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Results 351 - 400 of 2840
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Kanimozhi Catherine - - 2012
In this communication, we report the synthesis of a novel diketopyrrolopyrrole-diketopyrrolopyrrole (DPP-DPP) based conjugated copolymer and its application in high mobility organic field-effect transistors. Copolymerization of DPP with DPP yields a copolymer with exceptional properties such as extended absorption characteristics (up to ~1100 nm) and field-effect electron mobility values of ...
Li Shanshan - - 2012
Objective. This article reviews panel studies of air pollution on children's respiratory health and proposes future research directions. Methods. The PubMed electronic database was used to search published original epidemiological studies in peer-reviewed journals from 2000 to November 2011. Children's age was limited to ≤18 years old. A total of ...
Gao Xiang - - 2012
With the discovery of several matrices which enable the ionization of DNA and RNA, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become a powerful platform for the study of nucleic acid sequence changes (e.g., mutations, single nucleotide polymorphisms (SNPs), insertion/deletion, alternative splicing, etc.), amount changes (e.g., copy number variation, gene ...
Zizzi A - - 2012
BACKGROUND AND OBJECTIVE: The accumulation of advanced glycation end-products (AGEs) seems to play an important role in the development of diabetes mellitus (DM)-associated periodontitis; however, some aspects of this issue are still scarcely known, such as the expression of AGEs in type 1 DM-associated periodontitis and the clinical factors able ...
Nielsen T H - - 2012
BACKGROUND: In patients with traumatic brain injury as well as stroke, impaired cerebral oxidative energy metabolism may be an important factor contributing to the ultimate degree of tissue damage. We hypothesize that mitochondrial dysfunction can be diagnosed bedside by comparing the simultaneous changes in brain tissue oxygen tension (PbtO(2) ) ...
Arao Kenshiro - - 2013
Various factors associated with worsening heart failure (HF) events have been investigated in HF subjects. The purpose of this study was to identify the predictive factor(s) for worsening HF events after cardiac resynchronization therapy (CRT) among baseline parameters, as well as baseline factors associated with responsiveness or non-responsiveness to CRT. ...
Fourcade Aurélie - - 2012
Because of increasing breast cancer incidence and improvement in long-term prognosis, follow-up of patients cannot be carried out entirely in specialized cancer centres. The Réseau Gynécomed was created to transfer the follow-up of patients to primary care physicians (PCP). In 2009, to evaluate the quality of PCP follow-up, a satisfaction ...
Choi Hye-Ryung - - 2012
The peptide Gly-His-Lys (GHK) is a naturally occurring copper(II)-chelating motifs in human serum and cerebrospinal fluid. In industry, GHK (with or without copper) is used to make hair and skin care products. Copper-GHK plays a physiological role in the process of wound healing and tissue repair by stimulating collagen synthesis ...
Lyle Mitchell - - 2012
The water cycle in the western United States changed dramatically over glacial cycles. In the past 20,000 years, higher precipitation caused desert lakes to form which have since dried out. Higher glacial precipitation has been hypothesized to result from a southward shift of Pacific winter storm tracks. We compared Pacific ...
Hu Yongxing - - 2012
By securing charged polymer ligands on the surface of superparamagnetic colloids with a layer of porous silica, a strong electrostatic interparticle repulsion with long-term stability can be established to balance the magnetically induced attraction and create 1D periodic chains that show magnetically responsive diffraction in the visible spectrum.
Girard Jean-Philippe - - 2012
In search of foreign antigens, lymphocytes recirculate from the blood, through lymph nodes, into lymphatics and back to the blood. Dendritic cells also migrate to lymph nodes for optimal interaction with lymphocytes. This continuous trafficking of immune cells into and out of lymph nodes is essential for immune surveillance of ...
Stack Steven - - 2012
This article provides the first quantitative review of the literature on music and suicidality. Multivariate logistic regression techniques are applied to 90 findings from 21 studies. Investigations employing ecological data on suicide completions are 19.2 times more apt than other studies to report a link between music and suicide. More ...
Tjellström Bo - - 2012
Abstract Objective. Exclusive enteral nutrition (EEN) is a first-line treatment in children with active Crohn's disease (CD) but is seldom used in adults with active disease. The mode of action of EEN in suppressing mucosal inflammation is not fully understood, but modulation of intestinal microflora activity is one possible explanation. ...
