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Paramasivam Nagarajan - - 2012
ABSTRACT: BACKGROUND: In Gram-negative bacteria, the outer membrane is composed of an asymmetric lipid bilayer of phopspholipids and lipopolysaccharides, and the transmembrane proteins that reside in this membrane are almost exclusively beta-barrel proteins. These proteins are inserted into the membrane by a highly conserved and essential machinery, the BAM complex. ...
Liang Liang-Han - - 2012
BACKGROUND: -Despite adequate rate control, the combination of atrial fibrillation (AF) with heart failure (HF) has been shown in a number of studies to hasten HF progression. In this context we aimed to test the hypothesis that an irregular ventricular rhythm causes an alteration in ventricular cardiomyocyte excitation-contraction coupling which ...
Ding Ling - - 2012
Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure-activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.
Fibla Juan J - - 2012
OBJECTIVES: A new revision of the international lung cancer staging system has been recently introduced. The revisions are largely focussed on the T descriptor. We sought to test the validity of this new system on a separate prospectively collected cohort of patients from a recent multicentre trial of early-stage lung ...
Rekvig Ole Petter - - 2012
Loss of immunological tolerance results in autoimmunity and may finally end in autoimmune disorders. For an autoimmune response against chromatin, autologous chromatin (nucleosomes) is assumed to activate both chromatin-specific B and T cells with a resulting anti-chromatin antibody response. As only fragmental elements of this process have been described, we ...
Friman Ville-Petri - - 2012
The impact of community complexity on pairwise coevolutionary dynamics is theoretically dependent on the extent to which species evolve generalised or specialised adaptations to the multiple species they interact with. Here, we show that the bacteria Pseudomonas fluorescens diversifies into defence specialists, when coevolved simultaneously with a virus and a ...
Ng Alphonsus H C - - 2012
We introduce a new format for particle-based immunoassays relying on digital microfluidics (DMF) and magnetic forces to separate and resuspend antibody-coated paramagnetic particles. In DMF, fluids are electrostatically controlled as discrete droplets (picoliters to microliters) on an array of insulated electrodes. By applying appropriate sequences of potentials to these electrodes, ...
Colbert James A - - 2012
In early August, we presented two cases involving persons who were potential candidates for preexposure prophylaxis (PrEP) for HIV in Clinical Decisions,(1) an interactive feature designed to assess how readers would manage a clinical problem for which there may be more than one appropriate approach to the care of the ...
Lee Mi Hyeon - - 2012
Background.  Compared with the blind technique, ultrasound-guided stellate ganglion block (SGB) reduces the amount of local anesthetic needed for a successful block. The purpose of this study is to determine the minimal, optimal volume of local anesthetic required for successful ultrasound-guided SGB and to reduce its adverse effects. Methods.  Thirty-five ...
Day Sara W - - 2012
BACKGROUND: Inadequate nursing care is a major impediment to development of effective programs for treatment of childhood cancer in low-income countries. When the International Outreach Program at St. Jude Children's Research Hospital established partner sites in low-income countries, few nurses had pediatric oncology skills or experience. A comprehensive nursing program ...
Zheng Jukuan - - 2012
A primary amine derivatized dibenzylcyclooctyne (DIBO) was synthesized and used to initiate ring opening polymerization of poly(γ-Benzyl-L-glutamate)(DIBO-PBLG). This initiator exhibits living polymerization characteristics and yields well-defined PBLG functionalized with DIBO at the chain end. The DIBO end-group survives an electrospinning process that yields nanofibers which are then derivatized post-assembly with ...
Mizuno Koji - - 2012
Although type 1 inositol 1,4,5-trisphosphate receptors (IP3Rs-1) are one of the major calcium channels to regulate intracellular Ca(2+) concentration, there have been few available data how their expression is modified by long-term exposure to ethanol. The present study attempted to clarify mechanisms of modification of IP3R-1 expression during long-term ethanol ...
Knapman Alisa - - 2012
Opioids are widely prescribed analgesics, but their use is limited due to development of tolerance and addiction, as well as high variability in individual response. The development of improved opioid analgesics requires high-throughput functional assays to assess large numbers of potential opioid ligands. In this study, we assessed the ability ...
Mina A - - 2012
Deficiency of or defects in the plasma protein von Willebrand factor (VWF) lead to bleeding and von Willebrand disease (VWD), which may be congenital or acquired. VWD is considered the most common inherited bleeding disorder and laboratory testing for VWF level and activity is critical for appropriate diagnosis and management. ...
