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Iwaki Jun - - 2012
Aminoacyl-tRNA synthetases play a key role in the translation of genetic code into correct protein sequences. These enzymes recognize cognate amino acids and tRNAs from noncognate counterparts, and catalyze the formation of aminoacyl-tRNAs. While several tyrosyl-tRNA synthetases (TyrRSs) from various species have been structurally and functionally well characterized, the crenarchaeal ...
Wagner Robert D - - 2012
ABSTRACT: Correction After publication of this article [1], we noticed that the acknowledgement of our funding source was not sufficiently specific. We hereby acknowledge that this research was supported in part by the Food and Drug Administration Office of Women's Health, USA.
Al-Salihi Kareema A - - 2012
Iraq has a long-standing, well-established history of veterinary education, says Kareema Al-Salihi of the College of Veterinary Medicine at Baghdad university. However, it is currently in an 'unenviable' situation, with depleted resources following years of economic sanctions, and a lack of facilities and equipment as a result of financial constraints ...
Boeckx Bram - - 2012
Due to the importance of the structure of amino acids for the folding and functionality of proteins, the conformational behavior of lysine has been investigated. Experimental matrix-isolation FT-IR spectra have been recorded. These spectra were interpreted using an extended theoretical DFT and MP2 study. Theoretically 23 (DFT) and 18 (MP2) ...
Jaiswal Amit - - 2012
We report the use of biopolymer-stabilized ZnS quantum dots (Q-dots) for cation exchange reaction-based easy sensing and removal of heavy metal ions such as Hg2+, Ag+ and Pb2+ in water. Chitosan-stabilized ZnS Q-dots were synthesized in aqueous medium and were observed to have been converted to HgS, Ag2S and PbS ...
- - 2012
A forthcoming symposium brings together medical and veterinary professionals to discuss the problem of antimicrobial resistance. Lord Trees talks to Ayshe Ismail about the thinking behind it.
Ginn J - - 2012
Glutathione-S-transferase enzymes (GSTs) play an important role in the detoxification of environmental carcinogens. Defective GST genotypes are over-represented in human cancers; in particular, low activity GSTT1 genotypes are risk factors for non-Hodgkin lymphoma. We hypothesized that defective GSTT1 genotypes would be associated with lymphoma risk in dogs. To address this, ...
Del Pino-García Raquel - - 2012
Roasting induces chemical changes in coffee beans that strongly affect the antioxidant activity of coffee. In this study, the polyphenol and melanoidin contents and the antioxidant activity of three instant coffees with different roasting degrees (light, medium, dark) were assessed. Coffee brews were separated into fractions and the potential biological ...
Holland Timothy - - 2012
Recently discovered material has yielded new information on the pectoral girdle and fin endoskeleton of Gogonasusandrewsae (Frasnian Gogo Formation, Kimberley Region, Western Australia). These elements permit the first comprehensive description of the anocleithrum, cleithrum, scapulocoracoid, and lepidotrichia. New autapomorphies of Gogonasus include a square exposed region on the supracleithrum, an ...
Nenov Artur - - 2012
A combination of experimental and theoretical techniques is used to study the photoinduced ring-opening/closure of a trifluoromethyl-indolylfulgide. Time resolved UV/Vis pump and IR probe measurements are performed in the sub-picosecond to 50 ps time range. Probing in the mid IR between 1200 cm-1 and 1900 cm-1 provides mode-specific dynamics and ...
Voronov Roman S - - 2012
As the field of tissue engineering develops, researchers are faced with a large number of degrees of freedom regarding the choice of material, architecture, seeding and culturing. In order to evaluate the effectiveness of a tissue engineered strategy, histology is typically done by physically slicing and staining a construct (crude, ...
Mader Reuven - - 2012
Objective. To revise the definition of DISH and suggest a classification that may better represent our current knowledge of this entity allowing earlier diagnosis.Methods. Seven rheumatologists and an orthopaedic surgeon suggested a list of 63 parameters that might be included in a future classification of DISH. Participants rated their level ...
Mutsuzaki Hirotaka - - 2012
ABSTRACT: BACKGROUND: Patients undergoing cementless total knee arthroplasty (TKA) sometimes suffer large blood loss. In a retrospective study, we explored whether postoperative intra-articular retrograde injection of tranexamic acid (TA) and leaving a drain clamp in place for 1 h reduced blood loss.Patients and methodsPatients (n = 140) treated with unilateral ...
