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García-Martín Patricia - - 2012
Erythropoietic protoporphyria arises from an inherited disorder of porphyrin metabolism which leads to an accumulation of protoporphyrin IX in the erythropoietic system and other tissues. It is characterized by cutaneous photosensitivity, usually difficult to keep under control. Among the scant therapeutic options proposed to reduce photosensitivity in erythropoietic protoporphyria, narrow-band ...
Misdaq Misbah - - 2012
: Thiopurine S-methyltransferase (TPMT) is an excellent example of an enzyme whose pharmacogenetic polymorphisms affect efficacy and toxicity of a drug. The association between TPMT activity and thiopurine-related myelosuppression is well recognized. To study the significance of TPMT deficiency in thiopurine metabolism and immunosuppressive activity in vitro, we established RNA ...
Prestwich R J D - - 2012
The aim of this study was to assess the accuracy of recombinant thyroid-stimulating hormone (rTSH)-stimulated 2-(18-fluoride)-flu-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography (PET)-CT in detecting recurrence in patients with differentiated thyroid cancer. Consecutive (18)F-FDG PET-CT scans performed with rTSH stimulation between 2007 and 2010 in patients with a history of papillary or ...
Zivadinov Robert - - 2012
To prospectively investigate the associations of baseline serum anti-phospholipid antibody (APLA) status on evolution of clinical and MRI measures in a multiple sclerosis (MS) patient cohort treated with interferon-beta (IFN-beta). Forty-seven relapsing-remitting (RR) MS patients, [26 APLA-positive (APLA(+)) and 21 APLA-negative (APLA(-))] matched for age, sex, disease duration, MRI characteristics, ...
Mosca F - - 2012
Respiratory failure in the premature infants remains a difficult challenge. An alternative to the use of nasal continuous positive airway pressure (NCPAP) as a non-invasive modality to support respiratory distress in premature infants has been the recent introduction of high flow nasal cannula (HFNC) devices in many neonatal units. There ...
Wheeler Tisha - - 2012
Debates have raged in development for decades about the appropriateness of participatory approaches and the degree to which they can be managed, scaled and measured. The Avahan programme confronted these issues over the last 7 years and concludes that it is advantageous to manage scaled community mobilisation processes so that ...
Drago Lorenzo - - 2012
: To evaluate cytokine stimulation with 3 strains of Lactobacillus salivarius in vitro and to assess changes in intestinal microflora and clinical improvements in adults with atopic dermatitis (AD) induced by the strain showing the best immunomodulatory features. : AD is a common skin disease in children and adults. It ...
Lista G - - 2012
Few years ago, elective tracheal intubation in the delivery room was considered as the routine approach in managing respiratory failure in extremely-low-birth-weight infants (ELBW), at least in terms of surfactant administration. Over recent years, the indications and principles of neonatal resuscitation of ELBW infants have been partially reviewed: many randomized ...
Bubbico Luciano L ISFOL/IAS Department of Biomedical Science, Italian Institute of Social Medicine, Rome, Italy. - - 2012
From year 2003, the UNHS nationwide survey was commenced in Italy by the Italian Institute of Social Medicine, and was conducted in all Italian maternity hospitals in 2003, 2006 and 2008. All maternity wards active in Italy were included. Our study showed that the coverage and penetration of the UNHS ...
Chuah Sai Yee - - 2012
Erythropoietic protoporphyria (EPP) is a rare autosomal dominant disorder of haem biosynthesis resulting from a partial decrease in ferrochelatase (FECH) activity which leads to the excessive accumulation of protoporphyrin in blood, erythrocytes and tissues. Cutaneous manifestations of photosensitivity usually appear in early infancy upon the first sun exposures. This normally ...
Bettinelli Maria Enrica - - 2012
Women should never be forced to make a choice between mother-work and other work. Many women mistakenly think they cannot breastfeed if they plan to return to work, and thus they may not talk with their employers about their intention to breastfeed or how breastfeeding might be supported at their ...
Faa G - - 2012
The identification of the different cell types involved in human nephrogenesis, when solely based on morphology, may lead to errors in its interpretation, given the complexity of the histological picture of the fetal and of the newborn kidney. In this study, the most recent works utilizing immunhistochemistry for the identification ...
