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Endres Courtney S - - 2012
During their long-distance migrations, sea turtles of several species feed on jellyfish and other invertebrates that are particularly abundant in ocean regions characterized by high productivity. An ability to distinguish productive oceanic regions from other areas, and to concentrate foraging activities in locations where prey density is highest, might therefore ...
Noblin Devin J DJ Department of Molecular Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT 06511, - - 2012
Small Molecule Microarrays (SMMs) represent a general platform for screening small molecule-protein interactions independent of functional inhibition of target proteins. In an effort to increase the scope and utility of SMMs, we have modified the SMM screening methodology to increase assay sensitivity and facilitate multiplex screening. Fusing target proteins to ...
Kloog Itai I Department of Environmental Health-Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Landmark Center 401 Park Drive West, Boston, Massachusetts 02215, USA. - - 2012
Satellite-derived aerosol optical depth (AOD) measurements have the potential to provide spatiotemporally resolved predictions of both long and short-term exposures, but previous studies have generally shown moderate predictive power and lacked detailed high spatio- temporal resolution predictions across large domains. We aimed at extending our previous work by validating our ...
Meier Jordan L - - 2012
Genomic applications of DNA-binding molecules require an unbiased knowledge of their high affinity sites. We report the high-throughput analysis of pyrrole-imidazole polyamide DNA-binding specificity in a 10(12)-member DNA sequence library using affinity purification coupled with massively parallel sequencing. We find that even within this broad context, the canonical pairing rules ...
Pore Nichole - - 2012
ABSTRACT: Takosubo cardiomyopathy is a rare but reversible type of cardiomyopathy that often mimics symptoms of acute coronary syndromes. It is essential that NPs differentiate the causes because treatment strategies vary.
Gay Sarah E - - 2012
ABSTRACT: Venous thromboembolism (VTE) refers to pulmonary embolism and deep venous thrombosis. Anticoagulation is the cornerstone of management for patients with VTE. This review will discuss current anticoagulation guidelines.
McLeod Judith D - - 2012
ABSTRACT: This review will discuss policies that influenced medical home establishment and involvement of nurse practitioners, the background of the pediatric medical home, challenges, successful programs, and recommendations.
O╩╝brien Patricia G - - 2012
ABSTRACT: The majority of patients with anxiety disorders present in primary care settings, and many are undiagnosed or undertreated-each disorder has defining characteristics. Anxiety disorders are debilitating, and proper treatment can improve quality of life. Preferred treatments are cognitive-behavior therapy and pharmacotherapy with selective serotonin reuptake inhibitors.
Raphel Jordan - - 2012
Photocrosslinkable, protein-engineered biomaterials combine a rapid, controllable, cytocompatible crosslinking method with a modular design strategy to create a new family of bioactive materials. These materials have a wide range of biomedical applications, including the development of bioactive implant coatings, drug delivery vehicles, and tissue engineering scaffolds. We present the successful ...
Mazzone Jennifer R - - 2012
A synthetic approach to the papyracillic acid family of natural products has been developed. The spiroacetal core is rapidly assembled through an unprecedented zinc carbenoid-mediated tandem chain extension-acylation reaction. Subsequent functional group manipulation provided access to papyracillic acid B and 4-epi-papyracillic acid C. The successful preparation of these molecules resulted ...
Fleming Gregory J - - 2012
Objective-To determine whether butorphanol induces thermal antinociception in green iguanas (Iguana iguana) and assess the human observer effect on quantitative evaluation of butorphanol-induced analgesia. Animals-6 juvenile green iguanas. Procedures-Skin temperature was recorded, and then a direct increasing heat stimulus was applied to the lateral aspect of the tail base of ...
Gong Wei - - 2012
In the present study, we investigated the effects of technetium-99 conjugated with methylene diphosphonate ((99) Tc-MDP), an agent used in radionuclide therapy, on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and explored the underlying mechanisms. The murine macrophage cell line RAW264.7 and bone marrow-derived-macrophages from C57BL/6 mice (BMM) were ...
