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Results 351 - 400 of 2195
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Lech-Maranda Ewa - - 2012
Tumor necrosis factor (TNF)-α and interleukin (IL)-10 are cytokines involved in the balance between cell-mediated and humoral immunity. We investigated whether serum TNF-α and IL-10 levels have any impact on clinical outcome of patients with chronic lymphocytic leukemia (CLL). TNF-α and IL-10 levels were determined in the serum of 160 ...
Beena - - 2012
A library of unsymmetrical cyclohexane-1,2-diamine derivatives were synthesized and evaluated for their activity against Mycobacterium tuberculosis H37Rv in vitro. Out of the 46 compounds synthesized, eight compounds (11h, 13a, 13e, 13f, 14a, 14c, 14d, and 15d) were found to be active at or below 6.25 µM concentration, with negligible toxicity to ...
Uehara Takeshi T Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Founders 6, Philadelphia, PA 19104, - - 2013
H. pylori (Hp) infection is a major risk factor in gastric carcinogenesis leading to epithelial mutagenesis, and may affect gastric epithelial stem cells. To characterize the expression of Lgr5, a marker of epithelial stem cells in human gastric mucosa, to determine whether Hp infection affects Lgr5-positive epithelial cells (LPECs) and ...
Jeya Marimuthu - - 2012
BPKS from Botrytis cinerea is a novel type III polyketide synthase that accepts C(4)-C(18) aliphatic acyl-CoAs and benzoyl-CoA as the starters to form pyrones, resorcylic acids and resorcinols through sequential condensation with malonyl-CoA. The catalytic efficiency (k(cat)/K(m)) of BPKS was 2.8 × 10(5) s(-1) M(-1) for palmitoyl-CoA, the highest ever ...
Van Sickels Joseph E - - 2012
INTRODUCTION: While closure of an anterior open bite with a mandibular procedure may predispose a surgical case to instability, there are instances where this type of treatment planning is indicated. METHODS AND MATERIALS: In this paper, the authors review the advantages and disadvantages of this approach and present three cases ...
Cavallo Luigi Maria - - 2012
BACKGROUND: Pituitary surgery is a continuous evolving specialty of neurosurgery, requiring precise anatomical knowledge, technical skills and integrated appreciation of the pathophysiology. METHODS: We herein detail the features of the endoscopic endonasal approach for the management of pituitary adenomas, as experienced at the Division of Neurosurgery of the Universita' degli ...
Nedashkovskaya Olga I - - 2012
A novel Gram-negative, facultatively anaerobic and motile bacterial strain, designated KMM 6351(T), was isolated from the sea urchin Strongylocentrotus intermedius and examined using a polyphasic taxonomic approach. A phylogenetic analysis based on 16S rRNA gene sequencing revealed that the strain formed a distinct phyletic line in the class Gammaproteobacteria and ...
Biering-Sørensen F F Clinic for Spinal Cord Injuries, Glostrup Hospital and Rigshospitalet, Copenhagen, Denmark. - - 2012
To develop an International Spinal Cord Injury (SCI) Musculoskeletal Basic Data Set as part of the International SCI Data Sets to facilitate consistent collection and reporting of basic musculoskeletal findings in the SCI population. International. A first draft of an SCI Musculoskeletal Basic Data Set was developed by an international ...
Heyn Holger H Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, - - 2012
Knowledge of epigenetic alterations in disease is rapidly increasing owing to the development of genome-wide techniques for their identification. The ever-growing number of genes that show epigenetic alterations in disease emphasizes the crucial role of these epigenetic alterations - particularly DNA methylation - for future diagnosis, prognosis and prediction of ...
Menees Stacy - - 2012
Diarrhoea and constipation are common clinical complaints that negatively affect quality of life, reduce work productivity and lead to considerable health-care expenditure. A variety of therapies have been used to treat these conditions. Unlike drugs that require systemic absorption to exert their effects, luminally acting agents improve diarrhoea and constipation ...
Wang Xiaojuan - - 2012
The regulatory activities of mouse CD4(+)Foxp3(+) T cells on various immune cells, including NK cells, have been well documented. Under some conditions, conventional CD4(+)Foxp3(-) T cells in the periphery are able to acquire inhibitory function on other T cells, but their roles in controlling innate immune cells are poorly defined. ...
Moody Laura A - - 2012
ARABIDILLO proteins regulate multicellular root development in Arabidopsis thaliana. Conserved ARABIDILLO homologues are present throughout land plants, even in early-evolving plants that do not possess complex root architecture, suggesting that ARABIDILLO genes have additional functions. Here, we have cloned and characterised ARABIDILLO gene homologues from two early-evolving land plants, the ...
