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Young J - - 2012
BackgroundPeople with type 1 diabetes may find diabetic control more difficult when working shifts.AimsTo investigate the proportion of people with type 1 diabetes in employment undertaking shift work and diabetic control as assessed by glycosylated haemoglobin (HbA1c) among individuals undertaking shift work compared to those not doing so.MethodsA postal questionnaire ...
Velmurugan Kalpana - - 2012
Glucagon-like peptide-1 (GLP-1)-based therapies are currently available for the treatment of type 2 diabetes, based on their actions on pancreatic β cells. GLP-1 is also known to exert neuroprotective actions. To determine its mechanism of action, we developed a neuron-rich cell culture system by differentiating human neuroprogenitor cells (NPCs) in ...
Knutson Sarah K - - 2012
EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive H3K27 hypertrimethylation. Here we report the discovery of EPZ005687, a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ005687 has greater than 500-fold selectivity ...
Kumar Anil - - 2012
A convenient synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles was achieved using an ionic liquid as a novel soluble support. Ionic liquid-supported sulfonyl hydrazine was synthesized and reacted with a number of ketone and 1,2-diketones to afford the corresponding ionic liquid-supported hydrazones that were converted to 1,2,3-thiadiazoles in the presence of thionyl ...
Lee Seung Hoon - - 2012
The extraordinary electronic properties of graphene provided the main thrusts for the rapid advance of graphene electronics. In photonics, the gate-controllable electronic properties of graphene provide a route to efficiently manipulate the interaction of photons with graphene, which has recently sparked keen interest in graphene plasmonics. However, the electro-optic tuning ...
Kitazawa Takehisa - - 2012
Hemophilia A is a bleeding disorder resulting from coagulation factor VIII (FVIII) deficiency. Exogenously provided FVIII effectively reduces bleeding complications in patients with severe hemophilia A. In approximately 30% of such patients, however, the 'foreignness' of the FVIII molecule causes them to develop inhibitory antibodies against FVIII (inhibitors), precluding FVIII ...
Hu Qiyue - - 2012
An unprecedented amount of parallel synthesis information was accumulated within Pfizer over the past 12 years. This information was captured by an informatics tool known as PGVL (Pfizer Global Virtual Library). PGVL was used for many aspects of drug discovery including Automated Reactant Mining and reaction product formation to build ...
Gerster Daniel - - 2012
Photosynthesis is used by plants, algae and bacteria to convert solar energy into stable chemical energy. The initial stages of this process-where light is absorbed and energy and electrons are transferred-are mediated by reaction centres composed of chlorophyll and carotenoid complexes. It has been previously shown that single small molecules ...
Pérez-Ruchel A - - 2012
The effect of yeast addition on intake and digestive utilization of pasture was studied in ovines under restricted time of access to forage. Eighteen wethers housed in metabolic cages and fed fresh forage (predominantly Lotus corniculatus) were randomly assigned to three treatments: forage available all day (AD); forage available only ...
Simoncini Claudio - - 2012
Moving objects generate motion information at different scales, which are processed in the visual system with a bank of spatiotemporal frequency channels. It is not known how the brain pools this information to reconstruct object speed and whether this pooling is generic or adaptive; that is, dependent on the behavioral ...
Rasmussen Amanda - - 2012
Strigolactones have recently been implicated in both above and below ground developmental pathways in higher plants. To facilitate the molecular and chemical properties of strigolactones in vitro and in vivo, we have developed a fluorescent strigolactone molecule, CISA-1, synthesised via a novel method which was robust, high-yielding and used simple ...
Irvine William T M - - 2012
Understanding the effect of curvature and topological frustration in crystals yields insights into the fragility of the ordered state. For instance, a one-dimensional crystal of identical charged particles can accommodate an extra particle (interstitial) if all the particle positions are readjusted, yet in a planar hexagonal crystal interstitials remain trapped ...
Cho Sung Tae - - 2012
OBJECTIVE: To determine the correlation between metabolic syndrome and the distribution of stone components in patients with urolithiasis. METHODS: Between January 2007 and December 2010, renal or ureteral stones were collected from 712 patients (432 males, 280 females) who underwent surgical intervention at three hospitals in South Korea. Metabolic syndrome ...
