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Results 601 - 650 of 4411
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Cho Sung Tae - - 2012
OBJECTIVE: To determine the correlation between metabolic syndrome and the distribution of stone components in patients with urolithiasis. METHODS: Between January 2007 and December 2010, renal or ureteral stones were collected from 712 patients (432 males, 280 females) who underwent surgical intervention at three hospitals in South Korea. Metabolic syndrome ...
Winter Georg E GE CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, - - 2012
Occurrence of the BCR-ABL(T315I) gatekeeper mutation is among the most pressing challenges in the therapy of chronic myeloid leukemia (CML). Several BCR-ABL inhibitors have multiple targets and pleiotropic effects that could be exploited for their synergistic potential. Testing combinations of such kinase inhibitors identified a strong synergy between danusertib and ...
Pérez-Ruchel A - - 2012
The effect of yeast addition on intake and digestive utilization of pasture was studied in ovines under restricted time of access to forage. Eighteen wethers housed in metabolic cages and fed fresh forage (predominantly Lotus corniculatus) were randomly assigned to three treatments: forage available all day (AD); forage available only ...
Gavara Núria - - 2012
The atomic force microscope can detect the mechanical fingerprints of normal and diseased cells at the single-cell level under physiological conditions. However, atomic force microscopy studies of cell mechanics are limited by the 'bottom effect' artefact that arises from the stiff substrates used to culture cells. Because cells adhered to ...
Chen Ying-Jia - - 2012
To evaluate the effect of glucose and fructose on the glycation of β-lactoglobulin (β-Lg) in intermediate moisture food (IMF), model systems consisted of β-Lg, glucose/fructose/sorbitol, glycerol and water were established. All systems were stored at 25 and 35 °C for two months. The progress of Maillard reaction and the mass ...
Young J - - 2012
BackgroundPeople with type 1 diabetes may find diabetic control more difficult when working shifts.AimsTo investigate the proportion of people with type 1 diabetes in employment undertaking shift work and diabetic control as assessed by glycosylated haemoglobin (HbA1c) among individuals undertaking shift work compared to those not doing so.MethodsA postal questionnaire ...
Velmurugan Kalpana - - 2012
Glucagon-like peptide-1 (GLP-1)-based therapies are currently available for the treatment of type 2 diabetes, based on their actions on pancreatic β cells. GLP-1 is also known to exert neuroprotective actions. To determine its mechanism of action, we developed a neuron-rich cell culture system by differentiating human neuroprogenitor cells (NPCs) in ...
Simoncini Claudio - - 2012
Moving objects generate motion information at different scales, which are processed in the visual system with a bank of spatiotemporal frequency channels. It is not known how the brain pools this information to reconstruct object speed and whether this pooling is generic or adaptive; that is, dependent on the behavioral ...
Rasmussen Amanda - - 2012
Strigolactones have recently been implicated in both above and below ground developmental pathways in higher plants. To facilitate the molecular and chemical properties of strigolactones in vitro and in vivo, we have developed a fluorescent strigolactone molecule, CISA-1, synthesised via a novel method which was robust, high-yielding and used simple ...
Busch Wolfgang W Department of Biology, Duke University, Durham, North Carolina, - - 2012
To fully describe gene expression dynamics requires the ability to quantitatively capture expression in individual cells over time. Automated systems for acquiring and analyzing real-time images are needed to obtain unbiased data across many samples and conditions. We developed a microfluidics device, the RootArray, in which 64 Arabidopsis thaliana seedlings ...
Aksoy Ezra E Centre for Cell Signaling, Barts Institute of Cancer, Queen Mary, University of London, London, UK. - - 2012
Lipopolysaccharide activates plasma-membrane signaling and endosomal signaling by Toll-like receptor 4 (TLR4) through the TIRAP-MyD88 and TRAM-TRIF adaptor complexes, respectively, but it is unclear how the signaling switch between these cell compartments is coordinated. In dendritic cells, we found that the p110δ isoform of phosphatidylinositol-3-OH kinase (PI(3)K) induced internalization of ...
Chien Pei-Ju - - 2012
Plasmapheresis not only removes circulating antibodies but also modulates cellular immunity, including lymphocyte subsets. To investigate the effect of double-filtration plasmapheresis (DFPP) on the ratio of lymphocyte subsets in patients with myasthenia gravis (MG), we examined the percentages of B-cells, T-cells, T helper (Th) cells, T suppressor (Ts) cells, natural ...
