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Fiandrino G - - 2012
MYD88 is a cytoplasmic adaptor protein involved in the antiviral response of blastic plasmacytoid dendritic cells.(1) A heterozygous mutation of exon 5 (c.794T>C) in MYD88 gene has been recently identified in diffuse large B-cell lymphomas (DLBCL) with activated B-cell-like phenotype,(2) primary cutaneous DLBCL,(3) primary central nervous system DLBCL,(4) as well ...
Smith Andrew P - - 2012
Research has shown that extraverts performing a working memory task benefit more from caffeine than do introverts. The present study aimed to replicate this and extend our knowledge by using a lower dose of caffeine (65 mg) and a range of tasks related to different components of working memory. In ...
Ortonne J P - - 2012
Background:  Nail psoriasis is common in patients with psoriasis and can seriously affect their quality of life. Current treatments are limited and there is no standard course of therapy. Objectives:  The objective of the NAIL study was to assess the efficacy and safety of etanercept (ETN) on nail psoriasis in ...
Jacobsen Gitte Højbjerg - - 2013
Acute lung function (LF) changes might predict an accelerated decline in LF. In this study, we investigated the association between cross-shift and longitudinal changes in forced expiratory volume in 1 s (FEV(1)) among woodworkers in a 6-year follow-up study. 817 woodworkers and 136 controls participated with cross-shift changes of FEV(1) ...
Jin Min M Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Dapital Hospital, Third Military University, Chongqing, - - 2012
Gain-of-function mutations in fibroblast growth factor receptor-3 (FGFR3) lead to several types of human skeletal dysplasia syndromes including achondroplasia, hypochondroplasia and thanatophoric dysplasia (TD). Currently, there are no effective treatments for these skeletal dysplasia diseases. In this study, we screened, using FGFR3 as a bait, a random 12-peptide phage library ...
Shao Jie J Department of Child Health Care, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2012
Iron deficiency (ID) is common in pregnant women and infants, particularly in developing countries. The relation between maternal and neonatal iron status remains unclear. This study considered the issue in a large sample of mother-newborn pairs in rural southeastern China. Hemoglobin (Hb) and serum ferritin (SF) were measured in 3702 ...
Tong Pan P Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, - - 2012
Identifying genes altered in cancer plays a crucial role in both understanding the mechanism of carcinogenesis and developing novel therapeutics. It is known that there are various mechanisms of regulation that can lead to gene dysfunction, including copy number change, methylation, abnormal expression, mutation and so on. Nowadays, all these ...
Hilsted Linda L Department of Clinical Biochemistry, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark. - - 2013
Paediatric reference intervals based on samples from healthy children are difficult to establish and consequently data are often from hospitalized children. Furthermore, biases may present in published data due to differences in the analytical methods employed. Blood samples from 1429 healthy Danish children were collected for establishing reference intervals for ...
Chen Qi - - 2012
How the human brain reconstructs the three-dimensional (3D) world from two-dimensional (2D) retinal images has received a great deal of interest as has how we shift attention in 2D space. In contrast, it remains poorly understood how visuospatial attention is shifted in depth. In this fMRI study, by constructing a ...
Espregueira Themudo G - - 2012
How frequently genes pass through a hybrid zone may be influenced by the environment. Accordingly, in long hybrid zones that span more than one environmental setting, different patterns may emerge. The varied conditions allow testing of hypotheses on dispersal as a function of the environment. We reconstruct the amount and ...
Viswanathan G N - - 2012
Type 2 diabetes mellitus (T2DM) is associated with higher rates of thrombotic complications in patients with coronary artery disease (CAD) despite optimal medical therapy. Thrombus area was measured in T2DM and non-diabetic patients receiving aspirin and clopidogrel 7-10 days after troponin positive Non ST-elevation acute coronary syndrome (NSTE-ACS). Secondly, we ...
Pei Wei - - 2012
We study the transient heat generation in a quantum dot system driven by a step-like or a square-shaped pulse bias. We find that a periodically oscillating heat generation arises after adding the sudden bias. One particularly surprising result is that there exists a heat absorption from the zero-temperature phonon subsystem. ...
Naumer Matthias - - 2012
Adeno-associated virus (AAV) capsid assembly requires expression of the assembly-activating protein (AAP) together with capsid proteins VP1, VP2, and VP3. AAP is encoded by an alternative open reading frame of the cap gene. Sequence analysis and site-directed mutagenesis revealed that AAP contains two hydrophobic domains in the N-terminal part of ...