Zhang Rong - - 2012
Tissue-engineered bone provides a promising method for the rehabilitation of acquired bone defects and congenital deformities. However, generating a vascular supply to the engineered graft remains a major challenge. We report a novel strategy to engineer vascularized bone grafts with osteogenic and angiogenic lineage differentiated marrow mesenchymal stem cells (MSCs). ...
Kerstjens Jorien M - - 2012
Aim  The aim of the study was to assess the influence of decreasing gestational age on the risk of developmental delay in various domains at age 4 years among children born at a wide range of gestational ages. Method  In a community-based cohort, the parents of 1439 preterm-born children (24 0/7 ...
Furukawa-Hibi Yoko - - 2012
Neuronal PAS domain 4 (NPAS4), a brain specific helix-loop-helix transcription factor, has recently been shown to regulate the development of GABAergic inhibitory neurons. We previously reported that Npas4 mRNA expression levels were reduced in the hippocampus of mice exposed to social isolation or restraint stress, which was accompanied by impairment ...
Sataranatarajan Kavithalakshmi - - 2012
We explored molecular events associated with aging-induced matrix changes in the kidney. C57BL6 mice were studied in youth, middle age and old age. Albuminuria and serum cystatin C level (an index of glomerular filtration) increased with aging. Renal hypertrophy was evident in middle-aged and old mice and was associated with ...
Halldén C - - 2012
Background: Haemophilia A (HA) has a high level of variation within the disease class with more than 1000 mutations listed in the HAMSTeRS database. At the same time a number of F8 mutations are present in specific populations at high frequencies. Objectives: The simultaneous presence of large numbers of rare ...
Ren Dong - - 2012
The pursuit of modern sustainable chemistry has stimulated the development of innovative catalytic processes that enable chemical transformations to be performed under mild and clean conditions with high efficiency. Herein, we report that gold nanoparticles supported on TiO2 catalyze the chemoselective hydrogenation of functionalized quinolines with H2 under mild reaction ...
Lee Stephanie S - - 2012
The nanoscale boundaries formed when neighboring spherulites impinge in polycrystalline, solution-processed organic semiconductor thin films have been shown to act as bottlenecks to charge transport, significantly reducing organic thin-film transistor (OTFT) mobility in devices comprising spherulitic thin films as the active layers. These interspherulite boundaries (ISBs) are structurally complex, with ...
Dziawa P - - 2012
Topological insulators are a class of quantum materials in which time-reversal symmetry, relativistic effects and an inverted band structure result in the occurrence of electronic metallic states on the surfaces of insulating bulk crystals. These helical states exhibit a Dirac-like energy dispersion across the bulk bandgap, and they are topologically ...
Tabara Y - - 2012
BACKGROUND: A recent genome-wide association study has successfully identified several genetic variations in the Chr17q25 locus as susceptible genotypes for white matter hyperintensities. We report the first replication study in subjects of non-European origin. We also investigated possible associations with other asymptomatic cerebrovascular diseases and cognitive function. METHODS: Study subjects ...
Shiiba Kyoko - - 2012
Abstract Conclusions: The changes in the cochlin isoforms in the perilymph may provide important insights to the understanding of cochlin function and the pathogenesis of related inner ear diseases. Objectives: Cochlin is involved in various pathologies of the inner ear. Altered levels of cochlin isoforms in developing inner ear tissue ...
Li Wei - - 2012
Haploids and double haploids are important resources for studying recessive traits and have large impacts on crop breeding, but natural haploids are rare in animals. Mammalian haploids are restricted to germline cells and are occasionally found in tumours with massive chromosome loss. Recent success in establishing haploid embryonic stem (ES) ...
Brinkmann Gunnar - - 2012
We describe an efficient new algorithm for the generation of fullerenes. Our implementation of this algorithm is more than 3.5 times faster than the previously fastest generator for fullerenes -- fullgen -- and the first program since fullgen to be useful for more than 100 vertices. We also note a ...
