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Persson Erik - - 2012
Abstract If we eventually discover extraterrestrial life, do we have any moral obligations for how to treat the life-forms we find; does it matter whether they are intelligent, sentient, or just microbial-and does it matter that they are extraterrestrial? In this paper, I examine these questions by looking at two ...
Browne Shane - - 2012
Gene therapy is a field which offers hope and promise for treatment of diseases and traumas both of a genetic nature and otherwise. However, progress towards the clinic has been delayed due to concerns over the safety of viral vectors and the efficacy of safer non-viral systems, which have low ...
Lozinska Magdalena M - - 2012
A series of univalent cation forms of zeolite Rho (M9.8Al9.8Si38.2O96, M = H, Li, Na, K, NH4, Cs) and ultrastabilised zeolite Rho (US-Rho) have been prepared. Their CO2 adsorption behaviour has been measured at 298 K and up to 1 bar, and related to the structures of the dehydrated forms ...
Perez Roman A - - 2012
Development of scaffolds to load and deliver therapeutic molecules like growth factors greatly enhances tissue regenerative capacity. Here, we report the core-shell design of fibrous scaffolds made of alginate and α-tricalcium phosphate (Alg/α-TCP) for in situ protein loading and controllable delivery. Direct deposition of Alg/α-TCP solution through designed coconcentric nozzle ...
Baselga José - - 2012
PURPOSE: In this first-in-human study of AEE788, a tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), HER-2, and vascular endothelial growth factor (VEGFR-2), a comprehensive pharmacodynamic program was implemented in addition to the evaluation of safety, pharmacokinetics, and preliminary efficacy of AEE788 in cancer patients. EXPERIMENTAL DESIGN: Patients with ...
Kawamura Kaz - - 2012
Zooids of the asexual strain of Polyandrocarpa misakiensis have a lifespan of 4-5 months; before dying, they produce many buds, enabling continuation of the strain. This study was designed to investigate the nature of gene inactivation and reactivation during this continuous process of senescence and budding. During senescence, the zooidal ...
Okada Ryo - - 2012
Two high-molecular-weight double-stranded RNAs (dsRNAs) of approximately 14 and 15 kbp were isolated from the common bean (Phaseolus vulgaris) cultivar Black Turtle Soup. These dsRNAs did not appear to cause obvious disease symptoms, and were transmitted through seeds at nearly 100% efficiency. Sequence information indicates that they are the genomes ...
Novak Theresa - - 2012
OBJECTIVE: The use of sensory rooms (also known as comfort rooms) to reduce seclusion rates has generated a great deal of interest. This study examined the outcomes associated with the introduction of a sensory room in an acute inpatient psychiatric unit. METHOD: Consumers rated distress and staff rated a variety ...
Men T-Y - - 2012
BACKGROUND: Multidrug-resistant (MDR) gram-negative bacilli pose a serious and rapidly emerging threat to recipients of solid organ transplants (SOTs). However, extended-spectrum β-lactamases (ESBLs), as one of the cardinal mechanisms of resistance to antimicrobial agents in SOT recipients, remain obscure. The aim of this study was to investigate the prevalence of ...
Correia Roberta T P - - 2012
Tropical fruit residues consisting of seeds, peels and residual pulp generated as by-products of fruit processing industry were investigated for bioactive compounds, the in vitro antioxidant capacity as well as alpha-glucosidase and alpha-amylase inhibitory activities. Cyanidin, quercetin, ellagic acid (EA) and proanthocyanidins were found in acerola, jambolan, pitanga and cajá-umbu ...
Singer Barbara - - 2012
Many children are surviving prematurity and serious childhood illnesses due to advances in technology and medical care. As a result, more children are entering public school systems with complex health care needs and intellectual and developmental disabilities. School nurses are responsible for caring for these children; however, many nurses feel ...
Ha Eun Ju - - 2012
Background: Surgical management of symptomatic benign thyroid nodules in patients with previous lobectomy poses a dilemma for physicians. Radiofrequency (RF) ablation may provide a treatment option that avoids surgery and preserves thyroid function. We evaluated whether RF ablation of benign thyroid nodules affects thyroid functions in patients with previous lobectomy. ...
