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Results 601 - 650 of 2839
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Matsumori Nobuaki - - 2012
Lipid rafts have attracted much attention because of their significant functional roles in membrane-associated processes. It is thought that sphingomyelin and cholesterol are essential for forming lipid rafts; however, their motion characteristics are not fully understood despite numerous studies. Here we show accurate local motions encompassing an entire sphingomyelin molecule, ...
Nosova Elena Yu - - 2013
The purpose of the present study was to analyse mutations in the gyrA and gyrB genes of Mycobacterium tuberculosis and define the possible correlation between these mutations and resistance to levofloxacin (LVX), moxifloxacin (MFX) and gatifloxacin (GAT), based on their MICs. One hundred and forty-two M. tuberculosis clinical isolates were ...
Tamari Yuki - - 2012
Abstract Superoxide dismutases (SODs) are antioxidant proteins that convert superoxide to hydrogen peroxide. In vertebrate cells, SOD1 is mainly present in the cytoplasm, with small levels also found in the nucleus and mitochondrial inter-membrane space, and SOD2 is present in the mitochondrial matrix. Previously, we conditionally disrupted the SOD1 or ...
Scosyrev Emil - - 2012
What's known on the subject? and What does the study add? Over the last few years, several observational studies examined the association of statin use with the risk of biochemical recurrence of prostate cancer after definitive local therapy. The objective of our present study was to summarise available evidence on ...
Elliott Andrea - - 2012
BACKGROUND: Thromboelastography measures the dynamics of coagulation. There are limited data about thromboelastography in acute ischemic stroke other than a single study from 1974 suggesting that acute ischemic stroke patients are hypercoagulable. There have been no studies of thromboelastography in the thrombolytic era despite its potential usefulness as a measure ...
González Hernández Jonay I - - 2012
Type Ia supernovae are thought to occur when a white dwarf made of carbon and oxygen accretes sufficient mass to trigger a thermonuclear explosion. The accretion could be slow, from an unevolved (main-sequence) or evolved (subgiant or giant) star (the single-degenerate channel), or rapid, as the primary star breaks up a ...
Schillinger Eric - - 2012
Polymeric sorbents targeting endocrine-disrupting estrogen active compounds (EAC) were prepared by terpolymer imprinting using 17β-estradiol (E2) as template. From a group of eight functional monomers representing Brønsted acids, bases, hydrogen-bond donors and acceptors, as well as π-interacting monomers, a terpolymer library that comprises all possible binary combinations of the functional ...
Ciammaichella Alina - - 2012
A "frozen" electron donor-acceptor array that bears porphyrin and fullerene units covalently linked through the ortho position of a phenyl ring and the nitrogen of a pyrrolidine ring, respectively, is reported. Electrochemical and photophysical features suggest that the chosen linkage supports both through-space and through-bond interactions. In particular, it has ...
Balucani Nadia - - 2012
The dynamics of the H-displacement channels in the reaction N(2D) + C2H4 have been investigated by the crossed molecular beam technique with mass spectrometric detection and time-of-flight analysis at two different collision energies (17.2 and 28.2 kJ/mol). The interpretation of the scattering results is assisted by new electronic structure calculations ...
Johnson Laura A - - 2012
Despite standard treatment with resection, radiation and chemotherapy, glioblastoma (GBM) remains a deadly disease with a dismal prognosis. Redirecting patient T cells to target the GBM-associated antigen, IL13Rα2, offers a promising translational immunotherapy with the potential to make a meaningful impact for patients with this disease.
McGeary Donald D - - 2012
Although telehealth-based pain management research has grown over the last decade, it is difficult to determine the state of the research because of methodological differences and variability in quality among existing studies. In a previous systematic review, we outlined these differences and preliminarily explored the promise of telehealth for pain ...
Xia Min - - 2012
SiC nanowires (NWs) are commonly prepared in a Si-C-N system, but its formation mechanism is not fully understood. High resolution transmission electron microscopy and electron energy loss spectroscopy observation recorded the growth process of how Si(3)N(4) NWs were transformed into SiC NWs, and demonstrated the validity of an intermediate template ...
Hayes Risa P - - 2012
Abstract Background: The Ability to Perform Physical Activities of Daily Living Questionnaire (APPADL) measures the self-reported ability of individuals with type 2 diabetes mellitus (T2DM) and obesity to perform daily physical activities. The primary objective of this study was to estimate APPADL test-retest reliability, responsiveness, and minimal important change (MIC). ...
