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Yan Bin - - 2012
Using a photosensitive hybrid hydrogel loaded with upconverting nanoparticles (UCNPs), we show that continuous-wave near infrared (NIR) light (980 nm) can be used to induce the gel-sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution 'on-demand', where their bioactivity is resumed. This ...
Chang Vivian Y VY Department of Pediatrics, Division of Hematology/Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA. - - 2013
Gastric adenocarcinoma is a rare diagnosis in childhood. A 14-year-old male patient presented with metastatic gastric adenocarcinoma, and a strong family history of colon cancer. Clinical sequencing of CDH1 and APC were negative. Whole exome sequencing was therefore applied to capture the majority of protein-coding regions for the identification of ...
Fuehrer Hans-Peter - - 2012
The primers traditionally used to detect Plasmodium ovale infections are known for not binding all P. ovale parasites within the small-subunit rRNA gene when used alone. We describe a simple, cost- and time-efficient multiplex nested PCR and a nested PCR using a novel set of primers for the simultaneous detection ...
de Courcey Francine - - 2012
Cultured primary epithelial cells are used to examine inflammation in cystic fibrosis (CF). We describe a new human model system using cultured nasal brushings. Nasal brushings were obtained from 16 F508del homozygous patients and 11 healthy controls. Cells were resuspended in airway epithelial growth medium and seeded onto collagen coated ...
Kreit Eric - - 2012
Adaptive reflective surfaces have been a challenge for both electronic paper (e-paper) and biological organisms. Multiple colours, contrast, polarization, reflectance, diffusivity and texture must all be controlled simultaneously without optical losses in order to fully replicate the appearance of natural surfaces and vividly communicate information. This review merges the frontiers ...
Reznik Carmen C Department of Chemistry, Rice University, Houston, Texas 77005, - - 2012
Functional polymers have a wide variety of applications ranging from energy storage to drug delivery. For energy storage applications, desirable material properties include low cost, high charge storage and/or mobility, and low rates of degradation. Isotropic thin films have been used for many of these types of applications, but research ...
Shi Yuyan - - 2012
Abstract Adverse health and productivity outcomes have imposed a considerable economic burden on employers. To facilitate optimal worksite intervention designs tailored to differing employee risk levels, the authors established cutoff points for an Individual Well-Being Score (IWBS) based on a global measure of well-being. Cross-sectional associations between IWBS and adverse ...
Jarvis Joseph N - - 2012
HIV-associated cryptococcal meningitis (CM) is estimated to cause over half a million deaths annually in Africa. Many of these deaths are preventable. Screening patients for subclinical cryptococcal infection at the time of entry into antiretroviral therapy programs using cryptococcal antigen (CRAG) immunoassays is highly effective in identifying patients at risk ...
Bommakanti Gayathri - - 2012
The hemagglutinin protein (HA) on the surface of influenza virus is essential for viral entry into the host cells. The HA1 subunit of HA is also the primary target for neutralizing antibodies. The HA2 subunit is less exposed on the virion surface and more conserved than HA1. We have previously ...
Chiba Soutaro - - 2012
The RNA silencing suppression properties of Beet necrotic yellow vein virus (BNYVV) and Beet soil-borne mosaic virus (BSBMV) cysteine rich protein p14s have been investigated. Suppression of RNA silencing activities were evidenced using viral infection of silenced Nicotiana benthamina 16C, N. benthamina agroinfiltrated with GFP and GF-FG triggers supplemented with ...
Mortz C G - - 2012
Background:  A cohort of 1501 unselected 8(th) grade schoolchildren was established 15 years ago with the aim to follow the course of contact allergy and allergic contact dermatitis from school age into adult life. To date no studies have evaluated incidence rates and persistence of contact allergy and allergic contact ...
Thompson Melissa Emery - - 2012
An important adaptive problem for mammals in general, and primates in particular, is how females can manage the high costs of reproduction in the face of fluctuating energetic supplies. For many species, the best solution is to breed seasonally such that high costs are temporally coincident with predictable periods of ...
Qi Tingting - - 2012
A methodology is described for atomistic simulations of shock compressed materials that incorporates quantum nuclear effects on the fly. We introduce a modification of the multi-scale shock technique (MSST) that couples to a quantum thermal bath described by a colored noise Langevin thermostat. The new method, which we call QB-MSST, ...