Thaler Josef - - 2012
ABSTRACT: BACKGROUND: Integument-related toxicities are common during epidermal growth factor receptor (EGFR)-targeted therapy. Panitumumab is a fully human monoclonal antibody targeting the EGFR that significantly improves progression-free survival when added to chemotherapy in patients with metastatic colorectal cancer who have wild-type (WT) KRAS tumours. Primary efficacy and tolerability results from ...
Langford Gabriel J - - 2012
Abstract Experimental infections and field collected lizards were used to investigate issues of transmission, host specificity, and seasonal occurrence in the nematode Cyrtosomum penneri (Cosmocercoidea: Atractidae). Anolis sagrei (87M : 42F) were captured from the Florida Southern College campus, Polk County, Florida, from October 2010 - September 2011, and 8,803 ...
Jeon Hee Jung - - 2012
We performed retrospective, multi-center study of the impacts of parathyroidectomy (PTX) after or before kidney transplantation on allograft outcomes. A total of 63 patients who underwent PTX after kidney transplantation were identified. Deterioration in eGFR by more than 25% at 1 month after PTX occurred in 20% of the patients. The ...
Wegner Nicholas C - - 2012
For ram-gill ventilators such as tunas and mackerels (family Scombridae) and billfishes (families Istiophoridae, Xiphiidae), fusions binding the gill lamellae and filaments prevent gill deformation by a fast and continuous ventilatory stream. This study examines the gills from 28 scombrid and seven billfish species in order to determine how factors ...
Purenne Emilien - - 2012
OBJECTIVES: Intussusception is the most frequent cause of bowel obstruction in children. Although enema is usually used as the initial treatment, surgery may be required in more than 50% of patients. General anesthesia (GA) has been suggested to increase the rate of enema success. The purpose of this study was ...
Krueger Whitney S - - 2012
Because pigs are susceptible to both avian and human influenza viruses, genetic reassortment between avian, human, and/or swine influenza viruses in the pig host can lead to the generation of novel influenza A viruses (Ma et al. 2009). Since the first serological evidence of a swine influenza virus (SIV) infecting ...
Yamamoto Wataru - - 2012
Abstract Primary mediastinal (thymic) large B-cell lymphoma (PMLBCL) and nodular sclerosis classical Hodgkin lymphoma (NSCHL) are the major histological types of lymphoma affecting the mediastinum. We reviewed 27 patients with PMLBCL and 14 patients with NSCHL. A poor performance status, high serum lactate dehydrogenase level, and strong positivity for PAX5 ...
Bernaert Nathalie - - 2012
Extracts of 31 leek cultivars were analyzed using liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to determine the distribution of the two most abundant S-alk(en)yl-L-cysteine sulfoxides (ACSOs) in leek, i.e., isoalliin and methiin. The isoalliin concentration of the white shaft and green leaves of the 31 leek cultivars varied from 15 to ...
Arnaldo Del Cerro Daniel - - 2012
Droplets are able to levitate when deposited over a hot surface exceeding a critical temperature. This is known as the Leidenfrost effect. This phenomenon occurs when the surface is heated above the so-called Leidenfrost point (LFP), above which the vapor film between the droplet and hot surface is able to ...
Duchateau François-Xavier - - 2012
The study aimed to evaluate the response time (RT) of a French physician-staffed emergency medical service unit in both first-line and second-line service zones a part of its performance and how best to integrate it into its geographical specificity and showed acceptable RTs (mostly <10 min). Interestingly, because of the ...
Zhou Lin - - 2012
Catalytic enantioselective Baeyer-Villiger (BV) oxidations of racemic and meso-cyclic ketones were achieved in the presence of chiral N,N'-dioxide-ScIII complex catalysts. The BV oxidations of both prochiral cyclohexanones and cyclobutanones could afford a series of optically active epsilon- and gamma-lactones in up to 99% yield and 95% ee. Meanwhile, the kinetic ...
Hayashi Hidetoshi - - 2012
OTS11101 is a novel peptide vaccine that acts as an angiogenesis inhibitor by inducing cytotoxic T lymphocyte (CTL) cells that specifically target vascular endothelial cells expressing vascular endothelial growth factor (VEGF) receptor 1. We conducted a phase I study to evaluate the safety, tolerability, maximum tolerated dose, and pharmacodynamic biomarker ...