Oelkers Benjamin - - 2012
Metal-metal bonding in heterobimetallic complexes is of fundamental interest due to its implications to both bonding theory and new reactivities. In this Concept, structurally authenticated molecular compounds with direct bonds between rare-earth metals or actinoids and transition or main group metals are summarized. Special attention is given to the use ...
Tischer Thomas - - 2012
Mitotic divisions result from the oscillating activity of cyclin-dependent kinase-1 (Cdk1). Cdk1 activity is terminated by the anaphase-promoting-complex/cyclosome (APC/C), a ubiquitin-ligase that targets cyclin-B for destruction. In somatic divisions, Emi1 and the spindle-assembly-checkpoint (SAC) regulate cell-cycle progression by inhibiting the APC/C. Early embryonic divisions lack these APC/C-inhibitory components, raising the ...
Phillips Kristina T - - 2012
Bacterial infections are widespread problems among drug injectors, requiring novel preventive intervention. As part of a NIDA-funded study, we developed an intervention based on the Information-Motivation-Behavioral Skills model, past research, injection hygiene protocols, and data collected from focus groups with 32 injectors in Denver in 2009. Qualitative responses from focus ...
Kaur A - - 2012
Objective Estrogen deprivation after menopause is associated with increased oxidative stress. The present study was designed to study the role of sesamol (3,4-methylenedioxyphenol), a phenolic antioxidant and anti-inflammatory molecule, in oxidative stress-induced changes in three major affected organ systems, the central nervous system, the cardiovascular system and the skeletal system ...
Zhao Liang - - 2012
Biologics, specifically monoclonal antibody (mAb) drugs, have unique pharmacokinetic (PK) and pharmacodynamic (PD) characteristics as opposed to small molecules. Under the paradigm of model-based drug development, PK-PD/clinical response models offer critical insight in guiding biologics development at various stages. On the basis of the molecular structure and corresponding properties of ...
Tarasov Alexey - - 2012
Silicon nanowire field-effect transistors have attracted substantial interest for various biochemical sensing applications, yet there remains uncertainty concerning their response to changes in the supporting electrolyte concentration. In this study, we use silicon nanowires coated with highly pH-sensitive hafnium oxide (HfO(2)) and aluminum oxide (Al(2)O(3)) to determine their response to ...
Doronin Konstantin - - 2012
Although coagulation factors play a role in host defense for "living fossils" such as horseshoe crabs, the role of the coagulation system in immunity in higher organisms remains unclear. Here, we modeled the interface of human species C adenovirus (HAdv) interaction with coagulation factor X (FX) and introduced a mutation ...
Takatsui Fabiana - - 2012
The aim of this study was to analyze the color alterations performed by the CIE L*a*b* system in the digital imaging of shade guide tabs, which were obtained photographically according to the automatic and manual modes. This study also sought to examine the observers' agreement in quantifying the coordinates. Four ...
Goeggel Simonetti Barbara - - 2012
Purpose:  Sodium channel gene aberrations are associated with a wide range of seizure disorders, particularly Dravet syndrome. They usually consist of missense or truncating gene mutations or deletions. Duplications involving multiple genes encoding for different sodium channels are not widely known. This article summarizes the clinical, radiologic, and genetic features ...
Veling Harm - - 2012
OBJECTIVE: Exposure to palatable foods in the environment can trigger impulsive reactions to obtain them, which may lead to unhealthy food choices and eating behaviour. Two studies tested the fundamental question whether impulsive unhealthy food choices can be altered by means of linking unhealthy palatable foods to behavioural stop signals. ...
Kim Hyun Su - - 2012
PURPOSE: To investigate the changes in apparent diffusion coefficients (ADCs) in cervical cancer patients receiving concurrent chemoradiotherapy (CCRT), and to assess the relationship between tumor ADCs or changes in tumor ADCs and final tumor responses to therapy. MATERIALS AND METHODS: Twenty-four patients with cervical cancer who received CCRT were examined ...
Li Zibiao - - 2012
A cyclodextrin-based supramolecular hydrogel system with supramolecularly anchored active cationic copolymer/plasmid DNA (pDNA) polyplexes was studied as a sustained gene delivery carrier. A few biodegradable triblock copolymers of methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly[2-(dimethylamino)ethyl methacrylate] (MPEG-PCL-PDMAEMA) with well-defined cationic block lengths were prepared to condense pDNA. The MPEG-PCL-PDMAEMA copolymers exhibit good ability to condense ...