Buchan Blake W - - 2012
We compared the Portrait Toxigenic C. difficile Assay, a new semiautomated sample-to-result molecular test, to a toxigenic bacterial culture/cell cytotoxin neutralization assay (TBC/CCNA) for the detection of toxigenic Clostridium difficile in 549 stool specimens. Stool specimens were also tested by one of three alternative FDA-cleared molecular tests for toxigenic C. ...
Bradshaw William E WE Institute of Ecology and Evolution, University of Oregon, Eugene, OR 97403-5289, USA. - - 2012
Identifying regions of the genome contributing to phenotypic evolution often involves genetic mapping of quantitative traits. The focus then turns to identifying regions of 'major' effect, overlooking the observation that traits of ecological or evolutionary relevance usually involve many genes whose individual effects are small but whose cumulative effect is ...
Seto Hirokazu - - 2012
A novel surface modification method was investigated. The surface of siliceous materials was modified using polystyrene, poly(acrylic acid), poly(N-isopropylacrylamide), and poly(p-acrylamidophenyl-α-mannoside) synthesized by reversible addition fragmentation chain transfer polymerization. Thiol-terminated polymers were obtained by reduction of thiocarbonate group using sodium borohydride. The polymers were immobilized on the surface via the ...
Luo Jun-Jie - - 2012
Redistribution of charged lipids induced by polyelectrolytes is an intriguing phenomenon. Proteins, due to their nature as polyelectrolytes, should also have this capacity. But their highly ordered structures may bring about more complex mechanisms. We studied the interaction between positively charged lysozyme and liposomes consisting of neutral dipalmitoylphosphatidylcholine (DPPC) and ...
Tsimicalis Argerie - - 2012
BACKGROUND: Families of children with cancer are confronted with a broad range of direct costs (out-of-pocket expenses), but the nature of these costs is poorly understood. This study aimed to disaggregate and describe these costs. PROCEDURE: A prospective, mixed method, cost-of-illness design was utilized. Starting in the fourth week following ...
Rifkin Samara B - - 2012
Objective: Identify factors associated with false-positive rapid HIV antibody tests. Design: This retrospective cohort study with nested case-controls involved patients tested for HIV by Boston Medical Center (BMC) affiliates. METHODS: Cases had a reactive fingerstick OraQuick ADVANCE rapid HIV 1/2 antibody test and a negative Western blot. Controls had nonreactive ...
Macdonald Tim - - 2012
OBJECTIVE: To determine how accurately psychiatry and general medical doctors can differentiate epileptic and psychogenic non-epileptic seizures based on videotaped events (closest proxy to witnessed events). This study aims to establish how confidently this distinction can be made, the reasons why a particular diagnosis is reached, and inter-rater agreement. METHODS: ...
Weintraub Steven J SJ Department of Medicine, St Louis Veterans Affairs Medical Center-John Cochran Division, St Louis, MO 63106, USA. - - 2012
African Americans with genotype 1 chronic hepatitis C attain a sustained virologic response (SVR) at only approximately one-half the rate of whites after peginterferon and ribavirin treatment. The serum concentration of 25-hydroxyvitamin D [25(OH)D] has recently been established as a predictor of treatment response. Therefore, the low serum concentrations of ...
Xu Q - - 2012
Pharmacogenetic (PG) dosing algorithms have been confirmed to predict warfarin therapeutic dose more accurately; however, most of them are based on standard intensity of warfarin anticoagulation, and their utility outside this range is limited. This study was designed to develop and validate a PG refinement algorithm in Chinese patients mainly ...
Xu Song - - 2012
Similar to other positive-sense, single-stranded RNA viruses, hepatitis C virus (HCV) replicates its genome in a remodeled intracellular membranous structure known as the membranous web (MW). To date, the process of MW formation remains unclear. It is generally acknowledged that HCV nonstructural protein 4B (NS4B) can induce MW formation through ...
Ariyaratnam Priyadharshanan - - 2012
OBJECTIVES: The role of coronary endarterectomy (CE) in modern cardiac surgery has been an extant debate as coronary artery bypass grafting (CABG) has advanced. However, as cardiac surgeons are being referred ever more complex coronary disease for surgical correction, adjunctive strategies may need re-evaluation. The long-term results of CE are ...
Young Cora J - - 2012
Photolabile nighttime radical reservoirs, such as nitrous acid (HONO) and nitryl chloride (ClNO(2)), contribute to the oxidizing potential of the atmosphere, particularly in early morning. We present the first vertically resolved measurements of ClNO(2), together with vertically resolved measurements of HONO. These measurements were acquired during the California Nexus (CalNex) ...
