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Landovitz Raphael J RJ UCLA Center for Clinical AIDS Research & Education, UCLA Center for HIV Identification, Prevention, and Treatment Services, David Geffen School of Medicine, University of California, Los Angeles, CA 90035, USA. - - 2013
Young men who have sex with men (YMSM) are at alarming risk for HIV acquisition, demonstrating the highest rates of incident infection of any age-risk group. GRINDR is a global positioning service-based social networking application popular with YMSM for sexual partnering. To assess the characteristics of YMSM who use GRINDR, ...
Makelarski Jennifer A JA Department of Obstetrics and Gynecology, The University of Chicago, Chicago, IL, USA. - - 2013
Secondary data sources are widely used to measure the built asset environment, although their validity for this purpose is not well-established. Using community-engaged research methodology, this study conducted a census of public-facing, built assets via direct observation and then tested the performance of these data against widely used secondary datasets. ...
O'Leary Ann A Prevention Research Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, NCHHSTP, 1600 Clifton Road, MSE-37, Atlanta, GA 30333, USA. - - 2013
Personal responsibility beliefs of HIV-positive individuals to protect sex partners are an important determinant of engagement in transmission risk behavior. However, the degree to which such beliefs vary across different partners is unknown. HIV-positive men who have sex with men (n = 248) completing an online survey rated their personal ...
Miltenburg André M M AM Early Stage Development, MSD (NV Organon), PO Box 20, 5340 BH, Oss, The Netherlands. - - 2013
Conjugation to antithrombin III ATIII-binding pentasaccharides has been proposed as a novel method to extend the half-life of therapeutic proteins. We aim to validate this technological concept in man by performing a first-in-human study using CarboCarrier® insulin (SCH 900948) as an example. A rising single dose phase 1 study was ...
Gajdos Csaba - - 2013
To examine the postoperative complications and death rate of major elective vascular surgery procedures in patients with end-stage renal disease (ESRD). Patients with ESRD undergoing elective major vascular surgical procedures are thought to have a high rate of postoperative complications and death. The American College of Surgeons-National Surgical Quality Improvement ...
Chawes Bo L K BL Copenhagen University Hospital, Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Gentofte, - - 2013
The fixed combination of beclomethasone (BDP) and formoterol pressurized metered dose inhaler (pMDI) (Foster®, Chiesi Farmaceutici) is being developed in the lower strength (BDP/formoterol: 50/6 μg) to provide an appropriate dosage for children with asthma. The aim of this work was to investigate the systemic bioavailability of beclomethasone-17-monoproprionate (B17MP, the active ...
Yang Tao T Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, - - 2013
G6PC2, also known as islet-specific glucose 6-phosphatase catalytic subunit-related protein (IGRP), is a major target of autoreactive CD8(+) T cells in both diabetic human subjects and the non-obese diabetic (NOD) mouse. However, in contrast to the abundant literature regarding the CD8(+) response to this antigen, much less is known about ...
Cherniawsky Avital S AS University de Montreal, Montreal, Quebec, Canada. - - 2013
Impulsivity is characterized in part by heightened sensitivity to immediate relative to future rewards. Although previous research has suggested that "high discounters" in intertemporal choice tasks tend to prefer immediate over future rewards because they devalue the latter, it remains possible that they instead overvalue immediate rewards. To investigate this ...
Kearney Staci S Integrated Department of Immunology, University of Colorado School of Medicine, Aurora, CO, - - 2013
The type I and II interferons (IFNs) play important roles in regulating immune responses during viral and bacterial infections and in the context of autoimmune and neoplastic diseases. These two IFN types bind to distinct cell surface receptors that are expressed by nearly all cells to trigger signal transduction events ...
Wang Yang Y Integrated Department of Immunology, National Jewish Health & University of Colorado School of Medicine, Denver, CO 80206, - - 2013
Metal hypersensitivity is a common immune disorder. Human immune systems mount the allergic attacks on metal ions through skin contacts, lung inhalation and metal-containing artificial body implants. The consequences can be simple annoyances to life-threatening systemic illness. Allergic hyper-reactivities to nickel (Ni) and beryllium (Be) are the best-studied human metal ...