Macko Jill A - - 2012
We demonstrate series-integrated multijunction organic photovoltaics fabricated monolithically by vapor-deposition in a transposed subcell order with the near-infrared-absorbing subcell in front of the green-absorbing subcell. This transposed subcell order is enabled by the highly complementary absorption spectra of a near-infrared-absorbing visibly-transparent subcell and a visible-absorbing subcell and motivated by the ...
Katagiri Fumihiko - - 2012
A119 peptide (LSNIDYILIKAS), derived from the mouse laminin α1 chain sequence (1321--1332) promotes cell attachment, neurite outgrowth, and amyloid-like fibril formation. In this study, we evaluated the structural requirements of A119 for the biological activities and amyloid-like fibril formation. The cell attachment to A119 was inhibited by heparin and using ...
Vázquez-Rodríguez Juan G - - 2012
Background:&nbsp;Pregnancy in patients with kidney grafts is considered high-risk. Objectives: Determine perinatal complications in women with kidney transplants treated by our hospital and compare them with complications reported in national and international literature. Material and Method: We studied perinatal complications in 18 patients with renal transplantation who delivered 19 newborns ...
Pan Pengju - - 2012
Linear and miktoarm star-shaped diblock copolymers consisting of single-stranded DNA and poly(N-isopropylacrylamide) (PNIPAAm) with various compositions were synthesized via atom transfer radical polymerization and click chemistry. The temperature-responsive phase transition behavior, micellization, was systematically examined using UV-vis spectrometry, high-sensitivity differential scanning calorimetry, dynamic light scattering, and small-angle X-ray scattering. The ...
Dziopa Florian - - 2012
Chemotherapy products in hospitals include a reconstitution step of manufactured drugs providing an adapted dosage to each patient. The administration of highly iatrogenic drugs raises the question of patients' safety and treatment efficiency. In order to reduce administration errors due to faulty preparations, we introduced a new qualitative and quantitative ...
Perryman Michael - - 2012
Abstract I summarize the early developments of the more quantitative aspects of exoplanet detection. After a brief overview of the observational methods currently applied to exoplanet searches and a summary of the first true exoplanet detections resulting from these various techniques, the more relevant historical background is organized according to ...
Morales-Fernández Marta - - 2012
Abstract Objectives: Toanalyze the scientific literature and compare in the results of conventional orthopedic appliances with those obtained from recent bone-anchored orthopedics for Class III malocclusion. Materials and Methods: The literature was systematically reviewed using PubMed/Medline, Scopus, and Scirus databases up to January 2012. Articles were selected by two different ...
Piękoś Lukasz - - 2012
In this study ab initio Car-Parrinello molecular dynamics simulations, extended transition state (ETS)-natural orbitals for chemical valence (NOCV) and QTAIM bonding analyses, were performed to characterize the ansa-bridged molybdocene complexes [(C(5) H(4) )(2) XMe(2) MoH(3) ](+) for X = C, Si, Ge, Sn, Pb, and nonbridged Cp(2) MoH 3+ system. The ...
Doi Kentaro - - 2012
Deoxyribonucleic acid (DNA) is a vital molecule for life since it contains genetic information. However, DNA has recently been reported to have unique properties that make it suitable for bionanoelectronic applications, such as the possibility of electrical conductivity and self-organisation. Self-assembled DNA network structures have been observed on several substrates, ...
Israels Trijn - - 2012
Wilms tumour is a relatively common and curable paediatric tumour. Known challenges to cure in low income countries are late presentation with advanced disease, malnutrition, failure to complete treatment and limited facilities. In this article, management recommendations are given for a low income setting where only the minimal requirements for ...
Kirchen-Peters Sabine - - 2012
Objectives: Many patients benefit from interventions performed by the psychiatric liaison service.Methods: Prospective longitudinal study of community dwelling elderly patients supplemented by a questionnaire answered by family members, as well as expert interviews with the members of the consultation-liaison team and semi-structured interviews with family members.Results: The majority of patients ...
Martínez-Esteban M Dolores - - 2012
Despite advances in the pharmacological treatment of arterial hypertension (AHT) and the use of multiple antihypertensive drugs, a small but significant percentage of true severe refractory arterial hypertension patients are still not reaching their target blood pressure. In these cases, renal sympathetic denervation (RSD) seems to be a safe and ...
Pepper Henry P - - 2012
The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy based on biosynthetic speculation. The key biomimetic transformation is a cascade of 7-endo-trig and 5-exo-trig radical cyclizations followed by a terminating aromatic substitution reaction.
