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Results 501 - 550 of 2252
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Li J - - 2013
The influence of an immunosuppressive cytokine, interleukin-10 (IL-10), on the outcome of hepatitis C virus (HCV) infection has been increasingly reported recently. A number of polymorphisms appear to control the level of IL-10 production. Among them, -592C/A, -819C/T and -1082G/A in the IL-10 gene are three most studied single nucleotide ...
Parisi Pasquale - - 2012
The term "ictal epileptic headache" has been recently proposed to classify the clinical picture in which headache is the isolated ictal symptom of a seizure. There is emerging evidence from both basic and clinical neurosciences that cortical spreading depression and an epileptic focus may facilitate each other, although with a ...
Lewis Andrew L - - 2013
Irinotecan eluting embolization beads (DEBIRI) are currently being evaluated in the clinic for the treatment of colorectal cancer metastases to the liver. The aim of this study was to determine the safety and pharmacokinetics associated with two cycles of hepatic embolization using DEBIRI followed by intravenous administration of irinotecan. Pigs ...
Hatipoglu Nihal - - 2013
Waist circumference, a proxy measure of abdominal obesity, is associated with cardio-metabolic risk factors in childhood and adolescence. Although there are numerous studies about waist circumference percentiles in children, only a few studies cover preschool children. The aim of this study was to develop age- and gender-specific waist circumference smoothed ...
Guzik Urszula - - 2013
The aim of this paper was to describe the effect of various metal ions on the activity of protocatechuate 3,4-dioxygenase from Stenotrophomonas maltophilia KB2. We also compared activity of different dioxygenases isolated from this strain, in the presence of metal ions, after induction by various aromatic compounds. S. maltophilia KB2 ...
Quintin Jacques - - 2012
Today, the frequency and the rate of success resulting from advances in medicine have made organ transplantations an everyday occurrence. Still, organ transplantations and donations modify the subjective experience of human beings as regards the image they have of themselves, of body, of life and of death. If the concern ...
Rogers Faye A - - 2013
Epidermal keratinocytes are particularly suitable candidates for in situ gene correction. Intraperitoneal administration of a triplex-forming oligonucleotide (TFO) was previously shown to introduce DNA base changes in a reporter gene in skin, without identifying which cells had been targeted. We extend those previous experiments using two triplex-forming molecules, a peptide ...
Rao Vikas Y - - 2013
Intracranial cerebral aneurysms in the pediatric population are infrequent, and those occurring in infants less than 1 year old are extremely rare. Of intracranial aneurysms in children, dissecting aneurysms are the most common type seen. While spontaneous dissecting aneurysms usually present with ischemia, hemorrhage can also occur. A retrospective review ...
Rastogi Shishir - - 2012
A prospective study was undertaken to evaluate the diagnostic and prognostic significance of serum levels of vascular endothelial growth factor (VEGF) in patients with primary localised osteosarcoma. Serum VEGF levels were measured by an enzyme-linked immunosorbent assay (ELISA) in blood samples collected prechemotherapy, postchemotherapy, and postsurgery in 40 patients with ...
Smith Carolyn L - - 2012
Silencing mediator of retinoic acid and thyroid hormone receptor (SMRT), also known as nuclear corepressor 2 (NCOR2) is a transcriptional corepressor for multiple members of the nuclear receptor superfamily of transcription factors, including estrogen receptor-α (ERα). In the classical model of corepressor action, SMRT binds to antiestrogen-bound ERα at target ...
Appelhans Bradley M - - 2012
The body adiposity index (BAI) is a proposed alternative to the body mass index (BMI) that has shown good cross-sectional agreement with percent body fat (%BF) in validation studies. The objective of this study was to examine the ability of BAI to track adiposity change over time in a biracial ...
Wayne Kyle J - - 2012
WalRK (YycFG) two-component systems (TCSs) of low-GC Gram-positive bacteria play critical roles in regulating peptidogylcan hydrolase genes involved in cell division and wall stress responses. The WalRK (VicRK) TCSs of Streptococcus pneumoniae (pneumococcus) and other Streptococcus species show numerous differences with those of other low-GC species. Notably, the pneumococcal WalK ...