Kern Andreas M - - 2012
The enhancement of fluorescence and Raman scattering by plasmonic nanostructures is studied theoretically with special focus on the effects of the observed molecule's properties and the realistic geometry of the plasmonic nanostructure. Numerical experiments show that the enhancement factor may vary by many orders of magnitude depending on a fluorophore's ...
Oh Jihun - - 2012
Silicon nanowire and nanopore arrays promise to reduce manufacturing costs and increase the power conversion efficiency of photovoltaic devices. So far, however, photovoltaic cells based on nanostructured silicon exhibit lower power conversion efficiencies than conventional cells due to the enhanced photocarrier recombination associated with the nanostructures. Here, we identify and ...
Liu Chang C - - 2012
Bacterial regulators of transcriptional elongation are versatile units for building custom genetic switches, as they control the expression of both coding and noncoding RNAs, act on multigene operons and can be predictably tethered into higher-order regulatory functions (a property called composability). Yet the less versatile bacterial regulators of translational initiation ...
Cheng Han - - 2012
In the present study, we compared the transcriptome profiles of H2O2 treated dark grown Arabidopsis with those grown under the normal light. In total, 2050 and 8540 genes showed altered expression under H2O2 and light treatment respectively, in which 1595 were co-regulated by both H2O2 and light. Among the 1595 ...
Minamiyama Makoto - - 2012
Spinal and bulbar muscular atrophy (SBMA) is a motor neuron disease caused by the expansion of the CAG triplet repeat within the androgen receptor (AR) gene. Here, we demonstrated that pathogenic AR upregulates the gene encoding calcitonin gene-related peptide α (CGRP1). In neuronal cells, overexpression of CGRP1 induced cellular damage ...
Chien Pei-Ju - - 2012
Plasmapheresis not only removes circulating antibodies but also modulates cellular immunity, including lymphocyte subsets. To investigate the effect of double-filtration plasmapheresis (DFPP) on the ratio of lymphocyte subsets in patients with myasthenia gravis (MG), we examined the percentages of B-cells, T-cells, T helper (Th) cells, T suppressor (Ts) cells, natural ...
Rebora Paola - - 2012
In some exceptional circumstances, as in very rare diseases, nonrandomized one-arm trials are the sole source of evidence to demonstrate efficacy and safety of a new treatment. The design of such studies needs a sound methodological approach in order to provide reliable information, and the determination of the appropriate sample ...
Zhang H H - - 2012
The effect of different dietary protein levels and DL-methionine (Met) supplementation on hair growth and the resulting pelt quality in mink was studied. Four groups of male mink were fed with four isocaloric diets containing 32% (P32), 24% (P24), 16% (P16) or P24+Met (0.8%) crude protein of dry matter (DM) ...
Ding Jihua - - 2012
Photoperiod-sensitive male sterility (PSMS) is a valuable germplasm for hybrid rice breeding. Recently, we cloned pms3, a locus controlling PSMS, which encodes a long non-coding RNA called LDMAR required for normal male fertility of the rice plant under long-day conditions. Increased methylation in the promoter of LDMAR in the PSMS ...
Osmialowski Borys - - 2012
Intermolecular interactions of ten 2-acylamino and 2,4-bis(acylamino)pyrimidines (from which seven are previously unknown) have been investigated by X-ray structural, quantum chemical (DFT), and NMR spectral methods. Especially the concentration dependencies of the 1H NMR chemical shifts and titrations with other molecules capable for multiple hydrogen bonding provided useful information regarding ...
O'Malley A James - - 2012
The catalyst for this paper is the recent interest in the relationship between social networks and an individual's health, which has arisen following a series of papers by Nicholas Christakis and James Fowler on person- to-person spread of health behaviors. In this issue, they provide a detailed explanation of their ...
Ruhl Laura Suzanne - - 2012
The combustion of coal to generate electricity produces about 130 million tons of Coal Combustion Residues (CCRs) each year in the United States; yet their environmental implications are not well constrained. This study systematically documents the quality of effluents discharged from CCR settling ponds or cooling water at ten sites ...
Zahid M - - 2012
The treatment of acute coronary syndromes has been considerably improved in recent years with the introduction of highly efficient antiplatelet drugs. However, there are still significant limitations: the recurrence of adverse vascular events remains a problem and the improvement in efficacy is counterbalanced by an increased risk of bleeding of ...
