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Results 551 - 600 of 2252
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Kwak Jaesung - - 2012
Organometallic chelates are readily obtained upon coordination of metal species to multidentate ligands. Because of the robust structural nature, chelation frequently serves as a driving force in the molecular assembly and chemical architecture, and they are used also as an efficient catalyst in numerous reactions. Described herein is the development ...
Smith Karen L - - 2012
The putative endogenous imidazoline binding site ligand harmane enhances neuronal activation in response to psychological stress and alters behaviour in animal models of anxiety and antidepressant efficacy. However, the neurobiological mechanisms underlying harmane's psychotropic effects are poorly understood. We investigated the effects of intraperitoneal injection of harmane (2.5 and 10 ...
Algranti Eduardo - - 2012
BACKGROUND: This study was designed to assess the effect of asbestos exposure on longitudinal lung function decline. METHODS: A group of 502 former asbestos-cement workers with at least two spirometry tests 4 years apart. Repeated evaluations included respiratory symptoms questionnaire, spirometry and chest imaging. Asbestos exposure was ascertained as years ...
Agne-Djigo Anta - - 2012
To alleviate vitamin A (VA) deficiency (VAD) in Senegal, understanding the relationship between VA status of lactating women and their 6-mo-old infants is important. This study measured 6-mo-old infants' VA intake from human milk and assessed the VA status of mothers and infants. A comprehensive study was undertaken in 34 ...
Lloyd-Price Jason - - 2012
MOTIVATION: Cell growth and division affect the kinetics of internal cellular processes and the phenotype diversity of cell populations. Since the effects are complex, e.g., different cellular components are partitioned differently in cell division, to account for them in silico, one needs to simulate these processes in great detail. RESULTS: ...
Estevez Maureen E ME Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA. - - 2012
The photopigment melanopsin confers photosensitivity upon a minority of retinal output neurons. These intrinsically photosensitive retinal ganglion cells (ipRGCs) are more diverse than once believed, comprising five morphologically distinct types, M1 through M5. Here, in mouse retina, we provide the first in-depth characterization of M4 cells, including their structure, function, ...
Kang Hyun-Mi - - 2012
In Korea, a nationwide surveillance program has been implemented to identify highly pathogenic avian influenza virus since 2003. Avian influenza viruses (AIVs) belonging to one of the most common haemagglutinin subtypes, H4, were isolated from two domestic ducks and 52 wild birds in 2004-2010. These H4 AIVs could be further ...
Page Carly - - 2012
Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute lung injury (ALI) that often leads to severe lung disease. A mouse model of acute SARS-CoV infection has been helpful in understanding the host response to infection; however, there are still unanswered questions concerning SARS-CoV pathogenesis. We have shown that ...
Franco-Esteve Antonio - - 2012
Calcineurin inhibitors have reduced acute rejection rates and improved short-term graft survival, but without any improvement in long-term outcomes, since calcineurin inhibitors cause nephrotoxicity and death with a functioning graft. mTOR inhibitors have antiproliferative and anti-angiogenic effects with no nephrotoxicity. These properties could improve patient and graft long-term survival rates ...
Ge Qian - - 2012
A low-grade proinflammatory state contributes to the metabolic syndrome (MS). Adiponectin (ApN), which is reduced in the MS, has emerged as a master regulator of inflammation/immunity. We wanted to identify whether microRNAs (miRNAs) may mediate the antiinflammatory action of ApN on adipose tissue (AT). miRNA expression profiling was performed in ...
Xu Yijuan - - 2012
Catheter-associated urinary tract infection is caused by bacteria, which ascend the catheter along its external or internal surface to the bladder and subsequently develop into biofilms on the catheter and uroepithelium. Antibiotic-treated bacteria and bacteria residing in biofilm can be difficult to culture. In this study we used culture-based and ...
Suh Jae Yong - - 2012
Plasmonic lasers exploit strong electromagnetic field confinement at dimensions well below the diffraction limit. However, lasing from an electromagnetic hot spot supported by discrete, coupled metal nanoparticles (NPs) has not been explicitly demonstrated to date. We present a new design for a room-temperature nanolaser based on three-dimensional (3D) Au bowtie ...
