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Results 201 - 250 of 3033
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Arnulf Isabelle I National Reference Center for Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome, Sleep Disorders Unit and Inserm U975, Pitié-Salpêtrière Hospital (APHP), Pierre and Marie Curie University, Paris, France. - - 2012
Kleine-Levin syndrome is a rare sleep disorder that mainly affects adolescents and is characterised by relapsing-remitting episodes of severe hypersomnia, cognitive impairment, apathy, derealisation, and psychiatric and behavioural disturbances. Boys are more frequently affected than girls. Just over half of patients have hyperphagia, are hypersexual (mainly boys), or have depressed ...
Mineharu Yohei - - 2012
Immune-mediated gene therapy using adenovirus expressing Flt3 ligand and thymidine kinase followed by ganciclovir administration (Flt3/TK) effectively elicits tumor regression in preclinical glioma models. Herein, we assessed new strategies to optimize Flt3L/TK therapeutic efficacy in a refractory RG2 orthotopic glioblastoma model. Specifically, we aimed to optimize the therapeutic efficacy of ...
Elser Heather E - - 2012
To assess how different infant positions and peak sound levels affected cerebral oxygen saturation over time. Twenty-four premature infants who were born less than 32 weeks' gestational age without congenital cardiac, neurologic, and gastrointestinal anomalies. Repeated-measures design with the first observation between 2 and 48 hours of life; once again ...
Fidelman Nicholas - - 2012
The purpose of this article is to review the indications, outcomes, complications, patient selection, and technical aspects of creating a transjugular intrahepatic portosystemic shunt (TIPS). The best available evidence supports the use of TIPS in secondary prevention of variceal bleeding and in refractory ascites, although TIPS is also commonly used ...
Zhu Ying - - 2012
Intraductal papilloma of the breast can resemble invasive ductal carcinoma (IDC). The purpose of this study was to characterize MRI features of solitary intraductal papillomas and identify features that differentiate intraductal papillomas from small IDCs. Forty-four intraductal papillomas and 49 small (diameter ≤ 2.0 cm) IDCs confirmed by histopathology were ...
Dennis Ashley - - 2012
Background:  Effective communication with patients is a vital ability for a doctor, and therefore training in communication skills forms an important component of the undergraduate medical curriculum. However, some medical undergraduates experience anxiety in communicating with patients and this makes it difficult for them to communicate with patients effectively. We ...
Banner Natalie F NF Centre for the Humanities and Health, King's College London, London, UK. - - 2012
The recent Mental Capacity Act (2005) sets out a test for assessing a person's capacity to make treatment choices. In some cases, particularly in psychiatry, it is unclear how the criteria ought to be interpreted and applied by clinicians. In this paper, I argue that this uncertainty arises because the ...
Meij Pauline - - 2012
To treat patients with refractory cytomegalovirus (CMV) reactivation after allogeneic stem cell transplantation, a phase I/II clinical study on adoptive transfer of in vitro-generated donor-derived or patient-derived CMV pp65-specific CD8 T-cell lines was performed. Peripheral blood mononuclear cells from CMV seropositive donors or patients were stimulated with HLA-A*0201-restricted and/or HLA-B*0702-restricted ...
Khan I - - 2012
Confocal microscopy, a technique that has been extensively applied in cellular biological studies, may also be applied to the visualization and three-dimensional imaging of protein crystals at high resolution on synchrotron beamlines. Protein crystal samples are examined using a commercially available confocal microscope adapted for cryogenic use. A preliminary test ...
Plöttner Sabine - - 2012
Cigarette smoking is a risk factor for bladder cancer. Since urothelial cells express phase I and II enzymes these cells are able to metabolize precarcinogens into DNA reactive intermediates. Cigarette smoke is a complex mixture containing at least 80 known carcinogens. In this context especially aromatic amines and polycyclic aromatic ...
Hernandez Jennifer S - - 2012
: To estimate the effect of hydramnios on pregnancy outcomes in dichorionic and monochorionic twins. : This is a retrospective cohort study of women with twin pregnancies who underwent ultrasound evaluation between 1997 and 2010 and delivered liveborn neonates or stillborn fetuses at 24 weeks of gestation or more at ...
van der Steen Johannes - - 2012
We investigated under what conditions humans can make independent slow phase eye movements. The ability to make independent movements of the two eyes generally is attributed to few specialized lateral eyed animal species, for example chameleons. In our study, we showed that humans also can move the eyes in different ...
