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Results 301 - 350 of 2543
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McGuinn L - - 2012
The degree to which weather influences the occurrence of serious cardiac arrhythmias is not fully understood. To investigate, we studied the timing of activation of implanted cardiac defibrillators (ICDs) in relation to daily outdoor temperatures using a fixed stratum case-crossover approach. All patients attending ICD clinics in London between 1995 ...
Dabelea D D Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, 13001 East 17th Ave, Aurora, CO 80045, USA. - - 2012
Few studies have explored the epidemiology of beta cell loss in youth with diabetes. This report describes the evolution and major determinants of beta cell function, assessed by fasting C-peptide (FCP), in the SEARCH for Diabetes in Youth study. Participants were 1,277 youth with diabetes (948 positive for diabetes autoantibodies ...
Ricotti Leonardo - - 2012
A lifelong-implanted and completely automated artificial or bioartificial pancreas (BAP) is the holy grail for type 1 diabetes treatment, and could be a definitive solution even for other severe pathologies, such as pancreatitis and pancreas cancer. Technology has made several important steps forward in the last years, providing new hope ...
Lanceta Lilibeth - - 2012
Induction or ectopic overexpression of heme oxygenase 1 (HO-1) protects against a wide variety of disorders. These protective effects have been variably ascribed to generation of carbon monoxide (released during cleavage of the alpha methene bridge of heme) and/or to production of the antioxidant, bilirubin. We have investigated HO-1 overexpressing ...
Park So Hee - - 2012
Three dimensional tissue engineered scaffolds for the treatment of critical defect have been usually fabricated by salt leaching or gas forming technique. However, it is not easy for cells to penetrate the scaffolds due to the poor interconnectivity of pores. To overcome these current limitations we utilized a rapid prototyping ...
Simpson Candice - - 2012
Mycobacterium ulcerans causes significant morbidity in various endemic locations in Australia and West Africa. The commonest presentation is as a necrotic ulcer often with surrounding subcutaneous necrosis and oedema, which can cause significant morbidity, deformity and functional impairment. Traditional treatment was wide excision and debridement with grafting or flap reconstructions ...
Propastin Pavel - - 2012
Satellite and ground-based data were combined in a monitoring system to quantify the link between climate conditions and the risk of locust infestations in the southern part of Lake Balkhash's drainage basin in the Republic of Kazakhstan. In this monitoring system, the Normalized Difference Vegetation Index (NDVI), derived from the ...
Garberi Juan - - 2012
Early and rapid detection of the causative organism is necessary in tuberculosis. We present here an integrated and dedicated molecular biology system for tuberculosis diagnosis. One hundred and eighty-nine (189) biologic specimens from patients strongly suspected by clinical parameters of tuberculosis were studied by Ziehl-Neelsen staining, cultivation on a solid ...
Schlattl H - - 2012
A common dose-saving technique used in modern CT devices is automatic tube current modulation (TCM), which was originally designed to also reduce the dose in paediatric CT patients. In order to be able to deduce detailed organ doses of paediatric models, dose conversion coefficients normalized to CTDI(vol) for an eight-week-old ...
Osler Callum J CJ School of Sport and Exercise Sciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, - - 2012
The same pattern of vestibular afferent feedback may signify a loss of balance or a change in body orientation, depending upon the initial head posture. To resolve this ambiguity and generate an appropriate motor response, the CNS must transform vestibular information from a head-centred reference frame into relevant motor coordinates. ...
Marchei Emilia - - 2012
Atomoxetine (ATX) is a selective norepinephrine reuptake inhibitor approved since 2002 for the treatment of attention deficit hyperactivity disorder (ADHD) in children, adolescents, and adults as an alternative treatment to methylphenidate. Within the framework of a project evaluating the use of alternative biological matrices for therapeutic monitoring of psychoactive drugs ...
Pack Seung-Chul - - 2012
PURPOSE: The purpose of present study was to investigate the methylation status of the promoter region in five genes (mothers against decapentaplegic homolog 4, fragile histidine triad protein, death-associated protein kinase 1, adenomatous polyposis coli (APC), and E-cadherin), which are known to be involved in the pathogenesis of colorectal cancer ...
Strachan N J C NJ University of Aberdeen, School of Biological Sciences, Cruickshank Building, Aberdeen, UK. - - 2013
Human campylobacteriosis exhibits a distinctive seasonality in temperate regions. This paper aims to identify the origins of this seasonality. Clinical isolates [typed by multi-locus sequence typing (MLST)] and epidemiological data were collected from Scotland. Young rural children were found to have an increased burden of disease in the late spring ...
