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Lee Hae Ung - - 2012
Astrocytes, a major subtype of glia, interact with neurons as a supportive partner supplying energy sources and growth factors. Astrocytes regulate the activity of neighboring neurons by releasing chemical transmitters (gliotransmitters). However, the precise role of gilotransmitters in regulating neuronal activity is still under debate. Here, we report that a ...
Mazzotta Francesco - - 2012
One of the primary advantages of nanoscale sensors is that they often can provide conceptually new ways of performing sensing that are not feasible with their large-scale analogs. For example, the small size of nanoscale sensor elements, such as plasmonic metal nanoparticles, allows them to be combined with nanofluidic systems. ...
Ge Zhaofeng - - 2012
This study was conducted to develop a method for the simultaneous separation and detection of antimonite (Sb(III)), antimonate (Sb(V)) and trimethyl antinmony (TMSb) species in soils, using ultrasonic-aided citric acid extraction and high-performance liquid chromatography-inductively coupled plasma-mass spectrometry separation and detection. The extractions were performed using various chemical solutions. The ...
Henkelis James J - - 2012
Pyridyl functionalized host molecules are oxidized to their N-oxide analogues and form a series of coordination polymers and discrete complexes with transition metal cations. Complex {[Ag(3)(NMP)(6)(L1)(2)]·3(ClO(4))}(∞) where L1 = tris(isonicotinoyl-N-oxide)cyclotriguaiacylene, NMP = N-methylpyrrolidone, is a three-dimensional (3-D) 3,6-connected coordination polymer of pyrite-like (pyr) topology and features ligand unsupported argentophilic interactions, ...
Reddy Alavala Matta - - 2012
A 61-year-old male patient with atherosclerotic critical limb ischemia in the left leg underwent stent insertion into the left superficial femoral artery. Stenting procedures improved Rutherford grade from III-5 to II-4. Granulocyte colony-stimulating factor stimulated the production of white blood cells over four-fold and mononuclear cells (MNCs) 1.5-fold in the ...
Yamaguchi Hiroaki - - 2012
A column-switching liquid chromatography/electrospray ionization tandem mass spectrometry to determine paclitaxel and its metabolites, 6α-hydroxypaclitaxel and p-3'-hydroxypaclitaxel, in human plasma was developed. The analytical system had a Shim-Pack MAYI-ODS (10 × 4.6 mm i.d.) trapping column with deproteinization ability that concentrates analytes and removes water-soluble components. This method covered a linearity range of ...
Radtke Kendra K - - 2012
N-acetyl-l-cysteine (NAC), a well-known antioxidant, has been successfully used as adjuvant therapy for late-stage childhood cerebral adrenoleukodystrophy (c-ALD); however, the mechanisms of NAC action are poorly understood. Previous research indicates that NAC serves as a precursor to l-cysteine (Cys), the rate-limiting substrate in the biosynthesis of glutathione (GSH), a potent, ...
Emes Richard D - - 2012
Antiepileptic drugs (AEDs) can lower maternal folate and increase maternal homocysteine levels, which are known to affect the methyl cycle and hence DNA methylation levels. The influence of in utero exposure to AEDs on fetal DNA methylation was investigated. Genome-wide fetal epigenomic profiles were determined using the Infinium 27K BeadArray ...
Geerts Margot - - 2012
Objective.  To improve the care of patients with painful diabetic polyneuropathy (PDP) by a specialized outpatient clinic for individuals referred by general practitioners and to determine the effects on pain, quality of life, and patient satisfaction. Material and Methods.  One hundred twenty-one patients were prospectively enrolled. At baseline and after ...
Kirwan Matthew L - - 2012
About half of annual marine carbon burial takes place in shallow water ecosystems where geomorphic and ecological stability is driven by interactions between the flow of water, vegetation growth and sediment transport. Although the sensitivity of terrestrial and deep marine carbon pools to climate change has been studied for decades, ...
Törnquist Agneta - - 2012
Scand J Caring Sci; 2012 In search of legitimacy - Registered Nurses' experience of providing palliative care in a municipal context Background:  The palliative care approach was originally developed for hospice care and for persons with cancer diseases, but has gradually expanded to embrace other contexts and people of all ...
Gualtierotti Jean-Baptiste - - 2012
Mild and general alumina-promoted hydrolysis conditions for converting α-iminonitriles into carboxamides have been developed. In combination with the oxidative three-component Strecker reaction, the one-pot direct amidation of aldehydes and alcohols is reported. Subsequently, an Yb(OTf)(3) -catalyzed Michael addition of thiols to α,β-unsaturated α-iminonitriles is reported for the synthesis of β-mercapto-α-iminonitriles. ...