Sandberg Richard L - - 2012
Carrier multiplication (CM) is the process in which absorption of a single photon produces multiple electron-hole pairs. Here, we evaluate the effect of particle shape on CM efficiency by conducting a comparative study of spherical nanocrystal quantum dots (NQDs) and elongated nanorods (NRs) of PbSe using a time-resolved technique that ...
Jin Jin J Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, - - 2012
Immunoglobulin class switching is crucial for the generation of antibody diversity in humoral immunity and, when deregulated, also has severe pathological consequences. How the magnitude of immunoglobulin isotype switching is controlled is still poorly understood. Here we identify the kinase TBK1 as a pivotal negative regulator of class switching to ...
Xu Jianfeng J Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, - - 2012
Prostate cancer risk-associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk-associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this ...
Zhang Rong - - 2012
Tissue-engineered bone provides a promising method for the rehabilitation of acquired bone defects and congenital deformities. However, generating a vascular supply to the engineered graft remains a major challenge. We report a novel strategy to engineer vascularized bone grafts with osteogenic and angiogenic lineage differentiated marrow mesenchymal stem cells (MSCs). ...
Knutson Sarah K - - 2012
EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive H3K27 hypertrimethylation. Here we report the discovery of EPZ005687, a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ005687 has greater than 500-fold selectivity ...
Rothbart Scott B - - 2012
A fundamental challenge in mammalian biology has been the elucidation of mechanisms linking DNA methylation and histone post-translational modifications. Human UHRF1 (ubiquitin-like PHD and RING finger domain-containing 1) has multiple domains that bind chromatin, and it is implicated genetically in the maintenance of DNA methylation. However, molecular mechanisms underlying DNA ...
Dziawa P - - 2012
Topological insulators are a class of quantum materials in which time-reversal symmetry, relativistic effects and an inverted band structure result in the occurrence of electronic metallic states on the surfaces of insulating bulk crystals. These helical states exhibit a Dirac-like energy dispersion across the bulk bandgap, and they are topologically ...
Cheng Han - - 2012
In the present study, we compared the transcriptome profiles of H2O2 treated dark grown Arabidopsis with those grown under the normal light. In total, 2050 and 8540 genes showed altered expression under H2O2 and light treatment respectively, in which 1595 were co-regulated by both H2O2 and light. Among the 1595 ...
Leung Brian B Department of Biology, McGill University, Montreal, Quebec, Canada. - - 2012
Some alien species cause substantial impacts, yet most are innocuous. Given limited resources, forecasting risks from alien species will help prioritise management. Given that risk assessment (RA) approaches vary widely, a synthesis is timely to highlight best practices. We reviewed quantitative and scoring RAs, integrating > 300 publications into arguably the most ...
Minamiyama Makoto - - 2012
Spinal and bulbar muscular atrophy (SBMA) is a motor neuron disease caused by the expansion of the CAG triplet repeat within the androgen receptor (AR) gene. Here, we demonstrated that pathogenic AR upregulates the gene encoding calcitonin gene-related peptide α (CGRP1). In neuronal cells, overexpression of CGRP1 induced cellular damage ...
Doyle Alexander J AJ McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2012
Elevated transforming growth factor (TGF)-β signaling has been implicated in the pathogenesis of syndromic presentations of aortic aneurysm, including Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS). However, the location and character of many of the causal mutations in LDS intuitively imply diminished TGF-β signaling. Taken together, these data have engendered ...
Tabara Y - - 2012
BACKGROUND: A recent genome-wide association study has successfully identified several genetic variations in the Chr17q25 locus as susceptible genotypes for white matter hyperintensities. We report the first replication study in subjects of non-European origin. We also investigated possible associations with other asymptomatic cerebrovascular diseases and cognitive function. METHODS: Study subjects ...
Lee Seung Hoon - - 2012
The extraordinary electronic properties of graphene provided the main thrusts for the rapid advance of graphene electronics. In photonics, the gate-controllable electronic properties of graphene provide a route to efficiently manipulate the interaction of photons with graphene, which has recently sparked keen interest in graphene plasmonics. However, the electro-optic tuning ...
