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Lv Zhanyun - - 2012
Abstract Vitamin D and vitamin D receptor (VDR) have been postulated as environmental and genetic factors in neurodegenerative disorders including multiple sclerosis (MS), Alzheimer disease (AD), and recently Parkinson disease (PD). The purpose of this study is to explore the potential correlation between single nucleotide polymorphisms (SNP) of the VDR ...
Wu Gaobing - - 2012
The anthrax toxin is composed of three proteins: protective antigen (PA), lethal factor (LF), and edema toxin (EF). The PA moiety carries EF and LF into the cytosol of mammalian cells via a mechanism that depends on the oligomerization of PA and transmembrane pore formation by the PA oligomer. Certain ...
Mukhopadhyay S K - - 2012
An accurate and reliable ECG feature extraction algorithm is presented in this paper. ECG samples are de-noised and its first derivative and Hilbert transform are computed. Sample having maximum amplitude in the transformed domain is found out and those samples having amplitudes within a lead wise specified threshold of that ...
Randić Milan - - 2012
We describe a very efficient search for nucleotide alignments, which is analogous to the novel very efficient search for protein alignment. Just as it has been the case with the alignment of proteins, based on 20 × 20 adjacency matrices for amino acids, obtained from a superposition of labeled amino ...
Faghihnia N - - 2012
Small dense low-density lipoprotein (LDL) particles and apolipoprotein (apo) CIII are risk factors for cardiovascular disease (CVD) that can be modulated by diet, but there is little information regarding the effects of dietary saturated fat on their plasma levels. We tested the effects of high vs low saturated fat intake ...
Grove Erik Lerkevang EL Department of Cardiology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, 8200 Aarhus, Denmark. - - 2013
Clopidogrel prevents cardiovascular events, but has been linked with adverse gastrointestinal (GI) complications, particularly bleeding events. We aimed to investigate the risk of adverse GI events in patients treated with clopidogrel. A nationwide population-based cohort study based on linkage of three administrative registries in Denmark. All individuals who redeemed at ...
Lindskov Krog P - - 2012
Pridopidine is being developed for the treatment of impaired motor function associated with Huntington's disease and belongs to a new class of compounds known as dopidines, which act as dopaminergic stabilizers. In vitro studies have shown that pridopidine is a substrate for the P450 cytochrome 2D6 enzyme (CYP2D6), and clinical ...
Scheike T - - 2012
Granular superconductivity in powders of small graphite grains (several tens of micrometers) is demonstrated after treatment with pure water. The temperature, magnetic field and time dependence of the magnetic moment of the treated graphite powder provides evidence for the existence of superconducting vortices with some similarities to high-temperature granular superconducting ...
Goksedef B Pinar Cilesiz - - 2012
OBJECTIVE: To compare the diagnostic accuracy of endocervical curettage (ECC) and endocervical brushing (EB) in patients referred for colposcopic evaluation for low grade squamous intraepithelial lesion. MATERIALS AND METHODS: A prospective, randomized, comparative trial was conducted in an Education and Research Hospital, Gynecologic Oncology Clinic. After exclusion of 40 subjects, ...
Florou Dimitra - - 2012
Gastric cancer constitutes one of the most common neoplasms globally. Kallikrein-related peptidases have attracted interest as potential tumor markers and future targets for novel cancer therapeutics. We have recently reported KLK13 clinical importance as a favorable prognostic biomarker for gastric cancer patients' survival. By aiming to explore how the molecular ...
Davey Maureen P - - 2012
OBJECTIVES: The primary objective of this 2-year pilot study was to evaluate the effectiveness of a culturally adapted family intervention in improving family communication among African American parents coping with cancer and their school-age children. A secondary objective was to determine its impact on other symptoms of psychosocial distress (depression ...
Freedman Rachel A - - 2012
Although younger women with breast cancer have the most to gain from receipt of optimal care, few data are available regarding their receipt of locoregional breast cancer treatments. We identified 317,596 women aged 18-64 who were diagnosed with invasive breast cancer at hospitals reporting to the National Cancer Database, a ...
Tug Tuncer - - 2012
In this study, octreotide (OCT), a synthetic somatostatin analog, was tested for its beneficial effects in the prevention of interstitial pulmonary fibrosis (IPF) induced by bleomycin (BLM) in rats by histological examination and by evaluating tissue OH-proline levels. Thirty male Wistar rats were divided randomly into three groups: group I: ...