Javia Luv - - 2012
ObjectiveTo conduct a systematic review of published articles that describe simulators that could be used in otolaryngology for education, skill acquisition, and/or skill improvement.Data SourcesOvid and Embase databases searched July 14, 2011.Review MethodsThree hundred fifty-three abstracts were independently reviewed by both authors, then 154 eligible articles were reviewed by both ...
Gupta Monique - - 2012
  Warts are common and are a challenge to treat in some children, especially immunocompromised children and those who fail or cannot tolerate salicylic acid preparations and cryotherapy. Cidofovir, a nucleotide analogue with antiviral activity, has demonstrated promising results when compounded into a topical form to treat refractory warts. We ...
Freund Ronald K - - 2012
This commentary discusses the important contributions of the article published in this journal by Huang and colleagues, titled, "Acute ethanol exposure increases firing and induces oscillations in cerebellar Golgi cells of freely moving rats." In this manuscript, Huang and colleagues present a number of interesting and important findings. While it ...
Knorr Daniel Brainard - - 2012
In this work, we investigate the ability to tune the quantity of surface amine functional groups in the interfacial region of epoxy-diamine composites using NEXAFS, a technique that is extremely sensitive to surface composition. Thereby, we employ a model surface (silicon wafer with the native oxide present) and, after deposition ...
Menon V - - 2012
Rhodococcus equi is a pathogen that mainly causes infection in immunocompromised hosts. We report a case of relapsing R. equi pulmonary infection in a 57-year-old male renal transplant recipient who was treated with 12 months of antibiotics, adjunctive surgery, and a reduction in his immunosuppression. He suffered from relapsing disease, treatment-related ...
Ely E R - - 2012
Early-warning surveillance provides an essential component of the evidence required to protect animal health. Assessing the proportion of the population included in surveillance systems (coverage) provides a measure of the effectiveness of early-warning surveillance, and contributes to ensuring that these systems are efficient. This paper describes an investigation of methods ...
Venturini M - - 2012
Background:  Photodynamic therapy (PDT) with methyl-aminolevulinate (MAL) is an approved non-invasive treatment option for basal cell carcinoma (BCC). In vivo reflectance confocal microscopy (RCM) is a non-invasive imaging technique that proved useful for in vivo real-time cyto-morphologic analysis of cells of BCC infiltrating the epidermis. Objectives:  The aim of the ...
Dau Pham Thi - - 2012
The constitutive androstane receptor (CAR) not only displays a high basal transcriptional activity, but also acts as a ligand-dependent transcriptional factor. It is known that CAR exhibits different ligand profiles across species. However, the mechanisms underlying CAR activation by chemicals and the species-specific responses are not fully understood. The objectives ...
Geerligs Linda - - 2012
Temporal integration was examined using a missing element task, in which task performance depends on the ability to integrate brief successive stimulus displays. Previous studies have suggested that temporal integration is under endogenous control and that integration is more likely when stimuli match the observer's temporal expectancies. Beta oscillations have ...
Chen Lin - - 2012
Cren7, a novel chromatin protein highly conserved among crenarchaea, plays an important role in genome packaging and gene regulation. However, the detail dynamical structural characteristic of the Cren7-DNA complex and the detail study of the DNA in the complex have not been done. Focused on two specific Cren7-DNA complexes (PDB ...
Erogbogbo Folarin - - 2012
The development of multimodal nanoparticle platforms is desirable for cancer nanotechnology applications. Creating single nanoplatforms with both plasmonic and photoluminescent optical properties has remained a challenge, because combining discrete entities each having one of these unique properties typically results in the attenuation of one of the desirable properties. Here, we ...
Wu Yan - - 2012
A series of (E)-2-(4-cinnamylpiperazin-1-yl)-N-(1-substituted-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume on isolated rabbit heart preparations. This class of compounds presented favorable in vitro activity compared with the standard drug, milrinone, among which N-(1-(3-chlorophenyl)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(4-cinnamylpiperazin-1-yl)acetamide 5e was found to be the most ...
Sohrabi K - - 2012
Background: Respiratory flow detection with the aim of detecting sleep-related breathing disorders plays a major role in polysomnography. Due to the fact that pneumotachographs are too bulky and not suitable for measurements during sleep, the ThorAKUSTIK system has been developed. By attaching a noise sensor right next to larynx, it ...
