Search Results
Results 451 - 500 of 2743
< 5 6 7 8 9 10 11 12 13 14 15 >
Sestak Ivana - - 2012
Trials with tamoxifen have clearly shown that the risk of developing oestrogen receptor-positive breast cancer can be reduced by at least 50 % with prophylactic agents. The current challenge is to find new agents which achieve this or better efficacy, but with fewer side effects. Recent results indicate that the selective ...
Hermanns-Clausen M - - 2012
AIMS: Recently, several synthetic cannabinoids were identified in herbal mixtures consumed as recreational drugs alternatively to Cannabis products. The aim was to characterize the acute toxicity of synthetic cannabinoids as experienced by emergency patients. DESIGN: This was a retrospective study targeting patients seeking emergency treatment after recreational use of synthetic ...
Zhang Aihua - - 2012
Metabolomics is the systematic study of the unique chemical fingerprints of low molecular weight endogenous metabolites or metabolite profiles in a biological sample. Metabolites that are important indicators of physiological or pathological states can provide information for the identification of early and differential markers for disease and help to understand ...
Kühnisch Jan - - 2012
Objective: This epidemiological study aimed to assess the proportion and extent of manifestation of enamel hypomineralization, including molar-incisor-hypomineralization (MIH), in the permanent and primary dentition. Methods: A total of 693 children enrolled in an ongoing birth cohort study (GINIplus-10) were examined at their 10-year follow-up. Enamel hypomineralization was scored in ...
Choi Jaehoon - - 2012
In cell culture, medium supplemented with fetal bovine serum is commonly used, and it is widely known that fetal bovine serum supplies an adequate environment for culture and differentiation of stem cells. Nevertheless, the use of xenogeneic serum can cause several problems. We compared the effects of four different concentrations ...
Hajimasalaeh Warunee - - 2012
vp1, a gene encoding one of the capsid proteins of Taura syndrome virus, was cloned into the pGEX-6P-1 expression vector, and the resulting construct was then used to transform E. coli strain BL21. After induction, an N-terminally glutathione-S-transferase-tagged VP1 (GST-VP1) protein with a molecular mass of 80 kDa was obtained. This ...
Lajara Rosemarie - - 2012
Objective: Usability of a new prefilled insulin pen, FlexTouch® (FT; Novo Nordisk A/S, Bagsvaerd, Denmark), with no push-button extension and low injection force, was compared with vial and syringe (V&S). Research design and methods: People with diabetes, and healthcare professionals with diabetes management experience conducted test injections and answered questions ...
Xue Zhaohui - - 2012
This study was undertaken to determine the effects of chickpea albumin hydrolysate (CAH) on antihyperlipidemic and antitumor functions. The antihyperlipidemic results showed that CAH exhibited a dose dependent ability to decrease the levels of serum total cholesterol, triglyceride, LDL cholesterol (LDL-C), while increasing HDL cholesterol (HDL-C). Additionally, the appearance of ...
Banaee Mahdi - - 2012
The organophosphate insecticide diazinon is widely used to control pest in Iran. The purpose of the present study was to investigate the antioxidant and histopathological changes in the liver tissue of rainbow trout (Oncorhynchus mykiss) exposed to 0.1 and 0.2 mg/L of a commercial formula of diazinon for a period of ...
Saito Naoko - - 2012
PURPOSE: We report a case of type 1 proatlantal intersegmental artery (PIA) associated with multiple anomalies of the aortic arch, and discuss the possible embryonic mechanism and clinical importance of the multiple cerebrovascular variants in this patient. METHODS: A 65-year-old woman with dizziness underwent cerebral magnetic resonance (MR) imaging and ...
Zhang Pei-Pei - - 2012
Dietary oat or oat products may potentially help to fight against high risk of cardiovascular diseases and β-glucan in oat was considered as a central player. The present study aimed to investigate the effects of dietary oat whole meal or β-glucan on insulin sensitivity and energy metabolism of rats. Rats ...
Adhikarla Vikram - - 2012
A mathematical model which reconstructs the structure of existing vasculature using patient-specific anatomical, functional and molecular imaging as input was developed. The vessel structure is modelled according to empirical vascular parameters, such as the mean vessel branching angle. The model is calibrated such that the resultant oxygen map modelled from ...
Jeong Huisu - - 2012
A periodically aligned Pt nanocup array is employed as a counter electrode in dye-sensitized solar cells (DSSCs). The Pt nanocup array enhances the catalytic area, which results in a greater fill factor (FF) and higher short-circuit current (J(sc) ). A higher density of nanocups is preferable for the performance of ...