Lüttge U - - 2012
This essay juxtaposes modularity and emergence in the consideration of biological systems at various scalar levels of spatio-temporal organisation. It is noted that reductionism, specialisation and modularity are basic prerequisites for understanding life. It is realised that increased progress of scientific biology in elucidating mechanisms at the level of modular ...
Moskowitz Chaya S - - 2012
  Medical imaging tests of breast cancer patients can be used to detect and provide information on the location of multiple malignant lesions within a patient. Within this context, it is often the case that one needs to evaluate the accuracy of an imaging test for finding the multiple lesions ...
Low Teck Yew - - 2012
Ubiquitin (Ub) is a small protein modifier that is covalently attached to the ε-amino group of lysine residues of protein substrates, generally targeting them for degradation. Due to the emergence of specific anti-diglycine (-GG) antibodies and the improvement in mass spectrometry, it is now possible to identify more than 10,000 ...
Senovilla Laura - - 2012
Cancer cells accommodate multiple genetic and epigenetic alterations that initially activate intrinsic (cell-autonomous) and extrinsic (immune-mediated) oncosuppressive mechanisms. Only once these barriers to oncogenesis have been overcome can malignant growth proceed unrestrained. Tetraploidization can contribute to oncogenesis because hyperploid cells are genomically unstable. We report that hyperploid cancer cells become ...
Maric Marija - - 2012
Background: Cognitive-behavioural therapy (CBT) has proven to be effective for anxiety-based school refusal, but it is still unknown how CBT for school refusal works, or through which mechanisms. Aims: Innovative statistical approaches for analyzing small uncontrolled samples were used to investigate the role of self-efficacy in mediating CBT outcomes for ...
Lee Yong Sang - - 2012
BACKGROUND: The aims of this study were to assess the clinicopathologic features of patients with chyle leakage following thyroid cancer surgery without lateral neck dissection and to evaluate the factors associated with chyle leakage. METHODS: Of 3137 patients who underwent thyroid surgery between January 2006 and December 2007, 2314 patients ...
Alidori Simone - - 2012
The terminal rhenium(I) phosphaethynolate complex [Re(PCO)(CO)(2) (triphos)] has been prepared in a salt metathesis reaction from Na(OCP) and [Re(OTf)(CO)(2) (triphos)]. The analogous isocyanato complex [Re(NCO)(CO)(2) (triphos)] has been likewise prepared for comparison. The structure of both complexes was elucidated by X-ray diffraction studies. While the isocyanato complex is linear, the ...
Skoumas Ioannis - - 2013
Familial combined hyperlipidemia (FCH) is an inherited lipid disorder associated with premature cardiovascular disease. It has not been established whether the cardiometabolic risk factors, which frequently accompany FCH, such as diabetes, metabolic syndrome (MetS) and hypertension, modulate cardiovascular risk in FCH patients. In this single-center, retrospective study, 695 FCH patients ...
Jevnikar Zala - - 2012
Podosomes, specialized actin-rich structures in macrophages, degrade the extracellular matrix (ECM) and are involved in cell migration. On two-dimensional surfaces macrophages form spot-like podosomes at the ventral cell surface that develop into protrusive structures in a three-dimensional (3D) environment resembling the ECM. We have shown that the tips of these ...
Jambrina P G - - 2012
Quantum mechanical (QM) and quasiclassical trajectory (QCT) calculations have been carried out for the exchange reactions of D and Mu (Mu = muonium) with hydrogen molecules in their ground and first vibrational states. In all the cases considered, the QM rate coefficients, k(T), are in very good agreement with the ...
Jee Kowan Ja - - 2012
Mucoepidermoid carcinoma is the most common salivary gland malignancy, and includes a spectrum of lesions ranging from non-aggressive low-grade tumors to aggressive high-grade tumors. To further characterize this heterogeneous group of tumors we have performed a comprehensive analysis of copy number alterations and CRTC1-MAML2 fusion status in a series of ...
Joshi Deepak - - 2012
We are reporting the use of three-dimensional transesophageal echocardiography as a supplement to two-dimensional transesophageal echocardiography in the percutaneous suture closure of the left atrial appendage.
Di Noto Vito - - 2012
An extensive morphological and structural study of two bimetallic "core-shell" carbon nitride nano-electrocatalysts with active sites based on Pt and Ni or on Pt and Fe is reported. The core-shell electrocatalysts are obtained by the pyrolysis of a precursor obtained by decorating a support composed of conducting particles with a ...