Bowles Erin J Aiello EJ Group Health Research Institute, 1730 Minor Ave, Ste 1600, Seattle, WA 98101, USA. - - 2012
Clinical trials demonstrated that women treated for breast cancer with anthracycline or trastuzumab are at increased risk for heart failure and/or cardiomyopathy (HF/CM), but the generalizability of these findings is unknown. We estimated real-world adjuvant anthracycline and trastuzumab use and their associations with incident HF/CM. We conducted a population-based, retrospective ...
Horstmann Vibeke - - 2012
To study and compare associations between life satisfaction and standard of living, health, and coping behaviour in older single-living women in two countries with different political, economical and cultural situations: Latvia and Sweden. Cross sectional data included 260 Latvian and 288 Swedish women, aged 75-84 and 80-89, from the ENABLE-AGE ...
Ueda Tomoki - - 2012
In order to test for improved survival following autologous transplantation (ASCT), we conducted a prospective clinical trial of post-ASCT thalidomide therapy in Japanese patients with multiple myeloma (MM). Twenty-five newly diagnosed patients received double or single ASCT with high-dose melphalan (200 mg/m(2)). Two months after stem cell infusion, if the patients ...
Seidel Matthias F - - 2012
Arthritis is characterized by pain and inflammation. Recently, attention has been focused on nerve-growth factor (NGF), a neurotrophin that is a key regulator of peripheral nociception because it mediates overexpression of proinflammatory neuron-derived molecules such as substance P, serotonin, and calcitonin gene-related peptide. Antibodies have been generated for NGF and ...
Siebert Wendy J - - 2012
Guidelines recommend the use of cardiac telemetry when Phenytoin is administered intravenously. Clinical areas where telemetry is available may not always be the most suitable place to monitor and treat these sick patients. We sought to clarify the evidence regarding the need for cardiac telemetry during IV infusion of Phenytoin.
Moosavi A - - 2012
Blastocystis is an unusual enteric protozoan parasite of humans and many animals whose pathogenic potential is still controversial. To increase the understanding of the molecular epidemiology of this emerging parasite and due to its potential impact on public health, its subtypes (STs) in Iranian symptomatic and asymptomatic individuals were determined. ...
Wolf Peter - - 2012
Background: Previous work has indicated that extracorporeal photochemotherapy (ECP) may be a safe and effective treatment in patients with severe atopic dermatitis. Methods: We performed a prospective study to investigate the effect of a defined 20-week ECP protocol in patients with severe, refractory atopic dermatitis. The patient inclusion criteria included ...
Köck K - - 2012
Detailed knowledge regarding the influence of hepatic transport proteins on drug disposition has advanced at a rapid pace over the past decade. Efflux transport proteins located in the basolateral and apical (canalicular) membranes of hepatocytes play an important role in the hepatic elimination of many endogenous and exogenous compounds, including ...
Liu Ning - - 2012
A simple, rapid, and economic method of enzyme immobilization was developed for phospholipase Lecitase® ultra (LU) via interfacial adsorption. The effect of nature of the polystyrene supports and the kinetic behavior and stability of immobilized lecitase® ultra (IM-LU) were evaluated. Six macroporous resins (AB-8, X-5, DA-201, NKA-9, D101, D4006) and ...
de Espinosa Lucas Montero - - 2012
Olefin cross-metathesis is introduced as a versatile polymer side-chain modification technique. The reaction of a poly(2-oxazoline) featuring terminal double bonds in the side chains with a variety of functional acrylates has been successfully performed in the presence of Hoveyda-Grubbs second-generation catalyst. Self-metathesis, which would lead to polymer-polymer coupling, can be ...
Brugman V A - - 2012
SUMMARY West Nile virus (WNV) is a zoonotic arthropod-borne pathogen with continued geographical expansion in Europe. We present and evaluate data on the temporal, spatial and bird species focus of the WNV surveillance programme in dead wild birds in Great Britain (2002-2009). During this period all bird samples tested negative ...
Nambiar Mridula - - 2012
Chromosomal translocations are characteristic features of many cancers, especially lymphoma and leukemia. However, recent reports suggest that many chromosomal translocations can be found in healthy individuals, although the significance of this observation is still not clear. In this review, we summarize recent studies on chromosomal translocations in healthy individuals carried ...
