - 2012
Self-consistent calculations using the Perdew-Zunger self-interaction correction (PZ-SIC) to local density and gradient dependent energy functionals are presented for the binding energy and equilibrium geometry of small molecules as well as energy barriers of reactions. The effect of the correction is to reduce binding energy and bond lengths and increase ...
Komatsu Takayuki - - 2012
BACKGROUND: Bacteremia and its complications are important causes of morbidity and mortality in hospitalized patients. However, the yield of blood cultures is relatively low, with many false-positive results from bacterial contamination. METHODS: We investigated the relationship between patient food consumption and the presence of bacteremia. This was an observational analysis ...
Kim Seong-Kyu - - 2012
Objective. To investigate the health-related quality of life (HRQOL) and economic burden of patients with FM syndrome (FMS) and compare the changes in these parameters 3 months before and after FMS diagnosis.Methods. A total of 2098 patients with FMS (1818 previously diagnosed with FMS and 280 newly diagnosed with FMS) ...
Bell S F - - 2012
We compared insertion rates of single-use polyvinyl chloride laryngeal mask airways (LMAs) vs single-use silicone LMAs in 72 anaesthetised patients. Both airways were produced by Flexicare Medical. Laryngeal mask airway insertion was successful on the first attempt in 68/72 (94%) polyvinyl chloride LMAs vs 64/72 (89%) silicone LMAs (p = 0.39). Overall ...
McCrea Shane Joseph John - - 2012
Abstract Following tooth extraction, resorption of the buccal wall of the socket will occur; this will be true for both the maxilla and the mandible. Where the extraction site is surrounded by natural dentition, the loss of the buccal alveolar plate can degrade the visual aesthetics of an implant-supported prosthetic ...
Moe Børge - - 2012
OBJECTIVES: To prospectively examine the independent and combined effect of occupational physical activity and metabolic syndrome on all-cause and cardiovascular mortality in a large population-based cohort. METHODS: Data on 37 300 men and women participating in the Norwegian HUNT Study (1995-1997) were linked with the Cause of Death Registry at ...
Sharifi Tiva - - 2012
Heat treating nitrogen doped multiwalled carbon nanotubes containing up to six different types of nitrogen functionalities, transforms particular nitrogen functionalities into other types which are more catalytically active towards oxygen reduction reactions (ORR). In the first stage the unstable pyrrolic functionalities transform into pyridinic functionalities followed by an immediate transition ...
Gudas Rimtautas - - 2012
BACKGROUND:Various techniques have proven to be effective for treating articular cartilage defect (ACD) and osteochondral defect (OCD) of the knee joint, but knowledge regarding which method is best still remains uncertain. PURPOSE:To evaluate and compare the outcomes of mosaic-type osteochondral autologous transplantation (OAT) and microfracture (MF) procedures for the treatment ...
Lennartson Anders - - 2012
Round and round: A mononuclear Fe(II) complex with an N(4) S(2) coordination set has been characterized in four polymorphic forms. Two of the polymorphs display four-site cooperative spin crossover (SCO), shown conclusively by the crystal structure of a fully ordered 1:3 high-spin/low-spin state. The presence of S donor atoms in ...
Bennett Thomas P - - 2012
The predictions of several homogeneous nucleation theories are compared with experimental results for water for a range of temperatures and vapor supersaturations, S. The theoretical models considered are: classical theory (including the 1∕S correction factor), the Gibbs p-form, mean-field kinetic nucleation theory (MKNT), the extended modified liquid drop model-dynamical nucleation ...
Fuksa L - - 2012
Neoadjuvant chemotherapy (NCT) of breast cancer enabled improved outcomes especially in patients with advanced and inflammatory diseases. Biological heterogeneity of these tumors, however, requires better molecular characterization of the malignant tissue with consequent individualization in the selection of appropriate agents. To date, numerous molecular markers have been identified, and some ...
Pate Kathryn M - - 2012
Evidence from human and animal studies indicates that mechanical loads to breathing are stressful stimuli and evoke compensatory behaviors. Load compensation behaviors are reflexive and well-characterized in anesthetized animals while they are behaviorally modulated in conscious animals. Repeated presentations of stressful stimuli are known to cause changes in an animal's ...