Schmid Evi - - 2012
Aggregation of the high affinity IgE receptor (FcεRI) on mast cells (MCs) causes MC degranulation, a process that involves cortical F-actin disassembly. Actin depolymerization may be triggered by increase of cytosolic Ca(2+). Entry of Ca(2+) through the Ca(2+)-release activated Ca(2+) (CRAC) channels is under powerful regulation by the serum- and ...
Sabourin David - - 2012
A microfluidic component library for building systems driving parallel or serial microfluidic-based assays is presented. The components are a miniaturized eight-channel peristaltic pump, an eight-channel valve, sample-to-waste liquid management, and interconnections. The library of components was tested by constructing various systems supporting perfusion cell culture, automated DNA hybridizations, and in ...
Jiang Xiaoyan - - 2012
This study presents a first attempt to investigate the roles of fire aerosols in ozone (O3) photochemistry using an online coupled meteorology-chemistry model, the Weather Research and Foresting model with Chemistry (WRF-Chem). Four 1-month WRF-Chem simulations for August 2007, with and without fire emissions, were carried out to assess the ...
Khairy Mohamed - - 2012
Nanomagnet-selective supercaptors of heme-proteins (iron-porphyrin prosthetic group) based on mesoporous NiO and Fe(3)O(4) NPs were fabricated.
Wang Xiaofang - - 2012
This study is to investigate the effects of bortezomib on the angiogenesis of mesenchymal stem cells (MSCs). We examined the effects of bortezomib on the cellular proliferation, migration, and capillary network formation of HUVECs cocultured with CMs of MSCs. We found that Bortezomib inhibited the cellular proliferation and tube formation ...
Johnson William W Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, - - 2013
It is unknown whether the secular trend in childhood BMI reflects increases in fat-free mass as well as fat mass. This study decomposed BMI trends in 488 participants in the Fels Longitudinal Study born between 1958-1995 and aged 8-17.99 years into their fat and fat-free components. Generalized estimating equations estimated ...
Schechtman Eitan - - 2012
In humans, whose ears are fixed on the head, auditory stimuli are initially registered in space relative to the head. Eventually, locations of sound sources need to be encoded also relative to the body, or in absolute allocentric space, to allow orientation toward the sounds sources and consequent action. We ...
Wu Yan - - 2012
A series of (E)-2-(4-cinnamylpiperazin-1-yl)-N-(1-substituted-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume on isolated rabbit heart preparations. This class of compounds presented favorable in vitro activity compared with the standard drug, milrinone, among which N-(1-(3-chlorophenyl)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(4-cinnamylpiperazin-1-yl)acetamide 5e was found to be the most ...
Laurent Heidemarie K HK Department of Psychology, University of Wyoming, Laramie, WY 82071, USA. - - 2013
Child hypothalamic pituitary adrenal (HPA) activity was investigated as a moderator of parental depressive symptom effects on child behavior in an adoption sample (n = 210 families). Adoptive parents' depressive symptoms and child internalizing and externalizing were assessed at 18, 27, and 54 months, and child morning and evening HPA activity measured through ...
Sohrabi K K ThoraTech GmbH, Anwenderzentrum Medizintechnik, - - 2012
Respiratory flow detection with the aim of detecting sleep-related breathing disorders plays a major role in polysomnography. Due to the fact that pneumotachographs are too bulky and not suitable for measurements during sleep, the ThorAKUSTIK system has been developed. By attaching a noise sensor right next to larynx, it determines ...
McKay Rod - - 2012
OBJECTIVE: Evidence that feedback on outcome measures can improve consumer outcomes is building but clinician engagement remains inconsistent. Clinicians can interpret and utilize familiar measures but have difficulty in relating to routine outcome measures like the Health of the Nation Outcomes Scales (HoNOS). This paper aims to explore and illustrate ...
Reuter Gábor G Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary. - - 2012
Two novel picornaviruses were serendipitously identified in apparently healthy young domestic animals-cattle (Bos taurus) and, subsequently, sheep (Ovis aries)-in Hungary during 2008 and 2009. Complete genome sequencing and comparative analysis showed that the two viruses are related to each other and have identical genome organizations, VPg + 5' UTR(IRES-II)[L/1A-1B-1C-1D-2A(NPG↓P)/2B-2C/3A-3B(VPg)-3C(pro)-3D(pol)] 3' ...
Torguet-Escuder Pere - - 2012
Background and Objectives: The ample information available in relation to FGF 23, calcium, phosphorus, PTH, and 25/1,25 vitamin D has allowed us to define consistent values for each variable in each stage of chronic kidney disease (CKD). These values can define early stages, prognostic issues, and new treatment targets. We ...
