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Jenkins Nathan T NT Department of 1Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA. - - 2012
Adipose tissue inflammation plays a role in cardiovascular (CV) and metabolic diseases associated with obesity, insulin resistance, and type 2 diabetes mellitus (T2DM). The interactive effects of exercise training and metformin, two first-line T2DM treatments, on adipose tissue inflammation are not known. Using the hyperphagic, obese, insulin-resistant Otsuka Long-Evans Tokushima ...
Gründer Cordula - - 2012
Immunotherapy with innate immune cells has recently evoked broad interest as a novel treatment option for cancer patients. γ9δ2T-cells in particular are emerging as an innate cell population with high frequency and strong anti-tumor reactivity, which makes γ9δ2T-cells and their receptors promising candidates for immune-interventions. However, clinical trials have so ...
Farias de Novaes Juliana - - 2012
This cross-sectional study aimed to: (i) investigate whether obesity and overweight defined according to body mass index (BMI) are good predictors of body fat excess, abdominal adiposity and hypertension in 769 Brazilian children aged 6-11 years, (ii) assess the relationship between overweight/obesity and cardiovascular risk factors. Overweight and obesity were ...
Kedia George T - - 2012
What's known on the subject? and What does the study add? A previous study by Lexander et al. in 2005, using two-dimensional gel electrophoresis, demonstrated the expression of arginase type II in the different anatomical regions of the prostate; however, to date, no study has addressed, using an in vitro approach, ...
Aliaga S - - 2013
Late-preterm (LPT) neonates account for over 70% of all preterm births in the US. Approximately 60% of LPT births are the result of non-spontaneous deliveries. The optimal timing of delivery for many obstetric conditions at LPT gestations is unclear, likely resulting in obstetric practice variation. The purpose of this study ...
Gajjar Trushar - - 2012
Abstract  Supravalvar aortic stenosis is characterized by an obstruction of the left ventricular outflow tract distal to the aortic valve. Its association with left main coronary artery stenosis is well known but right coronary artery involvement has not been reported. We describe two cases of supravalvar aortic stenosis with coronary ...
Frumento G - - 2012
Adoptive T cell therapy can be effective for Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disease and melanoma. Transducing high-affinity TCR genes into T lymphocytes is an emerging method to improve potency and specificity of tumor-specific T cells. However, both methods necessitate in vitro lymphocyte proliferation, generating highly differentiated effector cells that ...
Akula Hari K - - 2012
The copper-catalyzed azide-alkyne cycloaddition (CuAAC) is a highly effective method for the selective incorporation of deuterium atom into the C-5 position of the 1,2,3-triazole structure. Reactions of alkynes and azides can be conveniently carried out in a biphasic medium of CH(2)Cl(2)/D(2)O, using the CuSO(4)/Na ascorbate system. The mildness of the ...
Cabrera José - - 2012
A set of heterogenized olefin-metathesis catalysts, which consisted of Ru complexes with the H(2) ITap ligand (1,3-bis(2',6'-dimethyl-4'dimethyl aminophenyl)-4,5-dihydroimidazol-2-ylidene) that had been adsorbed onto a silica support, has been prepared. These complexes showed strong binding to the solid support without the need for tethering groups on the complex or functionalized silica. ...
Vasileios Raptis - - 2012
Assymetricdimethylarginine (ADMA) is a naturally occurring aminoacid found in tissues and cells that circulates in plasma and is excreted in urine. It inhibits nitric oxide synthetases (NOs) and produces considerable cardiovascular biological effects. Several studies have suggested that plasma concentrations of ADMA provide a marker of risk for endothelial dysfunction ...
Jonassen Rune - - 2012
Down regulation of serotonin transporter (5-HTT) expression has been associated with brain function and major depression. The aim of this study was to explore the allelic variation (short and long) of the 5-HTTLPR polymorphism in attention bias associated with top-down processing of emotion. One hundred sixty-two healthy participants underwent genotyping ...
Kolditz Martin - - 2012
Community-acquired pneumonia (CAP) represents a major life threatening infection, but disease course and outcome is highly variable. Major drivers of prognosis are respiratory failure, sepsis related organ dysfunction and unstable comorbidities.Current risk stratification tools primarily have been designed to predict mortality and identify low risk patients potentially suitable for ambulatory ...