McKay Rod - - 2012
OBJECTIVE: Evidence that feedback on outcome measures can improve consumer outcomes is building but clinician engagement remains inconsistent. Clinicians can interpret and utilize familiar measures but have difficulty in relating to routine outcome measures like the Health of the Nation Outcomes Scales (HoNOS). This paper aims to explore and illustrate ...
Torguet-Escuder Pere - - 2012
Background and Objectives: The ample information available in relation to FGF 23, calcium, phosphorus, PTH, and 25/1,25 vitamin D has allowed us to define consistent values for each variable in each stage of chronic kidney disease (CKD). These values can define early stages, prognostic issues, and new treatment targets. We ...
Alves Cardoso D - - 2012
In the past two decades, nanotechnology has entered the field of regenerative medicine, resulting in the development of a novel generation of instructive, nanostructured biomaterials that are able to orchestrate cellular behavior by presenting specific morphological and biological cues. Using nanotechnology, materials containing nanosized features (e.g., pores, patterns, textures, grain ...
Shon W - - 2012
Cutaneous occlusive vascular disease results from various etiologies. By routine light microscopy, these intravasculuar deposits are indistinguishable and often diagnostic challenges especially when very limited clinical information is available. Cryoglobulins are reversibly cold-precipitable serum or plasma immunoglobulins associated with a number of infections, autoimmune and neoplastic disorders.
Anzalone Rita - - 2012
Abstract: Mesenchymal stem cells (MSC) are virtually present in all postnatal organs as well as in perinatal tissues. MSC can be differentiated towards severalmature cytotypes and interestingly hold potentially relevant immunomodulatory features. Myocardial infarction results in severe tissue damage, cardiomyocytes loss, and eventually heart failure. Cellular cardiomyoplasty represents a promising ...
Enayat S - - 2012
Platelet-type von Willebrand disease (PT-VWD) is a rare bleeding disorder with an intrinsic defect in platelets rather than von Willebrand factor (VWF), but has clinical and laboratory features similar to the more common type 2B VWD. The intriguing nature of the pathophysiology and molecular genetics of PT-VWD has created lengthy ...
Stuijver D J F - - 2012
Several coagulation and fibrinolytic parameters appear to be affected by thyroid hormone excess; however, the net effect on the haemostatic system remains unclear. We aimed to update our previous review and systematically summarise and meta-analyse the data by assessing the effects of thyrotoxicosis on the coagulation and fibrinolytic system in ...
de Giorgi V - - 2012
Background:  oncological research has been focused on evaluating estrogen receptors (ERs) in estrogen-related tumors and understanding the potential role of ERs in the pathophysiology of cancer. Objectives:  To investigate the significance of estrogen receptor beta (ERβ) in melanoma. Methods:  We prospectively evaluated ERβ expression in malignant melanoma (MM) tissue and ...
Antón-Pérez Gloria - - 2012
Approximately 4%-10% of incident patients on dialysis have a non-functioning kidney graft, and according to series, as many as 32% require transplantectomy for a variety of reasons. Mortality in these patients is significantly higher than in those with a functioning graft or on renal replacement therapy without having received a ...
Erdmann Markus - - 2012
The vicinal frustrated P/B Lewis pair (FLP) Mes(2)PCH(2)CH(2)B(C(6)F(5))(2) reacts with 9-borabicyclo[3.3.1]nonane (9-BBN) by C(6)F(5)vs. H exchange at boron to give the new [B]-H functionalized FLP Mes(2)PCH(2)CH(2)B(H)(C(6)F(5)) () and 9-C(6)F(5)-BBN. The latter was characterized as an isonitrile adduct by X-ray diffraction. The new FLP forms an adduct with pyridine and it ...
Adelstein David J - - 2012
Recent advances now permit resection of many pharyngeal tumors through the open mouth, an approach that can greatly reduce the morbidity of surgical exposure. These transoral techniques are being rapidly adopted by the surgical community and hold considerable promise. On November 6-7, 2011, the National Cancer Institute sponsored a Clinical ...
Combes Stephanie L - - 2012
This study aimed to estimate HIV incidence among women at higher HIV risk in Addis Ababa, Ethiopia using cross-sectional data. To refine the estimate, we sought to determine a local correction factor by estimating a false recent rate for the BED assay. The overall study had two parallel phases: cross-sectional ...
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