Wiecko Filip M - - 2012
This research focuses on a detailed exploration of late-onset offending. Using the National Youth Survey, this work seeks to answer three questions. First, is late-onset offending a real phenomenon? Second, if late onset does exist, is the evidence for it conditioned by how we define crime and delinquency? Finally, is ...
Flammer Andreas J AJ Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, - - 2012
Vascular calcification, an important feature of diabetic vasculopathy, is an active process potentially mediated by endothelial progenitor cells (EPCs) coexpressing the osteoblastic marker osteocalcin (OCN). In this study we tested the hypothesis that cells expressing these markers are associated with the presence of elevated glycated hemoglobin (HbA1c). This was a ...
Wolters Dirk A - - 2012
An approach to characterize the interactions of RAPTA-T, a novel ruthenium-based anticancer drug candidate with intriguing antimetastatic properties, with human ovarian cancer cells in vitro is described. The distribution profile of the metallodrug within the cancer cells was determined by (size exclusion chromatography)-inductively coupled mass spectrometry combined with subcellular fractionation ...
Qian Wei W Department of Pharmacology and Chemical Biology, Hillman Cancer Center Pittsburgh, PA 15213 - - 2012
Mitochondrial fission and fusion cycles are integrated with cell cycle progression. In this paper, we demonstrate that the inhibition of mitochondrial fission protein Drp1 causes an unexpected delay in G2/M cell cycle progression and aneuploidy. In investigating the underlying molecular mechanism, we revealed that inhibiting Drp1 triggers replication stress, which ...
Brittain John-Stuart - - 2012
The subthalamic nucleus (STN) is a key node in the network that supports response inhibition. It is suggested that the STN rapidly inhibits basal ganglia activity, to pause motor output during conflict until an appropriate motor plan is ready. Here, we recorded neural activity during a Stroop task from deep ...
Phillips R B - - 2012
We report the genetic map location of 14 genes involved in the inflammatory response to salmonid bacterial and viral pathogens, which brings the total number of immune genes mapped in rainbow trout (RT, Oncorhynchus mykiss) to 61. These genes were mapped as candidate genes that may be involved in resistance ...
Donaldson Cameron - - 2012
Hypertension (HTN) causes concentric left ventricular remodeling, defined as an increased relative wall thickness or overt left ventricular hypertrophy, and associated diastolic dysfunction. HTN and concentric remodeling are also common precursors to heart failure with a preserved ejection fraction. It is not known whether the myofilament contributes to diastolic dysfunction ...
Stahl James A JA Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, - - 2012
Several studies have previously defined host-derived signaling events capable of driving lytic gammaherpesvirus replication or enhancing immediate-early viral gene expression. Yet signaling pathways that regulate later stages of the productive gammaherpesvirus replication cycle are still poorly defined. In this study, we utilized a mass spectrometric approach to identify c-Jun as ...
Popa-Burke Ioana - - 2012
Early drug discovery laboratories often call for the precise weighing of 1- to 5-mg solids into 4- to 5-g glass vials. For the balance used in this study (Mettler Toledo XP205), the manufacturer rates its accuracy at ±0.01 mg over the working range of 1 mg to 220 g and ...
Korsatko S - - 2012
AIMS: To compare the pharmacodynamic properties of insulin detemir (detemir) and neutral protamine lispro insulin (NPL) using a euglycaemic glucose clamp. MATERIALS AND METHODS: In a double-blind, crossover study, thirty patients with C-peptide negative type 1 diabetes were randomly assigned to a single dose (0.4 U/kg) of detemir and NPL. ...
Gul Mehmet - - 2012
We report a case with a very rare complication of transcatheter aortic valve implantation. Rupture of the NovaFlex balloon (Edwards transfemoral balloon catheter) occurred during the inflation of the Edwards SAPIEN valve, resulting in dissection of the right common and external iliac arteries during withdrawal of the balloon catheter. The ...
Franco Wendy - - 2012
AIMS: To evaluate the interaction between yeasts and bacteria and associate their metabolic activity with secondary cucumber fermentation. METHODS AND RESULTS: Selected yeast and bacteria, isolated from cucumber secondary fermentations, were inoculated as single and mixed cultures in a cucumber juice model system. Our results confirmed that during storage of ...
Wang Pei-Yuan - - 2012
Toxoplasma gondii is an obligate intracellular parasite infecting humans and other warm-blooded animals, resulting in serious public health problems and economic losses worldwide. Rhoptries are involved in T. gondii invasion and host cell interaction and have been implicated as important virulence factors. In the present study, a DNA vaccine expressing ...