Morel Lucero Noguera LN DermatologyPathologyMicrobiology Services, Hospital Universitario La Paz, Madrid, - - 2013
Members of the genus Fusarium are ubiquitous filamentous fungi that can cause disease in immunocompromised patients. We present a case in which the resistance to conventional antifungal therapies led to a fatal outcome.
Testi M - - 2012
HLA-A*03:143 has one nucleotide change from A*03:01: 01:01 at nt 406 from G to C, resulting in an amino acid change at codon 112 of exon 3 from Gly to Arg.
Amit Moran - - 2012
BACKGROUND: We investigated the risk of neck metastases in patients undergoing salvage total laryngectomy in association with previous radiotherapy. METHODS: The medical records of 42 patients (51 neck specimens) with clinical N0 classification who underwent salvage total laryngectomy in 2 cancer centers were reviewed. Fourteen patients had previous radiotherapy to ...
Wrighton Kelly C - - 2012
BD1-5, OP11, and OD1 bacteria have been widely detected in anaerobic environments, but their metabolisms remain unclear owing to lack of cultivated representatives and minimal genomic sampling. We uncovered metabolic characteristics for members of these phyla, and a new lineage, PER, via cultivation-independent recovery of 49 partial to near-complete genomes ...
Kathawala Mustafa Hussain - - 2012
The rising production of nanomaterial-based consumer products has raised safety concerns. Testing these with animal and other direct models is neither ethically nor economically viable, nor quick enough. This review aims to discuss the strength of in vitro testing, including the use of 2D and 3D cultures, stem cells, and ...
Cushion Chris - - 2012
Abstract Coaches are central to talent development in youth soccer and what they say and do impacts on players' achievements and well-being. Researchers have systematically observed coach behaviour and practice activities within this setting (i.e. 'what coaches do'). We review this research in light of contemporary discussion that highlights a ...
Karamitopoulou Eva - - 2012
Although tumor budding is linked to adverse prognosis in colorectal cancer, it remains largely unreported in daily diagnostic work due to the absence of a standardized scoring method. Our aim was to assess the inter-observer agreement of a novel 10-high-power-fields method for assessment of tumor budding at the invasive front ...
Verhoef T I - - 2012
Anticoagulant treatment with phenprocoumon is challenging because of the narrow therapeutic range and the wide inter- and intra-patient variability in dose response. Frequent monitoring of the international normalized ratio (INR) is therefore required. Polymorphisms in two genes, CYP2C9 and VKORC1 explain approximately one third of the variation in dose requirements ...
Dang-Nguyen Thanh Quang TQ Department of Animal Breeding and Reproduction, NARO Institute of Livestock and Grassland Science, Ibaraki 305-0901, Japan. - - 2013
Telomere is a nucleoprotein structure at the ends of chromosomes that helps to protect the ends of chromosomes from being fused with other chromosomes. Knockout of histone methyltransferases Suv39h1 and Suv39h2 increases the telomere length in murine cells, whereas downregulation of SUV39H1 and SUV39H2 genes decreases the telomere length in ...
Garbutcheon-Singh K Benjamin - - 2012
Twelve metallointercalators of the type [Pt(I(L))(A(L))](2+), where A(L) is either the R,R or S,S enantiomer of 1,2-diaminocyclopentane (DACP) and I(L) is either 1,10-phenathroline, 4-methyl-1,10-phenanthroline, 5-methyl-1,10-phenanthroline, 4,7-dimethyl-1,10-phenanthroline, 5,6-dimethyl-1,10-phenanthroline or 3,4,7,8-tetramethyl-1,10-phenanthroline, were synthesised, characterised and the cytotoxicity to the L1210 cell line was determined. The crystal structures of PHENRRDACP and PHENSS were ...
England Matt W MW Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, - - 2012
A template-directed method for the synthesis and organization of partially oxidized polypyrrole (PPy) nanoscale arrays within the solvent channels of glutaraldehyde-cross-linked lysozyme single crystals is presented. Macroscopic single crystals of the periodically arranged protein-polymer superstructure are electrically conductive, insoluble in water and organic solvents, and display increased levels of mechanical ...
Cunningham Alexander - - 2012
A new design to synthesize thiol-responsive degradable polylactide (PLA)-based micelles having a disulfide linkage in the middle of triblock copolymers is reported. They were synthesized by a new method that centers on the use of a disulfide-labeled diol as an initiator for ring-opening polymerization, followed by controlled radical polymerization. These ...