Kumar Santosh - - 2012
Bacteria belonging to α-proteobacteria normally harbour multiple copies of the heat shock sigma factor (σ32 or σH or RpoH). Azospirillum brasilense, a non-photosynthetic rhizobacterium, harbours 5 copies of rpoH genes, out of which one is an rpoH2 homolog. The genes around rpoH2 locus in A. brasilense show synteny with that ...
Yatsenko Svetlana A - - 2012
We performed karyotype and aCGH analyses on 177 prenatal samples, including 162 (92%) samples from fetuses with sonographic anomalies. Overall 12 fetuses (6.8%) had abnormal karyotype and 42 (23.7%) fetuses had abnormal microarray results: 20 (11.3%) with pathogenic copy number variations (CNVs), 16 with CNVs of uncertain clinical significance, four ...
Honemeyer Ulrich - - 2012
Abstract Objectives: The aim of this study was to evaluate the clinical value of Kurjak's Antenatal Neurodevelopmental Test (KANET), a new test for fetal neurodevelopment. Methods: One hundred seventeen prenatal neurological tests were performed by the KANET scoring system between 28 and 38 weeks of gestation in 24 low-risk (24 ...
Elmalem Einat - - 2012
We present a fast and efficient in-situ synthetic approach to obtain fully π-conjugated polymers with degrees of polymerization (DP) up to 23 and near quantitative (>95%) hetero-bis-functionalization. The synthesis relies on the key advantages of controlled Suzuki chain-growth polymerization: control over molecular weight (MW), narrow polydispersity (PDI) and the ability ...
do Nascimento Naila C - - 2012
ABSTRACT: Mycoplasma haemocanis is a hemotrophic mycoplasma (hemoplasma), blood pathogen that may cause acute disease in immunosuppressed or splenectomized dogs. The genome of the strain Illinois, isolated from blood of a naturally infected dog, has been entirely sequenced and annotated to gain a better understanding of the biology of M. ...
Tong Seo-Yun - - 2012
PRKCDBP is a putative tumor suppressor located at 11p15.4, where frequent genomic loss has been observed in human cancers. We explored the possible association between an intra-exonic single nucleotide polymorphism (SNP), rs1051992, that results in a Leu to Pro substitution, and risk for endometrial carcinogenesis. We assessed the genotype of ...
French Sarah - - 2012
BACKGROUND: (131) I-metaiodobenzylguanidine (MIBG) produces a 37% response rate in relapsed/refractory neuroblastoma, and could be used to improve remission status prior to myeloablative chemotherapy with autologous stem cell transplant (ASCT). The purpose of our report was to evaluate safety and response with MIBG therapy followed by myeloablative busulfan and melphalan ...
Ferketich Amy K - - 2012
BACKGROUND: The objectives of this study were to evaluate survival among current smokers, former smokers, and never smokers who are diagnosed with non-small cell lung cancer (NSCLC). METHODS: The study included patients who participated in the National Comprehensive Cancer Network's NSCLC Database Project. Current, former, and never smokers were compared ...
Nichols Larry - - 2012
The sudden unexpected death of a hospitalized patient is distressing to the family and the healthcare team. It is also common. Assessment of the causes without autopsy is frequently incorrect. To elucidate the causes of death, 175 cases of adult hospital patients in the University of Pittsburgh Medical Center Health ...
Heilman K M - - 2012
The cerebellum has extensive connections with the frontal lobes. Cerebellar injury has been reported to induce frontal-executive cognitive dysfunction and blunting of affect. We examined a patient with idiopathic cerebellar degeneration with impaired family relationships attributed to an "emotional disconnection." Examination revealed ataxia, dysmetria, and adiadochokinesia more severe on the ...
Zhang Tao - - 2012
A salt and battery: The combination of single-walled carbon nanotubes (SWNTs) and an ionic liquid (IL) cross-linked network gel (CNG) allows the conventional three-phase reactive interface to be expanded to the whole cross-linked network. Thus, it integrates high specific energy and specific power with the feasibility of operating in ambient ...
