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Kymre Ingjerd G - - 2012
BACKGROUND: Consequences of separation between preterm newborns and their parents have been discussed in many aspects, thus skin-to-skin care (SSC) has become common practice in Scandinavian Neonatal Intensive Care Units (NICUs) since the 1980s. The International workshop on Kangaroo Mother Care (KMC), 2009, recommends implementation of continuous KMC as the ...
Yu Shasha - - 2012
Going ber(zirc): Zirconium-butadiyne complexes react with acyl cyanide derivatives through diverse reaction pathways. The complexes react with two molecules of carbamoyl cyanide to form 1,4-benzodiazepin-2-one-derivatives containing azazirconacycles. Reactions with either aroyl cyanides or alkyl cyanoformates lead to azazirconacyclopentenes containing a quaternary carbon center.
Chen Dehong - - 2012
A complex titania nanostructure of monodisperse spiky mesoporous anatase beads composed of anatase nanocrystals with diameters of less than 15 nm in the core and much larger hollow-cone shaped spikes on the surface was fabricated using a facile solvothermal process in the presence of ammonia. This proceeded through a controllable phase ...
Lee Min Hee - - 2012
We synthesized a new probe, Mito-Naph, to visualize mitochondrial Trx activity in cells. A fluorescence off-on change is induced by disulfide cleavage of the probe, resulting from a reaction with Trx and subsequent intramolecular cyclization by the released thiolate to give a fluorescent product. By measuring the fluorescence at 540 ...
Wilson Robert - - 2012
This phase II, randomised, double-blind, multicentre study (NCT00930982) investigated the safety and efficacy of ciprofloxacin dry powder for inhalation (DPI) in patients with non-cystic fibrosis bronchiectasis.Adults who were culture positive for pre-defined potential respiratory pathogens (including Pseudomonas aeruginosa and Haemophilus influenzae) were randomised to ciprofloxacin DPI 32.5 ;mg or placebo ...
Cure S - - 2012
Abstract BACKGROUND & AIMS: To indirectly compare the efficacy of telaprevir (TVR) and boceprevir (BOC) combined with peginterferon/ribavirin α-2a/2b (PR) in achieving sustained viral response (SVR) in treatment-naïve and treatment-experienced patients with genotype 1 chronic hepatitis C virus (HCV) infection. METHODS: A systematic literature review was conducted to identify randomized ...
Bernhard J J IBCSG Coordinating Center, Bern, Switzerland. - - 2013
The purpose was to investigate patient-doctor agreement on clinical trial discussion cross-culturally. In the International Breast Cancer Study Group Trial 33-03 on shared decision-making for early breast cancer in Australian/New Zealand (ANZ) and Swiss/German/Austrian (SGA) centers, doctor and patient characteristics plus doctor stress and burnout were assessed. Within 2 weeks ...
Raino Gabriele - - 2012
Exciton dynamics within the band-edge state manifold of CdSe/ZnS and CdSe/CdS quantum dots (QDs) have been investigated. Low-temperature time-resolved photoluminescence (PL) experiments demonstrate that exciton relaxation is mediated by LO phonons, whereas an acoustic phonon bottleneck has been observed for splitting energies lower than the optical phonon energy. This has ...
Wei Wei - - 2012
Quantities can be represented using either mathematical language (i.e., numbers) or natural language (i.e., quantifiers). Previous studies have shown that numerical processing elicits greater activation in the brain regions around the intraparietal sulcus (IPS) relative to other semantic processes. However, little research has been conducted to investigate whether the IPS ...
Kirwan Matthew L - - 2012
About half of annual marine carbon burial takes place in shallow water ecosystems where geomorphic and ecological stability is driven by interactions between the flow of water, vegetation growth and sediment transport. Although the sensitivity of terrestrial and deep marine carbon pools to climate change has been studied for decades, ...
Törnquist Agneta - - 2012
Scand J Caring Sci; 2012 In search of legitimacy - Registered Nurses' experience of providing palliative care in a municipal context Background:  The palliative care approach was originally developed for hospice care and for persons with cancer diseases, but has gradually expanded to embrace other contexts and people of all ...
Gualtierotti Jean-Baptiste - - 2012
Mild and general alumina-promoted hydrolysis conditions for converting α-iminonitriles into carboxamides have been developed. In combination with the oxidative three-component Strecker reaction, the one-pot direct amidation of aldehydes and alcohols is reported. Subsequently, an Yb(OTf)(3) -catalyzed Michael addition of thiols to α,β-unsaturated α-iminonitriles is reported for the synthesis of β-mercapto-α-iminonitriles. ...