Bissonnette Robert - - 2012
Despite the fact that most people apply less sunscreen than the 2 mg/cm(2) required to measure sun protection factor (SPF), there is a lack of clinical data on the protection afforded from lower applied quantities. The aim of this study was to compare the ability of sunscreens to protect against UV-induced ...
Diaconu Claudiu I - - 2012
To establish a detailed technical procedure for studying the anatomical correlates of chronic cerebrospinal venous insufficiency in cadavers of multiple sclerosis and control subjects, and to present our findings of the normal anatomic venous structures, with reference to previous descriptions from the literature. This study examined the internal jugular veins ...
Haslemo Tore - - 2012
: Preliminary reports have indicated that valproic acid (VPA) reduces serum concentrations of olanzapine (OLZ). The aim of this study was to investigate the impact of VPA and other antiepileptic drugs (AEDs) on serum concentrations of OLZ and 3 of its major metabolites in a large-scale material of therapeutic drug ...
Iemoli Enrico E Allergy and Clinical Immunology Unit, L. Sacco Hospital, Milan, - - 2012
It has been suggested that probiotics modulate atopic dermatitis (AD) progression, but no data are actually available on their mechanisms of action and on their ability to act as immunomodulators in this pathology. The aim of this randomized double-blinded active treatment versus placebo study was to evaluate clinical efficacy of ...
Cerbo R M - - 2012
Near infrared spectroscopy (NIRS) measures the regional tissue oxygen saturation (rSO2) of various organs and provides a reflection of the balance between tissue oxygen supply and demand. Oxymetry assessed via NIRS has been proposed as a 'standard of care' and today it is already widely used in the NICU. This ...
Sellitto Maria M Neonatal Intensive Care Unit, Villa Betania Evangelical Hospital, Naples, Italy. - - 2012
Very low birth weight and other critically ill neonates require prolonged vascular access, which is achieved in current practice with central venous catheters. The initiation of adequate parenteral nutrition and prolonged intravenous medications represent the most important applications. Central vascular access in neonates is associated with a high risk for ...
Feng Wei - - 2012
To study blood flow characteristics through the internal jugular veins (IJVs) at the cervical levels C2/C3 and C5/C6 in the neck of multiple sclerosis (MS) patients. Magnetic resonance imaging at 3T was performed on 323 MS patients. Phase contrast imaging was used to quantify blood flow at both the C2/C3 ...
Kaplan Yusuf Cem - - 2012
ABSTRACT:: This case report describes a false-positive amphetamine/ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] and ecstasy (MDMA) screen after therapeutic use of antihyperlipidemic drug, fenofibrate. A 60-year-old male patient was admitted to inpatient psychiatry unit with the diagnosis of alcohol dependency. He was prescribed diazepam 30 mg/day, thiamine 300 mg/day, and naltrexone 50 mg/day. ...
Song Rhonnie - - 2012
Objective: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants born prior to 32 weeks gestation or with a birth weight less than 1500 grams. In this article, we review hematological abnormalities associated with NEC. Methods: A literature search was performed using the databases PubMed, ...
Lisa Dentici Maria - - 2012
In 2011, the RDDR network was developed in central Italy to provide support in the diagnosis of dysmorphic newborns. RDDR has been developed as an online electronic system that currently links 20 neonatology centres in central Italy, representing the submitting nodes that transmit patient clinical histories and the relevant photographical ...
Fukunaga-Kalabis Mizuho - - 2012
It has been shown that a side population (SP), which is characterized by high chemical efflux capacity, is present in human melanoma cell lines. However, it was not clear whether patients' samples contain the same subpopulation. In this issue, Luo et al. (2012) report that they have isolated SP cells ...
Vélez-García G M - - 2012
A complete sample preparation procedure used to determine three-dimensional fiber orientation from optical micrographs of glass fiber-reinforced thermoplastic composites is presented. Considerations for elimination of irregularities in the elliptical footprints, contrast enhancement between fibers and surrounding polymer matrix, controlled-etching that allows the identification of small shadows where fiber recedes into ...