Jenkins Michael B - - 2012
Abstract Because of outbreaks of cryptosporidiosis in humans, Cryptosporidium has become a public health concern. Commercial swine operations can be a source of this protozoan parasite. Although the species distribution of Cryptosporidium is likely dominated by C. suis, a fraction may be comprised of other Cryptosporidium species infectious to humans ...
Mortensen Deborah L - - 2012
Modulating the binding affinities to IgE or changing the FcγR binding properties of anti-IgE antibodies offers an opportunity to enhance the therapeutic potential of anti-IgE antibodies, but the influence of increased affinity to IgE or reduced Fc effector function on the pharmacological properties of anti-IgE therapies remains unclear. Our studies ...
Sudakaran Sailendharan - - 2012
Symbiotic bacteria often play an essential nutritional role for insects, thereby allowing them to exploit novel food sources and expand into otherwise inaccessible ecological niches. Although many insects are inhabited by complex microbial communities, most studies on insect mutualists so far have focused on single endosymbionts and their interactions with ...
Clover Kerrie - - 2012
OBJECTIVE: ]Although effective treatments for pain and distress are available, many patients do not access them. Improved understanding of patients' desire for help may improve uptake of services. METHODS: Data were collected as part of the QUICATOUCH screening program at an Australian regional hospital. Patients over threshold for pain were ...
Mandal P P MRC Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK. - - 2013
The aim of our study was to assess the impact of 8-weekly intravenous (IV) antibiotics on exacerbation frequency and health-related quality of life in bronchiectasis. Patients were recruited prospectively from June 2008 to December 2010. Patients with recurrent exacerbations (five or more exacerbations per year) and subjectively reporting ill health ...
Sung Kyung Rim - - 2012
Optical coherence tomography (OCT) is an interferometry-based imaging modality that generates high-resolution cross-sectional images of the retina. Circumpapillary retinal nerve fibre layer (cpRNFL) and optic disc assessments are the mainstay of glaucomatous structural measurements. However, because these measurements are not always available or precise, it would be useful to have ...
A Maris - - 2012
Aim:  Common problems after rectal resection are loose stools, fecal incontinence, increased frequency and evacuation difficulties, for which there are various therapeutic options. A systematic review was conducted to assess the outcome of treatment options aimed to improve anorectal function after rectal surgery. Method:  Publications including a therapeutic approach to ...
Moncada-Pazos Angela A Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain. - - 2012
ADAMTSs (a disintegrin and metalloprotease with thrombospondin domains) are a family of enzymes with both proteolytic and protein interaction functions, which have been implicated in distinct pathologies. In this work, we have investigated the putative role of ADAMTS-12 in inflammation by using a mouse model deficient in this metalloprotease. Control ...
Murozono Yukichi - - 2013
We previously reported that baroreflex sensitivity (BRS) or cardiac iodine 123 metaiodobenzylguanidine ((123)I-MIBG) scintigraphic findings can predict cardiovascular prognosis in type 2 diabetic patients. We therefore tested the hypothesis that the combination of BRS and (123)I-MIBG scintigraphic findings could strengthen the predictive power for major adverse cerebral and cardiovascular events ...
Battaglini Nicolas - - 2012
We report on the elaboration of networks of SAM domains. More precisely, we show the feasibility in making arrays of functionalized alkylthiol nanodomains bordered with an alkylthiol matrix. The several step process relies on the replication of a self-organized cobalt array grown on Au(111). SAM process takes place in solution. ...
Geffers Lars - - 2013
METscout (http://metscout.mpg.de) brings together metabolism and gene expression landscapes. It is a MySQL relational database linking biochemical pathway information with 3D patterns of gene expression determined by robotic in situ hybridization in the E14.5 mouse embryo. The sites of expression of ∼1500 metabolic enzymes and of ∼350 solute carriers (SLCs) ...
Kamishiraki Etsuko - - 2012
CONTEXT: Autopsy is a useful tool for understanding the cause and manner of unexpected patient death. However, the attitudes of the general public and physicians in Japan about clinical autopsy are limited. OBJECTIVE: To describe the beliefs of the general public about whether autopsy should be performed and ascertain if ...
Seifert Ashley W - - 2012
Evolutionary modification has produced a spectrum of animal defence traits to escape predation, including the ability to autotomize body parts to elude capture. After autotomy, the missing part is either replaced through regeneration (for example, in urodeles, lizards, arthropods and crustaceans) or permanently lost (such as in mammals). Although most ...