Lazaros L - - 2012
Follicle-stimulating hormone (FSH), interacting with its receptor (FSHR), participates in the production of spermatozoa and androgens. Androgens exert their effects on male sex determination, development and sperm production by binding to androgen receptor (AR). In the present study, we sought to explore the potential synergistic effects of FSHR and AR ...
Qureshi Shabir H SH Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, MO 63104, - - 2012
Factor IXa (FIXa) is a vitamin K-dependent coagulation serine protease which binds to factor VIIIa (FVIIIa) on negatively charged phospholipid vesicles (PCPS) to catalyse the activation of factor X (FX) to factor Xa (FXa) in the intrinsic pathway. Fluorescence resonance energy transfer (FRET) studies have indicated that the Gla-domain-dependent interaction ...
Barigye Stephen J - - 2012
Graph-theoretic matrix representations constitute the most popular and significant source of topological molecular descriptors (MDs). Recently, we have introduced a novel matrix representation, named the duplex relations frequency matrix, F, derived from the generalization of an incidence matrix whose row entries are connected subgraphs of a given molecular graph G. ...
Risotto Stephen - - 2012
The article accepted for publication in Indoor Air suggesting an association between polyvinyl chloride (PVC) flooring and uptake of phthalates in infants (Carlstedt et al. accepted May 7, 2012) furthers a disturbing trend of advocacy masquerading as science. What makes this article of particular concern is the significant amount of ...
Obama Barack - - 2012
The editors asked the Democratic and Republican presidential nominees, President Barack Obama and former Massachusetts Governor Mitt Romney, to describe their health care platforms and their visions for the future of American health care. Their statements follow. From the moment I took office, the central challenge we have confronted as ...
Davis Stephanie E - - 2012
L-type voltage-gated calcium channels (L-VGCCs) in the basolateral nucleus of the amygdala (BLA) are necessary for long-term memory of fear conditioning, where they are thought to drive the activation of protein kinases and to initiate gene transcription. However, their role in fear extinction learning is unclear given that systemic injections ...
Ta Truong Minh - - 2012
The isoprenoid squalene is an important precursor for the biosynthesis of sterols. The cellular storage of squalene and its impact on membrane properties have been the subject of recent investigations. In a screen for abnormal lipid droplet morphology and distribution in the yeast Saccharomyces cerevisiae, we found significant lipid droplet ...
Bloetzer Clemens - - 2012
AIM: Determine the frequency and predictors of sleep disorders in boys with Duchenne Muscular Dystrophy (DMD). METHOD: Cross-sectional study by postal questionnaire. Sleep disturbances were assessed using the Sleep Disturbance Scale for Children (validated on 1157 healthy children). A total sleep score and six sleep disturbance factors representing the most ...
Nieuwlaat R - - 2012
Excellent control of the international normalised ratio (INR) is associated with improved clinical outcomes in patients receiving warfarin, and can be achieved by anticoagulation clinics but is difficult in general practice. Anticoagulation clinics have often used validated commercial computer systems to manage the INR, but these are not usually available ...
Peterson Eliza J R - - 2012
The human commensal pathogen Streptococcus pneumoniae expresses a number of virulence factors that promote serious pneumococcal diseases, resulting in significant morbidity and mortality worldwide. These virulence factors may give S. pneumoniae the capacity to escape immune defenses, resist antimicrobial agents, or a combination of both. Virulence factors also present possible ...
Kochem Amélie - - 2012
Square planar cobalt(II) complexes of salen ligands N,N'-bis(3-tert-butyl-5R-salicylidene)-1,2-cyclohexanediamine), where R = OMe (1) and tert-butyl (2), were prepared. 1 and 2 were electrochemically reversibly oxidized into cations [1-H(2)O](+) and [2-H(2)O](+) in CH(2)Cl(2). The chemically generated [1-H(2)O](SbF(6))·0.68 H(2)O·0.82CH(2)Cl(2) and [2-H(2)O](SbF(6))·0.3H(2)O·0.85CH(2)Cl(2) were characterized by X-ray diffraction and NIR spectroscopy. Both complexes are ...
Li Qing - - 2012
Self-assembled monolayers are the basis for molecular nanodevices, flexible surface functionalization and dip-pen nanolithography. Yet self-assembled monolayers are typically created by a rather inefficient process involving thermally driven attachment reactions of precursor molecules to a metal surface, followed by a slow and defect-prone molecular reorganization. Here we demonstrate a non-thermal, ...