Tatewaki Naoto - - 2012
Antioxidant biofactor (AOB) is one of the fermented grain food supplements commercially available in Japan and other countries. Herein, we investigated the effect of AOB on the UVC (254 nm) induced DNA damage in A549 cells. Both distilled water and MeOH extracts of AOB did not show any significant cell ...
Paschal R D - - 2012
Hypoprothrombinemia associated with a lupus anticoagulant (LA) was first reported in the literature over 50 years ago. The hypoprothrombinemia-lupus anticoagulant syndrome (HLAS) is a rare bleeding diathesis that has been associated with LAs in adult and paediatric patients with systemic lupus erythematosus (SLE) and with transient LAs due to other causes. ...
Harris P - - 2012
Polyinosinic:polycytidylic acid (poly I:C) is a synthetic analogue of double-stranded (ds)RNA, a molecular pattern associated with viral infections, that is used to exacerbate inflammation in lung injury models. Despite its frequent use, there are no detailed studies of the responses elicited by a single topical administration of poly I:C to ...
Rivas-San Vicente Mariana - - 2012
Sphingolipids play an important role in signal transduction pathways that regulate physiological functions and stress responses in eukaryotes. In plants, recent evidence suggests that their metabolic precursors, the long-chain bases (LCBs) act as bioactive molecules in the immune response. Interestingly, the virulence of two unrelated necrotrophic fungi, Fusarium verticillioides and ...
Miners A H - - 2012
A number of studies examining the cost effectiveness of haemophilia prophylaxis have been published, but they report a wide range of results. The aim of this study was to explain why the results from existing economic evaluations of prophylaxis with clotting factor vary so much and to suggest areas of ...
Zhang Yanqiong Y Department of Biology, East Carolina University, N108 Howell Science Complex, Greenville, NC 27858, - - 2013
The economic, environmental, and human health impacts of the deepwater horizon (DWH) oil spill have been of significant concern in the general public and among scientists. This study employs parallel experiments to test the effects of crude oil from the DWH oil well, chemical dispersant Corexit 9500A, and dispersant-oil mixture ...
Borguet Yannick - - 2012
The deprotonation of 1,3-dimesitylbenzimidazolium tetrafluoroborate with a strong base afforded 1,3-dimesitylbenzimidazol-2-ylidene (BMes), which was further reacted in situ with rhodium or ruthenium complexes to afford three new organometallic products. The compounds [RhCl(COD)(BMes)] (COD is 1,5-cyclooctadiene) and cis-[RhCl(CO)(2)(BMes)] were used to probe the steric and electronic parameters of BMes. Comparison of ...
Al-Owain Mohammed - - 2012
Our study describes a novel phenotype in a series of nine Saudi patients with lactic acidosis, from four consanguineous families three of which are related. Detailed genetic studies including linkage, homozygosity mapping and targeted sequencing identified a causative mutation in the BCS1L gene. All affected members of the families have ...
Fan Ting - - 2012
In this Feature article, we have reviewed theoretical studies of transition-metal mediated and catalysed reactions involving carbon dioxide. We have discussed fundamental steps related to organometallic reactions of carbon dioxide and presented and analyzed reported theoretical studies of transition-metal mediated and catalysed reactions of carbon dioxide.
Nadda Neeti - - 2012
This study explored the role of pro- and anti-inflammatory cytokines in dimethyl benz(a)anthracene (DMBA)-induced lung cancer and its subsequent correction with a COX-2 inhibitory NSAID, etoricoxib. A single dose of DMBA (20 mg/kg body weight) in 0.9 % NaCl administered intratracheally was used to induce tumors in the rat lungs in 20 weeks. ...
Rama Luís - - 2012
Immune changes and increased susceptibility to infection are often reported in elite athletes. Infectious episodes can often impair training and performance with consequences for health and sporting success. This study monitored the occurrence of episodes of upper respiratory symptoms (URS) and the variation in circulating NK cells, CD56(bright) and CD56(dim) ...
Euchner Holger - - 2012
Periodic approximants to quasicrystals offer a unique opportunity to better understand the structure, physical properties and stabilizing mechanisms of their quasicrystal counterparts. We present a detailed study of the order-disorder phase transition occurring at about 160 K in the Zn(6)Sc cubic approximant to the icosahedral quasicrystal i-MgZnSc. This transition goes along ...
