Search Results
Results 501 - 550 of 2840
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Husain O M - - 2012
BACKGROUND: Alcohol-related presentations to hospital have been increasing in the UK in recent years, including the occurrence of acute withdrawal. This study sought to better characterize the clinical features, patterns of treatment and outcomes in this patient group. METHODS: Patients admitted to the Acute Medical Unit of York Hospital due ...
Jin Wenbiao - - 2012
It is an emerging concern that a series of disinfection byproducts (DBPs) produced in wastewater effluent have adversely impacted the downstream aquatic system and drinking water resources. The occurrence, fate, and transport of DBPs on receiving waterbodies, however, are currently not well-documented. To fill the knowledge gap, this study simulated ...
Abell Robin G - - 2012
To investigate and compare the rate of endophthalmitis after intravitreal injections performed in an in-office (dedicated procedure room) versus in-theatre setting. A retrospective comparative cohort study was performed of all patients consecutively treated by a single surgeon with intravitreal injection with either ranibizimab or bevacizumab for any recognised clinical indication. ...
He Chuan - - 2012
A novel silver-mediated highly selective C-H/N-H oxidative cross-coupling/cyclization between 2-aminopyridines and terminal alkynes has been demonstrated. This approach provided a simple way to construct heteroaromatic imidazo[1,2-a]pyridines. By using this protocol, the marketed drug zolimidine (antiulcer) could be synthesized easily.
Wang Xu-Dong - - 2012
We report on the first dual nanosensors for imaging of pH values and oxygen partial pressure in cells. The sensors have a unique nanostructure in that a soft core structure is rigidized with a silane reagent, while poly(ethylene glycol) chains form an outer shell. Lipophilic oxygen-sensitive probes and reference dyes ...
Brok Jesper - - 2012
Results from meta-analyses significantly influence clinical practice. Both simulation and empirical studies have demonstrated that the risk of random error (i.e. spurious chance findings) in meta-analyses is much higher than previously anticipated. Hence, authors and users of systematic reviews and meta-analyses have a responsibility to carefully consider the risk of ...
Bürstel Ingmar - - 2012
Hydrogen-cycling [NiFe] hydrogenases harbor a dinuclear catalytic center composed of nickel and iron ions, which are coordinated by four cysteine residues. Three unusual diatomic ligands in the form of two cyanides (CN(-)) and one carbon monoxide (CO) are bound to the iron and apparently account for the complexity of the ...
Townsend Julie S JS Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. - - 2013
The purpose of this study was to compare health behaviors and cancer screening among Californians with and without a family history of cancer. We analyzed data from the 2005 California Health Interview Survey to ascertain cancer screening test use and to estimate the prevalence of health behaviors that may reduce ...
Choi Ki Young - - 2012
8-Cl-cAMP (8-chloro-cyclic AMP), which induces differentiation, growth inhibition and apoptosis in various cancer cells, has been investigated as a putative anti-cancer drug. However, the exact mechanism of 8-Cl-cAMP functioning in cancer cells is not fully understood. Akt/PKB (protein kinase B) genes (Akt1, Akt2, Akt3) encode enzymes belonging to the serine/threonine-specific ...
Vassard Ditte - - 2012
Do social support and social strain from social relations have an impact on the decision to terminate fertility treatment among men and women after 1 year of unsuccessful treatment? Several functional aspects of social relations show an impact on the probability to terminate treatment; social support from family significantly decreases ...
Freys Jonathan C - - 2012
We report on the synthesis and characterization of a donor-acceptor ruthenium polypyridyl complex as a photosensitizer for p-type dye-sensitized solar cells (DSSCs). The electrochemical, photophysical, and photovoltaic performance of two ruthenium-based photosensitizers were tested in NiO-based DSSCs; bis-(2,2'-bipyridine-4,4'-dicarboxylic acid)(2)N-(1,10-phenanthroline)-4-nitronaphthalene-1,8-dicarboximide ruthenium(ii), ([Ru(dcb)(2)(NMI-phen)](PF(6))(2)) and tris-(2,2'-bipyridine-4,4'-dicarboxylic acid)(3) ruthenium(ii), [(Ru(dcb)(3))Cl(2)]. The presence of an ...
Lin Yiyun - - 2012
ABSTRACT: INTRODUCTION: The aim of this study was to explore the use of dexmedetomidine as a safe and efficacious sedative agent in post-cardiac surgery patients. METHODS: A systematic literature search of MEDLINE, EMBASE, the Cochrane Library and Science Citation Index until January 2012 and review of studies was conducted. Eligible ...