Kollin C - - 2012
Context:A randomized controlled study was conducted comparing the outcome of surgery for congenital cryptorchidism at 9 months or 3 yr of age.Objective:The aim of the study was to investigate whether surgery at 9 months is more beneficial than at 3 yr and to identify early endocrine markers of importance for ...
Klawitter Jelena - - 2012
AIMS: Dilated cardiomyopathies from chronic ischemia (ISCM) or idiopathic (IDCM) pathological mechanisms accompany similar clinical symptoms but may differ in protein expression, cell metabolism, and signaling processes at the cellular level. Using a combination of proteomic and metabolomic profiling, we sought to decipher the relationships between the metabolism and cellular ...
Sandberg M - - 2012
Overexpression of α2A-adrenoceptors contributes to type 2 diabetes in GK rats. We aimed to investigate if α2-adrenoceptor inhibition affected islet blood flow in these rats. Anesthetized GK and Wistar-F rats were given the α2-adrenoceptor inhibitor yohimbine (2.5 mg/kg BW) intravenously. The GK rats had higher blood glucose and serum insulin concentrations ...
Turpie A G G - - 2012
A number of novel oral anticoagulants that directly target factor Xa or thrombin have been developed in recent years. Rivaroxaban and apixaban (direct factor Xa inhibitors) and dabigatran etexilate (a direct thrombin inhibitor) have shown considerable promise in large-scale, randomised clinical studies for the management of thromboembolic disorders, and have ...
Fuller Brian F - - 2012
Environmental tobacco smoke (ETS) exposure is linked to developmental deficits and disorders with known cerebellar involvement. However, direct biological effects and underlying neurochemical mechanisms remain unclear. We sought to identify and evaluate underlying neurochemical change in the rat cerebellum with ETS exposure during critical period development. We exposed rats to ...
Mauvoisin Daniel - - 2012
Stearoyl-CoA Desaturase-1 (SCD1) is an ER anchored enzyme catalysing the synthesis of monounsaturated fatty acids (MUFAs) mainly palmytoleyl- and oleyl-CoA. Recent studies have revealed a function for SCD1 in the modulation of signaling processes related to cell proliferation, survival and transformation to cancer. We used MCF7 and MDA-MB-231 cells to ...
McNulty Cliodna A M - - 2012
On 18 November 2012, the UK will once again support the annual European Antibiotic Awareness Day (EAAD). In particular, hospitals will be asked to promote the Start Smart-Then Focus guidance for hospitals launched in 2011, while the Royal College of General Practitioners will publish the TARGET Antibiotics toolkit on their ...
Harenberg J - - 2012
New oral anticoagulant (NOAC) regimens [dabigatran 150 mg (D150) and 220 mg (D220), rivaroxaban 10 mg (R20), and apixaban 2.5 mg bid (A5)] were effective and safe compared to enoxaparin for the prevention of venous thromboembolism (VTE) following elective total knee (TKR) or hip replacement (THR) surgery. First a cluster ...
Barrera-Chimal Jonatan - - 2013
Acute kidney injury (AKI) has been recognized as a risk factor for the development of chronic kidney disease (CKD). Aldosterone has a critical role in promoting renal injury induced by ischemia. Here, we evaluated whether spironolactone administered before or after AKI caused by ischemia protects against CKD. In the first ...
Chen Shangbin - - 2012
We have developed an approach to directly probe neuronal excitability during the period beginning with induction of global ischemia and extending after reperfusion using transgenic mice expressing channelrhodopsin-2 (ChR2) to activate deep layer cortical neurons independent of synaptic or sensory stimulation. Spontaneous, ChR2, or forepaw stimulation-evoked electroencephalogram (EEG) or local ...
Neogi Subhadip - - 2012
A stoichiometric variant of the HETPYP concept (HETeroleptic PYridine and Phenanthroline metal complexes) opens the venue to heteroleptic metallosupramolecular HETPYP-I assemblies both in solution and the solid state, involving the trigonal [Cu(phenAr(2))(py)](+) coordination motif (phenAr(2) = 2,9-diarylphenanthroline; py = various oligopyridines). Combining the same building blocks at another stoichiometric ratio ...
Gernigon Nicolas - - 2012
The importance of amides as a component of biomolecules and synthetic products motivates the development of catalytic, direct amidation methods employing free carboxylic acids and amines that circumvent the need for stoichiometric activation or coupling reagents. ortho-Iodophenylboronic acid 4a has recently been shown to catalyze direct amidation reactions at room ...
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