Kitazawa Takehisa - - 2012
Hemophilia A is a bleeding disorder resulting from coagulation factor VIII (FVIII) deficiency. Exogenously provided FVIII effectively reduces bleeding complications in patients with severe hemophilia A. In approximately 30% of such patients, however, the 'foreignness' of the FVIII molecule causes them to develop inhibitory antibodies against FVIII (inhibitors), precluding FVIII ...
Kumar Anil - - 2012
A convenient synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles was achieved using an ionic liquid as a novel soluble support. Ionic liquid-supported sulfonyl hydrazine was synthesized and reacted with a number of ketone and 1,2-diketones to afford the corresponding ionic liquid-supported hydrazones that were converted to 1,2,3-thiadiazoles in the presence of thionyl ...
Gautier Emmanuel L - - 2012
We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively expressed by macrophages rather than dendritic cells, and many of these were not present in all macrophages. Nonetheless, well-characterized ...
GugoĊ‚ek A - - 2012
The aim of this study was to determine whether farming leads to changes in gastrointestinal function and nitrogen metabolism in farmed mink (FA), as compared with their wild-living counterparts. Three digestibility and balance trials were carried out. Experiment I was performed in May, and experiments II and III were conducted ...
Miyake Hideaki - - 2012
Although radical prostatectomy has been the mainstay of treatment for men with clinically organ-confined prostate cancer, a certain proportion of men undergoing radical prostatectomy fail to achieve a complete cure of this disease; that is, postoperative biochemical recurrence develops in approximately 30% of men, some of whom will ultimately die ...
Furt Fabienne - - 2012
Tip growth is essential for land colonization by bryophytes, plant sexual reproduction, and water and nutrient uptake. Because this specialized form of polarized cell growth requires both a dynamic actin cytoskeleton and active secretion, it has been proposed that the F-actin-associated motor myosin XI is essential for this process. Nevertheless, ...
Okoro Chinyere K - - 2012
A highly invasive form of non-typhoidal Salmonella (iNTS) disease has recently been documented in many countries in sub-Saharan Africa. The most common Salmonella enterica serovar causing this disease is Typhimurium (Salmonella Typhimurium). We applied whole-genome sequence-based phylogenetic methods to define the population structure of sub-Saharan African invasive Salmonella Typhimurium isolates ...
Yamane Takashi - - 2012
The MERA monopivot centrifugal pump has been developed for use in open-heart surgery, circulatory support, and bridge-to-decision for up to 4 weeks. The pump has a closed-type, 50-mm diameter impeller with four straight paths. The impeller is supported by a monopivot bearing and is driven by a radial-flux magnet-coupling motor. Because ...
Rossier Olivier O Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR 5297, F-33000 Bordeaux, - - 2012
Integrins in focal adhesions (FAs) mediate adhesion and force transmission to extracellular matrices essential for cell motility, proliferation and differentiation. Different fibronectin-binding integrins, simultaneously present in FAs, perform distinct functions. Yet, how integrin dynamics control biochemical and biomechanical processes in FAs is still elusive. Using single-protein tracking and super-resolution imaging ...
Matteoli Gianluca - - 2012
The central nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. Recently, in animal models of sepsis, the vagus nerve (VN) has been proposed to play a crucial role in the regulation of the immune response, also referred to as the cholinergic anti-inflammatory ...
Jaiswal Amit - - 2012
We report the use of biopolymer-stabilized ZnS quantum dots (Q-dots) for cation exchange reaction-based easy sensing and removal of heavy metal ions such as Hg2+, Ag+ and Pb2+ in water. Chitosan-stabilized ZnS Q-dots were synthesized in aqueous medium and were observed to have been converted to HgS, Ag2S and PbS ...
Muteeb Ghazala - - 2012
One of the important role of Rho-dependent transcription termination in bacteria is to prevent gene expressions from the bacteriophage DNA. The transcription anti-termination systems of the lambdoid phages have been designed to overcome this Rho action. The anti-terminator protein N has three interacting regions, which interact with the mRNA, with ...
Pengelly Steven - - 2012
Aim:  To determine the long term outcomes of patients in whom no initial cause for their anaemia is established. Methods:  639 patients presenting to an iron deficiency anaemia pathway were prospectively entered onto a database. Initial assessment included haematological review, coeliac screen, OGD and colonic imaging as per BSG guidelines. ...