Hüsch Jan - - 2012
Boswellia serrata gum resin extracts are used widely for the treatment of inflammatory diseases. However, very low concentrations in the plasma and brain were observed for the boswellic acids (1-6, the active constituents of B. serrata). The present study investigated the effect of phospholipids alone and in combination with common ...
Gast Gerrie-Cor M - - 2012
Independent effects of changes in biologic risk factors on type 2 diabetes incidence remain unclear. The authors examined whether associations between changes in biologic risk factors and diabetes risk are driven by initial or attained risk factor levels. Biologic risk factors were measured at baseline and at each 5-year interval ...
Kloog Itai - - 2012
Satellite-derived Aerosol Optical Depth (AOD) measurements have the potential to provide spatio-temporally resolved predictions of both long and short term exposures, but previous studies have generally shown moderate predictive power and lacked detailed high spatio- temporal resolution predictions across large domains. We aimed at extending our previous work by validating ...
Watanabe Shizu - - 2012
Plant viruses of the families Luteoviridae and Geminiviridae rely on hemipteran vectors for the infection of their hosts. Several lines of evidence have revealed that these viruses are transmitted by competent vectors in a circulative manner, involving entry into the vector's body and the crossing of epithelial tissues forming the ...
Chandrasekhar Vadapalli - - 2012
The reaction of the cyclometalated chloro-bridged iridium(III) dimers [(ppy)(2) Ir(μ-Cl)](2) (ppyH = 2-phenyl pyridine) and [(tpy)(2)Ir(μ-Cl)](2) (tpyH = 2-p-tolylpyridine) with 3,5-diphenylpyrazole (Ph(2)PzH) in the presence of sodium methoxide resulted in the formation of heterobridged dimers [(ppy)(2)Ir(μ-OH)(μ-Ph(2)Pz)Ir(ppy)(2)] (1) and [(tpy)(2)Ir(μ-OH)(μ-Ph(2)Pz)Ir(tpy)(2)] (2). Interestingly, the reaction of [(ppy)(2)Ir(μ-Cl)](2) with 3(5)-methyl-5(3)-phenylpyrazole (PhMePzH) afforded both ...
He Ye-Xin - - 2012
Amyloid β protein (Aβ) is responsible for the deficits of learning and memory in Alzheimer's disease (AD). The high affinity between Aβ and nicotinic acetylcholine receptors (nAChRs) suggests that the impairment of cognitive function in AD might be involved in the Aβ-induced damage of nAChRs. The present study investigated the ...
Gu Yihai - - 2012
Correlation has been widely accepted between quinolone resistance and topoisomerase point mutations in quinolone resistance determination regions (QRDRs). Acquirement of point mutations in QRDRs usually increases the microbial resistance to both nalidixic acid and fluoroquinolones. The quinolone-resistant mechanisms accumulated in a lab-selected mutant were characterized through the construction of isogenic ...
Fryer Anthony A - - 2012
Healthcare budgets worldwide are facing increasing pressure to reduce costs and improve efficiency, while maintaining quality. Laboratory testing has not escaped this pressure, particularly since pathology investigations cost the National Health Service £2.5 billion per year. Indeed, the Carter Review, a UK Department of Health-commissioned review of pathology services in ...
Gibeaux Romain - - 2012
We report about the mechanistic basis guiding the migration pattern of multiple nuclei in hyphae of Ashbya gossypii. Using electron tomography we reconstructed the cytoplasmic microtubule (cMT) cytoskeleton in three tip regions with a total of 13 nuclei and also the spindle microtubules of four mitotic nuclei. Each spindle pole ...
Comarmond Marie-Christine Josick - - 2012
Uranium (U(VI)) sorption in systems containing titanium dioxide (TiO2) and various Fe(III)-oxide phases was investigated in the acidic pH range (pH 2.5 to pH 6). Studies were conducted with physical mixtures of TiO2 and ferrihydrite, TiO2 with co-precipitated ferrihydrite, and with systems where Fe(III) was mostly present as crystalline Fe(III) ...
Parajuli Laxmi Kumar - - 2012
R-type calcium channels (RTCCs) are well known for their role in synaptic plasticity, but little is known about their subcellular distribution across various neuronal compartments. Using subtype-specific antibodies, we characterized the regional and subcellular localization of Ca(v)2.3 in mice and rats at both light and electron microscopic levels. Ca(v)2.3 immunogold ...