Watanabe Isao - - 2012
BACKGROUND: A national survey in Japan reported that the prevalence of smoking among high school students has sharply decreased in recent years. However, the survey only considered students who attended regular high schools (RHSs), and Japan offers part-time high schools (PHSs) that are often attended by academically and socioeconomically disadvantaged ...
Gong Zhihong Z Department of Epidemiology and Biostatistics, University of California San Francisco, 3333 California Street, Suite 280, San Francisco, CA 94118-1944, USA. - - 2012
Obesity has been consistently associated with increased risk of pancreatic cancer incidence and mortality. However, studies of obesity and overall survival in patients with pancreatic cancer are notably lacking, especially in population-based studies. Active and passive follow-up were used to determine vital status and survival for 510 pancreatic cancer patients ...
Matheson Brittany E BE Uniformed Services University of the Health Sciences (USUHS), Department of Medical and Clinical Psychology, Bethesda, MD 20814, - - 2012
To compare the characteristic meal patterns of adolescents with and without loss of control (LOC) eating episodes. The Eating Disorder Examination was administered to assess self-reported LOC and frequency of meals consumed in an aggregated sample of 574 youths (12-17 years; 66.6% female; 51.2% Caucasian; BMI-z: 1.38 ± 1.11), among ...
Spinelli Amy M AM Center for Cardiovascular Sciences, Albany Medical College, Mail Code 8, 47 New Scotland Ave, Albany, NY 12208, - - 2012
Airway smooth muscle cell (ASMC) remodeling contributes to the structural changes in the airways that are central to the clinical manifestations of asthma. Ca(2+) signals play an important role in ASMC remodeling through control of ASMC migration and hypertrophy/proliferation. Upregulation of STIM1 and Orai1 proteins, the molecular components of the ...
Badding M A MA Department of Pediatrics, Division of Neonatology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, - - 2013
Microtubule-based transport is required for plasmid translocation to the nucleus during transfections, and having stable structures could enhance this movement. In previous studies, in which the cytoskeleton was disrupted, we found that populations of microtubules remain that are stable and highly acetylated. By increasing the levels of acetylated tubulin through ...
Mulligan Kimberly A KA Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, - - 2012
Members of the Wnt family of secreted signaling proteins influence many aspects of neural development and function. Wnts are required from neural induction and axis formation to axon guidance and synapse development, and even help modulate synapse activity. Wnt proteins activate a variety of downstream signaling pathways and can induce ...
Martin Melissa L ML Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center, Rochester, NY, - - 2012
The cardiac fibroblast (CF) has historically been thought of as a quiescent cell of the heart, passively maintaining the extracellular environment for the cardiomyocytes (CM), the functional cardiac cell type. The increasingly appreciated role of the CF, however, extends well beyond matrix production, governing many aspects of cardiac function including ...
McClain Donald A DA Department of Internal Medicine, University of Utah and VA Medical Center, Salt Lake City, UT, - - 2013
In Chuvash polycythemia, a homozygous 598C>T mutation in the von Hippel-Lindau gene (VHL) leads to an R200W substitution in VHL protein, impaired degradation of α-subunits of hypoxia-inducible factor (HIF)-1 and HIF-2, and augmented hypoxic responses during normoxia. Chronic hypoxia of high altitude is associated with decreased serum glucose and insulin ...
Raghuraman Sairamesh S Research Center Magnetic Resonance Bavaria (MRB), Am Hubland, 97074, Wuerzburg, Germany. - - 2013
To construct an optimised, high-density receive array and a movement device to achieve dynamic imaging of the knee in orthopedic large animal models (e.g., minipigs) at 1.5 T. A 13-channel RF receive array was constructed, and the crucial choice of the array element size (based on considerations like region of ...
