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Piehler D - - 2012
Interleukin (IL)-33 enhances T helper (Th)2 immunity via its receptor T1/ST2. Infection with the yeast-like pathogen Cryptococcus neoformans is usually controlled by a Th1-mediated immune response. The mechanisms responsible for nonprotective Th2 immunity leading to allergic inflammation in pulmonary cryptococcosis are still not fully understood. Using a murine pulmonary model ...
Positano Vincenzo V Fondazione CNR Regione Toscana G. Monasterio, Via Moruzzi, 1, 56124 Pisa, Italy. - - 2013
The objective of this study was to develop an automatic image registration technique capable of compensating for kidney motion in renal perfusion MRI, to assess the effect of renal artery stenosis on the kidney parenchyma. Images from 20 patients scheduled for a renal perfusion study were acquired using a 1.5 T ...
Lee Yin-Ying - - 2012
Mesoporous silica nanoparticles functionalized with both sulfonic acid (HSO(3)) and ionic liquid (ILs) were synthesized and applied as effective and recyclable catalysts for generating 5-hydroxymethylfurfural (HMF) from fructose. For the first time a high HMF yield of 72.5% was achieved in DMSO systems under mild conditions (90 °C and 3 ...
Kim Taeyong - - 2012
A strategy to fabricate nanostructured poly(3-hexylthiophene) (P3HT) films for organic photovoltaic (OPV) cells by a direct transfer method from a reusable soft replica mold is presented. The flexible polyfluoropolyether (PFPE) replica mold allows low-pressure and low- temperature process condition for the successful transfer of nanostructured P3HT films onto PEDOT/PSS-coated ITO ...
Bain C C - - 2012
Macrophages (mφ) are essential for intestinal homeostasis and the pathology of inflammatory bowel disease (IBD), but it is unclear whether discrete mφ populations carry out these distinct functions or if resident mφ change during inflammation. We show here that most resident mφ in resting mouse colon express very high levels ...
Pedriali Alessandra - - 2012
Drugs of abuse and their human metabolites have been recently recognized as emerging environmental contaminants. Notwithstanding the fact that these kinds of compounds share some features with pharmaceuticals, their ecotoxicology has not yet been extensively investigated, although some of their characteristics may potentially threaten aquatic ecosystems. One of the most ...
Okamura Masaya - - 2012
Two new ruthenium(ii) complexes bearing dissociable protons, [Ru(trpy)(H(2)bim)Cl]PF(6) () and [Ru(trpy)(H(2)bim)(OH(2))](PF(6))(2) () (H(2)bim = 2,2'-biimidazole and trpy = 2,2':6',2''-terpyridine), were synthesized and characterized, where the H(2)bim and M-OH(2) moieties are expected to serve as proton-dissociation sites. Single crystal X-ray diffraction analyses revealed that the H(2)bim and M-OH(2) moieties act as ...
Al-Khaled Mohamed - - 2012
INTRODUCTION: According to the most recent definition of transient ischemic attack (TIA) and the recommendations of the American Heart Association, magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) is considered a mandatory tool in evaluating and treating patients with TIA. This study aims to determine the incidence of TIA-related acute ...
Jensen-Johansen M B - - 2012
OBJECTIVE: To examine the effects of an expressive writing intervention (EWI) on cancer-related distress, depressive symptoms, and mood in women treated for early stage breast cancer. METHODS: A nationwide sample of 507 Danish women who had recently completed treatment for primary breast cancer were randomly assigned to three 20-min home-based ...
Sun Qi - - 2012
We report here a successful preparation of a heterogeneous chiral catalyst from copolymerization of mesoporous cross-linked polymer with chiral BINAP ligands, followed by coordination of the BINAP with a ruthenium species, which exhibits high activity, excellent enantioselectivity, and extraordinary recyclability in asymmetric hydrogenation.
Gonçalves Jamile F - - 2012
The present study aimed to investigate the influence of N-acetylcysteine (NAC) on cadmium (Cd) poisoning by evaluating Cd concentration in tissues, hematological indices as well as the activity of NTPDase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes of rats exposed to Cd and co-treated with NAC. For this purpose, the rats ...
Yang Jing - - 2012
The crested ibis, one of the most endangered birds in the world, could benefit from research into its genetic diversity as a tool for conservation in the future. Tyrosinase is thought to play a major role in the production of common yellow to black melanins in birds. We have cloned ...