Funk Georg-Christian - - 2012
The epidemiology of chronic obstructive pulmonary disease (COPD) in critically ill patients is largely unknown. The aims of the study were (1) to determine whether COPD either as cause of intensive care unit (ICU) admission or as co-morbid condition is an independent risk factor for increased morbidity and mortality; and ...
Morrill Kira - - 2012
Abstract Objectives: Silver has historically and extensively been used as a broad-spectrum antimicrobial agent. However, the Food and Drug Administration currently does not recognize colloidal silver as a safe and effective antimicrobial agent. The goal of this study was to further evaluate the antimicrobial efficacy of colloidal silver. Design: Several ...
Freel E Marie - - 2012
BACKGROUND: -Primary Aldosteronism (PA) is common and associates with excess cardiovascular morbidity independent of blood pressure. Exposure to aldosterone and sodium leads to cardiac fibrosis and hypertrophy in humans and animals possibly mediated by inflammation and oxidative stress. We aimed to clarify the effects of aldosterone excess on myocardial structure ...
Bonardelli Stefano - - 2012
The crossover femoro-femoral bypass, classically used for the treatment of unilateral iliac arterial obstruction, has recently become an integral part of aorto-uni-iliac endovascular aneurysm repair. We therefore, reconsider the therapeutic problems related to thrombosis and in particular to infection of the femoro-femoral prosthesis, when many attempts have been made to ...
Brightwell Alexandra - - 2012
Competency based training describes progression through training referenced to the demonstrated ability to perform certain tasks. In recent years, this has become the dominant curriculum model. We seek to examine who benefits from a competency based approach to medical education. For the regulators and service, the apparent advantage is in ...
Zekry Attia Tamer - - 2012
The investigation of cytochrome P450 (CYP) mediated metabolism reactions by determination of enzyme kinetic parameters, Michaelis constant (K(m)), maximum reaction velocity (V(max)), and intrinsic clearance (CL(int)) is important aspects in discovery and development of drugs. The kinetic parameters can be used to predict the clearance prior to human administration and ...
Walker A P - - 2012
There have been few testicular histology reports of adult patients with congenital adrenal hypoplasia/hypogonadal hypogonadism (AHC/HH), but Leydig cell hyperplasia has been observed, an indicator of the possibility of malignant transformation. We aimed to define the basis of AHC/HH in 4 pedigrees of different ethnic backgrounds. One patient was elected ...
Fratelli Nicola - - 2012
Objective. To compare perinatal outcomes of late small-for-gestational age (SGA, birthweight <10th percentile) infants, according to antenatal recognition. Design: Retrospective study. Setting: Tertiary referral centre. Population: All singleton pregnancies with SGA (birthweight <10th percentile) infants born ≥ 36 weeks' gestation from January 2007 to April 2009. Methods: Chart review of ...
Pokrajac Lisa - - 2012
The bacterial toxin pyolysin (PLO) belongs to the family of cholesterol-dependent cytolysins (CDCs), which form large, ring-shaped oligomeric pores in cholesterol-containing membranes. Monomeric CDC molecules have a structure of four domains, with domains 2 and 3 packed against each other. After binding to target membranes containing cholesterol, toxin monomers oligomerize ...
Shin Ji-Ae - - 2012
In several human malignancies, overexpression of myeloid cell leukemia-1 (Mcl-1) confers resistance to induction of apoptosis; however, Mcl-1-mediated inhibition of apoptosis in oral squamous cell carcinoma (OSCC) is not fully understood and has been investigated in this study. The Mcl-1 promoter activators, 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) enhanced ...
Hakemi Monir Sadat - - 2012
Background: Associations between patient survival and baseline urine volume (UV), ultrafiltration (UF) volume, and combined UV and UF were evaluated in Iranian continuous ambulatory peritoneal dialysis (CAPD) patients. Methods: From 1995 to 2006, data on 1472 CAPD patients from 26 centers were collected. Demographic, clinical, and laboratory characteristics were analyzed ...
Mace John H - - 2012
Involuntary memory chains are spontaneous recollections of the past that occur as a sequence of associated memories. This memory phenomenon has provided some insights into the nature of associations in autobiographical memory. For example, it has shown that conceptually associated memories (memories sharing similar content, such as the same people ...
Hussman Jm - - 2012
Abstract Objective: To review and summarize the literature concerning the cost-effectiveness of palivizumab compared to no prophylaxis in infants and young children with congenital heart disease (CHD). Methods: A systematic literature search (MEDLINE to March 2012, limited to English language) identified studies that examined the cost effectiveness of palivizumab in ...