Patel Uday B - - 2012
The Magnetic Resonance Imaging and Rectal Cancer European Equivalence (MERCURY) Study validated the use of MRI for posttreatment staging and its correlation with survival outcomes. As a consequence, reassessment of MRI scans after preoperative therapy has implications for surgical planning, the timing of surgery, sphincter preservation, deferral of surgery for ...
Helmons Pieter J - - 2012
Purpose The effects of a direct refill program for automated dispensing cabinets (ADCs) on medication-refill errors were studied. Methods This study was conducted in designated acute care areas of a 386-bed academic medical center. A wholesaler-to-ADC direct refill program, consisting of prepackaged delivery of medications and bar-code-assisted ADC refilling, was ...
Lindahl Cecilia - - 2012
ABSTRACT Animal-related injuries are among the most common occupational injuries in agriculture. Despite the large number of documented animal-related injuries in dairy farming, the issue has received relatively limited attention in the scientific literature. The farmers' own perspectives and views on risks and safety during livestock handling and what they ...
Patel Sameer J - - 2012
: To describe health care providers' missed opportunities for preventing and treating congenital syphilis in New York City. : Review of congenital syphilis cases reported to the New York City Department of Health and Mental Hygiene from January 1, 2000 to December 31, 2009. Receipt and timing of prenatal care, ...
Moro C - - 2012
Acetylcholine, and to a lesser extent ATP, mediates neurogenic contractions of bladder smooth muscle. Recently, the urothelium and lamina propria have also been shown to have contractile properties, but the neurotransmitters involved in mediating responses to nerve stimulation have not been investigated. Isolated strips of porcine urothelium with lamina propria ...
Baker David - - 2012
Introduction:  International Medical Graduates (IMGs) are more likely to be involved in complaints and have lower pass rates for professional examinations. Language barriers and differences in culture and consulting style are suggested to be the cause. A programme was developed in Dumfries and Galloway to address these issues, aiming to ...
Seeger Christian - - 2012
The kinetic and mechanistic details of the interaction between caldendrin, calmodulin and the B-domain of AKAP79 were determined using a biosensor-based approach. Caldendrin was found to compete with calmodulin for binding at AKAP79, indicating overlapping binding sites. Although the AKAP79 affinities were similar for caldendrin (K(D)  = 20 n m) and calmodulin ...
Kim Shin-Hee - - 2012
The complete genome sequence of an African Newcastle disease virus (NDV) strain isolated from a chicken in Togo in 2009 was determined. The genome is 15,198 nucleotides (nt) in length and is classified in genotype VII in the class II cluster. Compared to common vaccine strains, the African strain contains ...
Wright Jason D - - 2012
: Despite the efficacy of vaccines against human papillomavirus (HPV), vaccination rates remain low in many countries. We estimated the acceptability and satisfaction of HPV vaccination in postpartum women. : Postpartum women aged 18-26 years were offered the quadrivalent HPV vaccine. Women were vaccinated during hospitalization after delivery, at the ...
Massad L Stewart LS Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, Missouri 63110, USA. - - 2012
To estimate the accuracy of Pap testing for women who are human immunodeficiency virus (HIV)-seropositive, with a focus on negative predictive value. Participants in the Women's Interagency HIV Study were monitored with conventional Pap tests every 6 months. After excluding those with abnormal Pap test results before study, cervical disease, ...
Lim Michelle H - - 2012
The jumping-to-conclusions bias has not been examined in a new religious movement (NRM) group. Twenty-seven delusion-prone NRM individuals were compared with 25 individuals with psychotic disorders and 63 non-delusion-prone individuals on four probabilistic inference tasks, together with measures of psychotic symptoms and delusion proneness. The NRM individuals requested significantly less ...
Tedner S G - - 2012
Early genetic and environmental factors have been discussed as potential causes for the high prevalence of asthma and allergic disease in the western world, and knowledge on fetal growth and its consequence on future health and disease development is emerging. This review article is an attempt to summarize research on ...
