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Muharemagic Darija - - 2012
Oncolytic viruses are promising therapeutics that can selectively replicate in and kill tumour cells. However, repetitive administration of viruses provokes the generation of neutralizing antibodies (nAbs) that can diminish their anticancer effect. In this work, we selected DNA aptamers against the antigen binding fragment (Fab) of anti-vesicular stomatitis virus polyclonal ...
Shimura Misato - - 2012
Although interleukin-6 (IL-6) is an important biological mediator playing an indispensable role in inflammation and cancer, few inhibitors and suppressors are known. In the present study, the underlying mechanisms of a novel chemically synthesized compound SK-1009, which has suppressive properties on IL-6 production in human macrophage cells, were examined. SK-1009 ...
Zhang Cuimiao - - 2012
Luminescent materials have found a wide variety of applications, including information displays, lighting, X-ray intensification and scintillation, and so on. Therefore, much effort has been devoted to exploring novel luminescent materials so far. In the past decade, defect-related luminescent materials have inspired intensive research efforts in their own right. This ...
Haange Sven-Bastiaan - - 2012
The digestion of food ingredients depends on the action of the gut microbiota and has a significant influence on the health, especially in case of metabolic diseases of the host organism. Despite the relevance of the structure and functionalities in the microbiota for the metabolism of the host the spatial ...
Valverde Alexander - - 2012
Objectives  To compare the effects of sedative doses of acepromazine, xylazine or xylazine/ketamine administered to horses after isoflurane anesthesia on the quality of recovery and anesthesia recovery times. To determine if recovery scores improve after repeated consecutive anesthetic episodes. Study design  Prospective, randomized, crossover study. Animals  Fifteen adult research horses, ...
King Brian A - - 2012
OBJECTIVE: Exposure to secondhand smoke (SHS) from burning tobacco products causes disease and premature death among non-smoking adults and children. The objective of this study was to determine the nature, extent and demographic correlates of SHS exposure among adults in low- and middle-income countries with a high burden of tobacco ...
Conroy Pauline C - - 2012
Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a wide range of human diseases. Centrosomes are the principal microtubule-organizing centers of animal cells and contain ...
Margreiter M - - 2012
The impact of vesicoureteral reflux (VUR) on renal allograft outcomes is debatable, with small cohort studies reporting controversial results. The objective of this retrospective study was to evaluate long-term clinical effects of early VUR in a large cohort of kidney transplant patients. Posttransplantation voiding cystourethrography was used to evaluate 646 ...
Vijayalakshmi I B - - 2012
Introduction:  Transcatheter closure of patent ductus arteriosus (PDA) has replaced surgery in most institutions. Despite improvements in techniques and the devices available, closure of large PDA in very small infants remains a challenge. Aim : To assess the challenges, feasibility, and efficacy of device closure of large PDA, in infants ...
Miyazawa Kenji - - 2012
The murine macrophage-like cell line J774.1 was treated with heat-killed cells of Lactobacillus GG (LGG) and L. gasseri TMC0356 (TMC 0356). Interleukin (IL)-6, IL-12, and tumor necrosis factor-α were profiled from the J774.1 cells using enzyme-linked immunoSorbent assay methods. The conditioned medium from cultured J774.1 cells was transferred to the ...
McCarron Jesse A - - 2012
BACKGROUND:Ten to seventy percent of rotator cuff repairs form a recurrent defect after surgery. The relationship between retraction of the repaired tendon and formation of a recurrent defect is not well defined.Purpose/ HYPOTHESES:To measure the prevalence, timing, and magnitude of tendon retraction after rotator cuff repair and correlate these outcomes ...
Urena Marina - - 2012
Abstract  Acute coronary obstruction is one of the most feared complications associated with transcatheter aortic valve-in-valve implantation. Strategies for assessing the risk of coronary occlusion during these procedures as well as preventive measures are discussed. (J Card Surg 2012;**:1-4).
Else Monica - - 2012
Splenic marginal zone lymphoma (SMZL) is a rare B-cell malignancy, with no standard treatment other than splenectomy. Rituximab has shown encouraging results. We therefore retrospectively assessed 43 patients from two centres, who received rituximab, either alone or with chemotherapy. All patients responded, 34/43 (79%) achieving a complete response (CR), compared ...