Böttcher Artur - - 2012
Molecular oxygen etching of HOPG surfaces prepatterned by Ga(+) focused-ion-beam irradiation (FIB) has been used to generate large-area arrays of nanometer-sized graphite blocks. AFM and SEM imaging show that structures with lateral sizes down to ∼100 nm and heights of between 30 and 55 nm can be routinely fabricated. The trenches separating ...
Ruff Christian M - - 2012
The complexation of Cm(iii) and Eu(iii) with 2,6-bis(5,6-di(sulfophenyl)-1,2,4-triazin-3-yl)pyridine (aq-BTP) is studied in water at pH 3.0 applying time-resolved laser fluorescence spectroscopy. With increasing ligand concentration [M(H(2)O)(9-3n)(aq-BTP)(n)] (M = Cm(iii)/Eu(iii), n = 1, 2, 3) complex species are spectroscopically identified. The conditional stability constants of the M(iii) 1 : 3 complex species with ...
Sopha Pattarawut - - 2012
Misfolded proteins in the endoplasmic reticulum (ER) are dislocated out of the ER to the cytosol, polyubiquitinated, and degraded by the ubiquitin-proteasome system in a process collectively termed ER-associated degradation (ERAD). Recent studies have established that a mammalian ER-localized transmembrane J-protein, DNAJB12, cooperate with Hsc70, a cytosolic Hsp70 family member, ...
Zhang Yanfeng - - 2012
An efficient three-component reaction toward the facile synthesis of structurally diverse 1-carboxamido-isoindoles has been developed. The resultant isoindoles can be used in Diels-Alder reactions.
Patai Eva Zita - - 2012
In everyday situations, we often rely on our memories to find what we are looking for in our cluttered environment. Recently, we developed a new experimental paradigm to investigate how long-term memory (LTM) can guide attention and showed how the pre-exposure to a complex scene in which a target location ...
Buettner Katherine M - - 2012
Ascorbic acid is among the biorelevant ligands that render Ti(IV) stable in aqueous solution. A series of pH-dependent titanium(IV) coordination complexes of l-ascorbic acid is described. Directed by spectropotentiometric methods, important aspects of the aqueous interactions in this system are investigated, including ligand binding mode, pH-dependent metal-ligand stoichiometry, and the ...
Soh Nerissa - - 2012
OBJECTIVES: This study aimed to qualitatively explore medical students' reasons for suspending, or thinking of suspending, their studies and the types of support services they request. METHOD: Data were collected through an anonymous online survey. Medical students' responses to open-ended questions were analyzed thematically. RESULTS: Responses were received from 475 ...
Deksne Gunita - - 2012
Abstract We sampled 339 fecal samples, 296 intestines, and 82 lungs from 371 lynx hunted during the 2010-2011 season in Finland. The fecal samples were analyzed for endoparasites by a quantitative flotation method and helminths from intestines were studied morphologically, while lungs were investigated for pulmonary parasites. From fecal samples, ...
Maher Mohammad Ahmed - - 2012
Objective. To assess efficacy and tolerability of vaginal compared to intramuscular progesterone in reducing the rate of recurrent preterm birth before 34 weeks gestation. Design. Prospective randomized study. Setting. Obstetrics and Gynecology Department, Armed Forces Hospital Southern Region, Kingdom of Saudi Arabia. Sample. Five-hundred and eighteen patients with a prior ...
Do Ngoc Quang - - 2012
Guanine-rich sequence motifs, which contain tracts of three consecutive guanines connected by single non-guanine nucleotides, are abundant in the human genome and can form a robust G-quadruplex structure with high stability. Herein, by using NMR spectroscopy, we investigate the equilibrium between monomeric and 5'-5' stacked dimeric propeller-type G-quadruplexes that are ...
Monajemi Hadieh - - 2012
Finding a proper transition structure for the peptide bond formation process can lead one to a better understanding of the role of ribosome in catalyzing this reaction. Using computer simulations, we performed the potential energy surface scan on the ester bond dissociation of P-site aminoacyl-tRNA and the peptide bond formation ...
Yoo Jejoong - - 2012
The concept of "ion atmosphere" is prevalent in both theoretical and experimental studies of nucleic acid systems, yet the spatial arrangement and the composition of ions in this at- mosphere remain elusive, in particular when several ionic species (e.g., Na+, K+, and Mg2+) compete to neutralize the charge of a ...