Kagi Ruth - - 2012
On June 15, 2011, Washington became the first state in the United States to enact legislation aimed at preventing adverse childhood experiences (ACE), reducing their prevalence, and mitigating their effects. House Bill 1965 (HB 1965) was established on the understanding among legislators and Washington communities of the need for policies ...
Rath Eva - - 2012
In inflammatory bowel disease, the intestinal microbiota is a key driver of inflammation. Hence, efficient sensing of luminal antigens and subsequent initiation of adequate immune responses is crucial for maintaining homeostasis, particularly in intestinal epithelial cells. Pathways such as Toll-like receptor-mediated signaling and autophagy sense microbial products to activate inflammatory ...
Gancia Paolo - - 2012
Therapeutic hypothermia is now the standard of care for brain injury control in term infants with perinatal hypoxic ischemic encephalopathy (HIE). Accumulated evidence shows a reduction in mortality and long-term neurodevelopmental disability at 12-24 months of age, with more favourable effects in the less severe forms of HIE. Only few ...
Del Giudice Michele Miraglia - - 2012
Over the last decade, there has been a growing interest in the use of probiotics for allergic diseases. In the last years, some studies showed a significant improvement for atopic eczema by the administration of probiotics during pregnancy and postnatally. About food allergy, probiotics administration seems to be effective in ...
Biasini Augusto - - 2012
Extremely-low-birth-weight infants (ELBW) should be given nutrients to enable them to grow at the same rate as foetuses of the same gestational age, and lean body components, particularly the brain, are dependent on protein intake. Fortified human milk remains the best food for these preterms. Two groups of preterm infants ...
Resta Nicoletta - - 2012
Background: Birth defects are very common, affecting two to three infants in every 100 births, and often represent a diagnostic and management challenge. The birth of a child with multiple malformations is the beginning of a complex diagnostic process, where the primary purpose is to determine a precise nosological definition. ...
Ritzman Terrence B - - 2012
This study investigates the gross anatomy of the original and the regenerated tail in the green anole (Anolis carolinensis). Dissections were conducted on 24 original and 13 regenerated tails. While the extrinsic muscles of the original tail in A. carolinensis are similar to those in other known Anolis lizard species, ...
Vitaliti S M - - 2012
The authors after a brief introduction on the development of the perception of pain in the fetus and newborn, focus attention on the problem of painful procedures that are performed in the neonatal intensive care units reported in the scientific literature. Then report the design of the double-blind study that ...
Knobler Robert R Department of Dermatology, Medical University of Vienna, Vienna, Austria. - - 2012
Extracorporeal photopheresis (ECP) is effective for treating cutaneous T-cell lymphoma. In 1987, a pivotal trial showed 81% overall response rate (ORR) using outdated criteria. No long-term follow-up was available for assessing survival. This study applies modern criteria to the 1987 trial to assess the impact of ECP on skin responses ...
Piano Mario D - - 2012
: Beneficial findings concerning probiotics are increasing day by day. However, one of the most important parameters able to significantly affect the probiotic value of a microorganism is its survival during the transit through the stomach and the duodenum. Some techniques may be applied that aim to improve this parameter, ...
Chiellini Carolina - - 2012
Biofouling in water treatment processes represents one of the most frequent causes of plant performance decline. Investigation of clogged membranes (reverse osmosis membranes, microfiltration membranes and ultrafiltration membranes) is generally performed on fresh membranes. In the present study, a multidisciplinary autopsy of a reverse osmosis membrane (ROM) was conducted. The ...
Larkin Heather - - 2012
The Restorative Integral Support (RIS) model is a comprehensive, whole person approach to addressing adversity and trauma. The Adverse Childhood Experiences (ACE) Study conducted by the Centers for Disease Control (CDC) and Kaiser Permanente reveals a relationship between childhood trauma and adult health and social problems. The current empirical case ...
Flurry Mitchell - - 2012
ABSTRACT: Simulation has become an integral part of education at all levels within the medical field. The ability to allow personnel to practice and learn in a safe and controlled environment makes it a valuable tool for initial training and continued competence verification. An area of specific interest to the ...
