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Results 601 - 650 of 2252
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Friman Ville-Petri - - 2012
The impact of community complexity on pairwise coevolutionary dynamics is theoretically dependent on the extent to which species evolve generalised or specialised adaptations to the multiple species they interact with. Here, we show that the bacteria Pseudomonas fluorescens diversifies into defence specialists, when coevolved simultaneously with a virus and a ...
Ng Alphonsus H C - - 2012
We introduce a new format for particle-based immunoassays relying on digital microfluidics (DMF) and magnetic forces to separate and resuspend antibody-coated paramagnetic particles. In DMF, fluids are electrostatically controlled as discrete droplets (picoliters to microliters) on an array of insulated electrodes. By applying appropriate sequences of potentials to these electrodes, ...
Colbert James A - - 2012
In early August, we presented two cases involving persons who were potential candidates for preexposure prophylaxis (PrEP) for HIV in Clinical Decisions,(1) an interactive feature designed to assess how readers would manage a clinical problem for which there may be more than one appropriate approach to the care of the ...
Levy Yael - - 2012
To describe the use of ultra-brief electroconvulsive therapy (ECT) in three postnatal women with severe, treatment resistant depression. The indications and evidence for the use of ECT in the treatment of postnatal depression are discussed. We present a case series and review relevant literature. Three patients with severe episodes of ...
Stanford Kim - - 2012
ABSTRACT: BACKGROUND: Cattle shedding at least 104 CFU Escherichia coli O157:H7/g feces are described as super-shedders and have been shown to increase transmission of E. coli O157:H7 to other cattle in feedlots. This study investigated relationships among fecal isolates from super-shedders (n = 162), perineal hide swab isolates (PS) from ...
Bergrem A - - 2012
Limited data exist on thrombophilia and the risk of venous thrombosis (VT) during pregnancy and postpartum. The objectives of the present study were to investigate the role of haemostatic risk factors for pregnancy-related VT and their phenotypic expression in deep-vein thrombosis (DVT) and pulmonary embolism (PE). Total 313 cases with ...
Hald A - - 2012
Background:  The Jak/STAT signalling pathway is known to play an important role in many cellular processes including inflammation. The activation of STAT1 is dependent on tyrosine701 and serine727 phosphorylation, which leads to the formation of the STAT dimer and modulation of STAT1 activity, respectively. Objective:  The aim of this study ...
Su Longxiang - - 2012
ABSTRACT: BACKGROUND: Sepsis is a common syndrome in critically ill patients and easily leads to the occurrence of acute kidney injury (AKI), with high mortality rates. This study aimed to investigate the diagnostic value of urine soluble CD163 (sCD163) for identification of sepsis, severity of sepsis, and for secondary AKI, ...
Saint-Remy Annie - - 2012
ABSTRACT: BACKGROUND: In kidney transplant (Kt) recipients, hypertension is a major risk for cardiovascular complications but also for graft failure. Blood pressure (BP) control is therefore mandatory. Office BP (OBP) remains frequently used for clinical decisions, however home BP (HBP) have brought a significant improvement in the BP control. Sodium ...
Choisy Marc M MIVEGEC (UM1-UM2-CNRS 5290-IRD 224), Centre IRD, 911 avenue Agropolis BP 64501, 34394 Montpellier Cédex 5, France. - - 2012
Prediction and control of the geographical spread of emerging pathogens has become a central public health issue. Because these infectious diseases are by definition novel, there are few data to characterize their dynamics. One possible solution to this problem is to apply lessons learnt from analyses of historical data on ...
Fourtounas Costas - - 2012
Mechanical problems of the Peritoneal Dialysis (PD) catheter remain a significant cause of temporary or even permanent transfer to hemodialysis. Until recently, the most popular approach was to remove the problematic PD catheter than to try to salvage it. We report a case of severe (two-way) PD catheter obstruction that ...
Prasad Shalini - - 2012
A silicon nanosensor technology based on electrical impedance measurements has been developed for the detection of proteins. The nanosensor miniaturizes the high-density, low-volume multiwell plate concept. The scientific core of this technology lies in integrating nanoporous membranes with microfabricated chip platforms. This results in the conversion of individual pores into ...
van der Bilt Arne R M - - 2012
PURPOSE: The mammalian target of rapamycin (mTOR) pathway is frequently activated in ovarian cancers. mTOR inhibitors, like everolimus, can reduce vascular endothelial growth factor-A (VEGF-A) production by cancer cells. We investigated whether early everolimus treatment effects could be monitored by positron emission tomography (PET) with 89Zr-bevacizumab. Experimental design: The effect ...
