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Termén Stefan - - 2012
Epithelial plasticity characterizes embryonic development and diseases such as cancer. Epithelial-mesenchymal transition (EMT) is a reversible and guided process of plasticity whereby embryonic or adult epithelia acquire mesenchymal properties. Multiple signaling pathways control EMT, and the transforming growth factor β (TGFβ) pathway plays a central role as its inducer. Here, ...
Raskatov Jevgenij A - - 2012
(π-Allyl)Ir complexes derived from dibenzocyclooctatetraene and phosphoramidites by cyclometalation are effective catalysts for allylic substitution reactions of linear monosubstituted allylic carbonates. These catalysts provide exceptionally high degrees of regioselectivity and allow the reactions to be run under aerobic conditions. A series of (π-allyl)Ir complexes were prepared and characterized by X-ray ...
Asano Fumihiro - - 2012
SUMMARY AT A GLANCE: A questionnaire survey performed in Japan in 2010 (response rate: 95.0%) showed that mobile/thin bronchoscopes (outer diameter ? 4 mm) were used in ? 50% of the facilities accredited by our society, and fluoroscopy systems were used in 99.8%. Intravenous sedation was performed in only 36.1%. ...
Leejae Sukanlaya - - 2012
Antibacterial mechanisms of rhodomyrtone, a member of acylphloroglucinols isolated from Rhodomyrtus tomentosa leaves, against important hospital-acquired antibiotic-resistant pathogenic bacteria were assessed. The results indicated that rhodomyrtone exhibited pronounced antibacterial activity against key antibiotic-resistant pathogens including epidemic methicillin-resistant Staphylococcus aureus (EMRSA), vancomycin-intermediate S. aureus (VISA), and vancomycin-resistant enterococci (VRE) strains. EMRSA-16, ...
Daly Robin - - 2012
A library of glycosylated porphyrins (glycoporphyrins) was prepared and the compounds were evaluated for their photodynamic therapy (PDT) activity against the oesophageal squamous-cell carcinoma cell line OE21 in vitro. A synthetic methodology was developed to allow incorporation of biologically active carbohydrates, including the histo-blood-group antigen trisaccharide Lewis(X) , onto the ...
Chen Shuai - - 2012
The first Dakin oxidation fueled by molecular oxygen as the terminal oxidant is reported. Flavin and NAD(P)H coenzymes, from natural enzymatic redox systems, inspired the use of flavin organocatalysts and a Hantzsch ester to perform transition-metal-free, aerobic oxidations. Catechols and electron-rich phenols are achieved with as low as a 0.1 ...
Baade Peter D - - 2012
Study Type - Prognosis (cohort series) Level of Evidence 2b What's known on the subject? and What does the study add? Men diagnosed with prostate cancer are increasingly involved in making their own treatment decisions and the current recommendations for treatment are based on informed choice. The absence of scientific evidence ...
Popp Albrecht W - - 2012
BACKGROUND AND AIM: The Trabecular Bone Score (TBS) is an index of bone microarchitectural texture calculated from antero-posterior DXA scans of the lumbar spine (LS) that predicts fracture risk, independent of BMD. The aim of this study was to compare the effects of yearly intravenous zoledronate (ZOL) versus placebo (PLB) ...
Zhao S - - 2012
In this work, photoluminescence and micro-Raman scattering experiments were performed on undoped InN nanowires. It was found that, besides the main photoluminescence peak, a clear phonon sideband emission peak, with an extremely narrow linewidth ∼9 meV, was measured. The phonon spectrum revealed by micro-Raman scattering indicates only uncoupled LO phonons are ...
Sharpley Christopher F - - 2012
OBJECTIVE: This study aimed to compare the prevalence of depressed mood and anhedonia in a sample of men with prostate cancer (PCa) and to determine which of these key symptoms contributed most to the overall depressive status of that sample. METHOD: From Zung Self-rating Depression Scale (SDS) responses collected on ...
McCarty W Jeffrey - - 2012
The ruthenium phosphite hydride complexes H(2)Ru(P(OR)(3))(4) (R = Me (), Et (), (i)Pr ()) were used as CVD precursors for the deposition of films of amorphous ruthenium-phosphorus alloys. The as-deposited films were X-ray amorphous and XPS analysis revealed that they were predominantly comprised of Ru and P in zero oxidation ...
Husain O M - - 2012
BACKGROUND: Alcohol-related presentations to hospital have been increasing in the UK in recent years, including the occurrence of acute withdrawal. This study sought to better characterize the clinical features, patterns of treatment and outcomes in this patient group. METHODS: Patients admitted to the Acute Medical Unit of York Hospital due ...