Kasai Takatoshi - - 2012
OBJECTIVE: The association between triglyceride level and the risk of coronary artery disease (CAD) remains controversial. In particular, the prognostic significance of triglyceride levels in established CAD is unclear. We aimed to assess the relationship between triglyceride levels and long-term (>10 years) prognosis in a cohort of patients after complete ...
Plever Sally - - 2012
OBJECTIVE: In 2008, Queensland Health mental health services participated in a quality incentive payment scheme referred to as the Clinical Practice Improvement Payment. Services across the state engaged in local improvement projects with the collective aim of improving the number of consumers, diagnosed with schizophrenia, followed up within seven days ...
Chaaban Mohamad R - - 2012
Objectives/HypothesisConventional treatment of frontal sinus posterior table fractures has included osteoplastic flap or cranialization procedures despite considerable advances in endoscopic technique and experience. The objective of the current study was to evaluate outcomes of frontal sinus fractures involving the posterior table managed using endoscopic approaches.Study DesignProspective cohort.SettingTertiary care, academic university ...
Tofanelli Marcus A - - 2012
The exceptional stability of ligand-stabilized gold nanoclusters such as Au25(SC6H13)18-1, Au39(PR3)14X6-1, and Au102(SR)44 arises from the total filling of superatomic electron shells resulting in a "noble-gas superatom" electron configuration. Electrochemical manipulation of oxidation state can add or remove electrons from superatom orbitals creating species electronically analogous to atomic radicals. Herein ...
Aburai Nobuhiro - - 2012
In the course of our screening program for a new inhibitor of the Ca(2+) signalling pathway using mutant yeast [Saccharomyces cerevisiae (zds1Δ erg3Δ pdr1Δ pdr3Δ)], a mouse PP2Cα activator, pisiferdiol, isolated from Chamaecyparis pisifera, was found to alleviate the Ca(2+) signal-mediated growth inhibition. Pisiferdiol showed growth inhibition activity against the ...
Schwartz Raymond S - - 2012
Few studies have examined the relationship between cerebrovascular disease, vascular risk factors, and Parkinson's disease (PD), although 1 study found small-vessel disease (SVD) to be the main subtype of cerebrovascular disease. In this study we compared the extent and topography of SVD and assessed associated vascular risk factors in autopsy-proven ...
Hung Shih-Wei - - 2012
Understanding protein adsorption onto solid surfaces is of critical importance in the field of bioengineering, especially for applications such as medical implants, diagnostic biosensors, drug delivery systems, and tissue engineering. This study proposed the use of molecular dynamic simulations with potential of mean force (PMF) calculations to identify and characterize ...
An Xu - - 2012
Motion perception is qualitatively invariant across different objects and forms, namely, the same motion information can be conveyed by many different physical carriers, and it requires the processing of motion signals consisting of direction, speed, and axis or trajectory of motion defined by a moving object. Compared with the representation ...
Pruijm Menno - - 2012
Controlling the extracellular volume in hemodialysis patients is a difficult task. The aim of this study was to evaluate the capacity of different methods of stimulated sweating to reduce mean interdialytic weight gain (IWG), to improve blood pressure regulation, and potassium/urea balance. Two center, crossover pilot study. In Lausanne, hemodialysis ...
Segarra-Medrano Alfonso - - 2012
One of the major challenges modern nephrology should face is the identification of biomarkers that are associated with histopathological patterns or defined pathogenic mechanisms that might aid in the non-invasive diagnosis of the causes of nephrotic syndrome, or in establishing prognosis sub-groups based on each type of disease, thus predicting ...
Shuai Lanjun - - 2012
Renal disease is caused by tubular interstitial injury and renal interstitial fibrosis. Previous studies have shown that transplantation of endothelial progenitor cells (EPCs) may provide an appropriate treatment for repair and reversing renal pathology. However, EPCs are typically low in abundance and have poor replication ability. Therefore, the this study ...
Ferroni P - - 2012
The most convincing evidence for the participation of platelets in arterial thrombosis in humans comes from studies of platelet activation in patients with acute coronary syndromes (ACS) and from trials of antiplatelet drugs. Both strongly support the concept that repeated episodes of platelet activation over the thrombogenic surface of a ...
Porta Josep M - - 2012
The conformational space of a flexible molecular loop includes the set of conformations fulfilling the geometric loop-closure constraints and its energy landscape can be seen as a scalar field defined on this implicit set. Higher-dimensional continuation tools, recently developed in dynamical systems and also applied to robotics, provide efficient algorithms ...