Jiang Li L Cornell University, 240 Upson Hall, Ithaca, New York 14853, - - 2013
Light-based flow systems for point-of-care devices are of interest because, in principle, sunlight could be used to operate them, potentially allowing for high functionality with minimal device complexity and expense. A light-operated method to drive flow using poly(N-isopropylacrylamide), a 'smart' polymer that changes wettability as a function of temperature, is ...
Subramanian Veedamali S VS Departments of Medicine, Physiology and Biophysics, University of California, Irvine, CA 92697, USA. - - 2013
Ascorbic acid (AA) is required for normal human health and development. Human intestine expresses two sodium-dependent vitamin C transporters (hSVCT-1 and -2) that mediate cellular AA transport, with hSVCT1 targeting to the apical membrane of polarized epithelia. Studies have shown a role for the Rab8a in the apical membrane targeting ...
Parisi Rosa R School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, - - 2013
The worldwide incidence and prevalence of psoriasis is poorly understood. To better understand this, we performed a systematic review of published population-based studies on the incidence and prevalence of psoriasis. Three electronic databases were searched from their inception dates to July 2011. A total of 385 papers were critically appraised; ...
Redelmeier Donald A DA Department of Medicine, University of Toronto, Toronto, ON, - - 2012
Physicians' warnings to patients who are potentially unfit to drive are a medical intervention intended to prevent trauma from motor vehicle crashes. We assessed the association between medical warnings and the risk of subsequent road crashes. We identified consecutive patients who received a medical warning in Ontario, Canada, between April ...
Sato Hiroko H Department of Pediatrics, Yamagata University School of Medicine, Yamagata, - - 2013
Breastfeeding jaundice is a well-known phenomenon, but its pathogenesis is still unclear. Increased production of bilirubin, impaired hepatic uptake and metabolism of bilirubin, and increased enterohepatic circulation of bilirubin account for most cases of pathological neonatal hyperbilirubinemia. We previously reported that 211G>A (G71R) mutation of the UGT1A1 gene is prevalent ...
Andrade Pablo P Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands. - - 2013
Previous experimental models have shown that proinflammatory cytokines modulate peripheral and central nociception. However, the direct correlation between inflammation and pain in patients remains unclear. Our aim is to correlate the levels of inflammation in the spine with pre- and postoperative pain scores after discectomy. Paravertebral muscle, annulus fibrosus (AF) ...
Ingram Verina V Centre for International Forestry Research (CIFOR), BP 2008, Messa, Yaoundé, Cameroon. - - 2013
Bamboo is a well know and versatile material, which is a common sight across Cameroon's diverse ecosystems, from dry to humid tropical and Afromontane forests. Its numerous uses range from storage jars to decorating restaurant-bars, beehives to knives, fences, fodder, and fuel. Responding to the paucity of data on species ...
Ali Muhammad Aslam MA Department of Environmental Science, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh. - - 2013
A field experiment was conducted in Bangladesh Agricultural University Farm to investigate the mitigating effects of soil amendments such as calcium carbide, calcium silicate, phosphogypsum, and biochar with urea fertilizer on global warming potentials (GWPs) of methane (CH4) and nitrous oxide (N2O) gases during rice cultivation under continuous and intermittent ...
Pishvaian Michael J MJ Lombardi Comprehensive Cancer Center, Developmental Therapeutics Program, Washington, DC 20007, USA. - - 2012
Pre-clinical data suggest that combining imatinib with traditional cytotoxic chemotherapy may improve imatinib efficacy. We conducted a Phase I study of imatinib in combination with paclitaxel in patients with advanced or metastatic solid tumors. Patients were accrued to the study in a standard 3 + 3 design. Patients were restaged ...
Jenkinson Sarah E SE Epithelial Cell Research Group, Institute for Cell and Molecular Biosciences, Medical School, Framlington Place, Newcastle upon Tyne, UK. - - 2012
Acquiring a mechanistic understanding of the processes underlying the renal clearance of drug molecules in man has been hampered by a lack of robust in vitro models of human proximal tubules. Several human renal epithelial cell lines derived from the renal cortex are available, but few have been characterised in ...