Khodakovskaya Mariya V - - 2012
Multi-walled carbon nanotubes (CNTs) can affect plant phenotype and the composition of soil microbiota. Tomato plants grown in soil supplemented with CNTs produce two times more flowers and fruit compared to plants grown in control soil. The effect of carbon nanotubes on microbial community of CNT-treated soil is determined by ...
Matsubara Yohei - - 2012
Substitution therapy of glucocorticoid is a major part of the treatment for 21-OHD (21-hydroxylase deficiency). However, the therapy causes two major adverse effects, impairment of linear growth and obesity, so that collecting precise growth data is essential for optimizing the therapy. We longitudinally evaluated the linear growth and the body ...
Ahmed Shaimaa M - - 2012
We report the first account of a comparative analysis of the binding affinities of nine FDA approved drugs against subtype B as well as the South African subtype C HIV PR (C-SA). A standardised protocol was used to generate the inhibitor/C-Sa PR complexes with the relative positions of the inhibitors ...
Murphy Elizabeth - - 2012
Background: Nonattendance rates remain high for first therapy appointments, despite initiatives to increase access to psychological therapy. The reasons for nonattendance are poorly understood and studies of demographic and clinical predictors have produced conflicting findings. Aims: We aimed to pilot a method for investigating psychological factors associated with first appointment ...
Gessmann Renate - - 2012
The atomic resolution structures of samarosporin I have been determined at 100 and 293 K. This is the first crystal structure of a natural 15-residue peptaibol. The amino acid sequence in samarosporin I is identical to emerimicin IV and stilbellin I. Samarosporin is a peptide antibiotic produced by the ascomycetous fungus ...
Zhu Gaohua - - 2012
A facile soap-free miniemulsion polymerization of methyl methacrylate (MMA) was successfully carried out via a reverse ATRP technique, using a water-soluble potassium persulfate (KPS) or 2,2'-azobis(2-methylpropionamidine) dihydrochloride (V-50) both as the initiator and the stabilizer, and using an oil-soluble N,N-n-butyldithiocarbamate copper (Cu(S(2) CN(C(4) H(9) )(2) )(2) ) as the catalyst ...
Hoff Philipp von den - - 2012
Optimal control theory and optimal control experiments are state-of-the-art tools to control quantum systems. Both methods have been demonstrated successfully for numerous applications in molecular physics, chemistry and biology. Modulated light pulses could be realized, driving these various control processes. Next to the control efficiency, a key issue is the ...
George Trevor W - - 2012
Epidemiological studies indicate that diets rich in fruits and vegetables (F&V) are protective against CVD. Puréed F&V products retain many beneficial components, including flavonoids, carotenoids, vitamin C and dietary fibres. The present study aimed to establish the physiological effects of acute ingestion of a F&V purée-based drink (FVPD) on vasodilation, ...
Kobayashi Kayo - - 2012
We established three lines of transgenic medaka, a heat-shock element (HSE) monitor line (hse-GFP line), heat-inducible driver lines (hse-cre lines), and effector lines (gapdh-loxP[DsRed]-GFP lines). We employed these to comprehensively analyze gene induction at different time points in various tissues. These analyses demonstrate a good response of synthetic HSEs by ...
Matsuzawa Shingo - - 2012
BACKGROUND: Epithelioid hemangioendotheliomas (EHEs) of the head and neck region are uncommon malignant neoplasms that exhibit various biologic behaviors characteristic of both low- and high-grade malignancy. A subgroup of EHEs identified as "high-risk" EHEs because of their size and mitotic activity is associated with an unfavorable clinical course and poor ...
Khobta Nataliya - - 2012
β-HCG belongs to the glycoprotein hormone family and is usually assess to exclude pregnancy for patients potentially eligible to chemotherapy, especially during clinical trials. We studied non-small-cell lung cancer (NSCLC) patients that were found with elevated serum β-HCG level during clinical trial screening. The first case is a 45-year-old woman ...
Gutman R - - 2012
The estimation of causal effects has been the subject of extensive research. In unconfounded studies with a dichotomous outcome, Y, Cangul, Chretien, Gutman and Rubin (2009) demonstrated that logistic regression for a scalar continuous covariate X is generally statistically invalid for testing null treatment effects when the distributions of X ...
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