Kao Hsiu-Fen - - 2012
We develop a 16-band atomic bond-orbital model (16ABOM) to compute the spin splitting induced by bulk inversion asymmetry in zincblende materials. This model is derived from the linear combination of atomic-orbital (LCAO) scheme such that the characteristics of the real atomic orbitals can be preserved to calculate the spin splitting. ...
Baan Elly - - 2012
The human immunodeficiency virus type 1 (HIV-1) envelope protein provides the primary contact between the virus and host and is the main target of the adaptive humoral immune response. The length of the gp120 variable loops and the number of N-linked glycosylation events are key determinants for virus infectivity and ...
Spassova Maria A - - 2012
Mutagenic agents have long been inferred to act through low-dose linear, nonthreshold processes. However, there is debate about this assumption, with various studies interpreting datasets as showing thresholds for DNA damage and mutation. We have applied rigorous statistical analyses to investigate the shape of dose-response relationships for a series of ...
Carpane Pablo - - 2012
Corn stunt disease has become a factor limiting maize production in some areas of the Americas in recent years. Although resistant maize genotypes have been developed in the past, this resistance has been unstable over time or in some geographical locations. To better understand disease components that could affect the ...
Zong Geng G Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate University of the Chinese Academy of Sciences, Shanghai, - - 2012
Palmitoleic acid has been shown to regulate adipokine expression and systemic metabolic homeostasis in animal studies. However, its association with human metabolic diseases remains controversial. We aimed to investigate associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and metabolic syndrome (MetS) in a Chinese population. Erythrocyte fatty acids were ...
White Elizabeth A EA Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, - - 2012
We have begun to define the human papillomavirus (HPV)-associated proteome for a subset of the more than 120 HPV types that have been identified to date. Our approach uses a mass spectrometry-based platform for the systematic identification of interactions between human papillomavirus and host cellular proteins, and here we report ...
Andreu-Periz Lola - - 2012
Introduction: Age and the comorbidities associated with ESRD impair the functional autonomy of patients on haemodialysis (HD). Our objectives were to assess the level of dependence in patients on HD and their mortality rates after three years of treatment. To do so, we followed the criteria established by the "Ley ...
Chokalingam Kumar - - 2012
The mechanisms of estrogen receptor (ER)-α activity can be categorized into those involving direct (classical) or indirect (nonclassical) DNA binding. Although various mouse models have demonstrated the importance of ERα in bone, the specific gene expression patterns affected by these modes of ERα action are unknown. In this report, the ...
Polanski Jaroslaw - - 2012
Polarimetric detection in high-performance liquid chromatography (HPLC) might seem like a matter of course, especially in areas such as control of the optical purity of drugs or fingerprinting of herbal extracts. However, there are well founded reasons for the relatively low popularity of polarimetric detection in HPLC. Such reasons include, ...
Munson Erik - - 2012
Recent literature has reported increased accuracy of Trichomonas vaginalis transcription-mediated amplification (TMA)-based analyte-specific reagent (ASR) testing in female populations. A retrospective investigation assessed 7,277 female first-void urine, cervical, or vaginal specimens submitted from a high-prevalence sexually transmitted infection (STI) community to characterize prevalence of disease etiologies. The most common STI ...
Hong Huixiao - - 2012
Endocrine disrupting chemicals interfere with the endocrine system in animals, including humans, to exert adverse effects. One of the mechanisms of endocrine disruption is through binding of receptors such as the estrogen receptor (ER) in target cells. The concentration of any chemical in serum is important for its entry into ...
Maraki Sofia - - 2012
Abstract Background: In this era of increasing antimicrobial resistance, infections caused by multi-drug-resistant (MDR) gram-negative bacilli (GNB) are becoming more common and pose a challenge to all clinicians, including surgeons. Methods: We evaluated the epidemiology and antimicrobial sensitivities of GNB isolated from patients treated on surgical wards at the University ...