Gotor Raúl - - 2012
Two calixpyrrole derivatives were synthesised. A p-dimethylaminobenzoyl group was electronically attached to a pyrrole ring, establishing an intramolecular hydrogen bond in a 1,3-alternate conformation. The formation of the H-bond was corroborated by IR, NMR, and X-ray measurements. NMR titration studies reveal that the H-bond is strong enough to block the ...
Perales-Montilla Carmen M - - 2012
Objectives: To assess health-related quality of life (HRQOL) of chronic renal failure patients undergoing dialysis replacement therapy, and to evaluate the predictive power of psychosocial variables (social support, self-efficacy, optimistic outlook, depression, anxiety and coping strategies) on the different levels of HRQOL. Methods: We evaluated the HRQOL of 39 haemodialysis ...
Chan Kar-Weng - - 2012
Statistical validation is crucial for the clustering of unknown samples. This study aims to demonstrate how statistical techniques can be optimized using simulated heroin samples containing a range of analyte concentrations that are similar to those of the case samples. Eight simulated heroin distribution links consisting of 64 postcut samples ...
Picou Laura A - - 2012
The limited supply of traditional fossil based fuels, and increased concern about their environmental impact has driven the interest in the utilization of biomass based energy sources, including those that are underutilized or otherwise nuisance species such as Chinese tallow trees (Triadica sebifera [L.]). This species is a prolific seeds ...
Quist Jos - - 2012
We present a novel concept of filtering based on depletion zone isotachophoresis (dzITP). In the micro/nanofluidic filter, compounds are separated according to isotachophoretic principles and simultaneously released selectively along a nanochannel-induced depletion zone. Thus, a tunable low-pass ionic mobility filter is realized. We demonstrate quantitative control of the release of ...
Annunziata Onofrio - - 2012
Diffusion of a solute can be induced by the concentration gradient of another solute in solution. This transport mechanism is known as cross-diffusion. We have investigated cross-diffusion in a ternary protein-salt-water system. Specifically, we measured the two cross-diffusion coefficients for the lysozyme-NaCl-water system at 25 ºC and pH 4.5 as ...
Zander Esther - - 2012
OBJECTIVES: Three clinical Acinetobacter baumannii isolates (A-C) were isolated from three separate patients during an outbreak in a hospital in Krakow, Poland. Isolate A was recovered first and was susceptible to carbapenems, whereas isolates B and C were resistant. The aim of this study was to investigate the differences in ...
Turner Alyna - - 2012
Objective:To determine whether a six-session group cognitive behaviour therapy (CBT) programme results in a greater reduction in depression symptoms than a brief intervention alone in cardiac patients with clinically significant symptoms of depression.Method:Fifty-seven community dwelling cardiac patients scoring >13 on the Beck Depression Inventory-II (BDI-II) received a single-session brief intervention. ...
Barlow R J - - 2012
In considering the management of their patient with DFSP, Martin et al review the literature comparing Mohs' micrographic surgery (MMS) with wide local excision (WLE) as treatments for this tumour. They examine five open retrospective case series (245 patients), each of which directly compared MMS and WLE within the same ...
Bruet Vincent - - 2012
Background -  In dogs, flea infestation (FI), flea bite hypersensitivity (FBH) and canine atopic dermatitis (CAD) have been mainly characterized by their lesions but never by their pruritus. In clinical practice, many of these dogs exhibit only pruritus. Hypothesis/Objectives -  The purpose of this study was to evaluate the characteristics of pruritus ...
Liang Li Jiao - - 2012
As one vital member among the family of phosphates, guanosine triphosphate (GTP) not only plays a very important role in many critical biological processes but also closely associates with definite pathological states. Based on the ratiometric fluorescence response of the zinc complex of 1,4-bis(imidazol-1-ylmethyl) benzene (bix) in this contribution, a ...
Tharmaraj Vairaperumal - - 2012
4-Methoxy-N-((thiophen-2-yl)methyl)benzenamine was found to be a highly selective chemosensor for Ag(+) ion in methanol-water (1 : 1 v/v) mixture over other metal ions such as Na(+), K(+), Li(+), Cu(+), Ba(2+), Cd(2+), Co(2+), Cu(2+), Fe(2+), Hg(2+), Mn(2+), Ni(2+), Pb(2+) and Zn(2+) with a limit of detection (LOD) is 5.0 × 10(-6) mol L(-1). ...
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