Sy-Cordero Arlene A - - 2012
Enniatins are cyclohexadepsipeptides isolated largely from Fusarium species of fungi, although they have been isolated from other genera, such as Verticillium and Halosarpheia. They were first described over 60 years ago, and their range of biological activities, including antiinsectan, antifungal, antibiotic and cytotoxic, drives contemporary interest. To date, 29 enniatins ...
Guo Rui - - 2012
We demonstrate the use of a new vibrational transition density cube (VTDC) method for determining the geometry of complexes in a molecular liquid mixture from electron-vibration-vibration two-dimensional infrared (EVV 2DIR) spectra. The VTDC method was used to calculate the electrically-mediated intermolecular vibrational coupling and thereby the EVV 2DIR spectra. Using ...
Kim Kyoung Ju - - 2012
The formation of carbon nanotubes (CNTs) through precipitated carbons emerging from supersaturated metal catalysts is an established mechanism for their growth during the CVD process. Here, the CNT growth mode is determined by the interaction between the substrate and the catalyst nanoparticle, e.g., the tip-growth mode for the weak adhesion ...
Coyle Jason P - - 2012
A copper(i) iminopyrrolidinate was synthesized and evaluated by thermal gravimetric analysis (TGA), solution based (1)H NMR studies and surface chemistry to determine its thermal stability and decomposition mechanism. Copper(i) tert-butyl-imino-2,2-dimethylpyrrolidinate () demonstrated superior thermal stability and showed negligible decomposition in TGA experiments up to 300 °C as well as no ...
Dixon John B JB Obesity Research Unit, Department of General Practice, Monash University, Melbourne, Victoria, Australia. - - 2012
Obstructive sleep apnea (OSA) is strongly related to obesity. Weight loss is recommended as part of the overall management plan for obese patients diagnosed with OSA. To determine whether surgically induced weight loss is more effective than conventional weight loss therapy in the management of OSA. A randomized controlled trial ...
Doihara Chiho - - 2012
Suicide attempt is a risk factor for suicide. To investigate trait impulsivity among suicide attempters, 93 attempters admitted to an emergency department and 113 healthy controls were evaluated using the Japanese version of the Barratt Impulsiveness Scale (BIS-11J). Impulsivity was analyzed in relation to clinical data in the attempters. Total ...
Suzuki Toshiro - - 2012
Mixed epithelial and stromal tumor of the kidney is a rare benign tumor that consists of both epithelial and stromal cells. To date, eight malignant cases have previously been reported in female patients only. We report the first case of malignant mixed epithelial and stromal tumor of the kidney in ...
Hajian-Tilaki Karimollah - - 2012
OBJECTIVE: The objective of this study is to determine the role of different health belief model components in practice of breast cancer screening among Iranian women. SUBJECTS AND METHODS: A cross-sectional study of 500 women aged 18-65 years was conducted in an urban population under the coverage of a health therapeutic ...
Sartorelli D S - - 2012
BACKGROUND/OBJECTIVES:To assess the performance of a food frequency questionnaire (FFQ) for estimating ω-3, ω-6 and trans fatty acid intake during pregnancy. Moreover, we determined whether the fatty acid composition of mature breast milk represents a valuable biomarker for fatty acid intake during pregnancy.SUBJECTS/METHODS:A prospective study in 41 pregnant women, aged ...
Paul Somnath - - 2012
In the state of West Bengal in India, over 26 million individuals are exposed to arsenic via drinking water. Dermatological, non-dermatological disorders and cancers are associated with arsenic toxicity. Of late, there has been a decrease in the arsenic concentration in drinking water owing to governmental efforts, raising the possibility ...
Kurashige Takashi - - 2012
Alpha-synuclein (αS) is one of the major constituents of Lewy bodies (LBs). Several lines of evidence suggest that the autophagy-lysosome pathway (ALP) is involved in the removal of αS. We have previously reported that granulovacuolar degeneration (GVD) in neurons involved a subunit of the endosomal sorting complexes required for transport ...
Swift Luther M LM Department of Pharmacology and Physiology, The George Washington University Medical Center, 2300 Eye Street, Washington, DC 20037, - - 2012
Blebbistatin is a recently discovered myosin II inhibitor. It is rapidly becoming a compound of choice to reduce motion artifacts during cardiac optical mapping, as well as to study cell motility and cell invasion. Although blebbistatin has a number of advantages over other electromechanical uncouplers, many of its properties have ...