Xu Pengcheng - - 2012
Noble metal nanoparticles are directly and homogeneously grown onto graphene-oxide (GO) sheets in oleylamine. After the oleylamine is removed, the GO sheets are exfoliated by the nanoparticle pillars to further form hierarchical GO nanostructures with molecule accessible nanopores. With specific sensing-groups modified, the porous-layered nanostructure can be constructed onto resonant ...
Wu Haoxi - - 2012
As a simple and flexible 2D platform, the water-air interface is envisioned as an environmentally-friendly approach to prepare ultrathin free-standing nanomembranes (FNMs) of monolayered nanoparticles of interest via interfacial self-assembly. However, attempts so far have been rather rare due to the lack of efficient methods. In this article, we report ...
Lee J H - - 2012
BACKGROUND: Endoscopic submucosal dissection is gaining popularity in the treatment of early gastric cancer. This study aimed to identify clinicopathological factors predictive of lymph node metastasis in patients with the poorly differentiated early gastric cancer to assess the feasibility of using endoscopic submucosal dissection for these cancers. METHODS: The records ...
Latosińska Jolanta Natalia - - 2012
The application of combined 35Cl-NQR/X-Ray/DFT/QTAIM methods to study the temperature variation of anisotropic displacement parameters and ultra-low frequency modes of anharmonic torsional vibrations in solid state is illustrated on the example of 2,4-dichloro-5-sulfamolybenzoic acid (lasamide, DSBA) which is a diuretic and an intermediate in the synthesis of furosemide and thus ...
Belli S - - 2012
Due to remarkable advances in colloid synthesis techniques, systems of squares and cubes, once an academic abstraction for theorists and simulators, are nowadays an experimental reality. By means of a free minimization of the free-energy functional, we apply fundamental measure theory to analyze the phase behavior of parallel hard squares ...
Aquilina Kristian - - 2012
Object The optimal management of neonatal intraventricular hemorrhage (IVH) and posthemorrhagic ventricular dilation is challenging. The importance of early treatment has been demonstrated in a recent randomized study, involving early ventricular irrigation and drainage, which showed significant cognitive improvement at 2 years. The objective of this study was to define ...
Rykaczewski Konrad - - 2012
Surfaces with special wetting properties can not only efficiently repel or attract liquids like water and oils but can also prevent formation of biofilms, ice, and clathrate hydrates. Predicting the wetting properties of these special surfaces requires detailed knowledge of the composition and geometry of the interfacial region between the ...
Hanson Margaret A - - 2012
Germanium-73 is an extremely challenging nucleus to examine by NMR spectroscopy due to its unfavorable NMR properties. Through the use of an ultrahigh (21.1 T) magnetic field, a systematic study of a series of simple organogermanes was carried out. In those cases for which X-ray structural data were available, correlations were ...
Riesenberg Lee Ann - - 2012
Paracentesis is an invasive procedure known to result in complications. Procedure skills should be taught and evaluated more effectively to improve health care quality. Validated checklists are central to teaching and assessing procedural skills. The results of the first step of the validation of a paracentesis checklist are described. A ...
Zaobornyj Tamara - - 2012
Heart mitochondria play a central role in cell energy provision and in signaling. Nitric oxide (NO) is a free radical with primary regulatory functions in the heart and involved in a broad array of key processes in cardiac metabolism. Specific NO synthase (NOS) isoforms are confined to distinct locations in ...
Choi Sunhwa - - 2012
Brassinosteroids (BRs) are essential for various aspects of plant development. Cellular BR homeostasis is critical for proper growth and development of plants; however, its regulatory mechanism remains largely unknown. BAT1 (BR-related AcylTransferase1), a gene encoding a putative acyltransferase, was found to be involved in vascular bundle development in our full-length ...
Dolgos Michelle R - - 2012
Off the axis: A new lead-free bismuth based perovskite has been formed at ambient pressure in the polar Pmc2(1) structure. Measurements give evidence for ferroelectricity and piezoelectricity. The material is significant due to a rotation of the polarization direction off the [111](p) axis, making it important to the design of ...
Littlewood Trevor D - - 2012
Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.