Jin Wenbiao - - 2012
It is an emerging concern that a series of disinfection byproducts (DBPs) produced in wastewater effluent have adversely impacted the downstream aquatic system and drinking water resources. The occurrence, fate, and transport of DBPs on receiving waterbodies, however, are currently not well-documented. To fill the knowledge gap, this study simulated ...
He Chuan - - 2012
A novel silver-mediated highly selective C-H/N-H oxidative cross-coupling/cyclization between 2-aminopyridines and terminal alkynes has been demonstrated. This approach provided a simple way to construct heteroaromatic imidazo[1,2-a]pyridines. By using this protocol, the marketed drug zolimidine (antiulcer) could be synthesized easily.
Wang Xu-Dong - - 2012
We report on the first dual nanosensors for imaging of pH values and oxygen partial pressure in cells. The sensors have a unique nanostructure in that a soft core structure is rigidized with a silane reagent, while poly(ethylene glycol) chains form an outer shell. Lipophilic oxygen-sensitive probes and reference dyes ...
Brok Jesper - - 2012
Results from meta-analyses significantly influence clinical practice. Both simulation and empirical studies have demonstrated that the risk of random error (i.e. spurious chance findings) in meta-analyses is much higher than previously anticipated. Hence, authors and users of systematic reviews and meta-analyses have a responsibility to carefully consider the risk of ...
Townsend Julie S - - 2012
Purpose:The purpose of this study was to compare health behaviors and cancer screening among Californians with and without a family history of cancer.Methods:We analyzed data from the 2005 California Health Interview Survey to ascertain cancer screening test use and to estimate the prevalence of health behaviors that may reduce the ...
Choi Ki Young - - 2012
8-Cl-cAMP (8-chloro-cyclic AMP), which induces differentiation, growth inhibition and apoptosis in various cancer cells, has been investigated as a putative anti-cancer drug. However, the exact mechanism of 8-Cl-cAMP functioning in cancer cells is not fully understood. Akt/PKB (protein kinase B) genes (Akt1, Akt2, Akt3) encode enzymes belonging to the serine/threonine-specific ...
Freys Jonathan C - - 2012
We report on the synthesis and characterization of a donor-acceptor ruthenium polypyridyl complex as a photosensitizer for p-type dye-sensitized solar cells (DSSCs). The electrochemical, photophysical, and photovoltaic performance of two ruthenium-based photosensitizers were tested in NiO-based DSSCs; bis-(2,2'-bipyridine-4,4'-dicarboxylic acid)(2)N-(1,10-phenanthroline)-4-nitronaphthalene-1,8-dicarboximide ruthenium(ii), ([Ru(dcb)(2)(NMI-phen)](PF(6))(2)) and tris-(2,2'-bipyridine-4,4'-dicarboxylic acid)(3) ruthenium(ii), [(Ru(dcb)(3))Cl(2)]. The presence of an ...
D'Antonio Francesco - - 2012
Background: It is often assumed by obstetricians, neonatologists and parents alike that the prenatal nomenclature used to identify twins on ultrasound is consistent with twin labelling after their birth. The aim of this study is to use a large regional twin ultrasound database to validate the effectiveness of a scan ...
Stather David Ryan - - 2012
SUMMARY AT A GLANCE: Trainees can negatively impact advanced bronchoscopy. ABSTRACT: Background and Objective:  Complications during advanced diagnostic bronchoscopy are rare and include: pneumothorax, bleeding, mediastinitis, pericarditis and lymphadenitis. Increased complications have been demonstrated in patients undergoing routine bronchoscopy procedures performed by trainees. This study aimed to determine the impact ...
Brewer L - - 2012
Despite advances in the acute management of stroke, a large proportion of stroke patients are left with significant impairments. Over the coming decades the prevalence of stroke-related disability is expected to increase worldwide and this will impact greatly on families, healthcare systems and economies. Effective neuro-rehabilitation is a key factor ...
Kang J H - - 2012
Vertically oriented GaAs nanowires (NWs) are grown on Si(111) substrates using metal-organic chemical vapor deposition. Controlled epitaxial growth along the ⟨111⟩ direction is demonstrated following the deposition of thin GaAs buffer layers and the elimination of structural defects, such as twin defects and stacking faults, is found for high growth ...
Wang Ying - - 2012
Purpose:Sickle cell disease is estimated to occur in 1:300-400 African-American births, with higher rates among immigrants from Africa and the Caribbean, and is less common among Hispanic births. This study determined sickle cell disease incidence among New York State newborns stratified by maternal race/ethnicity and nativity.Methods:Newborns with confirmed sickle cell ...