Alves Cardoso D - - 2012
In the past two decades, nanotechnology has entered the field of regenerative medicine, resulting in the development of a novel generation of instructive, nanostructured biomaterials that are able to orchestrate cellular behavior by presenting specific morphological and biological cues. Using nanotechnology, materials containing nanosized features (e.g., pores, patterns, textures, grain ...
Shon W - - 2012
Cutaneous occlusive vascular disease results from various etiologies. By routine light microscopy, these intravasculuar deposits are indistinguishable and often diagnostic challenges especially when very limited clinical information is available. Cryoglobulins are reversibly cold-precipitable serum or plasma immunoglobulins associated with a number of infections, autoimmune and neoplastic disorders.
Hoving Hendrik J T HJ Monterey Bay Aquarium Research Institute, Moss Landing, CA 95039, USA. - - 2012
Vampire squid (Vampyroteuthis infernalis) are considered phylogenetic relics with cephalopod features of both octopods and squids. They lack feeding tentacles, but in addition to their eight arms, they have two retractile filaments, the exact functions of which have puzzled scientists for years. We present the results of investigations on the ...
Anzalone Rita - - 2012
Abstract: Mesenchymal stem cells (MSC) are virtually present in all postnatal organs as well as in perinatal tissues. MSC can be differentiated towards severalmature cytotypes and interestingly hold potentially relevant immunomodulatory features. Myocardial infarction results in severe tissue damage, cardiomyocytes loss, and eventually heart failure. Cellular cardiomyoplasty represents a promising ...
Enayat S - - 2012
Platelet-type von Willebrand disease (PT-VWD) is a rare bleeding disorder with an intrinsic defect in platelets rather than von Willebrand factor (VWF), but has clinical and laboratory features similar to the more common type 2B VWD. The intriguing nature of the pathophysiology and molecular genetics of PT-VWD has created lengthy ...
Janku Filip - - 2012
We analyzed the outcomes of single-agent phase II clinical trials in non-small cell lung cancer (NSCLC) to determine trial parameters that predicted clinical activity. Data on response rate (RR), progression-free survival (PFS), and overall survival (OS) from all English language, single-agent phase II trials in advanced/metastatic NSCLC indexed by PubMed ...
Stuijver D J F - - 2012
Several coagulation and fibrinolytic parameters appear to be affected by thyroid hormone excess; however, the net effect on the haemostatic system remains unclear. We aimed to update our previous review and systematically summarise and meta-analyse the data by assessing the effects of thyrotoxicosis on the coagulation and fibrinolytic system in ...
de Giorgi V - - 2012
Background:  oncological research has been focused on evaluating estrogen receptors (ERs) in estrogen-related tumors and understanding the potential role of ERs in the pathophysiology of cancer. Objectives:  To investigate the significance of estrogen receptor beta (ERβ) in melanoma. Methods:  We prospectively evaluated ERβ expression in malignant melanoma (MM) tissue and ...
Lionetto Luana - - 2012
Migraine is a common neurovascular disorder characterized by recurrent episodes of disabling headache, autonomic nervous system dysfunction, and in some patients, neurological aura symptoms. Triptans are frequently prescribed drugs for the treatment of the acute migraine attack, considering their capability to provide wide efficacy and tolerability. This review discusses pharmacodynamics ...
Patel Suchit H SH Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10065, - - 2012
The activity of auditory afferent fibers depends strongly on the frequency of stimulation. Although the bullfrog's amphibian papilla lacks the flexible basilar membrane that effects tuning in mammals, its afferents display comparable frequency selectivity. Seeking additional mechanisms of tuning in this organ, we monitored the synaptic output of hair cells ...
Menon V - - 2012
Rhodococcus equi is a pathogen that mainly causes infection in immunocompromised hosts. We report a case of relapsing R. equi pulmonary infection in a 57-year-old male renal transplant recipient who was treated with 12 months of antibiotics, adjunctive surgery, and a reduction in his immunosuppression. He suffered from relapsing disease, treatment-related ...
Ely E R - - 2012
Early-warning surveillance provides an essential component of the evidence required to protect animal health. Assessing the proportion of the population included in surveillance systems (coverage) provides a measure of the effectiveness of early-warning surveillance, and contributes to ensuring that these systems are efficient. This paper describes an investigation of methods ...