Miller Rowan E RE Department of Medical Oncology, Mount Vernon Cancer Centre, Middlesex, - - 2013
To determine the differential response to systemic chemotherapy in patients undergoing simultaneous orchidectomy and retroperitoneal lymph node dissection (RPLND) after chemotherapy for metastatic testicular cancer. Patients who underwent simultaneous RPLND and orchidectomy after chemotherapy were identified from our clinical databases. Postoperative pathological findings and patient characteristics were reviewed. In all, ...
Tang Qun - - 2012
RecR is an important recombination mediator protein in the RecFOR pathway. RecR together with RecO and RecF facilitates RecA nucleoprotein filament formation and homologous pairing. Structural and biochemical studies of Thermoanaerobacter tengcongensis RecR (TTERecR) and its series mutants revealed that TTERecR uses the N-N dimer as a basic functional unit ...
McAdams-Demarco M A MA Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2012
Early hospital readmission (EHR) is associated with increased morbidity, costs and transition-of-care errors. We sought to quantify rates of and risk factors for EHR after kidney transplantation (KT). We studied 32 961 Medicare primary KT recipients (2000-2005) linked to Medicare claims through the United States Renal Data System. EHR was ...
Sultan Sherif - - 2012
Cardiovascular primary prevention and regeneration programs are the contemporary frontiers in functional metabolic vascular medicine. This novel science perspective harnesses our inherent ability to modulate the interface between specialized gene receptors and bioavailable nutrients in what is labeled as the nutrient-gene interaction. By mimicking a natural process through the conveyance ...
Ciere Yvette - - 2012
We conducted a systematic review of controlled trials and pre-post studies to examine whether the putative benefits of telehealth, notably, improvements in clinical outcomes and quality of life, are mediated by increases in knowledge, self-efficacy and self-care behaviour in patients with heart failure. Telehealth was defined as any system of ...
Todd Brittany A - - 2012
STUDY OBJECTIVE: As data that prompted a 2009 labeling change detailing contraindications, precautions, and dosing recommendations for the first branded colchicine product were limited to case reports of myotoxicity and blood dyscrasias ascribed to the drug, we sought to quantify the association of colchicine therapy with serious adverse outcomes in ...
Vigdorchik Jonathan M - - 2012
ABSTRACT: BACKGROUND: We have recently developed a subcutaneous anterior pelvic fixation technique (INFIX). This internal fixator permits patients to sit, roll over in bed and lie on their sides without the cumbersome external appliances or their complications. The purpose of this study was to evaluate the biomechanical stability of this ...
Holcombe Thomas W - - 2012
Four D-π-A sensitizers comprising a thienyl-diketopyrrolopyrrole (ThDPP) bridge were synthesized and tested in iodide/triiodide liquid electrolyte DSC devices. The dye series was strategically designed to develop a structure-property relationship. The best performing sensitizer utilized a phenyl-based anchor and triphenylamine donor (η = 5.03%).
Emilsson Ossur Ingi - - 2012
Nocturnal gastroesophageal reflux (nGER) is associated with asthma and obstructive sleep apnoea (OSA). Our aim was to investigate whether nGER is a risk factor for onset of asthma and onset of respiratory and OSA symptoms in a prospective population based study.We invited 2640 subjects from Iceland, Sweden and Belgium for ...
Ilani Niloufar N Department of Medicine, Division of Endocrinology, Harbor-University of California, Los Angeles, Medical Center and Los Angeles Biomedical Research Institute, 1000 W Carson Street, Torrance, CA 90509, - - 2012
Do exogenous male hormonal contraceptives that suppress intratesticular testosterone and spermatogenesis interfere with the blood-testis barrier integrity in men? When spermatogenesis was suppressed by testosterone alone or combined with levonorgestrel (LNG) treatment in men, the structural appearance of Sertoli cell tight junctions remained intact in the human testis. Testosterone promotes ...
Hobeika Nelly - - 2012
We report on the synthesis and the photophysical properties of a trans nitroalkoxystilbene dimer (DPNS). The fluorescence quantum yield (φf), the Stokes shift, and the quantum yield for the trans-to-cis photoisomerization (φt→c) are strongly dependent on the nature of the solvent. Upon increasing solvent polarity, φf increases together with the ...
Moller Soren - - 2012
Autonomic and cardiac dysfunction is frequent in cirrhosis, and includes increased sympathetic nervous activity, impaired heart rate variability (HRV) and baroreflex sensitivity (BRS). Quantified (123)I-metaiodobenzylguanidine (mIBG) scintigraphy reflects cardiac noradrenaline uptake and in patients with cardiac failure it predicts outcome. In this study we aimed to investigate cardiac sympathetic function ...
Jansen Klaus - - 2012
Atazanavir-based regimens have established efficacy and safety in both antiretroviral (ARV) -naïve and -experienced patients. However, data evaluating effectiveness beyond 2 years is sparse. Therefore, we assessed the long-term outcomes of ritonavir-boosted atazanavir (ATV/r) containing regimens in ARV-experienced patients in a clinical setting in a non-comparative, retrospective, observational study collecting ...