Hayes Risa P - - 2012
Abstract Background: The Ability to Perform Physical Activities of Daily Living Questionnaire (APPADL) measures the self-reported ability of individuals with type 2 diabetes mellitus (T2DM) and obesity to perform daily physical activities. The primary objective of this study was to estimate APPADL test-retest reliability, responsiveness, and minimal important change (MIC). ...
Oelkers Benjamin - - 2012
Metal-metal bonding in heterobimetallic complexes is of fundamental interest due to its implications to both bonding theory and new reactivities. In this Concept, structurally authenticated molecular compounds with direct bonds between rare-earth metals or actinoids and transition or main group metals are summarized. Special attention is given to the use ...
Tischer Thomas - - 2012
Mitotic divisions result from the oscillating activity of cyclin-dependent kinase-1 (Cdk1). Cdk1 activity is terminated by the anaphase-promoting-complex/cyclosome (APC/C), a ubiquitin-ligase that targets cyclin-B for destruction. In somatic divisions, Emi1 and the spindle-assembly-checkpoint (SAC) regulate cell-cycle progression by inhibiting the APC/C. Early embryonic divisions lack these APC/C-inhibitory components, raising the ...
Osawa Masanori - - 2012
Eukaryotic releasing factor GSPT/eRF3 mediates translation termination-coupled mRNA decay via interaction with a cytosolic poly(A)-binding protein (PABPC1). A region of eRF3 containing two overlapping PAM2 (PABPC1-interacting motif 2) motifs is assumed to bind to the PABC domain of PABPC1, on the poly(A) tail of mRNA. PAM2 motifs are also found ...
Phillips Kristina T - - 2012
Bacterial infections are widespread problems among drug injectors, requiring novel preventive intervention. As part of a NIDA-funded study, we developed an intervention based on the Information-Motivation-Behavioral Skills model, past research, injection hygiene protocols, and data collected from focus groups with 32 injectors in Denver in 2009. Qualitative responses from focus ...
Kaur A - - 2012
Objective Estrogen deprivation after menopause is associated with increased oxidative stress. The present study was designed to study the role of sesamol (3,4-methylenedioxyphenol), a phenolic antioxidant and anti-inflammatory molecule, in oxidative stress-induced changes in three major affected organ systems, the central nervous system, the cardiovascular system and the skeletal system ...
Zhao Liang - - 2012
Biologics, specifically monoclonal antibody (mAb) drugs, have unique pharmacokinetic (PK) and pharmacodynamic (PD) characteristics as opposed to small molecules. Under the paradigm of model-based drug development, PK-PD/clinical response models offer critical insight in guiding biologics development at various stages. On the basis of the molecular structure and corresponding properties of ...
Tarasov Alexey - - 2012
Silicon nanowire field-effect transistors have attracted substantial interest for various biochemical sensing applications, yet there remains uncertainty concerning their response to changes in the supporting electrolyte concentration. In this study, we use silicon nanowires coated with highly pH-sensitive hafnium oxide (HfO(2)) and aluminum oxide (Al(2)O(3)) to determine their response to ...
Chatterjee Satabdi - - 2012
BACKGROUND: Atypical antipsychotic agents have been associated with cerebrovascular adverse events, particularly in elderly dementia patients. However, limited evidence exists regarding comparative cerebrovascular profiles of individual atypical agents, particularly in community settings. OBJECTIVE: The objective of this study was to evaluate the risk of cerebrovascular events associated with use of ...
Lee Andy C H - - 2013
Although the role of the hippocampus in spatial cognition is well accepted, it is unclear whether its involvement is restricted to the mnemonic domain or also extends to perception. We used fMRI to scan neurologically healthy participants during a scene oddity judgment task that placed no explicit demand on long-term ...
Hsuchou Hung - - 2012
Background/Aims: Acute phase C-reactive protein (CRP), elevated in obesity and inflammation, is a major binding protein for leptin. It is thought that CRP contributes to leptin resistance by preventing leptin from crossing the blood-brain barrier (BBB). Here we determined how CRP interacts with the BBB and whether it deters leptin ...
Uebachs Mischa - - 2012
Purpose:  In chronic epilepsy, a substantial proportion of up to 30% of patients remain refractory to antiepileptic drugs (AEDs). An understanding of the mechanisms of pharmacoresistance requires precise knowledge of how AEDs interact with their targets. Many commonly used AEDs act on the transient and/or the persistent components of the ...