Heesterman Berdine L BL Department of Otolaryngology and ENT, LUMC, Leiden, The - - 2013
Hereditary paraganglioma is a benign tumor syndrome with an age-dependent penetrance. Carriers of germline mutations in the SDHB or SDHD genes may develop parasympathetic paragangliomas in the head and neck region or sympathetic catecholamine-secreting abdominal and thoracic paragangliomas (pheochromocytomas). In this study, we aimed to establish paraganglioma risk in 101 ...
Lei Jy - - 2012
BACKGROUND AND AIMS: Various downstaging therapies were introduced to liver recipients who could not meet the relative criteria for liver transplantation, and many endpoints were reported. The most common criteria used were the Milan criteria and the University of California, San Francisco (UCSF) criteria. However, no comparison was made between ...
Rossi Andrea S - - 2012
The present study analyses the effect of dietary chia seed rich in n-3 α-linolenic acid on the mechanisms underlying dyslipidaemia and liver steatosis developed in rats fed a sucrose-rich diet (SRD) for either 3 weeks or 5 months. The key hepatic enzyme activities such as fatty acid synthase (FAS), acetyl-CoA ...
Schnurr Christoph - - 2012
We performed this study to determine whether the use of imageless navigation reduces revision rates after total knee arthroplasty (TKA). Data of 1,121 consecutive primary TKA with a follow-up of one to six years were retrospectively analysed. Following the conversion of the standard technique from conventional to navigated procedures, these ...
van Dijk René E - - 2012
Maternal effects can influence offspring phenotype with short- and long-term consequences. Yet, how the social environment may influence egg composition is not well understood. Here, we investigate how laying order and social environment predict maternal effects in the sociable weaver, Philetairus socius, a species that lives in massive communal nests ...
Kędzierska Magdalena - - 2012
Different low-molecular-weight thiols, including glutathione, cysteine, and cysteinylglycine are physiological free radical scavengers. On the other hand, homocysteine may play a role as an oxidant. The aim of our present study was to establish in vitro the effects of the commercial extract of Aronia melanocarpa (Aronox(®)) on the amount of ...
Egede Leonard E LE Center for Disease Prevention and Health Interventions for Diverse Populations, Ralph H Johnson Veterans Affairs Medical Center, P.O. Box 250593, Charleston, SC 29425-0593, USA. - - 2013
To examine the differential effect of medication non-adherence over time on all-cause mortality by race/ethnicity. Data on a longitudinal cohort of veterans with type 2 diabetes was examined. The main outcome was time to death. Primary independent variables were race/ethnicity and mean medication possession ratio (MPR) categorized into quintiles over ...
Talebi-Garakani Elahe - - 2012
Inflammation plays an important role in the genesis and progression of diabetes. The purpose of this study was to investigate the effect of resistance training on serum levels of some inflammatory markers associated with diabetes mellitus. Twenty-four male Wistar rats (290 ± 19 g) were randomly divided into three groups: non-diabetic control (non-DC), ...
Aanaes Kasper - - 2012
PURPOSE: Anti-neutrophil cytoplasm autoantibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) are common in patients with cystic fibrosis (CF) and serum levels are correlated with lung colonisation by Pseudomonas aeruginosa and the severity of lung damage. The production of BPI-ANCA may be due to the co-stimulation of BPI when mounting an ...
Suga Hiraku - - 2012
Many patients with cutaneous T-cell lymphoma (CTCL) experience severe pruritus. This study evaluated serum levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in patients with CTCL. Although serum NGF and BDNF levels in patients with CTCL were not significantly higher than in healthy controls, serum NGF levels ...
Arora Natasha P - - 2012
Anemia and iron deficiency are quite prevalent in patients with heart failure (HF) and may overlap. Both anemia and iron deficiency are associated with worse symptoms and adverse clinical outcomes. In the past few years, there has been an enormous interest in the subject of iron deficiency and its management ...
Sanz M J - - 2012
Two of the domains most widely shared among R genes are the nucleotide binding site (NBS) and protein kinase (PK) domains. The present study describes and maps a number of new oat resistance gene analogues (RGAs) with two purposes in mind: (1) to identify genetic regions that contain R genes ...
McNamee Benjamin G BG Department of Anthropology, Decker School of Nursing, State University of New York, Binghamton, NY 13902, USA. - - 2012
Past studies have shown that diurnal blood pressure varies between working women with and without children. Understanding of how perceptual and behavioural factors affect this relationship is limited. The study aim was to evaluate whether perceptions and behaviours differentially influenced ambulatory blood pressure variation across changing daily environments between working ...