Wallis Laura - - 2012
Drive-through flu vaccination is proving convenient and safe.
Bergenstal Richard M RM International Diabetes Center at Park Nicollet , Minneapolis, Minnesota 55416, USA. - - 2012
This study evaluated whether education and use of the advanced meter features of the CONTOUR(®) (Bayer HealthCare LLC, Diabetes Care, Tarrytown, NY) blood glucose monitoring system (BGMS) affect the frequency and pattern of blood glucose testing in insulin-using subjects with diabetes who routinely perform self-monitoring of blood glucose (SMBG). Insulin-using ...
Hannemann P F W - - 2012
The use of pulsed electromagnetic fields (PEMF) to stimulate bone growth has been recommended as an alternative to the surgical treatment of ununited scaphoid fractures, but has never been examined in acute fractures. We hypothesised that the use of PEMF in acute scaphoid fractures would accelerate the time to union ...
Mason Sharon E - - 2012
Objective-To model the plasma tetracycline concentrations in swine (Sus scrofa domestica) treated with medication administered in water and determine the factors that contribute to the most accurate predictions of measured plasma drug concentrations. Sample-Plasma tetracycline concentrations measured in blood samples from 3 populations of swine. Procedures-Data from previous studies provided ...
Streit M R - - 2012
The Oxford mobile-bearing unicompartmental knee replacement (UKR) is an effective and safe treatment for osteoarthritis of the medial compartment. The results in the lateral compartment have been disappointing due to a high early rate of dislocation of the bearing. A series using a newly designed domed tibial component is reported. ...
Mendez-Tellez Pedro A - - 2012
Critically ill patients requiring mechanical ventilation are frequently subjected to long periods of physical inactivity, leading to skeletal muscle atrophy and muscle weakness. Disuse muscle atrophy is the result of complex mechanisms, including altered protein turnover and disturbed redox signaling. These ICU-acquired complications are associated with longer duration of mechanical ...
Cohen Noah D - - 2012
Objective-To determine whether the concentration of airborne virulent Rhodococcus equi varied by location (stall vs paddock) and month on horse farms. Sample-Air samples from stalls and paddocks used to house mares and foals on 30 horse breeding farms in central Kentucky. Procedures-Air samples from 1 stall and 1 paddock were ...
Sarmah S S - - 2012
Radiological assessment of total and unicompartmental knee replacement remains an essential part of routine care and follow-up. Appreciation of the various measurements that can be identified radiologically is important. It is likely that routine plain radiographs will continue to be used, although there has been a trend towards using newer ...
Macintyre Neil R - - 2012
The ventilator discontinuation process is an essential component of overall ventilator management. Undue delay leads to excess stay, iatrogenic lung injury, unnecessary sedation, and even higher mortality. On the other hand, premature withdrawal can lead to muscle fatigue, dangerous gas exchange impairment, loss of airway protection, and also a higher ...
Berghuis Han - - 2012
The distinction between general personality dysfunctioning (GPD) and specific personality traits (SPT) is an important focus of attention in the proposed revisions of the DSM-5. The present study explores the distinction between GPD and SPT using the self-report questionnaires General Assessment of Personality Disorder (GAPD) and Severity Indices for Personality ...
Spuls Ph I - - 2012
Aim  Papp et al. (N Engl J Med 2012; 366: 1181-9) and Leonardi et al. (N Engl J Med 2012; 366: 1190-9) respectively assessed the efficacy and safety of brodalumab (AMG 827), a human monoclonal antibody directed against interleukin (IL)-17RA, the receptor of IL-17A and ixekizumab (LY2439821), a humanized anti-IL-17 monoclonal antibody ...
Lake-Bakaar Geri A - - 2012
Objective-To describe clinical signs, treatment, and outcome of aortic thrombosis in dogs. Design-Retrospective case series. Animals-31 dogs with aortic thrombosis. Procedures-Records were retrospectively reviewed and data collected regarding signalment, historical signs, physical examination findings, laboratory testing, definitive diagnosis, and presence of concurrent disease. Results-The records of 31 dogs with clinical ...