Brown Teresa E - - 2012
BACKGROUND: The "Swallowing and Nutrition Guidelines for Patients with Head and Neck Cancer" were developed to guide early identification and management of dysphagia and nutritional risk before, during, and after cancer treatment. The purpose of this study was to validate these guidelines. METHODS: Patients attending a Combined Head and Neck ...
Tremaroli Valentina - - 2012
The link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer. However, because of the complexity of the microbial community, the functional connections are less well understood. Studies in both mice and humans are ...
Khan Rehan - - 2012
Multiple myeloma (MM) is classically illustrated by a desynchronized cytokine system with rise in inflammatory cytokines. There are recent reports which emphasized the potential role of angiogenesis in the development of MM. Role of cyclooxygenase 2 (COX-2) is well documented in the pathogenesis of solid tumors, but little is known ...
Song Youngkeun - - 2012
Drought-induced anomalies in vegetation condition over wide areas can be observed by using time-series satellite remote sensing data. Previous methods to assess the anomalies may include limitations in considering (1) the seasonality in terms of each vegetation-cover type, (2) cumulative damage during the drought event, and (3) the application to ...
Ogawa Yuri - - 2012
The tiered ommatidia of the Eastern Pale Clouded yellow butterfly, Colias erate, contain nine photoreceptor cells, four of which contribute their rhabdomeral microvilli to the distal tier of the rhabdom. We analyzed the visual pigments and spectral sensitivities of these distal photoreceptors in both sexes of Colias erate. A subset ...
Sakamaki Kensuke - - 2012
In a previous work, we identified 6-propylbenzofuran-7-ol as an off-flavor compound formed from ascorbic acid and (E)-hex-2-enal in a test apple beverage. In this study we elucidate the pathway by which 6-propylbenzofuran-7-ol formed. Isotope labeling studies revealed that the propyl group of 6-propylbenzofuran-7-ol derives from (E)-hex-2-enal and that 6-propylbenzofuran-7-ol contains ...
Teruya Kenta - - 2012
Peptide segment couplings are now widely utilized in protein chemical synthesis. One of the key structures for the strategy is the peptide thioester. Peptide thioester condensation, in which a C-terminal peptide thioester is selectively activated by silver ions then condensed with an amino component, is a powerful tool. But the ...
Barbosa Euzébio G - - 2012
A new Receptor-Dependent LQTA-QSAR approach, RD-LQTA-QSAR, is proposed as a new 4D-QSAR method. It is an evolution of receptor independent LQTA-QSAR. This approach uses the free GROMACS package to carry out molecular dynamics simulations and generates a conformational ensemble profile for each compound. Such an ensemble is used to build ...
Nouta Klaas Auke KA Department of Orthopaedics, Leiden University Medical Center, Postal Code J11R, PO Box 9600, 2300 RC Leiden, The Netherlands. - - 2012
Less than 1% of all primary TKAs are performed with an all-polyethylene tibial component, although recent studies indicate all-polyethylene tibial components are equal to or better than metal-backed ones. We asked whether the metal-backed tibial component was clinically superior to the all-polyethylene tibial component in primary TKAs regarding revision rates ...
Jagannathan Narasimhan - - 2012
OBJECTIVES: To assess the clinical performance of the Ambu Aura-i (Aura-i) in children. AIM: To compare the Aura-i with the air-Q intubating laryngeal airway (air-Q) for the purposes of fiberoptic-guided tracheal intubation. BACKGROUND: The Aura-i is a new supraglottic airway designed for tracheal intubation. MATERIALS/METHODS: One hundred twenty children, ages ...
Forment Josep V JV The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, - - 2012
Genomic alterations that lead to oncogene activation and tumour suppressor loss are important driving forces for cancer development. Although these changes can accumulate progressively during cancer evolution, recent studies have revealed that many cancer cells harbour chromosomes bearing tens to hundreds of clustered genome rearrangements. In this Review, we describe ...
Jutkowitz Eric E Department of Health Policy and Management, University of Minnesota School of Public Health, 420 Delaware Street SE, Minneapolis, MN 55455, USA. - - 2013
To compare societal values across three health-state classification systems in older African Americans with depression and to describe the association of these instruments to depression severity. We summarized baseline values for EQ-5D (US weights) and HUI2/3 (Canadian weights) and their subscales for 118 older African American participants enrolled in a ...