Andersson Charlotte C Department of Cardiology, Gentofte Hospital, Niels Andersens vej 65, 2900 Hellerup, Denmark. - - 2012
Pharmacodynamic studies have shown that persistently high platelet reactivity is common in patients with diabetes in spite of clopidogrel treatment. Clinical trials have not convincingly demonstrated that clopidogrel benefits patients with diabetes as much patients without diabetes. To estimate the clinical effectiveness associated with clopidogrel treatment after myocardial infarction (MI) ...
Brown Heather H Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK. - - 2013
Time preference describes how consideration of future events may affect present-day behavioural decisions. The aim was to establish whether time preference predicts smoking cessation in a longitudinal analysis. Secondary analysis of data from the Household Income and Labour Dynamics of Australia survey. Australian community. Members of the Household Income and ...
Shirali Saeed - - 2012
Crocin is the only water soluble carotenoid in nature, and it has a known powerful antioxidant activity. The aim of this work was to investigate the hypoglycemic and hypolipidemic effects of crocin in streptozotocin (STZ)-induced type 2 diabetic rats. Neonatal male Wistar rats (2-5 days old) were randomly divided into five ...
Fallaize Rosalind - - 2012
PURPOSE: To determine the relative impact of three iso-caloric breakfast meals, of variable composition, on satiety, hunger and subsequent intake of energy. METHODS: In a three-way, crossover design, 30 healthy men (age of 21.7 ± 1.2 years; BMI, 23.1 ± 2.7 kg/m(2)) were randomised to one of three test breakfasts, on three separate occasions, separated by ...
Wang Jin - - 2012
BACKGROUND: Iliosacral resection of pelvic malignant tumors and subsequent reconstruction have tested the ingenuity of orthopedic oncologists because of the difficulty of oncological wide resection and the complex biomechanics of the sacroiliac joint render reconstruction challenging. This study compared the functional and surgical outcomes of a biological reconstruction technique with ...
Jordan Timothy R - - 2012
Reading relies critically on processing text in foveal vision during brief fixational pauses, and high-quality visual input from foveal text is fundamental to theories of reading. However, the quality of visual input from foveal text that is actually functional for reading and the effects of this input on reading performance ...
Akhtar N - - 2012
Background  Parthenium dermatitis is a common chronic inflammatory disease with activated T lymphocytes that recognize the antigens, which leads to proliferation and differentiation. Telomeres and telomerase play an important role in the regulation of life span of the cell. Telomere length maintained by telomerase, are specialized repeats present at the ...
Wang Bin B Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, - - 2012
Heroin and cocaine have very different unconditioned receptor-mediated actions; however, in the brain circuitry of drug-reward and motivation, the two drugs establish common conditioned consequences. A single experience with either drug can change the sensitivity of ventral tegmental area (VTA) dopamine neurons to glutamatergic input. In the case of cocaine, ...
Nomura T - - 2012
In many eusocial Hymenoptera, a proportion of males are produced by workers. To assess the effect of male production by workers on the effective population size N(e), a general expression of N(e) in Hymenoptera with worker-produced males is derived on the basis of the genetic drift in the frequency of ...
Kim Jae Hui JH Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, #50 Irwon-dong, Kangnam-gu, Seoul 135-710, - - 2013
To measure the difference in subfoveal choroidal thickness between 1:1 pixel (horizontally compressed) images and 1:1 micron images in age-related macular degeneration. This study included 122 eyes from 122 patients diagnosed with age-related macular degeneration. Choroidal thickness was measured using enhanced-depth imaging optical coherence tomography. The measurement line was drawn ...
Huang Zheng-Hong - - 2012
Zinc-based metal-organic frameworks/graphene oxide (MOF-5/GO) composites were synthesized by solvothermal method. The materials were characterized by scanning electron microscopy (SEM), nitrogen adsorption, X-ray diffraction (XRD), FTIR and X-ray photoelectron spectroscopy (XPS), and their performances for H2S removal were evaluated by dynamic testing at room temperature. The composites exhibit microporous structure ...
Celestino Ricardo R Institute of Molecular Pathology and Immunology of the University of Porto, University of Porto, Porto, - - 2013
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, disclosing somatic KIT, PDGFRA and BRAF mutations. Loss of function of succinate dehydrogenase (SDH) complex is an alternative molecular mechanism in GISTs, namely in carriers of germline mutations of the SDH complex that develop Carney-Stratakis dyad ...
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