Escobar L F - - 2012
A total of 11 types of glycogen storage disorders have been recognized with variable clinical presentations. Type IV, also known as Andersen disease, represents a rare subtype that can induce severe clinical findings early in life. We report on a patient with early fetal onset of symptoms with severe neuromuscular ...
Benin Andrea L - - 2012
The objective of this study was to qualitatively describe the impact of a Rapid Response Team (RRT) at a 944-bed, university-affiliated hospital. We analysed 49 open-ended interviews with administrators, primary team attending physicians, trainees, RRT attending hospitalists, staff nurses, nurses and respiratory technicians. Themes elicited were categorised into the domains ...
Nelson Roxanne - - 2012
Some communities say 'yes,' but more needs to be done, and nurses can help.
Klein Claudia - - 2012
Objective-To determine the impact of antimicrobial-containing semen extender on the growth of Taylorella equigenitalis in semen culture-positive for contagious equine metritis (CEM) and the development of CEM after artificial insemination with CEM-positive semen extended with antimicrobial-containing semen extender. Design-Prospective study. Animals-21 mature mares free of CEM, 1 mature stallion experimentally ...
Singh Salil - - 2012
For gastroenterology, The Royal College of Physicians reiterates the common practice of two to three consultant ward rounds per week. The Royal Bolton Hospital NHS Foundation Trust operated a 26-bed gastroenterology ward, covered by two consultants at any one time. A traditional system of two ward rounds per consultant per ...
Carter David - - 2012
As sports programs are being cut, active commuting might fill the gap.
Chassanidis C G - - 2012
Periosteum is important for bone homoeostasis through the release of bone morphogenetic proteins (BMPs) and their effect on osteoprogenitor cells. Smoking has an adverse effect on fracture healing and bone regeneration. The aim of this study was to evaluate the effect of smoking on the expression of the BMPs of ...
Cummings C L - - 2012
Parental counseling becomes complex when considering the use of emerging technologies, especially if it is unclear whether the level of evidence is sufficient to transform the proposed therapy into accepted practice. This paper addresses ethical issues underlying medical decision-making and counseling in the setting of emerging treatments, when long-term outcomes ...
Paes Bosco A - - 2012
Pulmonary thromboembolism (PTE) is rare in neonates and infants; however evidence suggests it is underdiagnosed. The primary objective is to conduct a scientific review to determine if the presentation, diagnosis, treatment and outcomes of neonates and infants with PTE are consistent across studies. Secondly, to develop an algorithm to establish ...
Rickey Ellen J - - 2012
Objective-To determine whether a single contusive impact injury to the palmar aspect of the metacarpus would progress to post-traumatic osteoarthritis or palmar osteochondral disease in horses. Animals-12 horses. Procedures-In each horse, an impact injury was created on the palmar aspect of the medial metacarpal condyle of 1 randomly chosen limb ...
Beaufrère Hugues - - 2012
Objective-To assess the agreement and reliability of cardiac measurements obtained with 3 echocardiographic techniques in anesthetized red-tailed hawks (Buteo jamaicensis). Animals-10 red-tailed hawks. Procedures-Transcoelomic, contrast transcoelomic, and transesophageal echocardiographic evaluations of the hawks were performed, and cineloops of imaging planes were recorded. Three observers performed echocardiographic measurements of cardiac variables ...
Thomas Alec - - 2012
Medical students in the UK are encouraged to plan their career earlier than ever before. What do they need to do that? To explore the roles of the undergraduate curriculum and the foundation programme from the perspective of a foundation trainee looking towards a career in forensic psychiatry, and to ...
Tinkler Stacy H - - 2012
Objective-To determine whether plasma total CO(2) concentrations would vary with the size of the evacuated tube used to collect blood samples. Design-Randomized crossover study. Animals-Convenience sample of 20 healthy adult horses. Procedures-Jugular venous blood was collected from horses in random order into 8 types of evacuated tubes: 2-mL glass, 2- ...