Scherwath Angela - - 2012
BACKGROUND: Owing to its neurotoxicity, allogeneic hematopoietic stem cell transplantation (HSCT) carries risks for cognitive impairment. In this multicenter study, we prospectively evaluated cognitive functioning and its medical and demographic correlates in patients undergoing allogeneic HSCT. METHODS: A total of 102 patients were consecutively assessed prior to (T(0) ), 100 ± 20 days ...
Vystavna Y - - 2012
The research focuses on the monitoring of trace metals and pharmaceuticals as potential anthropogenic indicators of industrial and urban influences on surface water. This study includes analysis of tracers use for the indication of water pollution events and discussion of the detection method of these chemicals. The following criteria were ...
Zarit Steven H SH Department of Human Development and Family Studies, Penn State University, University Park, PA, USA. - - 2013
There has been growing interest in providing tailored or adaptive interventions to family caregivers as a way of addressing their heterogeneity of risk factors and other needs. A particular challenge in an adaptive study is to implement the individualized intervention protocol as planned (program fidelity). This study explores the fidelity ...
Marcellin Patrick - - 2012
Objective: This analysis examines the safety profile of standard- versus high-dose peginterferon alfa-2a. Methods: Data were pooled from five trials including HCV genotype 1- or 4-infected naive and treatment-experienced patients (n = 2,940). Patients were randomized to receive peginterferon alfa-2a at 180 μg/week (standard-dose; n = 1,672) or 360 μg/week ...
Wang Rui-Feng - - 2012
BACKGROUND: Functional dyspepsia-epigastric pain syndrome (FD-EPS) is characterized pathophysiologically by visceral hypersensitivity, but the effect of the temperature stimulation on gastric function has been seldom studied. AIM: The purpose of this study was to investigate the effects of liquid nutrients at different temperatures on the gastric accommodation, sensitivity, and gastric-wall ...
Wilkinson Anna - - 2012
To recognize that a picture is a representation of a real-life object is a cognitively demanding task. It requires an organism to mentally represent the concrete object (the picture) and abstract its relation to the item that it represents. This form of representational insight has been shown in a small ...
Kawayama Tomotaka - - 2012
Dear Editor: We appreciate the thoughtful comments of Dr Yohannes regarding our article. In our study(1) , we showed that 12 of 14 COPD patients diagnosed with depression had comorbid sleep disorders, while only 2 of these 14 (14%) COPD patients did not have sleep disorders. Exacerbations and hospitalizations were ...
Takahashi Satoshi - - 2012
We report on a patient with LGG, in whom NBS mapping confirmed relocation of the primary motor cortex (M1) concurrent with multistage surgery. Comparing the NBS results at 18 months with the initial results revealed that the M1 representation had shifted from the precentral to the postcentral gyrus. The patient underwent ...
Leblanc Gabriel - - 2012
Tuning the Fermi energy of silicon through doping leads to alignment of silicon bands with the redox active sites of photosystem I. Integrating photosystem I films with p-doped silicon results in the highest reported photocurrent enhancement for a biohybrid electrode based on photosystem I.
Gamboni Sarah E - - 2012
Gallic acid esters or gallates are antioxidants used as preservatives in food and cosmetics. Few cases of gallates causing allergic contact dermatitis (ACD) have been reported in the literature. We present a case report of a 42-year-old beauty therapist who presented with a swollen tongue. Patch testing was positive to ...
de Ville de Goyet Jean - - 2012
de Ville de Goyet J, Lo Zupone C, Grimaldi C, D'Ambrosio G, Candusso M, Torre G, Monti L. Meso-Rex bypass as an alternative technique for portal vein reconstruction at or after liver transplantation in children: Review and perspectives. Abstract:  Direct portal revascularization can be achieved by interposing a vascular graft ...
Reinebrant Hanna E - - 2012
Neuronal injury is a key feature of neonatal hypoxic-ischemic (HI) brain injury. However, the mechanisms underpinning neuronal losses, such as in the brainstem, are poorly understood. One possibility is that disrupted neural connections between the cortex and brainstem may compromise the survival of neuronal cell bodies in the brainstem. We ...
Wang Ying - - 2012
A fast and cheap in situ approach is presented for the characterization of gold nanoparticles from electrochemical experiments. The average size and number of nanoparticles deposited on a glassy carbon electrode are determined from the values of the total surface area and amount of gold obtained by lead underpotential deposition ...