Maiti Subhabrata - - 2012
This work demonstrates a remarkable enhancement in the peroxidase activity of mitochondrial membrane protein cytochrome c (cyt c) by perturbing its tertiary structure in the presence of surface-functionalised gold nanoparticles (GNPs) within cetyltrimethylammonium bromide (CTAB) reverse micelles. The loss in the tertiary structure of cyt c exposes its heme moiety (which is buried ...
Vahidi Siavash - - 2012
Mass spectrometry (MS)-based protein conformational studies are a rapidly growing field. The characterization of partially disordered conformers is of particular interest because these species are not amenable to classical high-resolution techniques. Such equilibrium intermediates can often be populated by exposure to mildly acidic pH. Hydroxyl radical (•OH) introduces oxidative modifications ...
Fukawa Tomoya - - 2012
Studies of renal cell carcinoma (RCC) have led to the development of new molecular-targeted drugs but its oncogenic origins remain poorly understood. Here we report the identification and critical roles in renal carcinogenesis for DDX31, a novel nucleolar protein upregulated in the vast majority of human RCC. Immunohistochemical overexpression of ...
Yang Cheng-Chang - - 2012
Suppressed Digit Span performance has been proposed as an embedded indicator for suboptimal effort detection in neuropsychological evaluations in Western societies, particularly in the USA. However, its effectiveness in Chinese countries remains unexplored. The purposes of this study were first to explore normative Digit Span performance patterns between the Taiwan ...
Elsharawy Mohamed A - - 2012
Most surgeons make their decision to amputate or perform limb salvage of a mangled extremity based on scoring systems and grading of acute ischemic limb. We report on a child in whom limb salvage was achieved in spite of a clinical picture of irreversible ischemia with high mangled severity scores. ...
Lenzi Tathiane Larissa - - 2012
The aim of this in vitro study was to compare the degradation of resin-dentin bonds of an etch-and-rinse adhesive system to primary and permanent teeth. Flat superficial coronal dentin surfaces from 5 primary second molars and 5 permanent third molars were etched with phosphoric acid and bonded with an adhesive ...
Riemann Iris - - 2012
OBJECTIVE/BACKGROUND: Aim of the current study was to localize and differentiate between tumor (glioma) and healthy tissue in rat brains on a cellular level. Near-infrared multiphoton microscopy takes advantage of the simultaneous absorption of two or more photons to analyze various materials such as cell and tissue components via the ...
Kang Minkyung - - 2012
We demonstrate highly efficient electocatalytic activities of single crystalline RuO2 nanorods grown on carbon fiber (CF), i.e., RuO2 nanorod-CF hybrid microelectrode, prepared by a simple thermal annealing process from the Ru(OH)3 precursor at 300°C. The general electrochemical activity of a RuO2 nanorod-CF microelectrode represents faster electron transfer for the [Fe(CN)6]3-/4- ...
Teng X - - 2012
Intermedin (IMD) plays an important regulatory role in cardiovascular function. We aimed to explore the protein expression of IMD and its receptors, calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs), and the role of endogenous IMD in myocardial ischemia/reperfusion (I/R) injury in rats. The rat model of I/R was ...
Evans Sarah F - - 2012
The periosteum serves as bone's bounding membrane, exhibits hallmarks of semipermeable epithelial barrier membranes, and contains mechanically sensitive progenitor cells capable of generating bone. The current paucity of data regarding periosteums's permeability and bidirectional transport properties provided the impetus for the current study. In ovine femur and tibia samples, periosteum's ...
Tuo Biguang - - 2012
The incidence of duodenal ulcer, especially H.pylori-negative duodenal ulcer, strongly increases with age. In humans, telomere length shortening is considered to be one critical factor in cellular senescens and organ survival. In this study, we compared basal and stimulated gastric acid and duodenal HCO(3)- secretory rates in aged late generation ...
Chatterjee Satabdi - - 2012
BACKGROUND: Atypical antipsychotic agents have been associated with cerebrovascular adverse events, particularly in elderly dementia patients. However, limited evidence exists regarding comparative cerebrovascular profiles of individual atypical agents, particularly in community settings. OBJECTIVE: The objective of this study was to evaluate the risk of cerebrovascular events associated with use of ...