Wang Guoliang - - 2012
The DNA damage checkpoint controls cell cycle arrest in response to DNA damage, and activation of this checkpoint is in turn cell cycle-regulated. Rad9, the ortholog of mammalian 53BP1, is essential for this checkpoint response and is phosphorylated by the cyclin-dependent kinase (CDK) in the yeast Saccharomyces cerevisiae. Previous studies ...
de Groot Jasper H B - - 2012
Can humans communicate emotional states via chemical signals? In the experiment reported here, we addressed this question by examining the function of chemosignals in a framework furnished by embodied social communication theory. Following this theory, we hypothesized that the processes a sender experiences during distinctive emotional states are transmitted to ...
Viitanen Tero - - 2012
The initial step in a synthesis of thyroid hormones is the uptake of iodide from the circulation. Iodide (I(-) ) is transported into thyroid cells via a Na(+) /I(-) symporter (NIS), which is electrogenic and thus sensitive to alterations in membrane potential (V(m) ). I(-) is then released to the ...
Pretorius Carel J - - 2012
BACKGROUND: Comparability of cholesterol measurement is clinically required and external quality assurance (EQA) programmes are important to verify the trueness of routine methods. METHODS: We developed a gas chromatography-isotope dilution mass spectrometry (GC-IDMS) total cholesterol assay to investigate the cause of a suspected matrix-related negative bias with the Beckman Coulter ...
Gumus Hatice - - 2012
PURPOSE: The purpose of this study was to identify the factors that may have an impact in upgrading atypical ductal hyperplasia (ADH) lesions to malignancy. MATERIALS AND METHODS: Between February 1999 and December 2010, the records of 150 ADH lesions that had been biopsied were retrospectively reviewed. The biopsy types ...
Zhang Hongfang - - 2012
A bienzyme electrode for the determination of cholesterol was prepared by the co-immobilization of cholesterol oxidase and alkaline phosphatase (ALP) on the carbon nanotubes modified electrode surface. The parameters influenced the performance of the bienzyme electrode such as the pH of the base solution; the concentration of DPP and the ...
Wei Qiao-Hua - - 2012
Two hexanuclear clusters, [Pt(2)Ag(4)(C≡CC(6)H(4)R)(8)] (R = CH(3), 1; R = H, 2), together with dimer [Pt(2)Ag(4)(C≡CC(6)H(5))(8)](2) (3), have been synthesized and characterized by elemental analyses, electrospray ionization mass spectrometry, and (1)H NMR spectroscopy and by X-ray crystallography for 1 and 3. A considerable enhancement of photoluminescence (PL) and a notable ...
de la Torre Adrián - - 2012
Concentrations of Dechlorane (Dec) 603 (0.75 ng/g lipid weight (lw); mean) and Dec 602 (0.38 ng/g lw; mean) were quantified in more than 95% of the franciscana (Pontoporia blainvillei) dolphin samples, while the frequency of detection decreased to 75% for Dechlorane Plus (DP) (1.53 ng/g lw; mean). The presence of ...
Jonstrup S P - - 2012
Viral haemorrhagic septicaemia (VHS) is a serious disease in several fish species. VHS is caused by the rhabdovirus viral haemorrhagic septicaemia virus (VHSV). To prevent spreading of the pathogen, it is important to use a fast, robust, sensitive and specific diagnostic tool to identify the infected fish. Traditional diagnosis based ...
Twidale Emily - - 2012
AIMS: Investigate risk factors for obstetric anal sphincter injury (OASI) and their incidence between 2006 and 2010 at a regional teaching hospital in Australia. Determine whether a correlation exists between a decrease in OASI rates and an increase in mediolateral episiotomies. MATERIALS AND METHODS: A retrospective observational study conducted at ...
Cuesta Luciano - - 2012
Novel cycloruthenated complexes 2 a-c, 4 a-c, and 6 a, b based on heteroaromatic cores have been synthesized by reaction of a series of heterocycle-based imines with [{RuCl(η(6) -p-cymene)}(2) (μCl)(2) ] and Cu(OAc)(2) . This approach has proved efficient for the cyclometalation of thiophene, benzothiophene, furan, benzofuran, pyrrole, and indole derivatives. In addition, even ...
Candy Mathieu - - 2012
The key is symmetry! A convergent synthetic approach of the highly cytotoxic natural product (-)-callystatin A was developed assembling three fragments through Julia-Kocienski olefination and Stille cross-coupling. The new strategy relies on a pivotal local symmetry of the target molecule. In this preliminary study, particular attention was devoted to facilitate the ...