Venturini M - - 2012
Background:  Photodynamic therapy (PDT) with methyl-aminolevulinate (MAL) is an approved non-invasive treatment option for basal cell carcinoma (BCC). In vivo reflectance confocal microscopy (RCM) is a non-invasive imaging technique that proved useful for in vivo real-time cyto-morphologic analysis of cells of BCC infiltrating the epidermis. Objectives:  The aim of the ...
Dau Pham Thi - - 2012
The constitutive androstane receptor (CAR) not only displays a high basal transcriptional activity, but also acts as a ligand-dependent transcriptional factor. It is known that CAR exhibits different ligand profiles across species. However, the mechanisms underlying CAR activation by chemicals and the species-specific responses are not fully understood. The objectives ...
Geerligs Linda - - 2012
Temporal integration was examined using a missing element task, in which task performance depends on the ability to integrate brief successive stimulus displays. Previous studies have suggested that temporal integration is under endogenous control and that integration is more likely when stimuli match the observer's temporal expectancies. Beta oscillations have ...
Chen Lin - - 2012
Cren7, a novel chromatin protein highly conserved among crenarchaea, plays an important role in genome packaging and gene regulation. However, the detail dynamical structural characteristic of the Cren7-DNA complex and the detail study of the DNA in the complex have not been done. Focused on two specific Cren7-DNA complexes (PDB ...
Yan Xi - - 2012
This study was conducted to determine whether dietary Se deficiency precluded overproduction of glutathione peroxidase-1 (GPX1) activity in mice overexpressing (OE) this gene and thus rescued their type 2 diabetes-like phenotypes. A total of 20 male OE and wild-type (WT) mice were fed an Se-deficient (<0.02 mg/kg) diet or an ...
Erogbogbo Folarin - - 2012
The development of multimodal nanoparticle platforms is desirable for cancer nanotechnology applications. Creating single nanoplatforms with both plasmonic and photoluminescent optical properties has remained a challenge, because combining discrete entities each having one of these unique properties typically results in the attenuation of one of the desirable properties. Here, we ...
Paramasivam Nagarajan - - 2012
ABSTRACT: BACKGROUND: In Gram-negative bacteria, the outer membrane is composed of an asymmetric lipid bilayer of phopspholipids and lipopolysaccharides, and the transmembrane proteins that reside in this membrane are almost exclusively beta-barrel proteins. These proteins are inserted into the membrane by a highly conserved and essential machinery, the BAM complex. ...
Liang Liang-Han - - 2012
BACKGROUND: -Despite adequate rate control, the combination of atrial fibrillation (AF) with heart failure (HF) has been shown in a number of studies to hasten HF progression. In this context we aimed to test the hypothesis that an irregular ventricular rhythm causes an alteration in ventricular cardiomyocyte excitation-contraction coupling which ...
Prakash Anand - - 2012
Adenovirus (Ad) mutants that lack early region 4 (E4) activate the phosphorylation of cellular DNA damage response proteins. In wild-type Ad type 5 (Ad5) infections, E1b and E4 proteins target the cellular DNA repair protein Mre11 for redistribution and degradation, thereby interfering with its ability to activate phosphorylation cascades important ...
Ding Ling - - 2012
Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure-activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.
Fibla Juan J - - 2012
OBJECTIVES: A new revision of the international lung cancer staging system has been recently introduced. The revisions are largely focussed on the T descriptor. We sought to test the validity of this new system on a separate prospectively collected cohort of patients from a recent multicentre trial of early-stage lung ...
Rekvig Ole Petter - - 2012
Loss of immunological tolerance results in autoimmunity and may finally end in autoimmune disorders. For an autoimmune response against chromatin, autologous chromatin (nucleosomes) is assumed to activate both chromatin-specific B and T cells with a resulting anti-chromatin antibody response. As only fragmental elements of this process have been described, we ...
Kassa Desta - - 2012
Characterizing host immune responses to molecular targets of Mycobacterium tuberculosis is essential to develop effective immunodiagnostics and better vaccines. We investigated the immune response against a large series of M. tuberculosis antigens, including 5 classical and 64 nonclassical (39 DosR regulon-encoded, 4 resuscitation-promoting factor [RPF], and 21 reactivation-associated) antigens in ...
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