Wu Hao - - 2012
It is well known that the regular likelihood ratio test of a bounded parameter is not valid if the boundary value is being tested. This is the case for testing the null value of a scalar variance component. Although an adjusted test of variance component has been suggested to account ...
Taneja Charu - - 2012
Objective: The objective of this study was to examine adherence and persistency in HIV patients initiating first-line combination antiretroviral therapy (cART) with a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen. Methods: Using US health insurance records, the authors identified all persons aged ≥ 18 years with HIV, who began NNRTI-based cART ...
Bobridge K S - - 2012
Evidence that fructose intake may modify blood pressure is generally limited to adult populations. This study examined cross-sectional associations between dietary intake of fructose, serum uric acid and blood pressure in 814 adolescents aged 13-15 years participating in the Western Australian Pregnancy Cohort (Raine) Study. Energy-adjusted fructose intake was derived ...
Min Joonkeun - - 2012
Poly(furfuryl isocyanate) (PFIC), which includes the reactive furan group, was synthesized by anionic polymerization using a sodium benzhydroxide (Na-BH), self-assembly initiator. We determined the optimum polymerization conditions by varying both the reaction time and the molar ratio of the monomer to the initiator. Block copolymer, poly(furfuryl isocyanate)-b-poly(n-hexyl isocyanate), was synthesized ...
Komatsu Haruki - - 2012
AIM: The relation between interleukin-28B (IL-28B) genotypes and treatment-induced hepatitis C virus (HCV) clearance in children is unknown. This was a retrospective study to evaluate the association between an IL-28B genotype (rs8099917) and pegylated (PEG) interferon (IFN) response. METHODS: Sixty-three children (median age, 7 years; range, 3-17 years; 22 with HCV genotype ...
Feria Cary S - - 2012
Multiple-object tracking (MOT) studies have shown that tracking ability declines as object speed increases. However, this might be attributed solely to the increased number of times that target and distractor objects usually pass close to each other ("close encounters") when speed is increased, resulting in more target-distractor confusions. The present ...
Papatsoris Athanasios - - 2012
The last decade flexible ureteroscopy has progressed from an awkward diagnostic procedure with limited visualization to a precise surgical intervention allowing access to the entire collecting system. In this review, we present the current status and future perspectives of the ureterorenoscopic management of urolithiasis and non-stone-related upper tract pathologies.
Erzengin Mahmut - - 2012
Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. In this study, in vitro inhibition effect of some dihydroxy coumarin compounds namely 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (A), 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (B) and 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (C) on ...
Crawford Jeffrey R JR Baylor College of Medicine, One Baylor Plaza, M.S. BCM620, Houston TX, 77030, - - 2012
Fibroblasts in the heart play a critical function in the secretion and modulation of extracellular matrix critical for optimal cellular architecture and mechanical stability required for its mechanical function. Fibroblasts are also intimately involved in both adaptive and nonadaptive responses to cardiac injury. Fibroblasts provide the elaboration of extracellular matrix ...
Kanakis George - - 2012
OBJECTIVE: The widespread application of abdominal computerized tomography (CT) imaging has revealed that 0.98-4.0% of individuals harbour adrenal lesions (incidentalomas). There is however paucity of information regarding the prevalence of adrenal lesions in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETS). Purpose of this study was to estimate the prevalence of adrenal ...
Ou Phalla - - 2012
Coronary sequelae of Kawasaki disease, post-surgical coronary lesions and cardiac allograft vasculopathy are the main causes of acquired coronary pathology in childhood. Surveillance and timely recognition of coronary problems in children who are at risk of ischemic events are imperative and noninvasive imaging is increasingly utilized for these purposes. Herein, ...
Nadarevic Lena - - 2012
Two theoretical frameworks have been proposed to account for the representation of truth and falsity in human memory: the Cartesian model and the Spinozan model. Both models presume that during information processing a mental representation of the information is stored along with a tag indicating its truth value. However, the ...
Cho Young Sun - - 2012
Transgenic marine medaka (Oryzias dancena) germlines were generated by the microinjection of the red fluorescent protein (RFP) reporter gene (rfp) driven by the endogenous choriogenin H gene (chgH) promoter. The selected transgenic lines contained multiple copies of the transgene (3-42 copies per cell) in their genomes. Although all the founders ...