Forsberg Jonathan Agner JA Regenerative Medicine, Naval Medical Research Center, 503 Robert Grant Ave, Silver Spring, MD 20910, USA. - - 2013
To avoid complications associated with under- or overtreatment of patients with skeletal metastases, doctors need accurate survival estimates. Unfortunately, prognostic models for patients with skeletal metastases of the extremities are lacking, and physician-based estimates are generally inaccurate. We developed three types of prognostic models and compared them using calibration plots, ...
Chen Kuen-Feng KF Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan. - - 2013
Previously, we have shown that sorafenib sensitizes hepatocellular carcinoma (HCC) to apoptosis induced by TNF-related apoptosis-inducing ligand (TNFSF10; TRAIL). Here, we report that sorafenib and SC-49 sensitize HCC cells to CS-1008, a novel anti-human death receptor 5 (TNFRSF10B) antibody. HCC cell lines (PLC5, Huh-7, and Hep3B) were treated with CS-1008 ...
Rao Nikhil N Department of Bioengineering, University of California, San Diego. 2880 Torrey Pines Scenic Drive, La Jolla, CA 92037, - - 2013
Myoblasts are precursor muscle cells that lie nascent to mature skeletal muscle. Once muscle is damaged, these cells migrate, fuse, and regenerate the muscle tissue. It is known that skeletal muscle can partially regenerate in vivo after muscle tissue damage. However, this regeneration does not always occur, especially in more ...
Berend Keith R KR Joint Implant Surgeons, Inc, 7277 Smith's Mill Road, Suite 200, New Albany, OH 43054, USA. - - 2013
Periprosthetic infection after total hip arthroplasty (THA) is a devastating complication. Reported rates of infection control range from 80% to 95% but mortality rates associated with treatment of infected THA are also substantial and we suspect underreported. For patients selected for two-stage treatment of infected THA we therefore determined (1) ...
Teshigawara Kiyoshi K Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, - - 2013
In the spinal cord injury (SCI) axon regeneration is inhibited by the glial scar, which contains reactive astrocytes that secrete inhibitory chondroitin sulphate proteoglycan (CSPG). We previously reported that a novel compound, denosomin, promotes axonal growth under degenerative conditions in cultured cortical neurons. In this study, we investigated the effects ...
Carland J E JE Discipline of Pharmacology, School of Medical Sciences, Bosch Institute, Sydney Medical School, University of Sydney, Sydney, NSW, - - 2013
Concentrations of extracellular glycine in the CNS are regulated by two Na(+)/Cl(-) -dependent glycine transporters, GlyT1 and GlyT2. Selective inhibitors of GlyT1 have been developed for the treatment of schizophrenia, whilst selective inhibitors of GlyT2 are analgesic in animal models of pain. We have assessed a series of endogenous lipids ...
Bauer C T CT Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, - - 2013
Monoamine releasers constitute a class of drugs that promote the release of dopamine (DA), serotonin (5-HT) and/or norepinephrine. Although some drugs in this class are well-known drugs of abuse (amphetamine, methamphetamine), others are thought to have reduced (3,4-methylenedioxy-N-methylamphetamine [MDMA]) or no (fenfluramine) abuse potential. The purpose of this study was ...
Valle Laticia A LA Department of Internal Medicine, The Ohio State University, Columbus, Ohio, - - 2013
The thyrotropin (TSH) level or duration of thyroid hormone withdrawal (THW) required to detect stimulated thyroglobulin (Tg) in differentiated thyroid cancer (DTC) monitoring is unknown. The objective of this study was to evaluate the TSH cutoff of >30 μU/mL as a means to detect stimulated Tg ≥2 ng/mL after THW (THW-Tg≥2), and ...