Macfarlane D J - - 2012
Knowing the inter-unit variability, especially the technological error, is important when using many physiological measurement systems, yet no such inter-unit analysis has been undertaken on duplicate automated gas analysis systems. This study investigated the inter-unit performance of two identical ParvoMedics TrueOne 2400 automated gas analysis systems during a range of ...
Taraszewska Anna - - 2012
Giant cell glioblastoma multiforme (GCGBM) is a rare variant of glioblastoma, occurring predominantly in the cerebral hemispheres. Its infratentorial localization has been documented occasionally, while GCGBM in the cerebellopontine angle (CPA) region has not been described so far. We report a case of GCGBM presenting primarily as an extraaxial bilateral ...
Qu Jie - - 2012
Curled up: TiO(2) -B nanotubes with two curled layers are successfully prepared by a facile hydrothermal route and subsequent calcination. The two curled layers produce a thin wall, and thus the obtained double-walled structure results in short distances of electron and lithium-ion transport, thereby leading to an improved high-rate performance.
Poirier Christophe C Vascular Biology Center, Georgia Health Sciences University, 1459 Laney-Walker Boulevard, CB-3701, Augusta, GA 30912, USA. - - 2012
Neutral sphingomyelinase 2 (nSMase2) upregulation was recently demonstrated to serve as a molecular link between smoke inhalation and emphysematous changes in lungs. Here we report that nSMase2 deficit impairs lung development in mice. We have shown previously that fragilitas ossium (fro) mice carry a mutation in the Smpd3 gene, rendering ...
Mosher Catherine E CE Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA. - - 2013
Although costs of lung cancer care have been documented, economic and social changes among lung cancer patients' family caregivers have yet to be fully examined. In addition, research has not focused on caregivers with greater need for support services. This study examined various economic and social changes among distressed family ...
Soto Paula C PC Department of Pathology, University of California, San Diego and Veterans Affairs San Diego Healthcare System, La Jolla, CA, - - 2013
Human and chimpanzee CD4+ T cells differ markedly in expression of the inhibitory receptor Siglec-5, which contributes towards differential responses to activating stimuli. While CD4+ T cells from both species are equally susceptible to HIV-1 infection, chimpanzee cells survive better, suggesting a cell-intrinsic difference. We hypothesized that Siglec-5 expression protects ...
Martin Caitlin C Tissue Mechanics Laboratory, Biomedical Engineering Program and Mechanical Engineering Department, University of Connecticut, 207 Bronwell Building, Storrs, CT 06269-3139, - - 2013
One of the major failure modes of bioprosthetic heart valves is non-calcific structural deterioration due to fatigue of the tissue leaflets. Experimental methods to characterize tissue fatigue properties are complex and time-consuming. A constitutive fatigue model that could be calibrated by isolated material tests would be ideal for investigating the ...
McKay Jennifer L - - 2012
Mercury (Hg) adversely affects the health and behavior of exposed wildlife; however, behavioral effects remain largely unknown. Changes in avian singing behavior may affect a male's fitness because song reveals male quality and thus influences female mate choice and male territory-holding ability. Nelson's sparrows (Ammodramus nelsoni) live exclusively on salt ...
Sørbye Liv W - - 2012
Scand J Caring Sci; 2012 Hip fracture and urinary incontinence - use of indwelling catheter postsurgery Background:  Norway has a higher incidence of hip fractures than any other country. For older individuals, a hip fracture may cause dramatic changes in health status like incontinence and daily activities. Patients with hip ...
Radtke Finn M - - 2012
PURPOSE: Systematic monitoring of sedation, pain and delirium in the ICU is of paramount importance in delivering adequate patient care. While the use of systematic monitoring instruments is widely agreed upon, these tools are infrequently implemented into daily ICU care. The aim of this study is to compare the effectiveness ...
de Ávila Erica Dorigatti - - 2012
INTRODUCTION: Patients with dentofacial deformities present difficulties at work and in social adaptation. At the same time, they often appear depressed, and as a consequence, the psychosocial aspects of surgery play an important role. The aim of this study was to investigate the effects that depression causes in the quality ...
Fan Jiang-Tao - - 2012
PURPOSE: To evaluate the diagnostic and prognostic value of serum YKL-40 in endometrial cancer (EC). METHODS: Serum YKL-40 levels were detected and compared in 34 of the 50 cases with EC before surgery, in 22 of the 34 with EC after surgery, in 30 cases with uterine myoma, and in ...
