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Colacino Joseph M - - 2012
Professor Erik De Clercq, recent recipient of the International Society for Antiviral Research (ISAR) 'Outstanding Contributions to the Society Award', recounts 25 years of antiviral research collaborating with his colleagues and friends in Japan.
Ho Tien D - - 2012
A high-throughput method for the production of solid-phase microextraction (SPME) sorbent coatings via ultraviolet (UV) photoinitiated copolymerization of IL monomers on a fused silica support is described. The copolymerization of monocationic and dicationic IL crosslinkers was performed "on-fiber" using UV initiated free radical polymerization. Mixtures comprised of various amounts of ...
Pöschke Antje - - 2012
Increased COX-2 expression and PGE(2) synthesis have been shown to be prerequisites for renal renin release after Na(+) deprivation. To answer the question whether EP4 receptor type of PGE(2) mediates renin regulation under low salt diet, we examined renin regulation in EP4(+/+), EP4(-/-) and in wild type mice treated with ...
Xia Xiao-Feng - - 2012
A palladium-catalyzed tandem cyclization/C-H functionalization of two alkynes was accomplished to construct a series of polycyclic functionalized indoles. A range of internal alkynes bearing synthetically useful functional groups were tolerated. A good regioselectivity was observed when alkyl-substituted alkynes were introduced into the reaction system and a single product was obtained. ...
Walker Torrance - - 2012
Patellofemoral arthritis is a relatively common condition, affecting up to 24% of women and 11% of men over the age of fifty-five years who have symptomatic osteoarthritis of the knee. Isolated patellofemoral arthritis is not as prevalent and has been reported to occur in 9% of radiographs of symptomatic knees ...
Veronese Guido - - 2012
We carried out qualitative research with 61 health professionals and volunteer workers to explore their perceptions of their own and their clients' well-being in a context of political violence. We applied content analysis to identify the themes emerging from 8 focus group and 11 individual interviews. Participants were found to ...
Rice Heather C HC Center for Neurologic Diseases, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, - - 2012
Neuronal precursor cell migration in the developing mammalian brain is a complex process requiring the coordinated interaction of numerous proteins. We have recently shown that amyloid precursor protein (APP) plays a role in migration into the cortical plate through its interaction with two cytosolic signaling proteins, disabled 1 (DAB1) and ...
Calabrese Massimiliano - - 2012
BACKGROUND:Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the CNS in which a pathogenic role of anti-aquaporin-4 (AQP4) antibodies has been suggested. Although AQP4 is expressed in human cortex, recent histologic studies have failed to find any evidence of cortical demyelination in NMO. OBJECTIVE:To evaluate, in vivo, the ...
Blair James A - - 2012
BACKGROUND: While combat spinal injuries have been documented since the fourth century BC, a comprehensive analysis of such injuries has not been performed for any American military conflict. Recent literature has suggested that spinal injuries account for substantial disability in wounded service members. METHODS: The Joint Theater Trauma Registry was ...
Scott Lesley E - - 2012
Increased access to antiretroviral drugs expands needs for viral load (VL) testing. South Africa's National Health Laboratory Service responded to demands by implementing two testing platforms in 17 laboratories within 8 months. An industry partner's collaboration, training programs, and method verification with a VL prequalification panel ensured testing quality and ...
Calatayud Marta - - 2012
This study evaluates metabolism of inorganic arsenic (iAs) [As(III) and As(V)] in human intestinal cells as a function of cell type, differentiation stage, type of support used for cell growth and exposure time. Additionally, mRNA expression of arsenic (+3 oxidation state) methyltransferase (AS3MT) was evaluated. For this purpose Caco-2 (absorptive ...
Zhang Peng - - 2012
The LHMDS promoted in-situ generation of difluoroenolates from readily available 1-aryl and 1-alkyl 2,2,4,4,4-pentafluorobutan-1,3-dione hydrates has been used to produce a series of pentafluorinated beta-hydroxy ketones in up to 95% yield. The reaction proceeds under mild conditions, tolerates a wide range of functional groups and is complete within 10 minutes. ...
Kazemi-Zanjani Nastaran - - 2012
In the ectopic biomineralization of kidney stones, the competition between calcium oxalate monohydrate (COM) formation and its inhibition by the phosphoprotein osteopontin (OPN) plays a key role in COM stone-forming processes. To get more insights into these processes, tip-enhanced Raman spectroscopy (TERS) was used to provide surface-specific information about the ...