Rudolph Abby E AE Department of Medicine, University of California San Diego School of Medicine, La Jolla, 92093-0507, USA. - - 2013
The "HIV risk environment" has been characterized as a dynamic interplay between structural and network factors. However, most HIV prevention research has not examined the independent and combined impact of network and structural factors. We aimed to identify individual, network, and neighborhood correlates of exchange sex (≥1 exchange sex partner, ...
Balasubramanian Mukundh N - - 2013
Amino acid deprivation of mammalian cells triggers several signalling pathways, the AAR (amino acid response), that results in transcriptional activation. For the ASNS (asparagine synthetase) and ATF3 (activating transcription factor 3) genes, increased transcription occurs in conjunction with recruitment of ATF4 to the gene. In HepG2 cells, analysis of the ...
Leinung Matthew C MC Division of Endocrinology and Metabolism, Albany Medical College, Albany, NY 12208, USA. - - 2013
To determine the effectiveness of insulin pump use (continuous subcutaneous insulin infusion; CSII) in patients with type 2 diabetes (DM2) who have failed multiple daily injection (MDI) therapy. In this retrospective study, charts of patients with DM2 who were started on CSII after failure of MDI were reviewed. Patients were ...
Giordano Thomas P TP Health Services Research and Development Center of Excellence, Michael E. DeBakey VA Medical Center, Houston, TX, USA. - - 2013
This demonstration study tested the impact of a 5-month clinic-wide social marketing campaign at improving adherence to antiretroviral therapy (ART). The intervention included a video, posters, pens, mugs, and lapel buttons with the campaign slogan "Live the Solution: Take Your Pills Every Day." Participants self-reported adherence over a 4-week interval, ...
Tillman Tommy T Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15261, - - 2013
pLGICs (pentameric ligand-gated ion channels) are a family of structurally homologous cation and anion channels involved in neurotransmission. Cation-selective members of the pLGIC family are typically inhibited by general anaesthetics, whereas anion-selective members are potentiated. GLIC is a prokaryotic cation pLGIC and can be inhibited by clinical concentrations of general ...
Baglinière François - - 2012
Pseudomonas fluorescens grows at low temperature and produces thermo-resistant protease(s) that can destabilize UHT (Ultra High Temperature) milk during its storage. The consequences of contamination of microfiltered milk with 9 strains of P. fluorescens on the stability of the corresponding UHT milk during storage had been investigated in this study. ...
Goriounova Natalia A - - 2012
More than 70% of adolescents report to have smoked a cigarette at least once. At the adolescent stage the brain has not completed its maturation. The prefrontal cortex (PFC), the brain area responsible for executive functions and attention performance, is one of the last brain areas to mature and is ...
Kirshtein Boris - - 2012
Gastric perforations are one of the intraoperative complications of laparoscopic gastric banding (LAGB). Delayed diagnosis can increase the mortality and morbidity rates. Retrospective analysis of surgery outcome and long-term follow-up of the patients with gastric perforations during primary LAGB and revisional band procedures was performed. Twenty-four patients with gastric perforations ...
Bussinguer Michelle - - 2012
Cardiac sarcoidosis can be life threatening if not promptly diagnosed and treated appropriately and aggressively. The diagnosis of myocardial disease is often difficult and circumstantial because there are no reliable diagnostic tests. Except for the finding of noncaseating granulomas on endomyocardial biopsy, most tests are limited and nonspecific. Therefore, the ...
Mohlke Karen L KL University of North Carolina, 5096 Genetic Medicine, 120 Mason Farm Drive, Chapel Hill, NC 27599-7264, USA. - - 2012
A new generation of genetic studies of diabetes is underway. Following from initial genome-wide association (GWA) studies, more recent approaches have used genotyping arrays of more densely spaced markers, imputation of ungenotyped variants based on improved reference haplotype panels, and sequencing of protein-coding exomes and whole genomes. Experimental and statistical ...