Kobashi Haruhiko H Department of Hepatology, Japanese Red Cross Okayama Hospital Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, - - 2013
  Although it is a common complication of sepsis, sepsis-associated liver injury has not been substantially recognized, because its diagnostic criteria and clinical implications are unclear. We aimed to elucidate the incidence, manifestation, disease type classification and prognosis of sepsis-associated liver injury.   The subjects were 588 patients admitted to ...
Bamborough Paul - - 2012
For well over a decade, significant effort has been devoted to the search for inhibitors of the human protein kinase family. This is increasingly translating into success in the clinic, with five new kinase inhibitor drugs approved since 2011. However, despite encouraging signs in other areas, success has been largely ...
Maynard Craig L CL Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama, - - 2012
The emergence of the adaptive immune system in vertebrates set the stage for evolution of an advanced symbiotic relationship with the intestinal microbiota. The defining features of specificity and memory that characterize adaptive immunity have afforded vertebrates the mechanisms for efficiently tailoring immune responses to diverse types of microbes, whether ...
Galvin Mairead - - 2012
Background Medication reconciliation has been mandated by the Irish government at transfer of care. Research is needed to determine the contribution of clinical pharmacists to the process. Objective To describe the contribution of emergency department based clinical pharmacists to admission medication reconciliation in Ireland. Main Outcome Measure Frequency of clinical ...
Shin J H - - 2012
The objective of this study was to use a nationwide epidemiological survey to investigate the factors that affect within-visit blood pressure (BP) variability. We analyzed the Korean National Health and Nutrition Examination Survey (KNHNES) data for 2005 (n=5488). We examined three within-visit BP variability parameters that include the following: the ...
Hepowit Nathaniel - - 2012
Proteins with JAB1/MPN/MOV34 metalloenzyme (JAMM/MPN+) domains are widespread among all domains of life, yet poorly understood. Here we report the purification and characterization of an archaeal JAMM/MPN+ domain protein (HvJAMM1) from Haloferax volcanii that cleaves ubiquitin-like small archaeal modifier proteins (SAMP1/2) from protein conjugates. HvJAMM1 cleaved SAMP1/2 conjugates generated in ...
Ebert Stefan - - 2012
Reactivation of latent cytomegalovirus (CMV) in the transient state of immunodeficiency after hematopoietic cell transplantation (HCT) is the most frequent and severe viral complication endangering leukemia therapy success. By infecting the bone marrow (BM) stroma of the transplantation recipient, CMV can directly interfere with BM repopulation by the transplanted donor-derived ...
Kamada Yuhei - - 2012
Single-nucleotide polymorphism genotyping microarray (SNP array) analysis provides detailed information on chromosomal copy number aberrations. To obtain detailed information on genomic abnormalities related to pathogenesis or prognosis of multiple myeloma (MM), we performed 250K SNP array analysis in 39 MM patients and 11 cell lines. We identified an accumulation of ...
Norman Peter - - 2012
The JAK family comprises of the four non-receptor tyrosine kinases JAK1, JAK2, JAK3 and Tyk2, which play key, but differing, roles in cytokine receptor signal transduction. A non-selective JAK inhibitor, ruxolitinib, has recently been approved to treat myelofibrosis whereas tofacitinib is poised for approval to treat rheumatoid arthritis. Selective inhibition ...
Vivo J - - 2012
The objective of this work was to analyse changes in morphometric characteristics related to growth in the trochlear nerve in dogs. Twenty beagles, split into four dog age groups (A, 7 days; B, 21 days; C, 35 days; D, 49 days and E, 4 years), were used. The right intracranial portion of the nerve was ...
Kanegae Ayaka - - 2012
Two new phenolic compounds (1 and 2, named as teasperol and teasperin, respectively) were isolated from fermented tea (Camellia sinensis L.) products, together with known phenolic compounds. Teasperol (1) was isolated from Chinese traditional post-fermented tea leaves (Liu-pao tea) and teasperin (2) was from a Japanese tea product which was ...
Jalili M - - 2012
A simple method for the reduction of aflatoxins B(1) (AFB(1)), B(2) (AFB(2)), G(1) (AFG(1)), G(2) (AFG(2)) and ochratoxin A (OTA) in white pepper was studied. Response surface methodology (RSM) was applied to determine the effect of four variables, which included time (20-60 min), temperature (30-70°C), calcium hydroxide (Ca(OH)(2)) (0-1%) and hydrogen ...
< 5 6 7 8 9 10 11 12 13 14 15 >