Werneck Miriam B F - - 2012
Chronic inflammation is a risk factor for the development of colon cancer, providing genotoxic insults, growth and pro-angiogenic factors that can promote tumorigenesis and tumor growth. Immunomodulatory agents can interfere with the inflammation that feeds cancer, but their impact on the transformed cell is poorly understood. The calcium/calcineurin signaling pathway, ...
Salphati Laurent - - 2012
PURPOSE: Glioblastoma(GBM), the most common primary brain tumor in adults, presents a high frequency of alteration in the PI3K pathway. Our objectives were to identify a dual PI3K/mTOR inhibitor optimized to cross the blood-brain barrier(BBB) and characterize its brain penetration, pathway modulation in the brain and efficacy in orthotopic xenograft ...
Kang Incheol I Department of Neurobiology, Harvard Medical School, Boston, MA, USA. - - 2012
Correlations between trial-to-trial fluctuations in the responses of individual sensory neurons and perceptual reports, commonly quantified with choice probability (CP), have been widely used as an important tool for assessing the contributions of neurons to behavior. These correlations are usually weak and often require a large number of trials for ...
Kimura Kenji - - 2012
Remodeling of the embryo surface after fertilization is mediated by the exocytosis of cortical granules derived from the Golgi complex. This process is essential for oocyte-to-embryo transition in many species. However, how the fertilization signal reaches the cortical granules for their timely exocytosis is largely unknown. In Caenorhabditis elegans, the ...
Shrestha Sadhana - - 2012
Background: Depression is emerging as a highly prevalent psychiatric condition among people living with HIV/AIDS (PLWHA). Perceived family support (PFS) buffers depression among chronic disease patients. However, a similar relationship among PLWHA is unexplored. Objective: To examine the relationship between PFS and depression among PLWHA in the Kathmandu Valley, Nepal. ...
Qian Huifeng - - 2012
We report single-atom doping of gold nanoclusters (NCs), and its drastic effects on the optical, electronic, and catalytic properties, using the 25-atom system as a model. In our synthetic approach, a mixture of Pt(1)Au(24)(SC(2)H(4)Ph)(18) and Au(25)(SC(2)H(4)Ph)(18) was produced via a size-focusing process, and then Pt(1)Au(24)(SC(2)H(4)Ph)(18) NCs were obtained by selective ...
Sun Chao - - 2012
MARK4, also known as Par-1d/MarkL1, is a member of the AMP-activated protein kinase (AMPK)-related family of kinases, which are implicated in the regulation of dynamic biological functions, including glucose and energy homeostasis. However, the physiological function of MARK4 in mammals remains elusive. Here, we investigated a role for MARK4 in ...
Schmuki Martina M - - 2012
Listeria monocytogenes is an important food-borne pathogen, and its bacteriophages find many uses in detection and biocontrol of its host. The novel broad-host-range virulent phage P70 has a unique morphology with an elongated capsid. Its genome sequence was determined by a hybrid sequencing strategy employing Sanger and PacBio techniques. The ...
Lin Jian - - 2012
Two isotypic cerium tellurite halides with the formulas [Ce(2)Te(7)O(17)]Cl(2) and [Ce(2)Te(7)O(17)]Br(2) have been synthesized hydrothermally via the reactions of CeCl(3) and CeBr(3) with TeO(2). The structures of these compounds feature a cationic inorganic framework. The Ce(IV) dimers are bound by a novel 3D Te(7)O(17)(6-) building unit, forming an unusual hexagonal-bipyramidal ...
Lidian Adnan - - 2012
Abstract Conclusion: Brain-derived neurotrophic factor (BDNF) protects the inner ear from PaExoA (exotoxin A from Pseudomonas aeruginosa)-induced sensory neural hearing loss when administered 12 h after exotoxin, but not after 72 h. Objective: BDNF is a peptide in the neurotrophin family with protective effects against noise-induced hair cell loss and ...
Hirata Taku T Dept. Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, - - 2012
Nephrolithiasis is a major public health problem with a complex and varied etiology. Most stones are composed of calcium oxalate (CaOx), with dietary excess a risk factor. Because of complexity of mammalian system, the details of stone formation remain to be understood. Here we have developed a nephrolithiasis model using ...
Riggall Adam C - - 2012
Does the sustained, elevated neural activity observed during working memory tasks reflect the short-term retention of information? Functional magnetic resonance imaging (fMRI) data of delayed recognition of visual motion in human participants were analyzed with two methods: a general linear model (GLM) and multivoxel pattern analysis. Although the GLM identified ...
Baldwin Austin S AS Department of Psychology, Southern Methodist University, Dallas, TX 75275- 0442, USA. - - 2013
We examined factors associated with information seeking about the human papillomavirus vaccine among mothers of adolescent girls by testing whether information seeking and vaccination intentions for their daughters are associated with perceived vulnerability, severity, and vaccine benefits in an ethnically diverse sample. Mothers (N = 256) of unvaccinated girls living ...