Shirakata Yukari - - 2012
Our aim was to study the efficacy of combined triple therapy with intravitreal bevacizumab injections (IVB), posterior sub-Tenon injection of triamcinolone acetonide (STTA), and reduced laser fluence photodynamic therapy (RFPDT) in Japanese patients with retinal angiomatous proliferation (RAP). This was a retrospective, observational, consecutive case series. Fifteen consecutive RAP treatment-naïve ...
Jones M L - - 2012
Background/Objectives:The percentage of hypercholesterolemic individuals not reaching their LDL-cholesterol (LDL-C) goal remains high and additional therapeutic strategies should be evaluated. The objective of this study was to evaluate the cholesterol-lowering efficacy and mechanism of action of bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 capsules in hypercholesterolemic adults.Subjects/Methods:A total of 127 ...
Booman Gisel Carolina - - 2012
Wetland loss is a frequent concern for the environmental management of rural landscapes, but poor disentanglement between climatic and land management causes frequently constrains both proper diagnoses and planning. The aim of this study is to address areal changes induced by non-climatic factors on lentic water bodies (LWB) within an ...
Stenzel Werner - - 2012
Immune-mediated necrotizing myopathies (IMNMs) are now well recognized among the so-called idiopathic inflammatory myopathies (IIMs), which also comprise dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (sIBM) and non-specific myositis. All of these conditions are defined on the basis of distinct clinical symptoms, in combination with results derived from muscle ...
Wang Zheng Z Department of Kinesiology, The Pennsylvania State University, 23 Rec Building, University Park, PA 16802, USA. - - 2012
The study of quiet standing has mainly been conducted in the foot side-by-side position with the assumption that the contribution of the lower limbs is structurally and functionally equivalent. The purpose of this study was to examine how the two mechanical factors of foot position and weight distribution interact to ...
Iasevoli Felice - - 2012
Synaptic plasticity represents the long lasting activity-related strengthening or weakening of synaptic transmission, whose well-characterized types are the long term potentiation and depression. Despite this classical definition, however, the molecular mechanisms by which synaptic plasticity may occur appear to be extremely complex and various. The post-synaptic density (PSD) of glutamatergic ...
Zuo Hui - - 2012
The aim of the present study was to examine the association between dietary patterns and insulin resistance in Chinese adults without known diabetes. Study subjects were 1070 Chinese adults aged 18 years and above in Jiangsu Province who participated in the 2006 wave of the China Health and Nutrition Survey. ...
Hou Yali - - 2012
Genomic structural variation is an important and abundant source of genetic and phenotypic variation. In this study, we performed an initial analysis of copy number variations (CNVs) using BovineHD SNP genotyping data from 147 Holstein cows identified as having high or low feed efficiency as estimated by residual feed intake ...
Seckert Christof K - - 2012
Low public awareness of cytomegalovirus (CMV) results from the only mild and transient symptoms that it causes in the healthy immunocompetent host, so that primary infection usually goes unnoticed. The virus is not cleared, however, but stays for the lifetime of the host in a non-infectious, replicatively dormant state known ...
Naughton Corina - - 2012
AIM: To evaluate the clinical appropriateness and safety of nurse and midwife prescribing practice. BACKGROUND: The number of countries introducing nurse and midwife prescribing is increasing; however, concerns over patient safety remain. DESIGN: A multi-site documentation evaluation was conducted using purposeful and random sampling. The sample included 142 patients' records ...
Makino N - - 2012
Objective: This study aimed to investigate the function of tissue plasminogen activator in the olfactory epithelium of mice following neural injury. Method: Transmission electron microscopy was used to study the changes in the morphology of the olfactory epithelium 1-7 days after surgical ablation of the olfactory bulb (bulbectomy). Results: Prior ...
Sun Xing-Yu - - 2012
In vivo, some proteins exist as monomers and others as oligomers. Oligomers can be further classified into homo-oligomers (formed by identical subunits) and hetero-oligomers (formed by different subunits), and they form the structural components of various biological functions, including cooperative effects, allosteric mechanism and ion-channel gating. Therefore, with the avalanche ...
Su Xin - - 2012
A "V"-shaped Hammett plot shows that resonance-assisted hydrogen bonding does not dictate the strength of the intramolecular hydrogen bond in the E isomers of hydrazone-based switches because it involves an aromatic pyridyl ring.
Li Xian-Hui - - 2012
AIM: To evaluate the protective effects of allicin on Ang II-induced cardiac hypertrophy. METHODS: Sprague-Dawley male rats were randomized into 3 groups:1)sham group (saline)(n = 12), 2) Ang II group(n = 9), 3) allicin group (Ang II + allicin)(n = 9). They received infusions of either saline or Ang II (250 ng/kg body weight per min) through ...