Dou Zhi-Feng - - 2012
X-shaped goethite iron oxide crystals were synthesized by a surfactant-free mild hydrothermal synthesis method with the aid of fluorine ion. The X-shaped goethite crystals could readily self-assembly into microscopic hollow spheres through oil-water interface induced self-assembly method. X-shaped hematite was obtained by phase topotactic transformation of the goethite precursors. The ...
Sun Chivin - - 2012
The trifluoropropynyl ligand -C≡CCF(3) was studied as a possible surrogate for the cyano ligand. Complexes of the type trans-[M(cyclam)(C≡CCF(3))(2)]OTf (where M = Cr(3+), Co(3+), and Rh(3+); OTf = trifluoromethanesulfonate) were prepared and then characterized by electronic spectroscopy and by cyclic voltammetry for the Co(3+) complex. The UV-vis spectra for all ...
Ståhlberg Anders - - 2012
BACKGROUND:The single cell represents the basic unit of all organisms. Most investigations have been performed on large cell populations, but understanding cell dynamics and heterogeneity requires single-cell analysis. Current methods for single-cell analysis generally can detect only one class of analytes.METHODS:Reverse transcription and the proximity ligation assay were coupled with ...
Xiao Qing - - 2012
Transition-metal-catalyzed carbene transformations and cross-couplings represent two major reaction types in organometallic chemistry and organic synthesis. However, for a long period of time, these two important areas have evolved separately, with essentially no overlap or integration. Thus, an intriguing question has emerged: can cross-coupling and metal carbene transformations be merged ...
Chen Mark - - 2012
In addition to being a hallmark of neurodegenerative disease, axon degeneration is used during development of the nervous system to prune unwanted connections. In development, axon degeneration is tightly regulated both temporally and spatially. Here, we provide evidence that degeneration cues are transduced through various kinase pathways functioning in spatially ...
Kronauer Daniel J C - - 2012
Asexual reproduction is particularly common among introduced species, probably because it helps to overcome the negative effects associated with low population densities during colonization. The ant Cerapachys biroi has been introduced to tropical and subtropical islands around the world since the beginning of the last century. In this species, workers ...
Cuello Susana - - 2012
Mercury toxicity and its implications in development are a major concern, due to the major threat to ecosystems and human health that this compound represents. Although some of the effects of methylmercury (MeHg) exposure have been extensively studied, the molecular mechanisms of interaction between this compound and developing organisms are ...
Kern Uwe - - 2012
Objectives.  Effective treatment of phantom limb pain (PLP, pain felt in the part of the body of an amputated limb) is still difficult to achieve, and improved treatment is needed. It is therefore of paramount interest to understand the current practice of PLP therapy outside pain centers. Design.  As a ...
O' Dwyer Sarah - - 2012
The aims of this paper are to briefly describe the need for psychoeducation for older adults with depression, the nature of the existing resources, the need for an alternative resource and the development and context of the St. Vincent's Hospital Psychogeriatrics Mental Health Service (SVHMHS) 'Homeward Bound' psychoeducation programme using ...
Nunes Marcio R T - - 2012
Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus complete genomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable ...
Arroyo David - - 2012
Hypercalcemia is a potential adverse effect of calcium-containing ion exchange resins, often used in the treatment and prevention of hyperkalemia in chronic kidney disease (CKD). We describe a series of seven outpatients with moderate CKD (mean glomerular filtration rate estimated with the CKD-EPI formula 41.29&plusmn;10.83mL/min/1.73m2), presenting mild hypercalcemia in relation ...
Puertas Maria C - - 2012
Antiretroviral drug susceptibility tests facilitate therapeutic management of HIV-1-infected patients. Although genotyping systems are affordable, inaccuracy in the interpretation of complex mutational patterns may limit their usefulness. Currently available HIV-1 phenotypic assays are based on the generation of recombinant viruses in which the specific viral gene of interest, derived from ...
Makimura Hideo H Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, - - 2012
Obesity is associated with reduced GH secretion and increased cardiovascular disease risk. We performed this study to determine the effects of augmenting endogenous GH secretion on body composition and cardiovascular disease risk indices in obese subjects with reduced GH secretion. A randomized, double-blind, placebo-controlled study was performed involving 60 abdominally ...