Connell Sean - - 2012
The clinical need for alternative strategies in bacterial remediation is apparent due to the rising global health concern of microbial drug resistance. In this work, we delineate a novel antibacterial concept that utilizes hyperosmotic stress (H) in concert with membrane disrupting nanoemulsions (NE). The antibacterial effects of either H or ...
Wada Masahiro - - 2012
Abstract Introduction: The purpose of this study was to examine the possibility of utilizing CT bone density data to predict the initial implant stability and stress around an integrated implant.Methods and Results: Multislice CT (MSCT) data for the mandibular bone density of a 62-year-old man were analyzed with simulation software ...
Remels Alexander H - - 2012
Pulmonary cachexia is a prevalent, debilitating and well-recognized feature of COPD associated with increased mortality and loss of peripheral and respiratory muscle function. The exact cause and underlying mechanisms of cachexia in COPD are still poorly understood. Increasing evidence however shows that pathological changes in intra-cellular mechanisms of muscle mass ...
Levis Hannah J - - 2012
Purpose: Cultured limbal epithelial cell transplantation is a commonly used clinical treatment for ocular surface repair. We have previously shown that plastic compressed (PC) type I collagen constructs are a suitable substrate for human limbal epithelial cell (HLEC) culture for transplantation. For this process to achieve compliance with Good Manufacturing ...
Jiang Longguang - - 2012
An important regulatory mechanism of serine protease is the proteolytic conversion of the inactive pro-enzyme, or zymogen, to the active enzyme. This activation process is generally considered as an irreversible process. We demonstrate here that an active enzyme can be converted back to its zymogen form. We determined the crystal ...
Harada Taishi - - 2012
SUMMARY AT A GLANCE: A significant correlation was demonstrated between histological findings and respiratory function in fibrosing interstitial pneumonia. Our findings indicate that fibroblastic foci are a reliable predictor of prognosis in usual interstitial pneumonia and fibrotic nonspecific interstitial pneumonia. ABSTRACT: Background and Objective:  Fibroblastic foci (FF) composed of an ...
Cabrera José - - 2012
A set of heterogenized olefin-metathesis catalysts, which consisted of Ru complexes with the H(2) ITap ligand (1,3-bis(2',6'-dimethyl-4'dimethyl aminophenyl)-4,5-dihydroimidazol-2-ylidene) that had been adsorbed onto a silica support, has been prepared. These complexes showed strong binding to the solid support without the need for tethering groups on the complex or functionalized silica. ...
Vasileios Raptis - - 2012
Assymetricdimethylarginine (ADMA) is a naturally occurring aminoacid found in tissues and cells that circulates in plasma and is excreted in urine. It inhibits nitric oxide synthetases (NOs) and produces considerable cardiovascular biological effects. Several studies have suggested that plasma concentrations of ADMA provide a marker of risk for endothelial dysfunction ...
Jonassen Rune - - 2012
Down regulation of serotonin transporter (5-HTT) expression has been associated with brain function and major depression. The aim of this study was to explore the allelic variation (short and long) of the 5-HTTLPR polymorphism in attention bias associated with top-down processing of emotion. One hundred sixty-two healthy participants underwent genotyping ...
Kolditz Martin - - 2012
Community-acquired pneumonia (CAP) represents a major life threatening infection, but disease course and outcome is highly variable. Major drivers of prognosis are respiratory failure, sepsis related organ dysfunction and unstable comorbidities.Current risk stratification tools primarily have been designed to predict mortality and identify low risk patients potentially suitable for ambulatory ...
Jenkins Michael B - - 2012
Abstract Because of outbreaks of cryptosporidiosis in humans, Cryptosporidium has become a public health concern. Commercial swine operations can be a source of this protozoan parasite. Although the species distribution of Cryptosporidium is likely dominated by C. suis, a fraction may be comprised of other Cryptosporidium species infectious to humans ...
Mortensen Deborah L - - 2012
Modulating the binding affinities to IgE or changing the FcγR binding properties of anti-IgE antibodies offers an opportunity to enhance the therapeutic potential of anti-IgE antibodies, but the influence of increased affinity to IgE or reduced Fc effector function on the pharmacological properties of anti-IgE therapies remains unclear. Our studies ...
Sudakaran Sailendharan - - 2012
Symbiotic bacteria often play an essential nutritional role for insects, thereby allowing them to exploit novel food sources and expand into otherwise inaccessible ecological niches. Although many insects are inhabited by complex microbial communities, most studies on insect mutualists so far have focused on single endosymbionts and their interactions with ...