Malho Pedro - - 2012
A 4-year-old, female, spayed, Labrador retriever was presented with a painless swelling of the left ventromedial eyelid and epiphora of 3 months duration. Bilateral patency of the nasolacrimal system was confirmed by the appearance of fluorescein dye at both nares. Ultrasonography revealed a well-demarcated fluid-filled structure containing echogenic ill-defined material in ...
Adamyan Vadym - - 2012
The thermal conductivity of doped graphene flake of finite size is investigated with emphasis on the influence of the mass of the substituting atoms on this property. It is shown that graphene doping by small concentrations of relatively heavy atoms results in a disproportionately large drop in lattice thermal conductivity.
Davis Catherine L CL Georgia Prevention Center, Institute for Public and Preventive Health, Department of Pediatrics, Medical College of Georgia, 1120 15th St, Ste 1640, Augusta, GA 30912, USA. - - 2012
Pediatric studies have shown that aerobic exercise reduces metabolic risk, but dose-response information is not available. To test the effect of different doses of aerobic training on insulin resistance, fatness, visceral fat, and fitness in overweight, sedentary children and to test moderation by sex and race. Randomized controlled efficacy trial ...
Prieto Minolfa C MC Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, - - 2013
Sustained stimulation of the intrarenal/intratubular renin-angiotensin system in a setting of elevated arterial pressure elicits renal vasoconstriction, increased sodium reabsorption, proliferation, fibrosis, and eventual renal injury. Activation of luminal AT(1) receptors in proximal and distal nephron segments by local Ang II formation stimulates various transport systems. Augmented angiotensinogen (AGT) production ...
Hoch Matthias - - 2012
PURPOSE: Pre-clinical experiments have shown that almorexant, a dual orexin receptor antagonist, is able to inhibit cytochrome P450 3A4 (CYP3A4). Therefore, a study was conducted to investigate the effects of multiple-dose almorexant on the pharmacokinetics of midazolam and simvastatin, two CYP3A4 model substrates. METHODS: Fourteen healthy male subjects were enrolled ...
Singendonk Maartje - - 2012
Although complementary and alternative medicine (CAM) is widely used in the pediatric population, research on the use of these therapies in the pediatric oncology population is of mixed quality. In this multicenter survey, we investigated the prevalence of CAM use, possible determinants of use, and parental attitude towards communication and ...
Hilder Matthias - - 2012
We describe for the first time the electrochemical co-deposition of composites based on a reactive base metal and graphene directly from a one-pot aqueous mixture containing graphene oxide and Zn(2+). In order to overcome stability issues the Zn(2+) concentration was kept below a critical threshold concentration, ensuring stable graphene oxide ...
Rawat R - - 2012
The transition and hysteresis widths of a disorder broadened first order magnetic transition vary in H-T space which influences the co-existing phase fraction at low temperature arising due to kinetic arrest of the first order transition. We explored the role of change in the relative width of the supercooling/superheating band ...
Kumar Krishan - - 2012
We have studied symmetric electron-electron and electron-hole bilayers to explore the stable homogeneous spin phase and the feasibility of inhomogeneous charge-/spin-density ground states. The former is resolved by comparing the ground-state energies in states of different spin polarizations, while the latter is resolved by searching for a divergence in the ...
Nualart Francisco - - 2012
Isoform 1 of the sodium-vitamin C co-transporter (SVCT1) is expressed in the apical membrane of proximal tubule epithelial cells in adult human and mouse kidneys. This study is aimed at analyzing the expression and function of SVCTs during kidney development. RT-PCR and immunohistochemical analyses revealed that SVCT1 expression is increased ...
Lekander Ingrid - - 2012
OBJECTIVE: The objective was to estimate the cost-effectiveness of TNF-inhibitors for the treatment of rheumatoid arthritis in Swedish clinical practice, both as a first and second biological treatment, with or without the combination of conventional DMARDs. Further sub-group analysis of etanercept treatment was performed. METHODS AND MATERIALS: Patient level data ...
Zhou Jing - - 2012
High-content cellomic analysis is a powerful tool for rapid screening of cellular responses to extracellular cues and examination of intracellular signal transduction pathways at the single-cell level. In conjunction with microfluidics technology that provides unique advantages in sample processing and precise control of fluid delivery, it holds great potential to ...