Gautier Romain - - 2012
The new lamellar phases [Zn(2,2'-bpy)(2)(H(2)O)(2)](ZrF(6))·3H(2)O (I) and [Ni(2,2'-bpy)(3)](MoO(2)F(4))·5H(2)O (II) (bpy = bipyridine), which are built from a chiral cation and respectively an inherently nonpolar and a polar anion, provide two contrasting structures with respect to chirality and polarity in the solid state. Each nonpolar layer of I contains enantiomers of ...
Taziaux Melanie - - 2012
Context:The recent report that loss-of-function mutations in either the gene encoding neurokinin B (NKB) or its receptor (NK3R) produce gonadotropin deficiencies in humans strongly points to NKB as a key regulator of GnRH release.Objectives:We used NKB immunohistochemistry on postmortem human brain tissue to determine: 1) whether the human NKB system ...
Chen Chien-Hsu CH Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, - - 2012
The ideal treatment of large prostates with symptomatic benign prostatic hyperplasia (BPH) remains controversial. We compare the efficacy and safety of monopolar transurethral resection of the prostate (TURP) with high-intensity diode laser in combination with bipolar TURP (DL + b-TURP) in the treatment of large prostates. We retrospectively analyzed all ...
Pietka Terri A TA Center for Human Nutrition, Washington University, St. Louis, Missouri 63110, - - 2012
Sarcolemmal CD36 facilitates myocardial fatty acid (FA) uptake, which is markedly reduced in CD36-deficient rodents and humans. CD36 also mediates signal transduction events involving a number of cellular pathways. In taste cells and macrophages, CD36 signaling was recently shown to regulate store-responsive Ca(2+) flux and activation of Ca(2+)-dependent phospholipases A(2) ...
Debold Edward P - - 2012
Muscle fatigue from intense contractile activity is thought to result, in large part, from the accumulation of inorganic phosphate (P(i)) and hydrogen ions (H(+)) acting to directly inhibit the function of the contractile proteins; however, the molecular basis of this process remain unclear. We used an in vitro motility assay ...
Jerosch-Herold Christina C Faculty of Medicine and Health Sciences, School of Allied Health Professions, University of East Anglia, Norwich NR4 7TJ, UK. - - 2012
Surgical treatment for carpal tunnel syndrome does not always alleviate sensory deficits, especially in patients with severe disease. No proven treatment is currently available for these patients. We conducted a pilot randomized, controlled trial to evaluate the feasibility, patient acceptability, and efficacy of a sensory relearning (SR) program in patients ...
Coppens Michiel - - 2012
AimsThe CHA(2)DS(2)-VASc score is a modification of the CHADS(2) score that aims to improve stroke risk prediction in patients with atrial fibrillation (AF) by adding three risk factors: age 65-74, female sex, and history of vascular disease. Whereas previous evaluations of the CHA(2)DS(2)-VASc score included all AF patients, the aim ...
Gonzalez-Martinez Jorge - - 2012
Purpose:  Stereo-electroencephalography (SEEG) enables precise recordings from deep cortical structures, multiple noncontiguous lobes, as well as bilateral explorations while avoiding large craniotomies. Despite a long reported successful record, its application in the United States has not been widely adopted. We report on our initial experience with the SEEG methodology in ...
Chalmers Kerry A - - 2012
BACKGROUND: up to 25% of older people in the USA and other Western countries are anaemic by World Health Organization (WHO) criteria. The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based sample of Australian adults surveyed in ...
Tamari Yuki - - 2012
Abstract Superoxide dismutases (SODs) are antioxidant proteins that convert superoxide to hydrogen peroxide. In vertebrate cells, SOD1 is mainly present in the cytoplasm, with small levels also found in the nucleus and mitochondrial inter-membrane space, and SOD2 is present in the mitochondrial matrix. Previously, we conditionally disrupted the SOD1 or ...
Scosyrev Emil - - 2012
What's known on the subject? and What does the study add? Over the last few years, several observational studies examined the association of statin use with the risk of biochemical recurrence of prostate cancer after definitive local therapy. The objective of our present study was to summarise available evidence on ...
Elliott Andrea - - 2012
BACKGROUND: Thromboelastography measures the dynamics of coagulation. There are limited data about thromboelastography in acute ischemic stroke other than a single study from 1974 suggesting that acute ischemic stroke patients are hypercoagulable. There have been no studies of thromboelastography in the thrombolytic era despite its potential usefulness as a measure ...