Murphy Robyn M - - 2012
To understand how glycogen affects skeletal muscle physiology we examined enzymes essential for muscle glycogen synthesis and degradation using single fibers from quiescent and stimulated rat skeletal muscle. Presenting a shift in paradigm, we show these proteins are differentially associated with glycogen granules. Protein diffusibility and/or abundance of glycogenin, glycogen ...
Banks D - - 2012
ACCESSIBLE SUMMARY: •  Mental health nursing has a long tradition of 'monitoring and managing' how nurses behave, this has not always benefitted either service users or nurses. •  Nurses are professionally required to seek guidance from more experienced colleagues to reflect, examine and improve on their practice. •  Formal and ...
Vuong Ann M AM Department of Epidemiology & Biostatistics, Texas A&M Health Science Center, College Station, TX, - - 2012
This study explored the impact of personal digital assistant (PDA) features, users' perceptions, and other factors that may have hindered PDA acceptability and usability as technology advances in e-health diabetes self-management. An ongoing study on PDA usage is set within the context of the advancements of Web 2.0 for type ...
Bongers-Schokking Jacoba Johanna - - 2012
Background: A main problem in the treatment of patients with congenital hypothyroidism (CHT) is that the optimal individual target values of thyroid stimulating hormone (TSH) and free thyroxine (fT4) are unknown. We investigated whether CHT patients have during treatment considered optimal stable fT4 and TSH steady state concentrations (SSC) that ...
Frank Otakar - - 2012
Six representative isotope-labeled samples of titanium dioxide were synthesized: Ti(16)O(2), Ti(17)O(2) and Ti(18)O(2), each in anatase and rutile forms. Their Raman scattering was analyzed at temperatures down to 5 K. Spectral assignment was supported by numerical simulation using DFT calculations. The combination of experimental and theoretical Raman frequencies with the ...
Wang Hongren H Vaccine Institute, 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, PR - - 2013
Analysis of partial hepatitis C virus sequences has revealed many novel genotype 6 variants that cannot be unambiguously classified, which obscure the distinctiveness of pre-existing subtypes. To explore this uncertainty, we obtained genomes of 98.0-98.8% full-length for eight such variants (KM35, QC273, TV257, TV476, TV533, L349, QC271 and DH027) and ...
Gotor Raúl - - 2012
Two calixpyrrole derivatives were synthesised. A p-dimethylaminobenzoyl group was electronically attached to a pyrrole ring, establishing an intramolecular hydrogen bond in a 1,3-alternate conformation. The formation of the H-bond was corroborated by IR, NMR, and X-ray measurements. NMR titration studies reveal that the H-bond is strong enough to block the ...
Götz Monika - - 2012
The whitefly Bemisia tabaci (Gennadius) is a major cosmopolitan pest capable of feeding on hundreds of plant species and transmits several major plant viruses. The most important and widespread viruses vectored by B. tabaci are in the genus Begomovirus, an unusual group of plant viruses owing to their small, single-stranded ...
Todorovic Biljana - - 2012
The human papillomavirus (HPV) E7 oncoprotein binds cellular factors, preventing or retargeting their function and thereby making the infected cell conducive for viral replication. A key target of E7 is the product of the retinoblastoma susceptibility locus (pRb). This interaction results in the release of E2F transcription factors and drives ...
Perales-Montilla Carmen M - - 2012
Objectives: To assess health-related quality of life (HRQOL) of chronic renal failure patients undergoing dialysis replacement therapy, and to evaluate the predictive power of psychosocial variables (social support, self-efficacy, optimistic outlook, depression, anxiety and coping strategies) on the different levels of HRQOL. Methods: We evaluated the HRQOL of 39 haemodialysis ...
Lee Sujin S Department of Pediatrics, Emory University, Atlanta, Georgia, - - 2012
CD8(+) T cells may contribute to vaccines for respiratory syncytial virus (RSV). Compared to CD8(+) T cells responding to RSV infection, vaccine-elicited anti-RSV CD8(+) T cells are less well defined. We used a peptide vaccine to test the hypothesis that vaccine-elicited RSV-specific CD8(+) T cells are protective against RSV pathogenesis. ...
Neal Carolyn O S - - 2012
Acremonium species cause a variety of human infections, while Lecanicillium species have not been reported as human pathogens. We describe a pseudo-outbreak involving both organisms, highlighting the role and limitations of molecular methods in the characterization of rare fungal isolates. Repeated isolation of these fungi from patient tissue samples raises ...