Miró-Herrans Aida T - - 2012
Humans' ability for rapid dispersal and adaptation has allowed us to colonize diverse geographic and climatic regions of the planet, creating a complex evolutionary history. This complexity can be understood, at least partially, by modeling the underlying demographic parameters in the evolutionary process. In this study, we analyze a model ...
- - 2012
Outbreaks of blackleg in cattle in southern Scotland Johne's disease, ovine pulmonary adenocarcinoma and maedi-visna cause illthrift and mortality in a hill flock Dilated cardiomyopathy confirmed in a 30-month-old Holstein heifer Prevotella melaninogenica associated with scald and footrot in four-month-old lambs Swine influenza diagnosed in 10-week-old pigs These are among ...
Kronborg Hanne - - 2012
BACKGROUND: Obesity is associated with early cessation of breastfeeding. Breastfeeding is multi-factorial, and several factors contribute to this association. Our aim was to investigate to what extent socio-demographic and psychosocial characteristics, parity and prenatal conditions could explain the association between high BMI and early cessation of breastfeeding. METHODS: We used ...
Arnold Robert G - - 2012
Abstract Water shortage arising from rapid population growth and relocation has produced an unprecedented degree of stress on regional water resources. Engineered solutions to relieve water stress are frequently based on the use of water of impaired initial quality. Chief among these impaired waters is reclaimed wastewater. For the most ...
Quercioli Cecilia - - 2012
BACKGROUND: During the 1990s, Italy privatised a significant portion of its healthcare delivery. The authors compared the effectiveness of private and public sector healthcare delivery in reducing avoidable mortality (deaths that should not occur in the presence of effective medical care). METHODS: The authors calculated the average rate of change ...
Lartillot Nicolas - - 2012
According to the nearly-neutral model, variation in long-term effective population size among species should result in correlated variation in the ratio of nonsynonymous over synonymous substitution rates (dN/dS). Previous empirical investigations in mammals have been consistent with this prediction, suggesting an important role for nearly-neutral effects on protein-coding sequence evolution. ...
- - 2012
The subject of firing was aired during a debate at this year's British Equine Veterinary Association congress. Keen to include debates on other controversial issues in future, the association tested the water by inviting Bruce Bladon and Roger Smith to take opposing positions on the topic. BEVA also welcomed its ...
Liu Jing - - 2012
Mitochondrial dynamics is highly involved in muscle atrophy, the slow twitch muscle as soleus, preferentially affected by hindlimb unloading (HU), was well characterized by mitochondrial dysfunction in biogenesis. However, the fast twitch muscles like tibialis anterior (TA) and gastrocnemius (GAS), which are the most massive parts of the hindlimb muscles, ...
Chen Jia-Rong - - 2012
BACKGROUND: De qi is a sensory response elicited by acupuncture stimulation. According to traditional Chinese medicine (TCM), de qi is essential for clinical efficacy. However, the understanding of the neurobiological basis of de qi is still limited. OBJECTIVE: To investigate the relationship between brain activation and de qi by taking ...
Yan Ying - - 2012
Proteasome inhibitors represent a novel class of anticancer agents that are used in the treatment of hematologic malignancies and various solid tumors. However, mechanisms underlying their anticancer actions were not fully understood. It has been reported that strong 14-3-3 protein expression is observed and associated with tumor genesis and progression ...
Nepomnyashchaya Yana N - - 2012
Abstract Rapidly developing next-generation sequencing (NGS) technologies produce a large amount of data across the whole human genome and allow a large number of DNA samples to be analyzed simultaneously. Screening cell-free fetal DNA (cffDNA) obtained from maternal blood using NGS technologies has provided new opportunities for non-invasive prenatal diagnosis ...
Rich P - - 2012
Background:  Interleukin-17A has major proinflammatory activity in psoriatic lesional skin. Objectives:  Assess the efficacy and safety of secukinumab, a fully human IgG1κ monoclonal anti-interleukin-17A antibody, in moderate-to-severe plaque psoriasis in a phase II regimen-finding study. Methods:  404 patients were randomised to subcutaneous placebo (67 patients) or one of three secukinumab ...
Li J-P - - 2012
B*37:04:02 has 1 nt change from B*37:04:01 at nt 618 where G→A (codon 206 GCG→GCA) resulting in no coding change, 206A is not changed.