Parle James - - 2012
Background:  Clinical teaching associates (CTAs) are human simulators who use themselves (i.e. their bodies and psyches) as an integral part of the teaching and assessing process. Increasingly, various CTAs are used in clinical education, for instance as stand-ins for clinical tutors or for high-stakes assessments. Context:  Four groups of people ...
Martin Stephanie J - - 2012
Background  Mycosis fungoides (MF) and the Sézary syndrome (SS) are non-Hodgkin's lymphomas that present with cutaneous lesions. Sézary syndrome is characterized by blood involvement, exfoliative eryrthroderma, lymphadenopathy, pruritus, keratoderma, and immunosuppression. This study was to estimate the prevalence of palmoplantar keratoderma and tinea pedis in Sézary syndrome and to analyze ...
Andreasen Jens Ove - - 2012
Abstract -  Diagnosis and treatment for traumatic dental injuries are very complex owing to the multiple trauma entities represented by six luxation types and nine fracture types affecting both the primary and the permanent dentition. When it is further considered that fracture and luxation injuries are often combined, the result is ...
Canton Karen - - 2012
ABSTRACT The objective of this study was to investigate how noise-induced hearing loss (NIHL) or noise injury (NI) affects individuals and others of dairy farm communities in New Zealand. Using "grab" or opportunistic sampling at DairyNZ discussion groups and a recreational function, a survey questionnaire was completed by 74 participants ...
Hu Y F - - 2012
Coxsackievirus B5 (CVB5) belongs to the human enterovirus B species within the family Picornaviridae. We report the complete genome sequence of a novel CVB5 strain, CVB5/SD/09, that is associated with neurological hand, foot, and mouth disease in China. The complete genome consists of 7,399 nucleotides, excluding the 3' poly(A) tail, ...
Wright Jason D - - 2012
: Cytoreductive surgery is associated with extensive morbidity and may delay chemotherapy. We examined the associations among cytoreduction, perioperative complications, and delay or omission of chemotherapy. : Women aged 65 years or older with stage III-IV ovarian cancer who were treated with surgery from 1991-2005 and recorded in the Surveillance, ...
Gómez-Peralta F - - 2012
Aim:  To evaluate whether administration of long-acting basal insulin analogue plus oral antidiabetic drugs (OADs) improves glycaemic control in type 2 diabetic patients with glycosylated haemoglobin (HbA1c) > 7% (53 mmol/mol) under premixed insulin therapy. Methods:  This is a multicentre, observational, retrospective study performed in type 2 diabetic patients switching from premixed ...
Dumkow Lisa E - - 2012
Purpose The case of a patient for whom reversal of dabigatran-induced bleeding was performed with a prothrombin complex concentrate (PCC) and fresh frozen plasma (FFP) is reported. Summary An 85-year-old man arrived at the emergency department with complaints of generalized weakness, fatigue, and one episode of dark stool. The patient's ...
Kamangar Faranak - - 2012
Acne vulgaris is a common reason why adult women present to dermatologists and can be a clinical challenge to treat. It may also be an important sign of an underlying endocrine disease such as Polycystic Ovary Syndrome (PCOS). Although standard acne therapies can be successfully used to treat acne in ...
Spodzieja Marta - - 2012
Serum amyloid A (SAA) is a multifunctional acute-phase protein whose natural role seems to be participation in many physiologic and pathological processes. Prolonged increased SAA level in a number of chronic inflammatory and neoplastic diseases gives rise to reactive systemic amyloid A amyloidosis, where the N-terminal 76-amino acid residue-long segment ...
Chow Wei Zhen - - 2012
A novel HIV-1 genotype designated CRF53_01B was recently characterized from three epidemiologically unrelated persons in Malaysia. Here we announced three recently isolated full-length genomes of CRF53_01B, which is likely to be phylogenetically linked to CRF33_01B, circulating widely in Southeast Asia. The genome sequences may contribute to HIV-1 molecular surveillance and ...
Buerkle Bernd - - 2012
: To compare the skills of performing a shoulder dystocia management algorithm after hands-on training compared with demonstration. : We randomized medical students to a 30-minute hands-on (group 1) and a 30-minute demonstration (group 2) training session teaching a standardized shoulder dystocia management scheme on a pelvic training model. Participants ...