Zakaria Rasheed R Department of Neurosurgery, The Walton Centre NHS Trust, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK. - - 2013
Dorsal herniation of the spinal cord through the dura is an uncommon phenomenon and this is only the fifth reported case in the thoracolumbar spine, the first following surgery at the thoracolumbar junction. A 57-year-old male underwent marsupialisation of a benign intramedullary cyst at the T12-L1 level and subsequently returned ...
Ducati Luis Gustavo LG Department of Neurology and Psychiatry, Hospital das Clinicas da Faculdade de Medicina de Botucatu, University of State of São Paulo (UNESP), District of Rubião Junior, Botucatu, SP, CEP 18618-970, Brazil. - - 2013
Intradural lumbar disc herniations are uncommon presentations of a relatively frequent pathology, representing less than 1% of all lumbar disc hernias. They show specific features concerning their clinical diagnosis, with a higher incidence of cauda equina syndrome, and their surgical treatment requires a transdural approach. In this article, we describe ...
Duncan F Jason FJ Department of Nutrition, The Ohio State University, Columbus, Ohio 43210, - - 2013
Alopecia areata (AA) is an autoimmune disease that attacks anagen hair follicles. Gene array in graft-induced C3H/HeJ mice revealed that genes involved in retinoic acid (RA) synthesis were increased, whereas RA degradation genes were decreased in AA compared with sham controls. This was confirmed by immunohistochemistry in biopsies from patients ...
Tu Chuqiao C Department of Biomedical Engineering, University of California, Davis, CA, USA. - - 2013
The emergence and rapid development of activatable contrast agents (CAs), whose relaxivity changes in response to the variation of a specific marker in the surrounding physiological microenvironment, have expanded the scope of MRI beyond anatomical and functional imaging to also convey information at the cellular and molecular level. The essence ...
Kaur Kulvinder Kochar KK Dr Kulvinder Kaur Centre for Human Reproduction, 721, GTB Nagar, Jalandhar, 144001 Punjab, India. - - 2012
Kisspeptins (Kps), were first found to regulate the hypothalamopituitary-gonadal axis (HPG) axis in 2003, when two groups-demonstrated that mutations of GPR54 causes idiopathic hypogonadotropic hypogonadism (IHH) characterized by delayed puberty. Objective of this review is to highlight both animal and human discoveries in KISS1/GPR54 system in last decade and extrapolate ...
Gauthier Marie M Department of Pediatrics, Sainte-Justine University Hospital Center, University of Montreal, Montreal, Canada. - - 2012
Acute bronchiolitis has been associated with an increasing hospitalization rate over the past decades. The aim of this paper was to estimate the impact of home oxygen therapy (HOT) on hospital stay for infants with acute bronchiolitis. A retrospective cohort study was done including all children aged ≤ 12 months ...
Zhang Bin B Department of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan No. 2 Road, Guangzhou 510080, - - 2012
Circulating and podocyte-bound urokinase receptor (uPAR) is a mediator of podocyte injury, proteinuria, and focal segmental glomerulosclerosis (FSGS) allowing pathological activation of the uPAR-β3 integrin signaling axis. Clinically, calcineurin inhibitors (e.g., cyclosporine A, CsA) are known to suppress T cells, yet are also being used to reduce proteinuria in FSGS, ...
Groessl Erik J EJ UCSD Health Services Research Center, University of California San Diego, 9500 Gilman Dr. #0994, La Jolla, CA 92037, USA. - - 2013
Cataracts are the leading cause of blindness worldwide and cause visual impairment for millions of adults in the United States. We compared the sensitivity of a vision-specific health-related quality of life (HRQOL) measure to that of multiple generic measures of HRQOL before and at 2 time points after cataract surgery. ...
Crouzet Olivier O LMGE, Clermont Université, Université Blaise Pascal, 63000, Clermont-Ferrand, France. - - 2013
This study aimed to investigate the dose-response effects of an herbicide on soil photosynthetic microbial communities, particularly cyanobacteria, using a microcosm approach. Pure mesotrione (active ingredient), and Callisto (a commercial formulation of this triketone herbicide), were spread at different rates on soil microcosm surfaces. Soil Chlorophyll concentrations were quantified to ...