Akulian J A JA Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2013
The maintenance of CMV-specific T cell memory in lung transplant recipients (LTRs) is critical for host defense and allograft durability, particularly in donor(+) /recipient(-) (D(+) R(-) ) individuals who demonstrate increased mortality. We studied CD4(+) and CD8(+) CMV-specific memory responses to phosphoprotein 65 (pp65) in a prospective cohort of 18 ...
Green Nathaniel M NM Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, - - 2012
The key step in the activation of autoreactive B cells is the internalization of nucleic acid containing ligands and delivery of these ligands to the Toll-like Receptor (TLR) containing endolysosomal compartment. Ribonucleoproteins represent a large fraction of autoantigens in systemic autoimmune diseases. Here we demonstrate that many uridine-rich mammalian RNA ...
Funk Georg-Christian - - 2012
The epidemiology of chronic obstructive pulmonary disease (COPD) in critically ill patients is largely unknown. The aims of the study were (1) to determine whether COPD either as cause of intensive care unit (ICU) admission or as co-morbid condition is an independent risk factor for increased morbidity and mortality; and ...
Morrill Kira - - 2012
Abstract Objectives: Silver has historically and extensively been used as a broad-spectrum antimicrobial agent. However, the Food and Drug Administration currently does not recognize colloidal silver as a safe and effective antimicrobial agent. The goal of this study was to further evaluate the antimicrobial efficacy of colloidal silver. Design: Several ...
Cutler Michael J - - 2012
Recently, we reported that sarcoplasmic reticulum Ca(2+) ATPase 2a (SERCA2a), the pump responsible for reuptake of cytosolic calcium during diastole, plays a central role in the molecular mechanism of cardiac alternans. Heart failure (HF) is associated with impaired myocardial calcium handling, deficient SERCA2a, and increased susceptibility to cardiac alternans. Therefore, ...
Freel E Marie - - 2012
BACKGROUND: -Primary Aldosteronism (PA) is common and associates with excess cardiovascular morbidity independent of blood pressure. Exposure to aldosterone and sodium leads to cardiac fibrosis and hypertrophy in humans and animals possibly mediated by inflammation and oxidative stress. We aimed to clarify the effects of aldosterone excess on myocardial structure ...
- - 2012
The Department of Veterans Affairs (VA) is taking direct final action to amend its regulations concerning per diem payments to State homes for the provision of nursing home care to veterans. Specifically, this rule removes the requirement that a veteran must have resided in a State home for 30 consecutive ...
Machan Charles W - - 2012
Herein, we report the one-pot synthesis of Fe(II) bis-terpyridine complexes with two peripheral square planar Pt(II) bis-phosphinoalkylthioether moieties. These novel structures, which exhibit allosterically controllable electronic properties, are made by taking advantage of two orthogonal and high-yielding reactions. The prototypical complex can be structurally regulated through the reversible abstraction and ...
Golub Alla A - - 2012
Recent research has shed light on the cost-effective contribution that agriculture can make to global greenhouse gas abatement; however, the resulting impacts on agricultural production, producer livelihoods, and food security remain largely unexplored. This paper provides an integrated assessment of the linkages between land-based climate policies, development, and food security, ...
Tang Bor Luen - - 2012
Cytokinesis, the last major step of cell division, is a complex multistage process involving specific rearrangement of cellular cytoskeleton and a flurry of vesicular transport activities at the cell division plane. Vesicular traffic from the exocytic pathway and the endocytic/recycling pathway, operating again after being shut down since prophase, are ...
Dolcetti Alessia - - 2012
Purpose:Rare, recurrent chromosome 1q21.1 duplications have been associated with developmental delay, congenital anomalies, and macrocephaly in children. Data on adult clinical expression would help to inform genetic counseling.Methods:A systematic review of 22 studies reporting 107 individuals (59 children and 48 adults) with 1q21.1 duplications was conducted. We compiled the available ...
Horne Steven D - - 2012
The archetype driving the drug targeting approach to cancer therapy is the success of imatinib against chronic phase chronic myeloid leukemia (CML-CP). Molecular targeting success of this magnitude has yet to be repeated for most solid tumors. To answer why imatinib remains an exception of cancer research, we summarize key ...