Hosein Adil I - - 2012
Perfluoroalkyl Grignard reagents react with phosphoryl halides at -78 °C to room temperature to selectively produce bis(perfluoroalkyl)phosphonyl halides, which after aqueous work up, give bis(perfluoroalkyl)phosphinic acids in high overall yields. Reaction of perfluoroalkyl Grignards with phenylphosphonic dichloride gives high yields of bis(perfluoroalkyl)phenyl phosphine oxides which are readily hydrolysed to perfluoroalkyl(phenyl)phosphinic ...
Ogawa Hatsune - - 2012
Thermally irreversible photochromic 1-tert-butyl-substituted 2,3-bisthiazolylindenol has been synthesized. It showed perfect diastereoselectivity and high ring-closing quantum yield with high conversion ratio to the closed form. The collaborative interaction of two intramolecular hydrogen bonds and the steric restriction fixed the conformation in favour of cyclization in a highly diastereoselective manner.
Campellone Timothy R - - 2012
During social interactions, we use available information to guide our decisions, including behaviour and emotional displays. In some situations, behaviour and emotional displays may be incongruent, complicating decision making. This study had two main aims: first, to investigate the independent contributions of behaviour and facial displays of emotion on decisions ...
Weber Manuel - - 2012
The development and further evolution of the first catalytic asymmetric conjugate additions of azlactones as activated amino acid derivatives to enones is described. Whereas the first-generation approach started from isolated azlactones, in the second-generation approach the azlactones could be generated in situ starting from racemic N-benzoylated amino acids. The third ...
Li Chung-Lin - - 2012
In this study, we synthesized core/shell structures comprising monodisperse 3-μm SiO2 microspheres and gold nanoparticles (AuNPs, ca. 6.7 nm) as the core and shell components, respectively. Using a layer-by-layer cross-linking process with a dithiol cross-linking agent, we prepared low-permittivity AuNP-encapsulated high-permittivity SiO2 core/shell microspheres with variable AuNP shell thicknesses. The ...
Sugimoto R - - 2012
Ischemia/reperfusion injury (IRI) is the most common cause of early mortality following lung transplantation (LTx). We hypothesized that nitrite, an endogenous source of nitric oxide (NO), may protect lung grafts from IRI. Rat lung grafts were stored in preservation solution at 4°C for 6 hours. Both grafts and recipients were ...
Tadić Jovan M - - 2012
There is no abstract in 'Comments' type of manuscripts.
Modh Rahul P - - 2012
In an attempt to afford possible antibacterial and anti-human immunodeficiency virus (HIV) agents, a series of 22 novel styryl quinazoline-based heterocyclic entities were designed and synthesized. Various substituted aryl urea and thiourea cores were incorporated at position 4 of quinazoline, followed by styrylation of position 2, aiming at an augmented ...
Pelaz Beatriz - - 2012
Colloidal nanoparticles (NPs) have become versatile building blocks in a wide variety of fields. Here, we discuss the state-of-the-art, current hot topics, and future directions based on the following aspects: narrow size-distribution NPs can exhibit protein-like properties; monodispersity of NPs is not always required; assembled NPs can exhibit collective behavior; ...
Park Sang O - - 2012
AIM: Untrained laypersons should perform compression-only cardiopulmonary resuscitation (COCPR) under a dispatcher's guidance, but the quality of the chest compressions may be suboptimal. We hypothesised that providing metronome sounds via a phone speaker may improve the quality of chest compressions during dispatcher-assisted COCPR (DA-COCPR). METHODS: Untrained laypersons were allocated to ...
Sheehan Connor M - - 2012
AIMS: To investigate differences in the presence of drugs, by gender, when considering deaths attributable to homicides and suicides. DESIGN: Logistic regression analysis of mortality data collected by the Colorado Violent Death Reporting System. PARTICIPANTS AND SETTING: 5,791 Colorado decedents who died of violent causes from 2004 through 2009. MEASUREMENT: ...
Wang Bo - - 2012
Memory for faces is important for social interactions. However, it is unclear whether negative or positive expression affects recollection and familiarity for faces and whether the effect can be modulated by retention interval. Two experiments examined the effect of emotional expression on recognition for faces at two delay conditions. In ...
Woodcock Ashley - - 2012
The Montreal Protocol was signed 25 years ago. As a result, the irreversible destruction of the ozone layer was prevented. However, stratospheric ozone will not recover completely until 2060 and the consequent epidemic in skin cancer cases will persist until 2100. Many millions of patients with asthma and chronic obstructive ...
Matsumori Nobuaki - - 2012
Lipid rafts have attracted much attention because of their significant functional roles in membrane-associated processes. It is thought that sphingomyelin and cholesterol are essential for forming lipid rafts; however, their motion characteristics are not fully understood despite numerous studies. Here we show accurate local motions encompassing an entire sphingomyelin molecule, ...
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