Tussiwand Roxane R Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, - - 2012
The AP1 transcription factor Batf3 is required for homeostatic development of CD8α(+) classical dendritic cells that prime CD8 T-cell responses against intracellular pathogens. Here we identify an alternative, Batf3-independent pathway in mice for CD8α(+) dendritic cell development operating during infection with intracellular pathogens and mediated by the cytokines interleukin (IL)-12 ...
Larisch Christina - - 2012
Understanding seasonality and longevity is a major challenge in tree biology. In woody species, growth phases and dormancy follow one another consecutively. In the oldest living individuals, the annual cycle may run for more than 1,000 years. So far, however, not much is known about the processes triggering reactivation from ...
Carroll Michael S MS Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, - - 2013
Rhythmically active networks are typically composed of neurons that can be classified as silent, tonic spiking, or rhythmic bursting based on their intrinsic activity patterns. Within these networks, neurons are thought to discharge in distinct phase relationships with their overall network output, and it has been hypothesized that bursting pacemaker ...
Albrecht Andreas A Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, - - 2013
To determine whether erosions appearing in MRI in patients with rheumatoid arthritis (RA) represent true erosions. 50 RA patients received 1.5 T MRI and microCT (μCT) of the dominant hand. Erosion counts were assessed in coronal T1 weighted MRI sections and in coronal as well as axial μCT sections of ...
Choi Ji Woong - - 2012
Background and Purpose: Visual internal urethrotomy (VIU) is an option for the management of urethral stricture. However, little is known regarding sexual function after surgery. Patients and Methods: Seventy six patients who underwent VIU were evaluated by using the Korean version of the Male Sexual Health Questionnaire (MSHQ). Three sexual ...
Gall Astrid - - 2012
Whole HIV-1 genome sequences are pivotal for large-scale studies of inter- and intrahost evolution, including the acquisition of drug resistance mutations. The ability to rapidly and cost-effectively generate large numbers of HIV-1 genome sequences from different populations and geographical locations and determine the effect of minority genetic variants is, however, ...
Bosch Daniel D Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, United - - 2012
Inositol phosphates are key signaling molecules affecting a large variety of cellular processes. Inositol-polyphosphate multikinase (IPMK) is a central component of the inositol phosphate biosynthetic routes, playing essential roles during development. IPMK phosphorylates inositol 1,4,5-trisphosphate to inositol tetrakisphosphate and subsequently to inositol pentakisphosphate and has also been described to function ...
Ayllon Juan J Department of Microbiology, Mount Sinai School of Medicine, New York, New York, - - 2012
Conserved tryptophan-187 facilitates homodimerization of the influenza A virus NS1 protein effector domain. We generated a mutant influenza virus strain expressing NS1-W187R to destabilize this self-interaction. NS1-W187R protein exhibited lower double-stranded RNA (dsRNA)-binding activity, showed a temporal redistribution during infection, and was minimally compromised for interferon antagonism. The mutant virus ...
Pavia Abel - - 2012
Abstract Objective: To compare the change in calculated coronary heart disease (CHD) risk using a proactive multifactorial intervention (PMI) versus usual care (UC), among Latin-American (LA) and non-LA patients enrolled in the CRUCIAL trial. Research design and methods: This is a sub-analysis of the Cluster Randomized Usual Care versus Caduet ...
Sharott Andrew A Medical Research Council Anatomical Neuropharmacology Unit and Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom. - - 2012
The striatum is comprised of medium-sized spiny projection neurons (MSNs) and several types of interneuron, and receives massive glutamatergic input from the cerebral cortex. Understanding of striatal function requires definition of the electrophysiological properties of neurochemically identified interneurons sampled in the same context of ongoing cortical activity in vivo. To ...
Johnson Russell A RA Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, - - 2012
Immunity against Vibrio cholerae O1 is serogroup specific, and serogrouping is defined by the O-specific polysaccharide (OSP) part of lipopolysaccharide (LPS). Despite this, human immune responses to V. cholerae OSP have not previously been characterized. We assessed immune responses against V. cholerae OSP in adults with cholera caused by V. ...
Wang Huajian - - 2012
The mechanism that triggers amyloid-β (Aβ) fibrillation and aggregation is still elusive. Evidence suggests that the extensional interactions of the amyloid precursor protein (APP) and Aβ with transition biometals, copper (Cu) and zinc (Zn), may be key occurrences in the processes of Aβ aggregation and toxicity. By using an immunogold ...