Bergh Christina - - 2012
SUMMARY QUESTION: Is vaginal progesterone gel equivalent to vaginal micronized progesterone tablets concerning ongoing pregnancy rate and superior concerning patient convenience when used for luteal support after IVF/ICSI? Equivalence of treatments in terms of ongoing live intrauterine pregnancy rate has not been demonstrated; the 95% confidence interval (CI) for the ...
Sevrioukova Irina F IF Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA. - - 2013
Cytochromes P450 (CYPs) represent a diverse group of heme-thiolate proteins found in almost all organisms. CYPs share a common protein fold but differ in substrate selectivity and catalyze a wide variety of monooxygenation reactions via activation of molecular oxygen. Among 57 human P450s, the 3A4 isoform (CYP3A4) is the most ...
Goel Sarika - - 2012
The synthesis protocols for encapsulation of metal clusters reported here expand the diversity in catalytic chemistries made possible by the ability of microporous solids to select reactants, transition states, and products based on their molecular size. We report a synthesis strategy for the encapsulation of noble metals and their oxides ...
Loridon Karine - - 2012
Extensive genomic resources are available in the model legume Medicago truncatula. Here, we present the discovery and design of the first array of single-nucleotide polymorphism (SNP) markers in M. truncatula through large-scale Sanger resequencing of genomic fragments spanning the genome, in a diverse panel of 16 M. truncatula accessions. Both anonymous fragments ...
Chowdhury Indranil - - 2012
In this study, a systematic approach has been followed to investigate the fate and transport of single walled carbon nanotubes (SWCNTs) from synthesis to environmentally relevant conditions. Three widely used SWCNT synthesis methods have been investigated in this study including high pressure carbon monoxide (HiPco), SWeNT CoMoCat, and electric arc ...
Noonan Kevin Joseph Taaffe - - 2012
A tetra(dialkylamino)phosphonium cation was evaluated as a functional group for alkaline anion exchange membranes (AAEMs). The base stability of [P(N(Me)Cy)4]+ was directly compared to that of [BnNMe3]+ in 1 M NaOD/CD3OD. The high base stability of [P(N(Me)Cy)4]+ relative to [BnNMe3]+ inspired the preparation of AAEM materials composed of phosphonium units ...
Braunschweig Holger - - 2012
Herein, we report the synthesis of boroles that are linked by a conjugated phenylene spacer. The characterization of these compounds was completed by NMR and UV/Vis spectroscopy, as well as X-ray crystal diffraction. Furthermore, the coordination behavior of these oligoboroles towards five electronically and sterically disparate pyridine derivatives was studied ...
Tan-Wong Sue Mei - - 2012
Eukaryotic genomes are extensively transcribed, forming both messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). ncRNAs made by RNA polymerase II often initiate from bidirectional promoters (nucleosome-depleted chromatin) that synthesize mRNA and ncRNA in opposite directions. We demonstrate that, by adopting a gene-loop conformation, actively transcribed mRNA encoding genes restrict divergent ...
Nemerovski Carrie W - - 2012
Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests that aspirin may ...
Carmel Ido - - 2012
MicroRNAs (miRNAs) are short, single-stranded RNAs that silence gene expression by either degrading mRNA or repressing translation. Each miRNA regulates a specific set of mRNA "targets" by binding to complementary sequences in their 3' untranslated region. In this study, we examined the importance of the base-pairing strength of the miRNA-target ...
Imura Yoshiro - - 2012
We report the synthesis of two-dimensional (2D) dendritic Au nanowires (DNWs) with diameters of 100-200 nm in an aqueous solution of long-chain amidoamine derivative (C18AA), which acted as both capping and reducing agents, and the preparation of large 2D DNWs with diameters of 400-700 nm by seeded growth of the ...
Murphy Eileen F EF Alimentary Health Ltd., Cork, - - 2013
Obesity is associated with a number of serious health consequences, including type 2 diabetes, cardiovascular disease and a variety of cancers among others and has been repeatedly shown to be associated with a higher risk of mortality. The relatively recent discovery that the composition and metabolic activity of the gut ...
Jin Kai - - 2012
Carbon nanotube (CNT) probes offer improved imaging resolution in atomic force microscopy (AFM) and nanomanipulating devices due to their excellent mechanical properties and high aspect ratios. The basis of ascertaining scanning image quality using CNT probes is often centered on whether axial buckling has occurred or not. Here we explore ...