Kymre Ingjerd G - - 2012
BACKGROUND: Consequences of separation between preterm newborns and their parents have been discussed in many aspects, thus skin-to-skin care (SSC) has become common practice in Scandinavian Neonatal Intensive Care Units (NICUs) since the 1980s. The International workshop on Kangaroo Mother Care (KMC), 2009, recommends implementation of continuous KMC as the ...
Yu Shasha - - 2012
Going ber(zirc): Zirconium-butadiyne complexes react with acyl cyanide derivatives through diverse reaction pathways. The complexes react with two molecules of carbamoyl cyanide to form 1,4-benzodiazepin-2-one-derivatives containing azazirconacycles. Reactions with either aroyl cyanides or alkyl cyanoformates lead to azazirconacyclopentenes containing a quaternary carbon center.
Chen Dehong - - 2012
A complex titania nanostructure of monodisperse spiky mesoporous anatase beads composed of anatase nanocrystals with diameters of less than 15 nm in the core and much larger hollow-cone shaped spikes on the surface was fabricated using a facile solvothermal process in the presence of ammonia. This proceeded through a controllable phase ...
Lee Min Hee - - 2012
We synthesized a new probe, Mito-Naph, to visualize mitochondrial Trx activity in cells. A fluorescence off-on change is induced by disulfide cleavage of the probe, resulting from a reaction with Trx and subsequent intramolecular cyclization by the released thiolate to give a fluorescent product. By measuring the fluorescence at 540 ...
Cure S - - 2012
Abstract BACKGROUND & AIMS: To indirectly compare the efficacy of telaprevir (TVR) and boceprevir (BOC) combined with peginterferon/ribavirin α-2a/2b (PR) in achieving sustained viral response (SVR) in treatment-naïve and treatment-experienced patients with genotype 1 chronic hepatitis C virus (HCV) infection. METHODS: A systematic literature review was conducted to identify randomized ...
Raino Gabriele - - 2012
Exciton dynamics within the band-edge state manifold of CdSe/ZnS and CdSe/CdS quantum dots (QDs) have been investigated. Low-temperature time-resolved photoluminescence (PL) experiments demonstrate that exciton relaxation is mediated by LO phonons, whereas an acoustic phonon bottleneck has been observed for splitting energies lower than the optical phonon energy. This has ...
Wei Wei - - 2012
Quantities can be represented using either mathematical language (i.e., numbers) or natural language (i.e., quantifiers). Previous studies have shown that numerical processing elicits greater activation in the brain regions around the intraparietal sulcus (IPS) relative to other semantic processes. However, little research has been conducted to investigate whether the IPS ...
Marinelli Fabrizio - - 2012
In this work a combined theoretical and experimental approach was used to elucidate and describe at the molecular level the basic interactions that drive the transfer of the chiral information from chiral surfactant molecules to dye/surfactant assemblies. It was found that both hydrophobic interactions and relative concentrations strongly influence the ...
van Gastel P - - 2012
Objective Hormone replacement therapy is the most effective treatment for postmenopausal flushing. Unfortunately, its use is often contraindicated. A limited amount of uncontrolled data suggests that stellate-ganglion block (SGB) may be useful for the treatment of hot flushes. In the present study, we examined whether previously reported results could be ...
Wei Guangcheng - - 2012
Under acidic conditions, reduced graphene oxide (rGO) was functionalized with p-aminobenzoic acid, which formed the diazonium ions through the diazotization with a wet-chemical method. Surfactants or stabilizers were not applied during the diazotization. After the functionalized rGO was treated through mild sonication in aqueous solution, these functionalized rGO sheets were ...
Cvelbar Uroš - - 2012
Sub-oxide-to-metallic highly-crystalline nanowires with uniformly distributed nanopores in the 3 nm range have been synthesized by a unique combination of the plasma oxidation, re-deposition and electron-beam reduction. Electron beam exposure-controlled oxide → sub-oxide → metal transition is explained using a non-equilibrium model.
Yin Xiangrui - - 2012
The objective of this study is to estimate the treatment effect of Pneumatic Lithotripsy (PL) versus holmium: YAG laser (LL) in the treatment of ureteric calculi. A bibliographic search covering the period from 1990 to April 2012 was conducted using search engines like MEDLINE,EMBASE and Cochrane library. Data were extracted ...