Lango Moses Oringo - - 2012
Introduction: There is wide variation in the feeding practices of extreme low birth weight (ELBW) preterms often guided by tradition and resources. The feeding regimen at Groote Schuur Hospital (GSH) nursery, a tertiary neonatal unit, follows a restricted use of parenteral nutrition and concentrates on early introduction of breast milk. ...
Wada Takeshi - - 2012
ABSTRACT: INTRODUCTION: Post-cardiac arrest syndrome (PCAS) often leads to multiple organ dysfunction syndrome (MODS) with a poor prognosis. Endothelial and leukocyte activation after whole-body ischemia/reperfusion following resuscitation from cardiac arrest is a critical step in endothelial injury and related organ damage. Angiogenic factors, including vascular endothelial growth factor (VEGF) and ...
Hu Jiongyu - - 2012
ABSTRACT: INTRODUCTION: Proteinuria in burn patients is common, and may be associated with acute kidney injury (AKI) and adverse outcomes. We evaluated the incidences, outcomes, characteristics, and determinants of proteinuria and its influence on AKI and outcomes in burn patients. METHODS: This retrospective study was carried out in a hospital's ...
Muteeb Ghazala - - 2012
One of the important role of Rho-dependent transcription termination in bacteria is to prevent gene expressions from the bacteriophage DNA. The transcription anti-termination systems of the lambdoid phages have been designed to overcome this Rho action. The anti-terminator protein N has three interacting regions, which interact with the mRNA, with ...
Matteoli Gianluca - - 2012
The central nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. Recently, in animal models of sepsis, the vagus nerve (VN) has been proposed to play a crucial role in the regulation of the immune response, also referred to as the cholinergic anti-inflammatory ...
Lin Jack J JJ Department of Neurology, University of California at Irvine, Irvine, CA, - - 2012
Epilepsy is a common neurological disorder that is complicated by psychiatric, cognitive, and social comorbidities that have become a major target of concern and investigation in view of their adverse effect on the course and quality of life. In this report we define the specific psychiatric, cognitive, and social comorbidities ...
van de Pas Niek C A NC The Netherlands Organization for Applied Scientific Research, 3700 AJ Zeist, The - - 2012
Increased plasma cholesterol concentration is associated with increased risk of cardiovascular disease. This study describes the development, validation, and analysis of a physiologically based kinetic (PBK) model for the prediction of plasma cholesterol concentrations in humans. This model was directly adapted from a PBK model for mice by incorporation of ...
Sirvent Audrey A CNRS UMR5237, University of Montpellier 1 and 2, CRBM, 34000 Montpellier, - - 2012
The non-receptor tyrosine kinase SRC is frequently deregulated in human colorectal cancer (CRC), and SRC increased activity has been associated with poor clinical outcomes. In nude mice engrafted with human CRC cells, SRC over-expression favors tumor growth and is accompanied by a robust increase in tyrosine phosphorylation in tumor cells. ...
Newton Charles R CR Muhimbili-Wellcome Programme, Dar-es-Salam, Tanzania. - - 2012
Epilepsy is a common disorder, particularly in poor areas of the world, and can have a devastating effect on people with the disorder and their families. The burden of epilepsy in low-income countries is more than twice that found in high-income countries, probably because the incidence of risk factors is ...
Alizad Azra - - 2012
ABSTRACT: INTRODUCTION: Vibro-acoustography (VA) is a recently developed imaging modality that is sensitive to the dynamic characteristics of tissue. It detects low-frequency harmonic vibrations in tissue that are induced by the radiation force of ultrasound. Here, we have investigated applications of VA for in vivo breast imaging. METHODS: A recently ...
Kim Don-Kyu DK National Creative Research Initiatives Center for Nuclear Receptor Signals, Hormone Research Center, Gwangju, Republic of - - 2013
The hepatic endocannabinoid system and cytochrome P450 2E1 (CYP2E1), a key enzyme causing alcohol-induced reactive oxygen species (ROS) generation, are major contributors to the pathogenesis of alcoholic liver disease. The nuclear hormone receptor oestrogen-related receptor γ (ERRγ) is a constitutively active transcriptional activator regulating gene expression. To investigate the role ...
Descalzo Miguel Á MÁ Research Unit, Sociedad Española de Reumatología, Madrid, - - 2013
To describe the results of different statistical ways of addressing radiographic outcome affected by missing data--multiple imputation technique, inverse probability weights and complete case analysis--using data from an observational study. A random sample of 96 RA patients was selected for a follow-up study in which radiographs of hands and feet ...
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