Ananthan Subramaniam - - 2012
In the search for opioid ligands with mixed functional activity, a series of 5'-(4-chlorophenyl)-4,5α-epoxypyridomorphinans possessing alkoxy or acyloxy groups at C-14 was synthesized and evaluated. In this series, the affinity and functional activity of the ligands were found to be influenced by the nature of the substituent at C-14 as ...
Li Xianchan - - 2012
This study demonstrates a facile yet effective electrochemical method to investigate the conformational flexibility of laccase active sites based on sensitive determination of copper ions (Cu2+) dissociated from laccase from Trametes versicolor with the cysteine-modified Au electrodes. In the native state, the multi-copper active sites are deeply buried in the ...
Ugarte Giorgia D - - 2012
Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls the expression of several sensory ...
Zhang Jie - - 2012
This paper presents a theoretical study of electrochemical affinity biosensors for the detection of DNA/protein that utilize nanoparticle labels for signal amplification. This study analyzes the effects of binding and mass transport of the analytes on biosensor performance by using numerical simulations. Four cases were considered: 1) nanoparticles used to increase ...
Pagac Martin - - 2012
All glycerophospholipids are made from phosphatidic acid, which, according to the traditional view, is generated at the cytosolic surface of the ER. In yeast, phosphatidic acid is synthesized de novo by two acyl-CoA dependent acylation reactions. The first is catalyzed by one of the two homologous glycerol-3-phosphate acyltransferases Gpt2p/Gat1p and ...
Yoon Ji Young - - 2012
PURPOSE: We aimed to compare clinical features and computed tomography (CT) findings of pulmonary tuberculosis (TB) in lower lobe basal segments and upper lobe apical or apicoposterior segments. MATERIALS AND METHODS: We retrospectively reviewed medical records and chest CT scans of 986 adults who were diagnosed with active pulmonary TB. ...
Cui Guanghui - - 2012
Controllable growth of newly born silver nanoparticles to fractal, cauliflower-like, microscale disks and continuous silver layers with high conductivity and reflectivity on plastic substrates has been developed via solid-liquid interfacial reduction and growing of ion-doped polymeric films. Such approaches involve polyimide (PI) films as substrates, its corresponding silver-ion-doped precursors as ...
Hinrichs Maike H - - 2012
Current models for the intracellular transport of Tau protein suggest motor protein-dependent co-transport with microtubule fragments and diffusion of Tau in the cytoplasm, whereas Tau is believed to be stationary while bound to microtubules and in equilibrium with free diffusion in the cytosol. Observations that members of the microtubule-dependent kinesin ...
Rideg Nóra Abrankó - - 2012
Molecular dynamics simulations of the adsorption layer of five different surfactant molecules, i.e., pentyl alcohol, octyl alcohol, dodecyl alcohol, sodium dodecyl sulfate and dodecyl trimethyl ammonium chloride are performed at the free surface of their aqueous solution at two surface densities, namely 1 and 4 μmol/m2 at 298 K. The ...
Phillips Ryan D - - 2012
A leading hypothesis for the immense diversity of the Orchidaceae is that skewed mating success and small, disjunct populations lead to strong genetic drift and switches between adaptive peaks. This mechanism is only possible under conditions of low gene flow that lead to high genetic differentiation among populations. We tested ...
Maheshwari Rajesh - - 2012
OBJECTIVE: Indian-Australians represent a distinct immigrant group both demographically and culturally. Yet, despite an expanding body of research on transcultural mental health in Australia, there is a paucity of studies regarding mental health of Indian-Australians. This paper explores the extent of psychological morbidity and related service use in a representative ...
Paronis Carol A CA Department of Pharmaceutical Sciences, Northeastern University, Mailstop 206, 140TF 360 Huntington Avenue, Boston, MA 02115, USA. - - 2013
In vivo effects of cannabinoid (CB) agonists are often assessed using four well-established measures: locomotor activity, hypothermia, cataleptic-like effects, and analgesia. The present studies demonstrate that doses of CB agonists that produce these effects also reliably increase diuresis. Diuretic effects of several CB agonists were measured in female rats over ...
Zhang Zhi-Jiang - - 2012
BACKGROUND: Oxidative stress may play an aetiological role in the development and progression of cardiovascular disease (CVD). However, evidence on its biochemical markers has been controversial. This article aimed to assess the role of F(2)-isoprostanes as a biomarker for CVD, including coronary artery disease, stroke and peripheral artery disease. METHODS: ...
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