Guirado D - - 2012
We propose and study a new model aimed at describing the low-dose hyper-radiosensitivity phenomenon appearing in the survival curves of different cell lines. The model uses the induced repair assumption, considering that the critical dose at which this mechanism begins to act varies from cell to cell in a given ...
Serino Matteo - - 2012
Each individual can be distinguished by the heterogeneity of the trillions of microbes inhabiting his gastrointestinal tract. This concept, together with the role that gut microbiota is considered to play in the induction of metabolic diseases, paves the way for the development of personalized medicine. By exploiting our unique animal ...
Calani Luca - - 2012
Dietary polyphenolic compounds are poorly absorbed in the small intestine. The absorbed fraction follows the common metabolic pathway of drugs, undergoing phase II enzymatic detoxification with the conjugation of glucuronic acid, sulfate, and methyl groups. However, the unabsorbed fraction can reach the colon, becoming available for the wide array of ...
Ancora Gina - - 2012
Infants receiving respiratory assistance may feel pain due to underlying disease or ventilation itself. Pain control during neonatal respiratory care reduces morbidity. This article summarizes the main scientific evidence about the use of drugs during ventilatory assistance, and provides some practical suggestions on pain management in neonates with respiratory support.
Bartsch Hella - - 2012
Earlier we reported that in a number of experiments pineal melatonin production in rats under constant laboratory conditions displayed seasonal rhythms but subsequently were not always able to confirm this. Since there was no indication under which conditions such rhythms may be present, we performed four consecutive identical experiments with ...
Eichorst J P JP Center of Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, - - 2012
Membrane type 1 matrix metalloproteinase (MT1-MMP) is a membrane-tethered collagenase primarily involved in the mechanical destruction of extracellular matrix proteins. MT1-MMP has also been shown to be upregulated in several types of cancers. Many coordinated functions of MT1-MMP during migration and invasion remain to be determined. In this paper, live ...
Romagnoli Costantino - - 2012
Objective: This study reports on an experience following contact by a large number of newborn babies with a nurse infected by active tuberculosis (TB). Methods: A large number of newborn babies were checked for possible contact with Mycobacterium tuberculosis (MTB) using interferon-gamma tests (IGTs) to determine specific treatment. Results: One ...
Guglin Maya - - 2012
Background:  Risk factors of pulmonary hypertension (PH) are poorly understood. The objective of this study was to identify the determinants of PH in young adults. Methods:  We analysed a limited access dataset from the CARDIA (Coronary Artery Risk Development in Young Adults) study provided by the National Heart, Lung and ...
Allen Valerie Dorsey - - 2012
Witnessing violence is one adverse childhood experience (ACE) associated with living in impoverished Black urban communities. Youth with higher violence avoidance self-efficacy and positive coping are more likely to avoid violence. This study evaluates educational entertainment (edutainment) as an intervention with Black adolescents exposed to community violence. Edutainment has shown ...
Toepker M - - 2012
The broad availability and use of multidetector computed tomography (MDCT) in recent years has increased the radiation dose for patients. Multiphase MDCT protocols are used in abdominal imaging for various indications. Dose reduction though novel technologies, such as dual energy CT or adapted contrast injection protocols (split bolus etc.) for ...
Serafini Mauro - - 2012
Herbs are used in Europe as medicinal products, food, food supplements, and related products. This paper will discuss the concepts of Traditional Herbal Medicines and Traditional Plant Food Supplements, defined in European legislation under differing legal frameworks, regarding Traditional Plant Food Supplements (including Claims Regulation) and the role of the ...
Zanini R - - 2012
The origins of the use of the Caesarean section date far back in human history. Traces of this procedure can be found in Greek mythology and in the history of Ancient Rome. Many documents about the history of religion make reference to a delivery from the abdomen.
Scoppa A - - 2012
Over the last decade, the survival of premature babies has improved dramatically. Such infants, especially those with extremely low birth weight, are still affected by dangerous complications occurring during the neonatal period that often cause brain damage. Intraventricular-intraparenchymal haemorrhage (IVH-IPH), periventricular leukomalacia (PVL), seizures, meningitis and hypoxic-ischaemic encephalopathy are the ...
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