Hsuchou Hung - - 2012
Background/Aims: Acute phase C-reactive protein (CRP), elevated in obesity and inflammation, is a major binding protein for leptin. It is thought that CRP contributes to leptin resistance by preventing leptin from crossing the blood-brain barrier (BBB). Here we determined how CRP interacts with the BBB and whether it deters leptin ...
Uebachs Mischa - - 2012
Purpose:  In chronic epilepsy, a substantial proportion of up to 30% of patients remain refractory to antiepileptic drugs (AEDs). An understanding of the mechanisms of pharmacoresistance requires precise knowledge of how AEDs interact with their targets. Many commonly used AEDs act on the transient and/or the persistent components of the ...
Villa Maria Pia - - 2012
Overnight polysomnography (PSG) is an expensive procedure can only be used in a minority of cases, although it remains the gold standard for the diagnosis of sleep disordered breathing (SDB). The objective of this study was to develop a simple tool, PSG validated, to screen SDB, reducing the use of ...
Bec Jean-Michel - - 2012
BACKGROUND AND OBJECTIVE: The optical stimulation of neurons from pulsed infrared lasers has appeared over the last years as an alternative to classical electric stimulations based on conventional electrodes. Laser stimulation could provide a better spatial selectivity allowing single-cell stimulation without prerequisite contact. In this work we present relevant physical ...
Shah Sanjiv J - - 2012
Sudden cardiac death (SCD) is a common cause of mortality, with an annual incidence in the United States ranging from 180,000 to 450,000 cases annually.(1) Given the frequency and gravity of SCD, there has been considerable effort directed towards decreasing the burden of SCD.(2) Most of these efforts have focused ...
Li Hongbao - - 2012
First principles simulations have been performed for near-edge X-ray absorption fine-structure (NEXAFS) spectra of neutral arginine at different K-edges in the solid phase as well as X-ray photoelectron spectra (XPS) of neutral, deprotonated, and protonated arginines in the gas phase. Influences of the intra- and inter-molecular hydrogen bonds (HBs) and ...
Zelmer Derek A - - 2012
Abstract Prevalence is one of the few estimates that rarely are reported with an appropriate measure of error in the parasitological literature. A minimum sample size recommendation of 15 samples, based on the relationship between sample size and standard error, likely has led to a false degree of confidence because ...
Delgado Almandoz J E - - 2012
BACKGROUND AND PURPOSE:The yield of DSA in patients with SAH and negative initial noninvasive neurovascular examinations (CTA or MRA) is not well-understood. This study aimed to determine the yield of DSA for the detection of causative vascular lesions in this clinical scenario.MATERIALS AND METHODS:We examined the yield of DSA for ...
Koch Juliette - - 2012
Endometriosis is common in women with infertility but its management is controversial and varied. This article summarises the consensus developed by a group of Australasian subspecialists in reproductive endocrinology and infertility (the Australasian CREI Consensus Expert Panel on Trial evidence group) on the evidence concerning the management of endometriosis in ...
Messier Gabrielle Dubuc - - 2012
The study of the spatial distribution of relatives in a population under contrasted environmental conditions provides critical insights into the flexibility of dispersal behaviour and the role of environmental conditions in shaping population relatedness and social structure. Yet few studies have evaluated the effects of fluctuating environmental conditions on relatedness ...
Freixa Xavier - - 2012
Cardiovascular disease accounts for significant morbidity and mortality in COPD. Its prevalence and mechanisms of association have not been elucidated. The study aimed to assess the prevalence of echocardiographic abnormalities and potential risk factors in patients with COPD at their first exacerbation requiring hospital admission.Transthoracic echocardiography was prospectively performed in ...
Salaün Mathieu - - 2012
Probe-based confocal laser endomicroscopy (pCLE) allows microscopic imaging of the alveoli during bronchoscopy. The objective of the study was to assess the diagnostic accuracy of pCLE for amiodarone-related pneumonia (AMR-IP).Methods: Alveolar pCLE was performed in 36 non-smoking patients including 33 consecutive patients with acute or subacute interstitial lung disease (ILD), ...
Sun Lin - - 2012
ABSTRACT Janus-type dendritic poly(amido amine) (PAMAM) amphiphiles Dm-Lac-D3DNQ were synthesized by connecting hydrophobic diazonaphthoquinone (DNQ)-decorated PAMAM dendron D3 (generation 3) and hydrophilic lactose (Lac)-decorated PAMAM dendrons Dm (generations 0 to 2, m = 02) via click chemistry. They self-assembled into the DNQ-cored micelles dangled by densely free Lac groups in ...
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