Parsaik Ajay - - 2012
To study the frequency and degree of deconditioning, clinical features, and relationship between deconditioning and autonomic parameters in patients with orthostatic intolerance. We retrospectively studied all patients seen for orthostatic intolerance at Mayo Clinic between January 2006 and June 2011, who underwent both standardized autonomic and exercise testing. A total ...
Türk Mustafa - - 2012
Bovine chondrocytes were seeded into scaffolds of a high molecular weight chitosan and alginate with a pore size of 50-350 μm with or without catechin. In polymerase chain reaction (PCR), unlike type II, collagen type I was no longer expressed at day 14. The DNA content increased until day 8 ...
Zhang Xu-Xiang - - 2012
This study aimed to explore the molecular mechanisms behind the stimulation effects of microcystin-LR (a well-known cyanobacterial toxin produced in eutrophic lakes or reservoirs) on cancer cell invasion and matrix metalloproteinases (MMPs) expression. Boyden chamber assay showed that microcystin-LR exposure (> 12.5 nM) evidently enhanced the invasion ability of the ...
El-Shamy Ahmed - - 2012
Hepatitis C virus genotype 4 (HCV-4) is the cause of approximately 20% of the 180 million cases of chronic hepatitis C in the world. HCV-4 infection is common in the Middle East and Africa, with an extraordinarily high prevalence in Egypt. Viral genetic polymorphisms, especially within core and NS5A regions, ...
Camilleri G - - 2012
Various studies suggest that increased levels of pro-inflammatory cytokines play a key role in the declining ovarian function and the resulting complications associated with menopause. In this review article, the authors outline the role of pro- and anti-inflammatory cytokines in cardiovascular disease during menopause.
Veldhuis Johannes D JD Endocrine Research Unit, Dept. of Internal Medicine, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, MN 55905, USA. - - 2012
Gonadotrophin-releasing hormone (GnRH) pulsatility is required for optimal luteinizing hormone (LH) secretion, but whether LH pulsatility is required for physiological testosterone (T) secretion is not known. To test the postulate that pulses of recombinant human (rh) LH stimulate greater T secretion than continuous infusion of the same dose, a potent ...
Reichert Adelina - - 2012
The reaction of [Cp(2)ZrCl(2)] with the lithium salt Li[FcBH(3)] in stoichiometric ratios of 1.5 : 1 or 0.4 : 1 furnishes the mixed-metallocene complexes [Cp(2)(Cl)Zr(H(3)BFc)] () and [Cp(2)Zr(H(3)BFc)(2)] (), respectively (Cp = cyclopentadienyl; Fc = ferrocenyl). When the two reagents are combined in a ratio of 0.6 : 1, complex is formed together with the zirconium ...
Gillery Philippe - - 2012
Abstract HbA1cwas discovered in the late 1960s and its use as marker of glycemic control has gradually increased over the course of the last four decades. Recognized as the gold standard of diabetic survey, this parameter was successfully implemented in clinical practice in the 1970s and 1980s and internationally standardized ...
Trotochaud Lena - - 2012
Water oxidation is a critical step in water splitting to make hydrogen fuel. We report the solution synthesis, structural/compositional characterization, and oxygen evolution reaction (OER) electrocatalytic properties of ~2 - 3 nm-thick films of NiOx, CoOx, NiyCo1-yOx, Ni0.9Fe0.1Ox, IrOx, MnOx, and FeOx. The thin-film geometry enables the use of quartz-crystal ...
Zant Janneke C - - 2012
The basal forebrain (BF) is a key structure in regulating both cortical activity and sleep homeostasis. It receives input from all ascending arousal systems and is particularly highly innervated by histaminergic neurons. Previous studies clearly point to a role for histamine as a wake-promoting substance in the BF. We used ...
Hoshikawa Hiroshi H Departments of Otolaryngology, Faculty of Medicine, Kagawa University, Kagawa, Japan. - - 2012
Despite low uptake of tracer, 3'-deoxy-3'-(18)F-fluorothymidine (FLT) PET could detect cervical lymph node metastases as well as 2-deoxy-2-(18)F-fluoro-d-glucose (FDG) PET. The diagnostic efficacy of FLT PET was compared with that of FDG PET regarding nodal staging of head and neck squamous cell cancers. Twenty-three patients were examined with FLT PET ...
Andersen Kell K - - 2012
The outer membrane protein OmpA from E. coli can fold into lipid vesicles and surfactant micelles from the urea-denatured state. However, a complete kinetic description of the folding and unfolding of OmpA, which can provide the basis for subsequent protein-engineering studies of the protein's folding pathway, is lacking. Here we ...
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