Skripconoka Vija - - 2012
Multidrug-resistant and extensively drug-resistant tuberculosis are associated with worse treatment outcomes for patients, including higher mortality, than for drug sensitive tuberculosis. Delamanid (OPC-67683) is a novel anti-tuberculosis medication with demonstrated activity against multidrug-resistant disease.Patients who participated in the previously reported randomised, placebo-controlled trial of delamanid and the subsequent open-label extension ...
Villa Maria Pia - - 2012
Overnight polysomnography (PSG) is an expensive procedure can only be used in a minority of cases, although it remains the gold standard for the diagnosis of sleep disordered breathing (SDB). The objective of this study was to develop a simple tool, PSG validated, to screen SDB, reducing the use of ...
Bec Jean-Michel - - 2012
BACKGROUND AND OBJECTIVE: The optical stimulation of neurons from pulsed infrared lasers has appeared over the last years as an alternative to classical electric stimulations based on conventional electrodes. Laser stimulation could provide a better spatial selectivity allowing single-cell stimulation without prerequisite contact. In this work we present relevant physical ...
Shah Sanjiv J - - 2012
Sudden cardiac death (SCD) is a common cause of mortality, with an annual incidence in the United States ranging from 180,000 to 450,000 cases annually.(1) Given the frequency and gravity of SCD, there has been considerable effort directed towards decreasing the burden of SCD.(2) Most of these efforts have focused ...
Li Hongbao - - 2012
First principles simulations have been performed for near-edge X-ray absorption fine-structure (NEXAFS) spectra of neutral arginine at different K-edges in the solid phase as well as X-ray photoelectron spectra (XPS) of neutral, deprotonated, and protonated arginines in the gas phase. Influences of the intra- and inter-molecular hydrogen bonds (HBs) and ...
Zelmer Derek A - - 2012
Abstract Prevalence is one of the few estimates that rarely are reported with an appropriate measure of error in the parasitological literature. A minimum sample size recommendation of 15 samples, based on the relationship between sample size and standard error, likely has led to a false degree of confidence because ...
Delgado Almandoz J E - - 2012
BACKGROUND AND PURPOSE:The yield of DSA in patients with SAH and negative initial noninvasive neurovascular examinations (CTA or MRA) is not well-understood. This study aimed to determine the yield of DSA for the detection of causative vascular lesions in this clinical scenario.MATERIALS AND METHODS:We examined the yield of DSA for ...
McIver Sally R - - 2012
Neuroinflammation is known to elicit numerous changes in brain physiology and is associated with various pathologies, including neurodegenerative diseases, and behaviors, such as sleep and acute illness. In addition, there is accumulating evidence that the behavioral response to alcohol is affected by perturbations to the neuroimmune system. Recent studies have ...
Machens Andreas - - 2012
Context:A prognostic classification system based on aggregate numbers of lymph node metastases may better estimate the risk of distant metastasis.Objective:This investigation sought to evaluate a papillary thyroid cancer (PTC) patient's risk of distant metastasis.Design:This was a retrospective analysis.Setting:The setting was a tertiary referral center.Patients:Included were 972 PTC patients.Intervention:The intervention was ...
Milara Javier - - 2012
Cigarette smoking, contributes to lung remodeling in chronic obstructive pulmonary disease (COPD). As part of remodeling, peribronchiolar fibrosis is observed in small airways of COPD patients and contributes to airway obstruction. Fibroblast to myofibroblast transition is a key step of the peribronchiolar fibrosis formation. This in vitro study examines the ...
Estrella Michelle M - - 2012
ABSTRACT: BACKGROUND: Early recognition and management of chronic kidney disease (CKD) are associated with better outcomes. Internal medicine residency should prepare physicians to diagnose and manage CKD. METHODS: To examine whether residency training and program characteristics were associated with CKD knowledge and investigate the effectiveness of an internet-based training module ...
Valckx S D M - - 2012
Is the metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment (ART) related to serum composition and BMI and is it associated with oocyte and embryo quality? We showed that metabolic alterations in the serum are reflected in the follicular fluid and that some of these alterations ...
Castillo Ana - - 2012
ABSTRACT: BACKGROUND: No studies on continuous renal replacement therapy (CRRT) have analyzed nutritional status in children. The objective of this study was to assess the association between mortality and nutritional status of children receiving CRRT. METHODS: Prospective observational study to analyze the nutritional status of children receiving CRRT and its ...
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