Pandyarajan V V Department of Biochemistry, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, - - 2012
Structure-based protein design has enabled the engineering of insulin analogs with improved pharmacokinetic and pharmacodynamic properties. Exploiting classical structures of zinc insulin hexamers, the first insulin analog products focused on destabilization of subunit interfaces to obtain rapid-acting (prandial) formulations. Complementary efforts sought to stabilize the insulin hexamer or promote higher-order ...
Battaglino Ricardo A RA The Forsyth Institute, Cambridge, MA 02142, USA. - - 2012
Spinal cord injury causes rapid, severe osteoporosis with increased fracture risk. Mechanical unloading after paralysis results in increased osteocyte expression of sclerostin, suppressed bone formation, and indirect stimulation of bone resorption. At this time, there are no clinical guidelines to prevent bone loss after SCI, and fractures are common. More ...
Brush D Eric DE Department of Emergency Medicine, Division of Toxicology, UMass Medical Center, Worcester, MA, USA. - - 2012
While opioids remain a valid and effective analgesic strategy for patients suffering from a wide variety of painful conditions, they are not a panacea. Increasingly, physicians must balance patient expectations of adequate pain control with known limitations of opioid pharmaceuticals including adverse effects, tolerance, addiction, withdrawal, and drug diversion. Further ...
Ballantyne Jane C JC Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA. - - 2012
Opioid analgesics have been used increasingly over the past 20 years for the management of chronic non-cancer pain in the USA under the assumption that they were safe and effective when used as directed. The accuracy of that assumption has not been tested against accumulated evidence. The safety of opioids used ...
Farren Conor K CK Trinity College Dublin, St Patrick's University Hospital, James Street, Dublin 8, Ireland. - - 2012
Bipolar disorder and alcohol use disorder represent a significant comorbid population, which is significantly worse than either diagnosis alone in presentation, duration, co-morbidity, cost, suicide rate, and poor response to treatment. They share some common characteristics in relation to genetic background, neuroimaging findings, and some biochemical findings. They can be ...
Wan Yuan Y Department of Bioengineering, University of Texas at Arlington, Arlington, Texas, - - 2012
Early detection and isolation of circulating tumor cells (CTC) can enable better prognosis for cancer patients. A Hele-Shaw device with aptamer functionalized glass beads is designed, modeled, and fabricated to efficiently isolate cancer cells from a cellular mixture. The glass beads are functionalized with anti-epidermal growth factor receptor (EGFR) aptamer ...
Radak Zsolt Z Faculty of Physical Education and Sport Science, Institute of Sport Science, Semmelweis University, Budapest, Hungary. - - 2013
The complexity of human DNA has been affected by aerobic metabolism, including endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an important role in the evolution of Homo sapiens, and oxygen was not important just for survival, but it was crucial to redox-mediated adaptation. The metabolic challenge during ...
Hefferon Kathleen Laura - - 2012
Transgenic plants present enormous potential as a cost-effective and safe platform for large-scale production of vaccines and other therapeutic proteins. A number of different technologies are under development for the production of pharmaceutical proteins from plant tissues. One method used to express high levels of protein in plants involves the ...
Sundar Isaac K IK Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, - - 2013
Chronic obstructive pulmonary disease (COPD) is predominantly a tobacco smoke-triggered disease with features of chronic low-grade systemic inflammation and aging (inflammaging) of the lung associated with steroid resistance induced by cigarette smoke (CS)-mediated oxidative stress. Oxidative stress induces various kinase signaling pathways leading to chromatin modifications (histone acetylation/deacetylation and histone ...
Abada Teresa - - 2012
Summary To date, very few studies have examined what contributes to unwanted and mistimed births in the Philippines. In a country where women have higher educational levels than their male counterparts, and their status is among the highest in Asia, it is expected that unwanted births will be low. The ...
Rozzi Tony - - 2012
Disposable filtering facepiece respirators (FFRs) used by health care workers are not designed to reduce the inhalation of volatile organic compounds (VOCs). Smoke-generating surgical procedures release VOCs and have been associated with the following complaints: foul smell, headaches, nausea, irritated throat and lungs, and asthma. Organic vapor FFRs that contain ...