Viscasillas Jaime - - 2012
Objective  To compare the success by inexperienced anaesthetists of using a modified infraorbital approach to the maxillary nerve with the traditional percutaneous approach. Study design  Prospective, randomized, blinded controlled study. Animals  Heads from 37 euthanized Beagle and Beagle cross dogs. Methods  Four anaesthetists were recruited to perform two different approaches ...
Horos Rastislav - - 2012
Diamond Blackfan Anaemia (DBA) is a rare congenital pure red cell aplasia that may be associated with facio-skeletal developmental defects. The disease is caused by mutations in one of at least ten ribosomal proteins, which results in haploinsufficiency and an imbalance between the synthesis of rRNA and ribosomal proteins during ...
Morris Adam - - 2012
OBJECTIVE: The present article presents a meta-analysis of studies examining the association between parent posttraumatic stress disorder (PTSD)/depression symptoms and child PTSD symptoms (PTSS) after a child's exposure to a traumatic event while considering multiple moderating factors to explain heterogeneity of effect sizes. METHODS: 35 studies were included: 32 involving ...
Castiñeiras Alfonso - - 2012
Octahedral 1 : 1 Ni(II) and square-planar 1 : 1 Pd(II) and Pt(II) complexes of formulae [Ni(HAcb4DM)(AcO)(H(2)O)(2)]·H(2)O (), [Pd(HAcb4DM)Cl]·5H(2)O () and [Pt(HAcb4DM)Cl]·3H(2)O (), where H(2)Acb4DM = 5-acetylbarbituric-4N-dimethylthiosemicarbazone (H(2) denoting its two dissociable protons, one enolic and one thiolic), have been synthesized and characterized by elemental analysis and by (1)H and (13)C NMR, UV-vis, and ...
Goryu Akihiro - - 2012
Nanoscale devices have the potential to measure biological tissues as well as individual cells/neurons. However, three-dimensional (3D) multi-site probing remains problematic because only planar-type device designs are applicable to sample surfaces. Herein we report 3D nanoscale electrode tipped microwire arrays with high aspect ratios. A nanoscale tipped wire is formed ...
Becce Fabio - - 2012
PURPOSE: To assess the value of adding axial traction to direct MR arthrography of the shoulder, in terms of subacromial and glenohumeral joint space widths, and coverage of the superior labrum-biceps tendon complex and articular cartilage by contrast material. MATERIALS AND METHODS: Twenty-one patients investigated by direct MR arthrography of ...
Wang Fei-Fei - - 2012
A new phenolate-based magnesium ion conducting electrolyte is prepared. The electrolyte exhibits air insensitive character and excellent electrochemical performances which make it highly promising for advanced rechargeable Mg battery systems.
Mor Zohar - - 2012
Childhood tuberculosis (CT) poses high-risk for morbidity and death. This study describes CT characteristics in Israel and examines treatment outcomes.Data sources were the National Tuberculosis Registry and the National Civil-Census.Between 1999 and 2010, 416 children (<18 years) had CT, averaging 1.5 per 100,000 children (range: 0.6-3.2) demonstrating a declining trend. ...
Felmy Andrew R - - 2012
Time-dependent reduction of PuO2(am) was studied over a range of pH values in the presence of aqueous Fe(II) and magnetite (Fe3O4) nanoparticles. At early time frames (up to 56 days) very little aqueous Pu was mobilized from PuO2(am), even though measured pH and redox potentials, coupled to equilibrium thermodynamic modeling ...
Ekshyyan Oleksandr - - 2012
OBJECTIVES/HYPOTHESIS: The early detection of persistent/recurrent disease of head and neck squamous cell carcinoma (HNSCC) after treatment can be challenging. The currently used radioisotope (18) F-fluorodeoxyglucose (FDG) is a nonspecific tracer for cancer cells as it detects all metabolically active cells including inflammation. (18) F-fluorodeoxythymidine (FLT) is a radioactive tracer ...
Klug Jennifer L - - 2012
Here we document the regional effects of Tropical Cyclone Irene on thermal structure and ecosystem metabolism in nine lakes and reservoirs in northeastern North America using a network of high-frequency, in situ, automated sensors. Thermal stability declined within hours in all systems following passage of Irene, and the magnitude of ...
Gloede Tristan D - - 2012
 Effective coordination among all members of hospital staff has been shown to be associated with better quality of care. The literature indicates that social capital, a form of organizational resource, may facilitate the task of coordination. However, to the best of our knowledge, no study has yet examined this link ...
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