Ashton Michael C - - 2012
The Personality Inventory for DSM-5 (PID-5), a new measure of maladaptive personality traits, has recently been developed by the DSM-5 Personality and Personality Disorders Workgroup. The PID-5 variables were examined within the seven-factor space defined by the six HEXACO factors and the Schizotypy/Dissociation factor (Ashton & Lee, 2012) using participant ...
Harris Tim - - 2012
Severe trauma is an increasing global problem mainly affecting fit and healthy younger adults. Improvements in the entire pathway of trauma care have led to improvements in outcome. Development of a regional trauma system based around a trauma centre is associated with a 15-50% reduction in mortality. Trauma teams led ...
Bendon C L - - 2012
Injectable collagenase is an alternative to surgical treatment for Dupuytren's disease. Previous studies have reported on the effectiveness of collagenase in finger contractures. This prospective study reports on the short-term safety and efficacy of collagenase treatment in five thumb and first web space Dupuytren's contractures. The thumb and first web ...
Giorgi Mario - - 2012
Objective-To evaluate the pharmacokinetics and pharmacodynamics of zolpidem after oral administration of a single dose (0.15 or 0.50 mg/kg) and assess any associated antianxiety and sedative effects in dogs. Animals-8 clinically normal sexually intact male dogs of various breeds. Procedures-Dogs were assigned to 2 groups (4 dogs/group) and administered zolpidem ...
Seah R B - - 2012
The success of total knee replacement (TKR) depends on optimal soft-tissue balancing, among many other factors. The objective of this study is to correlate post-operative anteroposterior (AP) translation of a posterior cruciate ligament-retaining TKR with clinical outcome at two years. In total 100 patients were divided into three groups based ...
Pulcini Joyce - - 2012
Here's what you need to know as the fall elections approach.
Sarrafian Tiffany L - - 2012
Objective-To determine major causes of death and the anatomic location of musculoskeletal injuries in Quarter Horse racehorses in California. Design-Retrospective case series. Animals-314 Quarter Horse racehorses with musculoskeletal injuries that were necropsied through the California Horse Racing Board Postmortem Program from 1990 to 2007. Procedures-Postmortem pathology reports were retrospectively reviewed. ...
Deborde Anne-Sophie - - 2012
Insecure attachment and the inability to identify emotions have both been put forward as possible explanations for dysfunction of the emotional system in borderline personality disorder (BPD). This study aimed to test a model according to which the influence of attachment on the development of BPD in adolescence is mediated ...
Brous Edie - - 2012
Although most health care professionals know that licensing boards can take disciplinary action against them for professional misconduct or gross negligence in clinical practice, nurses may not appreciate the true extent of authority the nursing boards maintain or the issues they address. This three-part series will discuss nursing disciplinary actions ...
Lahti Marius M Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland. - - 2012
We have previously shown that the temporary separation of Finnish children from both parents during World War II predicted any serious mental, substance use, and personality disorders in adulthood. Here we examine if parental separation is a specific vulnerability factor for any- and dramatic personality disorders relative to other mental ...
Bolwell Charlotte F - - 2012
Objective-To investigate the effect of exercise during yearling sales preparation on the risk of interruptions during training in Thoroughbred racehorses. Animals-114 Thoroughbred racehorses. Procedures-Information regarding the daily exercise of yearlings during sales preparation was obtained prospectively from a convenience sample of stud farms. Yearlings were followed to entry into race ...
Namba R S - - 2012
We examined patient and surgical factors associated with deep surgical site infection (SSI) following total hip replacement (THR) in a large integrated healthcare system. A retrospective review of a cohort of primary THRs performed between 2001 and 2009 was conducted. Patient characteristics, surgical details, surgeon and hospital volumes, and SSIs ...
Hess Dean R - - 2012
In recent years, there has been increasing interest in the use of noninvasive ventilation (NIV) in the post-extubation period to shorten the length of invasive ventilation, to prevent extubation failure, and to rescue a failed extubation. The purpose of this review is to summarize the evidence related to the use ...
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