Agostinelli S - - 2012
BACKGROUND AND PURPOSES: To determine the prevalence of SLC2A1 mutations in children with early-onset absence epilepsy (EOAE) and to investigate whether there were differences in demographic and electroclinical data between patients who became seizure-free with anti-epileptic drug (AED) monotherapy (group I) and those who needed add-on treatment of a second ...
Singh Manoj K - - 2012
Rho GTPase modifying bacterial protein toxins are useful for analysis of Rho signalling in animal cells, but these toxins cannot be taken up by plant cells. We demonstrate in vitro deamidation of Arabidopsis Rop4 by Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) and glucosylation by Clostridium difficile toxin B. Expression ...
Xu Huiping - - 2012
Medical cost data are typically highly skewed to the right with a large proportion of zero costs. It is also common for these data to be censored because of incomplete follow-up and death. In the case of censoring due to death, it is important to consider the potential dependence between ...
Ohsawa Shizue - - 2012
Mitochondrial respiratory function is frequently impaired in human cancers. However, the mechanisms by which mitochondrial dysfunction contributes to tumour progression remain elusive. Here we show in Drosophila imaginal epithelium that defects in mitochondrial function potently induce tumour progression of surrounding tissue in conjunction with oncogenic Ras. Our data show that ...
Furt Fabienne - - 2012
Tip growth is essential for land colonization by bryophytes, plant sexual reproduction, and water and nutrient uptake. Because this specialized form of polarized cell growth requires both a dynamic actin cytoskeleton and active secretion, it has been proposed that the F-actin-associated motor myosin XI is essential for this process. Nevertheless, ...
Yamane Takashi - - 2012
The MERA monopivot centrifugal pump has been developed for use in open-heart surgery, circulatory support, and bridge-to-decision for up to 4 weeks. The pump has a closed-type, 50-mm diameter impeller with four straight paths. The impeller is supported by a monopivot bearing and is driven by a radial-flux magnet-coupling motor. Because ...
GugoĊ‚ek A - - 2012
The aim of this study was to determine whether farming leads to changes in gastrointestinal function and nitrogen metabolism in farmed mink (FA), as compared with their wild-living counterparts. Three digestibility and balance trials were carried out. Experiment I was performed in May, and experiments II and III were conducted ...
Miyake Hideaki - - 2012
Although radical prostatectomy has been the mainstay of treatment for men with clinically organ-confined prostate cancer, a certain proportion of men undergoing radical prostatectomy fail to achieve a complete cure of this disease; that is, postoperative biochemical recurrence develops in approximately 30% of men, some of whom will ultimately die ...
Kida Toshiyuki - - 2012
Isotactic poly(methyl methacrylate) (it-PMMA)/syndiotactic poly(methacrylic acid) (st-PMAA) stereocomplex hollow capsules were fabricated by the deposition of stereocomplex films of it-PMMA and st-PMAA on silica particles by alternate Layer-by-Layer assembly and the subsequent removal of the silica particles with aqueous HF. The selective extraction of st-PMAA from the it-PMMA/st-PMAA stereocomplex capsule ...
Chae Ho Byoung - - 2012
Genevestigator analysis indicated heat shock induction of transcripts for NADPH-thioredoxin reductase, type C (NTRC) in the light. Here we show overexpression of NTRC in Arabidopsis (NTRCOE) resulting in enhanced tolerance to heat shock, whereas NTRC knockout mutant plants (ntrc1) exhibit a temperature sensitive phenotype. To investigate the underlying mechanism of ...
Loeffen R - - 2012
Background: Thrombin generation assays are sensitive methods to assess the overall clotting potential of plasma and despite their common use in thrombosis research, standardization of pre-analytical conditions is missing. In order to setup a standardized protocol, we analyzed different pre-analytical variables and validated the Calibrated Automated Thrombogram method. Methods and ...
Farago Marganit - - 2012
Although most genes are expressed biallelically, a number of key genomic sites-including immune and olfactory receptor regions-are controlled monoallelically in a stochastic manner, with some cells expressing the maternal allele and others the paternal allele in the target tissue. Very little is known about how this phenomenon is regulated and ...
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