Quang Thuy Tran - - 2012
OBJECTIVE: To evaluate the feasability and safety of rotablation atherectomy in a suboptimally expanded stent. METHODS: Seven pigs underwent suboptimal stent expansion in the left anterior descending coronary. Pulverization of the stent struts was performed by rotablation atherectomy with two different burr sizes. Two types of control porcine models were ...
Brown Paul - - 2012
DNA chains and their movement in solvent, may now be controlled simply by surfactant binding and the switching "on" and "off" of a magnetic field adding a new paradigm to the study and control, condensation and manipulation of DNA (and other biomolecules). Such control is essential for biotechnological applications such ...
Wang H F - - 2012
Study design:A retrospective hospital-based study.Objectives:To describe the epidemiologic features of traumatic spinal cord injury (TSCI) in Anhui Province.Setting:Two hospitals within Anhui Province, China.Methods:We retrospectively reviewed the hospital records on all patients with TSCI, admitted between 1 January 2007 and 31 December 2010 (n=761). Variables included age, gender, occupation, neurological level, ...
Ravinder - - 2012
The development of new therapeutic leads against leishmaniasis relies primarily on screening of a large number of compounds on multiplication of clinically irrelevant transgenic promastigotes. The advent of the successful in vitro culture of axenic amastigotes allows the development of transgenic axenic amastigotes as a primary screen which can test ...
Zhang Xuan - - 2012
Diethylstilbestrol (DES) is a nonsteroidal synthetic estrogen widely used in estrogen therapy. In animal models, exposure to DES disrupts the outgrowth of the gubernacula, leading to testis maldescent. However, it remains unclear whether the effects of DES on gubernaculum are direct or indirect, and the underlying mechanisms are largely obscure. ...
Flint Harry J HJ Microbiology group, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, UK. - - 2012
The microbial communities that colonize different regions of the human gut influence many aspects of health. In the healthy state, they contribute nutrients and energy to the host via the fermentation of nondigestible dietary components in the large intestine, and a balance is maintained with the host's metabolism and immune ...
Fan X - - 2012
Fan X, Borba CPC, Copeland P, Hayden D, Freudenreich O, Goff DC, Henderson DC. Metabolic effects of adjunctive aripiprazole in clozapine-treated patients with schizophrenia. Objective:  This study examined the effects of adjunctive aripiprazole therapy on metabolism in clozapine-treated patients with schizophrenia. Method:  In an 8-week randomized, double-blind, placebo-controlled study, subjects ...
Andrews William J - - 2012
IQGAPs are cytoskeletal scaffolding proteins which collect information from a variety of signalling pathways and pass it on to the microfilaments and microtubules. There is a well-characterised interaction between IQGAP and calmodulin through a series of IQ-motifs towards the middle of the primary sequence. However, it has been shown previously ...
Pemberton Barry C - - 2012
Cucurbiturils are a family of molecular container compounds with superior molecular recognition properties. The use of cucurbiturils for supramolecular catalysis is highlighted in this concept. Both photochemical reactions as well as thermal transformations are reviewed with an eye towards tailoring substrates for supramolecular catalysis mediated by cucurbiturils.
Streja Leanne - - 2012
We report on the results of a low-intensity behavioral intervention to reduce second hand smoke (SHS) exposure of children with asthma from low income minority households in Los Angeles, California. In this study, 242 child/adult dyads were randomized to a behavioral intervention (video, workbook, minimal counseling) or control condition (brochure). ...
Lean M E J ME Human Nutrition, School of Medicine, University of Glasgow, Glasgow, UK. - - 2013
To document changes in body mass index (BMI) and waist circumference (WC) over a 10-year period 1998-2008, in representative surveys of adults. Adults aged 18-72 in the Scottish Health Surveys conducted in 1998, 2003 and 2008 were divided, separately for men and women, into eleven 5-year age bands. 'Synthetic birth-cohorts' ...
Garala Kanai - - 2012
An audit identifying all surgical bone donors over a 10 year period was conducted. Postcodes were used to link data from the index of multiple deprivation (IMD) 2007 to give each donor a deprivation score. An audit from 2000 to 2010 of primary total hip replacement (THR) patients was also conducted, ...
Ye Danna - - 2012
Functional hepatocytes differentiated in vitro from mesenchymal stem cells (MSCs) need to be fully characterized before they could be applied as a therapy to treat liver disease. Here, we employed Fourier Transform Infrared (FTIR) microspectroscopy to investigate the characteristics of hepatocyte-like cells derived from rat bone marrow mesenchymal stem cells ...
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