Chambert Thierry T Department of Ecology, Montana State University, Bozeman, MT 59717, USA. - - 2012
Extreme events have been suggested to play a disproportionate role in shaping ecological processes, but our understanding of the types of environmental conditions that elicit extreme consequences in natural ecosystems is limited. Here, we investigated the impact of a massive iceberg on the dynamics of a population of Weddell seals. ...
Coen Muireann P - - 2012
An NMR-based metabonomic approach was applied to study the systems level metabolic effects of two closely related thiophene compounds, tienilic acid (TA) and tienilic acid isomer (TAI). The metabonomic data were anchored with traditional clinical chemistry and histopathologic analyses. TA was removed from the market as a result of suspected ...
O'Brien Michael J - - 2012
BACKGROUND: Sleep deprivation may slow reaction time, cloud judgment, and impair the ability to think. Our purpose was to study the cognitive and psychomotor performances of orthopaedic trauma surgeons on the basis of the amount of sleep that they obtained. METHODS: We prospectively studied the performances of thirty-two orthopaedic trauma ...
Chan Wing Keung WK Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, - - 2012
Leukemias with MLL gene rearrangement are associated with a poor prognosis. Natural killer (NK) cell therapy is a potential treatment, but leukemia cells may be resistant. Here, we sought to determine the susceptibility of MLL-rearranged leukemia cells to NK cell lysis and to develop a novel immunotherapeutic approach to optimize ...
Peacock Oliver - - 2012
BACKGROUND: Teaching may be delivered through different media in different settings. We aimed to evaluate four teaching modalities for medical students on a common surgical topic. We compared learning, student preferences and experiences as outcome measures. METHODS: This is a prospective observational study of all medical students undertaking their first ...
Lardone M C - - 2012
We characterised and correlated the histological and hormonal aspects of a cohort of 261 azo/oligozoospermic men, applying a quantitative/qualitative evaluation of testicular tissue and serum and intratesticular hormonal measurements. One hundred and 93 azo⁄oligozoospermic patients were diagnosed as: complete sertoli cell only syndrome (cSCOS), n = 76; focal SCOS, n = 31; maturation arrest, ...
Chopera Denis R - - 2012
Certain immune-driven mutations in HIV-1, such as those arising in p24(Gag), decrease viral replicative capacity. However, the intersubtype differences in the replicative consequences of such mutations have not been explored. In HIV-1 subtype B, the p24(Gag) M250I mutation is a rare variant (0.6%) that is enriched among elite controllers (7.2%) ...
Riely Brendan K - - 2012
The Medicago truncatula DMI2 gene encodes a leucine rich-repeat receptor-like kinase that is essential for symbiosis with nitrogen-fixing rhizobia. While phenotypic analyses have provided a description for the host's responses mediated by DMI2, a lack of tools for in vivo biochemical analysis has hampered efforts to elucidate the mechanisms by ...
Pu Xiong - - 2012
LiCoO(2) nanoparticles were coated with 3.4 and 5.5 wt% of lithium vanadate (Li(3)VO(4)) by a wet-chemical and sintering method. When the electrode containing 5.5-wt% Li(3)VO(4)-coated LiCoO(2) was overcharged to 4.5 V at a current of 30 mA g(-1) (∼0.2 C), ∼85% of the initial discharge capacity after 100 charge-discharge cycles ...
Simpson Eleanor H EH Department of Psychiatry, Columbia University, New York, NY, USA. - - 2012
The negative symptoms of schizophrenia include deficits in motivation, for which there is currently no treatment available. Animal models provide a powerful tool for identifying the potential pathophysiological mechanisms underlying the motivation deficits of schizophrenia with the aim of discovering novel treatment targets. The success of such an approach critically ...
Fournet Vincent - - 2012
Recent evidence underlines the crucial role of neuronal cytoskeleton in the pathophysiology of psychiatric diseases. In this line, the deletion of STOP/MAP6 (Stable Tubule Only Polypeptide), a microtubule-stabilizing protein, triggers various neurotransmission and behavioral defects, suggesting that STOP knockout (KO) mice could be a relevant experimental model for schizoaffective symptoms. ...
Lopez J Alberto - - 2012
AIMS: Current guidelines recommend that patients with infected cardiac rhythm management device (CRMD) sites undergo removal of all system components (pulse-generator and leads). However, lead removal may not be an option for patients who lack access to state-of-the-art technology, lack the necessary financial resources, or are at very high risk ...
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