Nepomnyashchaya Yana N - - 2012
Abstract Rapidly developing next-generation sequencing (NGS) technologies produce a large amount of data across the whole human genome and allow a large number of DNA samples to be analyzed simultaneously. Screening cell-free fetal DNA (cffDNA) obtained from maternal blood using NGS technologies has provided new opportunities for non-invasive prenatal diagnosis ...
Rich P - - 2012
Background:  Interleukin-17A has major proinflammatory activity in psoriatic lesional skin. Objectives:  Assess the efficacy and safety of secukinumab, a fully human IgG1κ monoclonal anti-interleukin-17A antibody, in moderate-to-severe plaque psoriasis in a phase II regimen-finding study. Methods:  404 patients were randomised to subcutaneous placebo (67 patients) or one of three secukinumab ...
Chen Jia-Rong - - 2012
BACKGROUND: De qi is a sensory response elicited by acupuncture stimulation. According to traditional Chinese medicine (TCM), de qi is essential for clinical efficacy. However, the understanding of the neurobiological basis of de qi is still limited. OBJECTIVE: To investigate the relationship between brain activation and de qi by taking ...
- - 2012
Outbreaks of blackleg in cattle in southern Scotland Johne's disease, ovine pulmonary adenocarcinoma and maedi-visna cause illthrift and mortality in a hill flock Dilated cardiomyopathy confirmed in a 30-month-old Holstein heifer Prevotella melaninogenica associated with scald and footrot in four-month-old lambs Swine influenza diagnosed in 10-week-old pigs These are among ...
Quercioli Cecilia - - 2012
BACKGROUND: During the 1990s, Italy privatised a significant portion of its healthcare delivery. The authors compared the effectiveness of private and public sector healthcare delivery in reducing avoidable mortality (deaths that should not occur in the presence of effective medical care). METHODS: The authors calculated the average rate of change ...
Lartillot Nicolas - - 2012
According to the nearly-neutral model, variation in long-term effective population size among species should result in correlated variation in the ratio of nonsynonymous over synonymous substitution rates (dN/dS). Previous empirical investigations in mammals have been consistent with this prediction, suggesting an important role for nearly-neutral effects on protein-coding sequence evolution. ...
Langford Gabriel J - - 2012
Abstract Experimental infections and field collected lizards were used to investigate issues of transmission, host specificity, and seasonal occurrence in the nematode Cyrtosomum penneri (Cosmocercoidea: Atractidae). Anolis sagrei (87M : 42F) were captured from the Florida Southern College campus, Polk County, Florida, from October 2010 - September 2011, and 8,803 ...
Kumar Raj - - 2012
Instability of CAG triplet repeat encoding polyglutamine (polyQ) stretches in the gene for target protein has been implicated as a putative mechanism in several inherited neurodegenerative diseases. Expansion of polyQ chain length in the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA) or Kennedy's disease. Although the mechanisms ...
Li J-P - - 2012
B*37:04:02 has 1 nt change from B*37:04:01 at nt 618 where G→A (codon 206 GCG→GCA) resulting in no coding change, 206A is not changed.
Al-Salihi Kareema A - - 2012
Iraq has a long-standing, well-established history of veterinary education, says Kareema Al-Salihi of the College of Veterinary Medicine at Baghdad university. However, it is currently in an 'unenviable' situation, with depleted resources following years of economic sanctions, and a lack of facilities and equipment as a result of financial constraints ...
Boeckx Bram - - 2012
Due to the importance of the structure of amino acids for the folding and functionality of proteins, the conformational behavior of lysine has been investigated. Experimental matrix-isolation FT-IR spectra have been recorded. These spectra were interpreted using an extended theoretical DFT and MP2 study. Theoretically 23 (DFT) and 18 (MP2) ...
Newton Charles R CR Muhimbili-Wellcome Programme, Dar-es-Salam, Tanzania. - - 2012
Epilepsy is a common disorder, particularly in poor areas of the world, and can have a devastating effect on people with the disorder and their families. The burden of epilepsy in low-income countries is more than twice that found in high-income countries, probably because the incidence of risk factors is ...
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