Zandberg Wesley F WF Department of Chemistry, Simon Fraser University, 8888 University Dr., Burnaby V5A 1S6, - - 2012
Sialyl-Lewis X (sLe(X)) is a tetrasaccharide that serves as a ligand for the set of cell adhesion proteins known as selectins. This interaction enables adhesion of leukocytes and cancer cells to endothelial cells within capillaries, resulting in their extravasation into tissues. The last step in sLe(X) biosynthesis is the α1,3-fucosyltrasferase ...
Ramachandran Pradeep L PL Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, - - 2012
Downstream regulatory element antagonistic modulator (DREAM/KChIP3), a neuronal EF-hand protein, modulates pain, potassium channel activity, and binds presenilin 1. Using affinity capture of neuronal proteins by immobilized DREAM/KChIP3 in the presence and absence of calcium (Ca(2+)) followed by mass spectroscopic identification of interacting proteins, we demonstrate that in the presence ...
Ma Yu - - 2012
Klinefelter syndrome (KS) is the most common male chromosome aneuploidy. Its pathophysiology is largely unexplained due to the lack of adequate models. Here, we report the derivation of induced pluripotent stem cell (iPSCs) lines from a KS patient with a karyotype of 47, XXY. Derived KS-iPSCs meet all criteria of ...
James A - - 2012
The relationship between power output and the time that it can be sustained during exercise (i.e., endurance) at high intensities is curvilinear. Although fatigue is implicit in this relationship, there is little evidence pertaining to it. To address this, we developed a phenomenological model that predicts the temporal response of ...
Mace John H - - 2012
Involuntary memory chains are spontaneous recollections of the past that occur as a sequence of associated memories. This memory phenomenon has provided some insights into the nature of associations in autobiographical memory. For example, it has shown that conceptually associated memories (memories sharing similar content, such as the same people ...
Hussman Jm - - 2012
Abstract Objective: To review and summarize the literature concerning the cost-effectiveness of palivizumab compared to no prophylaxis in infants and young children with congenital heart disease (CHD). Methods: A systematic literature search (MEDLINE to March 2012, limited to English language) identified studies that examined the cost effectiveness of palivizumab in ...
Syeda Ruhma R Department of Chemistry, University of Oxford, MansīŦeld Road, Oxford OX1 3TA, United - - 2012
Voltage-gated K(+) (Kv) channels are tetrameric assemblies in which each modular subunit consists of a voltage sensor and a pore domain. KvLm, the voltage-gated K(+) channel from Listeria monocytogenes, differs from other Kv channels in that its voltage sensor contains only three out of the eight charged residues previously implicated ...
Mancini Flavia - - 2012
Multisensory interactions can produce analgesic effects. In particular, viewing one's own body reduces pain levels, perhaps because of changes in connectivity between visual areas specialized for body representation, and sensory areas underlying pain perception. We tested the causal role of the extrastriate visual cortex in triggering visually induced analgesia by ...
Laurent Gabriel - - 2012
AIMS: Our group has recently shown that in some patients, heart failure with preserved ejection fraction (HFPEF) may be explained by 'atrial dyssynchrony syndrome' (ADS) due to interatrial conduction delay (IACD), a short left atrioventricular interval (LAVI), and increased left atrial (LA) stiffness. Our primary objective was to evaluate LA ...
Ivashkin Pavel - - 2012
New chiral fluorinated reagents (N-(dibromofluoroacetyl)oxazolidinones) were easily synthesized and used in an asymmetric cyclopropanation process. The Michael initiated ring closure reaction provided chiral cyclopropanes bearing a fluorinated quaternary stereocenter. Various electron-deficient alkenes can be used to efficiently obtain chiral polysubtituted fluorinated cyclopropanes in good yields. Moderate to very good cis/trans ...
Faure Élise É Groupe d'Étude des Protéines Membranaires (GÉPROM), Université de Montréal, Montréal, Quebec H3C 3J7, - - 2012
Voltage-gated ion channels are responsible for the generation of action potentials in our nervous system. Conformational rearrangements in their voltage sensor domains in response to changes of the membrane potential control pore opening and thus ion conduction. Crystal structures of the open channel in combination with a wealth of biophysical ...
Obara Keisuke - - 2012
External alkalization activates the Rim101 pathway in Saccharomyces cerevisiae. In this pathway, three integral membrane proteins, Rim21, Dfg16, and Rim9, are considered to be the components of the pH sensor machinery. However, how these proteins are involved in pH sensing is totally unknown. In this work, we investigated the localization, ...
Yuen Tsz-Ying - - 2012
A highly convergent total synthesis of 7',8'-dihydroaigialospirol is described. Key steps of the synthesis include a Nozaki-Hiyama-Kishi (NHK) coupling of an iodoalkyne with an advanced phthalide-aldehyde and a remarkable one-pot acid-mediated global deprotection/spiroacetalization.
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