Lin Tzu-Kai TK Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, California 94121, - - 2013
Systemic antagonists of the histamine type 1 and 2 receptors (H1/2r) are widely used as anti-pruritics and central sedatives, but demonstrate only modest anti-inflammatory activity. Because many inflammatory dermatoses result from defects in cutaneous barrier function, and because keratinocytes express both Hr1 and Hr2, we hypothesized that H1/2r antagonists might ...
Correa Cleiton Silva CS Physical Education School, Federal University of Rio Grande do Sul, Street Felizardo, 750, Jardim Botânico, CEP: 90690-200, Porto Alegre, Rio Grande do Sul RS, Brazil, - - 2013
Strength training seems to be an interesting approach to counteract decreases that affect knee extensor strength, muscle mass and muscle quality (force per unit of muscle mass) associated with ageing. However, there is no consensus regarding the changes in muscle mass and their contribution to strength during periods of training ...
Khan Maria M Stroke Service and the International Cerebrovascular Translational Clinical Research Training Program, Section of Neurology, Department of Medicine, Aga Khan University Hospital, Karachi, - - 2013
There are no descriptions of stroke mechanisms from intracranial atherosclerotic disease in native South Asian Pakistanis. Men and women aged ≥ 18 years with acute stroke presenting to four tertiary care hospitals in Karachi, Pakistan were screened using magnetic resonance angiography/transcranial Doppler scans. Trial of ORG 10172 in Acute Stroke ...
Yuan Hang H Department of Pathology, Georgetown University Medical Center, Washington, DC 20057, - - 2012
A patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion of the lung parenchyma. We used conditional reprogramming to generate cell cultures from the patient's normal and tumorous lung tissue. Analysis revealed that the laryngeal tumor cells contained a wild-type 7.9-kb human papillomavirus virus type ...
Phillips R B - - 2012
We report the genetic map location of 14 genes involved in the inflammatory response to salmonid bacterial and viral pathogens, which brings the total number of immune genes mapped in rainbow trout (RT, Oncorhynchus mykiss) to 61. These genes were mapped as candidate genes that may be involved in resistance ...
Popa-Burke Ioana - - 2012
Early drug discovery laboratories often call for the precise weighing of 1- to 5-mg solids into 4- to 5-g glass vials. For the balance used in this study (Mettler Toledo XP205), the manufacturer rates its accuracy at ±0.01 mg over the working range of 1 mg to 220 g and ...
Korsatko S - - 2012
AIMS: To compare the pharmacodynamic properties of insulin detemir (detemir) and neutral protamine lispro insulin (NPL) using a euglycaemic glucose clamp. MATERIALS AND METHODS: In a double-blind, crossover study, thirty patients with C-peptide negative type 1 diabetes were randomly assigned to a single dose (0.4 U/kg) of detemir and NPL. ...
Gul Mehmet - - 2012
We report a case with a very rare complication of transcatheter aortic valve implantation. Rupture of the NovaFlex balloon (Edwards transfemoral balloon catheter) occurred during the inflation of the Edwards SAPIEN valve, resulting in dissection of the right common and external iliac arteries during withdrawal of the balloon catheter. The ...
Franco Wendy - - 2012
AIMS: To evaluate the interaction between yeasts and bacteria and associate their metabolic activity with secondary cucumber fermentation. METHODS AND RESULTS: Selected yeast and bacteria, isolated from cucumber secondary fermentations, were inoculated as single and mixed cultures in a cucumber juice model system. Our results confirmed that during storage of ...
Lazaros L - - 2012
Follicle-stimulating hormone (FSH), interacting with its receptor (FSHR), participates in the production of spermatozoa and androgens. Androgens exert their effects on male sex determination, development and sperm production by binding to androgen receptor (AR). In the present study, we sought to explore the potential synergistic effects of FSHR and AR ...
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