Baptista A P - - 2012
Intestinal lymphoid tissues have to simultaneously ensure protection against pathogens and tolerance toward commensals. Despite such vital functions, their development in the colon is poorly understood. Here, we show that the two distinct lymphoid tissues of the colon-colonic patches and colonic solitary intestinal lymphoid tissues (SILTs)-can easily be distinguished based ...
Shirazi Reza - - 2012
The evidence of germ cell derivation from embryonic and somatic stem cells provides an in vitro model for the study of germ cell development, the associated epigenetic modification and mammalian gametogenesis. More importantly, in vitro derived gametes also represent a potential strategy for treating infertility. In mammals, male and female ...
Morris Douglas R - - 2012
Criminal defendants adjudicated incompetent to stand trial are typically hospitalized for competence restoration in state institutions. Prolonged restoration hospitalizations involve civil rights concerns and increasing financial costs, and there remains interest in determining which individuals are likely to be successfully restored. We retrospectively reviewed hospital records of 455 male defendants ...
Bastos Kleyton - - 2012
BACKGROUND: C.E.R.A. is a continuous erythropoietin receptor activator with characteristics that permit a once-monthly schedule of administration for the maintenance treatment for chronic kidney disease (CKD) patients. The main objective of this study was to assess the maintenance of Hb concentration with once-monthly intravenous and/or subcutaneous C.E.R.A. therapy in Latin ...
Ahmed Mona A - - 2012
Although the cardiovascular system is not a classical target for 1,25-dihydroxyvitamin D(3), both cardiac myocytes and vascular smooth muscle cells respond to this hormone. The present study aimed to elucidate the effect of active vitamin D(3) on cardiovascular functions in rats exposed to glucocorticoid excess. Adult male Wistar rats were ...
Fragaki Konstantina K Department of Medical Genetics, National Center for Mitochondrial diseases, Nice Teaching Hospital, Nice, - - 2013
We report two children, born from consanguineous parents, who presented with early-onset refractory epilepsy associated with psychomotor delay, failure to thrive, blindness and deafness. Polarographic and spectrophotometric analyses in fibroblasts and liver revealed a respiratory chain (RC) dysfunction. Surprisingly, we identified a homozygous nonsense mutation in the GM3 synthase gene ...
Adams Ted D TD Department of Internal Medicine, University of Utah School of Medicine, 420 Chipeta Way, Room 1160, Salt Lake City, UT 84108, USA. - - 2012
Extreme obesity is associated with health and cardiovascular disease risks. Although gastric bypass surgery induces rapid weight loss and ameliorates many of these risks in the short term, long-term outcomes are uncertain. To examine the association of Roux-en-Y gastric bypass (RYGB) surgery with weight loss, diabetes mellitus, and other health ...
Chen Peng-Jen - - 2012
Endoscopic submucosal dissection (ESD) is a technically difficult, hazardous, and time-consuming treatment option for superficial neoplasms of the esophagus. The aim of this pilot study was to determine the effectiveness and safety of percutaneous transgastric traction (PTT)-assisted ESD, a method that overcomes the drawbacks of conventional ESD, in a porcine ...
Matsumoto Morio M Department of Orthopaedic Surgery, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo 160-8582, Japan. - - 2013
To investigate the frequency of tandem lumbar and cervical intervertebral disc degeneration in asymptomatic subjects. We evaluated magnetic resonance imaging (MRI) results from 94 volunteers (48 men and 46 women; mean age 48 years) for age-related intervertebral disc degeneration in the lumbar and cervical spine. MRI indicated degenerative changes in ...
Miyamoto Ai - - 2012
Accumulating evidence suggests that cognitive declines in old (healthy) animals could arise from depression of intracortical inhibition, for which a decreased ability to produce GABA during senescence might be responsible. By simulating a neural network model of a primary visual cortical (V1) area, we investigated whether and how a lack ...
Fernández-Sanjuan María - - 2012
Perfluorinated chemicals (PFCs) have been used for many years in numerous industrial products and are known to accumulate in organisms. A recent survey showed that tissue levels of PFCs in aquatic organisms varied among compounds and species being undetected in freshwater zebra mussels Dreissena polymorpha. Here we studied the bioaccumulation ...
Oliveira Halley Caixeta - - 2012
Plants submitted to O(2) deficiency present a series of biochemical modifications, affecting overall root metabolism. Here, the effect of hypoxia on the metabolic fate of (15)N derived from (15)NO(3) (-), (15)NO(2) (-) and (15)NH(4) (+) in isolated soybean root segments was followed by gas chromatography-mass spectrometry, to provide a detailed ...
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