Cowan Alexander J - - 2012
The efficient use of sunlight to drive the production of solar fuels requires the photogeneration of suitably long-lived charge separated states capable of driving the multi-electron chemistry of fuel synthesis. Here we discuss a range of promising material design approaches to increasing charge carrier lifetimes, focusing upon semiconductor photoelectrodes for ...
Shu Xin - - 2012
High and dry fluorescence: Fluorogenic nanospheres (green, see scheme) are conjugated to DNA (pink) and used to detect target DNA (aqua). Upon addition of N-butylmorpholine (droplet), the nanospheres dissolve, releasing fluorophores, and intense blue fluorescence is emitted at the site of DNA hybridization. The separation of DNA hybridization and signal ...
Tirino Virginia - - 2012
Primary tumors are responsible for 10% of cancer deaths. In most cases, the main cause of mortality is the formation of metastases. Accumulating evidence suggests that a subpopulation of tumor cells with distinct stem-like properties is responsible for tumor initiation, invasive growth, and metastasis formation. This population is defined as ...
Campisi Jay - - 2012
Abstract Having a large social network is generally beneficial to health. However, it is unclear how Internet-based social networks might influence health. Chronic stress can have negative health consequences, and some data suggest that Facebook could be a new source of psychological stress. Thus, we examined undergraduate college student perceptions ...
West John B - - 2012
Extraordinary advances in respiratory physiology occurred between 1941 and 1956 in the Department of Physiology, University of Rochester. These were principally the result of a collaboration between Wallace Fenn, Hermann Rahn and Arthur Otis. Remarkably all three scientists had worked in very dissimilar areas of physiology before and, by their ...
Pinalli Roberta - - 2012
Molecular recognition is a recurrent theme in chemical sensing because of the importance of selectivity for sensor performances. The popularity of molecular recognition in chemical sensing has resulted from the progress made in mastering weak interactions, which has enabled the design of synthetic receptors according to the analyte to be ...
Derrey Stéphane - - 2012
Intracranial bleeding following stereoelectroencephalography (sEEG) is rare and commonly occurs early after electrode implantation. The authors report the case of a delayed intracranial hematoma following sEEG. This 10-year-old boy was referred to the authors' department to undergo an sEEG study for intractable epilepsy, with the hypothesis of a single localized ...
Gellrich Urs - - 2012
The structural integrity and flexibility provided by intermolecular hydrogen bonds leads to the outstanding properties of the 6-diphenylphosphinopyridin-(2H)-1-one ligand in the rhodium-catalyzed hydroformylation of terminal alkenes, as demonstrated by the combination of spectroscopic methods and DFT computations. Hydrogen bonds were also detected in a competent intermediate of the catalytic cycle.
Catalano Sarah Roseann - - 2012
Abstract Two new species of dicyemid parasites from Dicyema are described from 2 species of Australian cephalopods, i.e., Dicyema calamaroceum n. sp. from Sepioteuthis australis Quoy and Gaimard, 1832 (southern calamary) collected from Spencer Gulf (SG) and Gulf St Vincent (GSV), South Australia (SA), Australia and Dicyema pyjamaceum n. sp. ...
Zhou Jing - - 2012
An efficient synthesis of 2,2,6-trisubstituted morpholine is described which involves a multicomponent process by simply mixing epichlorohydrin, N-bromosuccinimide, nosyl amide, and an olefin. The products contain chloride handles which are suitable for further modification.
Cao Lili - - 2012
Rapid and efficient measurement of cancer cells is a major challenge in early cancer diagnosis. In the present study, a miniature multiplex chip was created for in situ detection of cancer cells by implementing a novel graphene oxide (GO)-based Förster resonance energy transfer (FRET) biosensor strategy, i.e. assaying the cell-induced ...
Yamaguchi Takashi - - 2012
The Cancer Control Act of Japan came into effect in 2007. Most physicians, however, have not yet had sufficient opportunity to learn about pain management and other clinical palliative care practices. In an attempt to rectify this situation, the Japanese Society for Palliative Medicine has initiated the Palliative care Emphasis ...
< 10 11 12 13 14 15 16 17 18 19 20 >