Mancini Flavia - - 2012
Multisensory interactions can produce analgesic effects. In particular, viewing one's own body reduces pain levels, perhaps because of changes in connectivity between visual areas specialized for body representation, and sensory areas underlying pain perception. We tested the causal role of the extrastriate visual cortex in triggering visually induced analgesia by ...
Laurent Gabriel - - 2012
AIMS: Our group has recently shown that in some patients, heart failure with preserved ejection fraction (HFPEF) may be explained by 'atrial dyssynchrony syndrome' (ADS) due to interatrial conduction delay (IACD), a short left atrioventricular interval (LAVI), and increased left atrial (LA) stiffness. Our primary objective was to evaluate LA ...
Ivashkin Pavel - - 2012
New chiral fluorinated reagents (N-(dibromofluoroacetyl)oxazolidinones) were easily synthesized and used in an asymmetric cyclopropanation process. The Michael initiated ring closure reaction provided chiral cyclopropanes bearing a fluorinated quaternary stereocenter. Various electron-deficient alkenes can be used to efficiently obtain chiral polysubtituted fluorinated cyclopropanes in good yields. Moderate to very good cis/trans ...
Yuen Tsz-Ying - - 2012
A highly convergent total synthesis of 7',8'-dihydroaigialospirol is described. Key steps of the synthesis include a Nozaki-Hiyama-Kishi (NHK) coupling of an iodoalkyne with an advanced phthalide-aldehyde and a remarkable one-pot acid-mediated global deprotection/spiroacetalization.
Gründer Cordula - - 2012
Immunotherapy with innate immune cells has recently evoked broad interest as a novel treatment option for cancer patients. γ9δ2T-cells in particular are emerging as an innate cell population with high frequency and strong anti-tumor reactivity, which makes γ9δ2T-cells and their receptors promising candidates for immune-interventions. However, clinical trials have so ...
Farias de Novaes Juliana - - 2012
This cross-sectional study aimed to: (i) investigate whether obesity and overweight defined according to body mass index (BMI) are good predictors of body fat excess, abdominal adiposity and hypertension in 769 Brazilian children aged 6-11 years, (ii) assess the relationship between overweight/obesity and cardiovascular risk factors. Overweight and obesity were ...
Kedia George T - - 2012
What's known on the subject? and What does the study add? A previous study by Lexander et al. in 2005, using two-dimensional gel electrophoresis, demonstrated the expression of arginase type II in the different anatomical regions of the prostate; however, to date, no study has addressed, using an in vitro approach, ...
Gajjar Trushar - - 2012
Abstract  Supravalvar aortic stenosis is characterized by an obstruction of the left ventricular outflow tract distal to the aortic valve. Its association with left main coronary artery stenosis is well known but right coronary artery involvement has not been reported. We describe two cases of supravalvar aortic stenosis with coronary ...
Frumento G - - 2012
Adoptive T cell therapy can be effective for Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disease and melanoma. Transducing high-affinity TCR genes into T lymphocytes is an emerging method to improve potency and specificity of tumor-specific T cells. However, both methods necessitate in vitro lymphocyte proliferation, generating highly differentiated effector cells that ...
Hauge Christian R - - 2012
ABSTRACT: BACKGROUND: Multiple chemical sensitivity (MCS) is a condition characterized by recurrent, self-reported symptoms from multiple organ systems, attributable to exposure to a wide range of chemically unrelated substances at low levels. The pathophysiology is unknown, and there are currently no evidence-based treatments for MCS. Nevertheless, there is a substantial ...
Bhatt Beenu - - 2012
A series of C3-O-functionalized 2-acetamido-2-deoxy-Δ4-β-D-glucuronides were synthesized to explore non-charge interactions in subsite 2 of the influenza virus sialidase active site. In complex with A/N8 sialidase the parent compound (C3 OH) inverts its solution conformation to bind with all substituents well positioned in the active site. The parent compound inhibits ...
Wu Shang-Gin - - 2012
In the era of targeted therapy, the association between lung adenocarcinoma patient survival and malignant pleural effusion (MPE) remains unclear. This study investigated the clinical characteristics, survival, and epidermal growth factor receptor (EGFR) mutation status of lung adenocarcinoma patients with MPE.During June 2005 to December 2010, consecutive pleural effusions were ...
Deftereos Spyridon - - 2012
Objectives: Soluble tumor necrosis factor-related apoptosis inducing ligand (sTRAIL) has been shown to exert protective action against atherosclerosis. The aim of this study was to investigate potential associations of coronary sTRAIL levels with indices of in-stent neointimal hyperplasia. Methods: 67 patients who underwent percutaneous coronary intervention with drug-eluting stent were ...
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