Roberge Raymond J - - 2012
Exhalation valves (EVs) are touted as useful in dissipating humidity, heat, and carbon dioxide from the dead space of N95 filtering facepiece respirators and decreasing exhalation resistance, thereby making the respirator more comfortable and less physiologically demanding. Despite decades of use, there is limited research on the psychophysiological impact of ...
Font Sarah A - - 2012
Using a national sample of 1,461 child protective services (CPS) investigations in the United States, we examine differences between black and white families with regard to caseworker ratings of risk and harm to the child, as well as the probability that a case is substantiated for maltreatment. We employ difference-in-difference ...
Mitchell Deborah M - - 2012
Vitamin D deficiency is highly prevalent in high-risk patient populations, but the prevalence among otherwise healthy adults is less well-defined. The goal of this study was to determine the prevalence and predictors of low 25-hydroxyvitamin D [25(OH)D] levels in healthy younger adults. This was a cross-sectional study of 634 healthy ...
Saxena Ashish A Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, - - 2013
We have shown earlier that inhibition of aldose reductase (AR), an oxidative stress-response protein, prevents colon cancer cell growth in vitro and in vivo. Changes in microribonucleic acid (miR) expression can contribute to cancer by modulating the functional expression of critical genes involved in cancer growth and metastasis. However, the ...
Wu Chu-Chiao CC Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, - - 2013
The intrinsic apoptosis pathway is conserved from worms to humans and plays a critical role in the normal development and homeostatic control of adult tissues. As a result, numerous diseases from cancer to neurodegeneration are associated with either too little or too much apoptosis. B cell lymphoma-2 (BCL-2) family members ...
Comini Marcelo A MA Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay. - - 2013
Glutaredoxins are ubiquitous small thiol proteins of the thioredoxin-fold superfamily. Two major groups are distinguished based on their active sites: the dithiol (2-C-Grxs) and the monothiol (1-C-Grxs) glutaredoxins with a CXXC and a CXXS active site motif, respectively. Glutaredoxins are involved in cellular redox and/or iron sulfur metabolism. Usually their ...
Rajapurkar Mohan M - - 2013
Compelling experimental evidence exists for the role of oxidants and iron in glomerular disease. In preliminary studies, we confirmed increased urinary catalytic iron in patients with glomerulonephritis and diabetic nephropathy. We conducted two separate single-center, prospective, single-armed, open-labeled, proof-of-concept studies to evaluate the safety and efficacy of an oral iron ...
Dikalov Sergey I SI Division of Clinical Pharmacology, Vanderbilt University Medical Center , Nashville, - - 2014
Mitochondrial and cellular reactive oxygen species (ROS) play important roles in both physiological and pathological processes. Different ROS, such as superoxide (O2(•-)), hydrogen peroxide, and peroxynitrite (ONOO(-)), stimulate distinct cell-signaling pathways and lead to diverse outcomes depending on their amount and subcellular localization. A variety of methods have been developed ...
Tharwat M - - 2012
This study was designed to establish the reference range for the cardiac biomarkers cardiac troponin I (cTnI) and creatine kinase myocardial band (CK-MB) in nonpregnant and pregnant goats, goats with normal birth, goats with prolonged birth associated with dystocia, and goats with pregnancy toxemia. Fifty-seven does, categorized into three groups ...
Kwak Seong-Sung - - 2012
We examined the expression patterns of porcine sirtuin 1 to 3 (Sirt1-3) genes in preimplantation embryos derived from parthenogenetic activation (PA), in vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT). We also investigated the effects of sirtuin inhibitors (5 mM nicotinamide [NAM] and 100 μM sirtinol) on embryonic development ...
Karniychuk U U - - 2012
Preventing congenital infection is important for the control of porcine reproductive and respiratory syndrome (PRRS). Recently, in our laboratory, an inactivated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine has been developed. Promising results in young pigs encouraged us to test the vaccine potency to prevent congenital infection. In the ...
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