Wang Jin - - 2012
The purpose of this article is to discuss whether diffusion-weighted imaging (DWI) shows new findings of injured bile ducts in patients with ischemic-type biliary lesions (ITBL) after orthotopic liver transplantation. Thirty-five transplant recipients with ITBL (ITBL group), 20 recipients without biliary abnormalities on MRCP (control group), and 20 volunteers who ...
Vin-Raviv N - - 2012
Aim:  The objective of the study was to examine the impact of WWII-related caloric restriction (CR) on subsequent breast cancer (BC) risk based on individual exposure experiences and whether this effect was modified by age at exposure. Methodology:  We compared 65 breast cancer patients diagnosed between 2005-2010 to 200 controls ...
Sander Ingrid - - 2012
The aim of our study was to develop specific enzyme-linked immunosorbent assays (ELISAs) and apply these to assess mold antigen exposure in composting plants. Sandwich ELISAs based on polyclonal antibodies to Aspergillus fumigatus (Af), Penicillium chrysogenum (Pc), and Cladosporium herbarum (Ch) antigens were developed and validated. Reactivity to 18 different ...
Hubbeling Dieneke - - 2012
Cartwright and Munro argued that extrapolation of findings from randomized controlled trials to other settings can be difficult because information about the underlying causal structure and subgroups is often not available. They advocated the use of 'capacities' - that is fixed causal contributions - in predicting effects of interventions. In ...
Pickett William - - 2012
ABSTRACT Major injury is an important occupational health problem for farming populations in North America. There are several well-established risk factors for injury in this setting, including lack of safety features on farm vehicles and machinery, and a lack of passive safety devices that offer protection from falls and drowning ...
Kraus Thomas - - 2012
In a German company polychlorinated biphenyls (PCB)-containing transformers and capacitors were recycled on a large scale. Human biomonitoring revealed a high PCB body burden in workers of the recycling company, in surrounding locations of this plant, in companies in the neighborhood of this plant, and in family members of these ...
Meng J - - 2012
Fungal exposures are believed to play an important role in the development of asthma and atopy, accounting for increased asthmatic symptoms and severe asthma exacerbation. Indoor fungal species vary both in taxa and concentration in different residences and in different regions. We explored the fungal species spectrum in 88 homes ...
Parekh Amit - - 2012
Background:  Simulation is increasingly used by medical schools to prepare final-year undergraduates for foundation year 1. But how should clinical teachers be delivering these simulation sessions to maximise the benefit to students? We sought to evaluate our own final-year simulation course, which uses two different styles of simulation, to identify the ...
Marcum James A - - 2012
Clinical reasoning is an important component for providing quality medical care. The aim of the present paper is to develop a model of clinical reasoning that integrates both the non-analytic and analytic processes of cognition, along with metacognition. The dual-process theory of cognition (system 1 non-analytic and system 2 analytic ...
Becher Paul - - 2012
We report here the complete genome sequence of pestivirus strain Aydin/04-TR, which is the prototype of a group of similar viruses currently present in sheep and goats in Turkey. Sequence data from this virus showed that it clusters separately from the established and previously proposed tentative pestivirus species.
Roberts G - - 2012
Skin prick testing (SPT) is fundamental to the practice of clinical allergy identifying relevant allergens and predicting the clinical expression of disease. There are only limited data on the natural history of SPT results over childhood and adolescence. We aimed to describe the natural history of SPT and patterns of ...
Alavi Afsaneh - - 2012
This study aimed to highlight the importance of routine screening for hyperglycemia and to develop a standardized, evidence-based approach for the management of pemphigus patients on prolonged systemic corticosteroid (CS) therapy. A cross-sectional study was conducted in two university-affiliated teaching hospitals using a referred sample of 200 patients with a ...
Kerry Roger - - 2012
This paper explores the nature of causation within the framework of evidence-based practice (EBP) for health care. The aims of the paper were first to define and evaluate how causation is presently accounted for in EBP; second, to present an alternative causal account by which health care can develop in ...
Bodmer-Roy Sonja - - 2012
To estimate the incidence of gestational diabetes mellitus (GDM) according to The International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria and the pregnancy complications in women fulfilling these criteria but who are not considered diabetic according to the Canadian Diabetes Association criteria. We estimated the rate of ...
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