Garcia Beate Hennie - - 2012
PURPOSE: Numerous studies have documented suboptimal adherence to guideline recommendations in secondary prevention of coronary heart disease (CHD(SP)). Clinical practice guidelines (CPGs) are continuously developed to define appropriate patient care, aiming to reduce risk of morbidity and death. The Medication Assessment Tool for CHD(SP) (MAT-CHD(SP)) was developed to assess adherence ...
Kruper Laura L Department of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USA. - - 2013
Reconstruction rates after mastectomy have been reported to range from 25-40%; however, most studies have focused on patients treated in an inpatient setting. We sought to determine the utilization of outpatient mastectomy and use of breast reconstruction in Southern California. Postmastectomy reconstruction rates were determined from the California Office of ...
Mahjouri Saara - - 2012
In May 2013 the APA will release DSM-5, which will restructure the diagnostic classification for autism spectrum disorders (ASDs) into a single category. The proposed changes in DSM-5 aim to better reflect the current state of research by consistently identifying the core features in social/communication and restrictive and repetitive behaviors ...
McCarthy Micheline - - 2012
Though well-known as a cause of liver disease, Hepatitis C virus infection is emerging as a cause of a variety of peripheral and central nervous system disorders. The virus causes chronic persistent infection with complex immune responses in the majority of individuals. Viral infection may have the potential to generate ...
Shirahata A - - 2012
We reported the results of a clinical pharmacological study of MC710 (a mixture of plasma-derived FVIIa and FX) in haemophilia patients with inhibitors during a non-haemorrhagic state. This report provides the results of a clot waveform analysis (CWA) and thrombin generation test (TGT) using blood samples obtained in this study. ...
Genaev Mikhail A - - 2012
Leaf pubescence (hairiness) in wheat plays an important biological role in adaptation to the environment. However, this trait has always been methodologically difficult to phenotype. An important step forward has been taken with the use of computer technologies. Computer analysis of a photomicrograph of a transverse fold line of a ...
Wu Ming-Hong - - 2012
Fourteen and 17 sediment samples were collected from three main rivers of Shanghai in July and November, respectively. Eight polybrominated diphenyl ether (PBDE) congeners (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183, and BDE-209) were detected in these samples to clarify the pollution status in the metropolis. Instrumental analyses showed that ...
Ali Ahmed Shazalia M - - 2012
A simple, accurate, precise spectrofluorimetric method has been proposed for the determination of three cephalosporins, namely, cefixime (cefi), cephalexine (ceph), and cefotaxime sodium (cefo) in pharmaceutical formulations. This method is based on a reaction between cephalosporins with 8-hydroxy-1,3,6-pyrenetrisulfonic acid trisodium salt (HPTS) in alkaline medium, at pH 12.0 for cefi ...
Li Heng - - 2012
In the standard nanosecond laser photolysis method for kinetic studies, a Q-switched laser generates transient species, and absorption spectrophotometry provides a measure of their concentrations. The sample is placed between the monitoring source (a pulsed xenon arc or a flash lamp) and a monochromator, and a photomultiplier tube (PMT) is ...
Rocha Beatriz - - 2012
Human mesenchymal stem cells (hMSCs), residing in bone marrow as well as in the synovial lining of joints, can be triggered to differentiate towards chondrocytes. Thus, hMSCs harbor great therapeutic potential for the repair of cartilage defects in osteoarthritis (OA) and other articular diseases. However, the molecular mechanisms underlying the ...
Franchak John M JM New York University, New York, NY, USA. - - 2012
Walkers need to modify their ongoing actions to meet the demands of everyday environments. Navigating through openings requires gait modifications if the size of the opening is too small relative to the body. Here we ask whether the spatial requirements for navigating horizontal and vertical openings differ, and, if so, ...
Shalev Idan - - 2012
How can adverse experiences in early life, such as maltreatment, exert such powerful negative effects on health decades later? The answer may lie in changes to DNA. New research suggests that exposure to stress can accelerate the erosion of DNA segments called telomeres. Shorter telomere length correlates with chronological age ...
Ciancetta Antonella - - 2012
We carried out a theoretical study to investigate the thermodynamics and the kinetics of the activation of the anticancer drug carboplatin in a carbonate buffer, a process which has been suggested to play an important role in the uptake, antitumor activity and toxicity of this drug. The initial stages of ...
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