Chan Kar-Weng - - 2012
Statistical validation is crucial for the clustering of unknown samples. This study aims to demonstrate how statistical techniques can be optimized using simulated heroin samples containing a range of analyte concentrations that are similar to those of the case samples. Eight simulated heroin distribution links consisting of 64 postcut samples ...
Picou Laura A - - 2012
The limited supply of traditional fossil based fuels, and increased concern about their environmental impact has driven the interest in the utilization of biomass based energy sources, including those that are underutilized or otherwise nuisance species such as Chinese tallow trees (Triadica sebifera [L.]). This species is a prolific seeds ...
Quist Jos - - 2012
We present a novel concept of filtering based on depletion zone isotachophoresis (dzITP). In the micro/nanofluidic filter, compounds are separated according to isotachophoretic principles and simultaneously released selectively along a nanochannel-induced depletion zone. Thus, a tunable low-pass ionic mobility filter is realized. We demonstrate quantitative control of the release of ...
Annunziata Onofrio - - 2012
Diffusion of a solute can be induced by the concentration gradient of another solute in solution. This transport mechanism is known as cross-diffusion. We have investigated cross-diffusion in a ternary protein-salt-water system. Specifically, we measured the two cross-diffusion coefficients for the lysozyme-NaCl-water system at 25 ºC and pH 4.5 as ...
Zander Esther - - 2012
OBJECTIVES: Three clinical Acinetobacter baumannii isolates (A-C) were isolated from three separate patients during an outbreak in a hospital in Krakow, Poland. Isolate A was recovered first and was susceptible to carbapenems, whereas isolates B and C were resistant. The aim of this study was to investigate the differences in ...
Griffiths Timothy D TD Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom. - - 2012
Functional magnetic resonance imaging (fMRI) in humans and macaques allows a test of the hypothesis that there is a specialized neural ensemble for pitch within auditory cortex: a pitch center. fMRI measures the blood oxygenation level-dependent (BOLD) response related to regional synaptic activity (Logothetis et al., 2001). The distinction between ...
Quinn C - - 2012
An adapted version of the Moral Justification Scale was used to assess moral decision-making orientation in veterinary students, comparing sex and year of study. The Scale consists of vignettes and related statements, each of which was classified as Justice, Care for People or Care for Animals. The importance of each ...
Couralet Melanie - - 2012
Developing quality indicators (QI) for national purposes (eg, public disclosure, paying-for-performance) highlights the need to find accessible and reliable data sources for collecting standardised data. The most accurate and reliable data source for collecting clinical and organisational information still remains the medical record. Data collection from electronic medical records (EMR) ...
Gambichler T - - 2012
we read with great interest the paper of Luci and co-workers (1) who recently observed that peripheral natural killer (NK) cells exhibit qualitative and quantitative changes in patients with psoriasis. Their findings prompted us to assess circulating NK cells as well as other lymphocyte subsets in a larger German cohort ...
Takashita Emi - - 2012
Influenza C virus replicates more efficiently at 33°C than at 37°C. To determine whether hemagglutinin-esterase-fusion protein (HEF), a surface glycoprotein of influenza C virus, is a restricting factor for this temperature sensitivity, we analyzed the biological and biochemical properties of HEF at 33°C and 37°C. We found that HEF exhibits ...
Sarwer David B - - 2012
This article reviews the literature on body dysmorphic disorder (BDD) in patients who seek aesthetic surgery and other appearance-enhancing medical treatments such as dermatologic treatment. It begins with a discussion of the growing popularity of aesthetic medical treatments. The literature investigating the psychological characteristics of individuals interested in these treatments ...
Messora Michel Reis - - 2012
Abstract Objective: The purpose of this study was to radiographically analyze the effect of autologous PRP on the healing of fresh frozen bone allograft (FFBA) placed in surgically created resection defects in mandibles of dogs. Materials and methods: Bilateral resection defects measuring 1.5 cm x 1 cm were surgically created ...
Akter Farhima - - 2012
An aptamer-based sandwich-type immunoassay is presented to detect human thrombin using a bioluminescent fusion protein, SSB-fLuc. Escherichia coli single-stranded DNA binding protein (SSB) is used as a linker between the aptamer and firefly luciferase (fLuc). For proof-of-principle, thrombin was used as the test analyte and thrombin aptamer as the sensing ...
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