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Results 251 - 300 of 2195
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Sudhinaraset May - - 2012
China's rates of internal migration increased to an all-time high of over 200 million individuals at the beginning of the twenty-first century. Yet, there is a dearth of information on the lives of young migrant populations. The aim of this study was to explore how migration influences the sexual attitudes ...
Allen K K Langford House, Equine Hospital, University of Bristol, Langford, UK. - - 2013
The effect of palatal instability (PI) on measures of ventilation and gas exchange is not well understood. To assess to what degree different severities of naturally occurring palatal dysfunction affect ventilation and gas exchange during strenuous exercise. A retrospective study was performed using data collected from 40 Thoroughbred racehorses diagnosed ...
Karlas Thomas - - 2012
Abstract Objective. Noninvasive investigation of liver fibrosis with ultrasound-based elastography and laboratory-based fibrosis indices have been established in various chronic liver diseases within the last years. We aimed to evaluate feasibility and diagnostic value of transient elastography (TE), acoustic radiation force impulse imaging (ARFI), and different serologic fibrosis indices in ...
Frascaroli Elisabetta - - 2012
Recent advances in high-throughput sequencing technologies have triggered a shift toward single-nucleotide polymorphism (SNP) markers. A systematic bias can be introduced if SNPs are ascertained in a small panel of genotypes and then used for characterizing a larger population (ascertainment bias). With the objective of evaluating a potential ascertainment bias ...
Limbers Christine A - - 2012
The objective of the present study was to assess demographic and disease-specific factors associated with perceived cognitive problems in children and adolescents with heart disease. 246 children with congenital heart disease ages 8-18 years and their parents completed the Cognitive Problems Scale of the Pediatric Quality of Life Inventory Cardiac Module. ...
Sauerborn Melody - - 2012
PURPOSE: The immunological processes underlying immunogenicity of recombinant human therapeutics are poorly understood. Using an immune tolerant mouse model we previously demonstrated that aggregates are a major trigger of the antidrug antibody (ADA) response against recombinant human interferon beta (rhIFNβ) products including Betaferon®, and that immunological memory seems to be ...
Ghazi Arjumand - - 2012
Aging and reproduction are two defining features of our life. Historically, research has focused on the well-documented decline in reproductive capacity that accompanies old age, especially with increasing maternal age in humans. However, recent experiments in model organisms such as worms, flies and mice have shown that a dialogue in ...
Besses Carlos - - 2012
Objective: To ascertain the role of patient age as an influencing factor in the pharmacokinetics of anagrelide and to clarify whether different dosing is required in young (18 - 50 years) vs. elderly (≥ 65 years) patients with essential thrombocythemia (ET). Method: This Phase II, multicenter, open-label study compared the ...
Charalambous Despina C DC Department of Biological Sciences, University of Cyprus, University Avenue 1, 1678, Nicosia, Cyprus. - - 2013
KIF1Bβ is a kinesin-like, microtubule-based molecular motor protein involved in anterograde axonal vesicular transport in vertebrate and invertebrate neurons. Certain KIF1Bβ isoforms have been implicated in different forms of human neurodegenerative disease, with characterization of their functional integration and regulation in the context of synaptic signaling still ongoing. Here, we ...
Bryan M - - 2012
Abstract AIMS: To determine if inequality in height between claws within each hindlimb of dairy cattle is a risk factor for the development of lameness and to determine the effect of preventive trimming of these claws on the subsequent risk of lameness. METHODS: Cows (n=2,695) on three dairy farms in ...
Sykes Dave - - 2012
Abstract The aim of this study was to assess the external validity and reliability of a novel rugby league match simulation protocol. With ethical approval, 16 males (age 22.4 ± 7.1 years, estimated [Formula: see text]52.1 ± 4.5 ml · kg(-1) · min(-1)) performed the rugby league match simulation protocol on two occasions 10 to 14 days apart. During ...
Louwen R - - 2012
Guillain-Barré syndrome (GBS) is a post-infectious disease in which the human peripheral nervous system is affected after infection by specific pathogenic bacteria, including Campylobacter jejuni. GBS is suggested to be provoked by molecular mimicry between sialylated lipooligosaccharide (LOS) structures on the cell envelope of these bacteria and ganglioside epitopes on ...
Rast Luzia - - 2012
This study was completed to determine the prevalence and distribution of Toxocara vitulorum infection in cattle and buffalo calves and investigate its clinical impact in northern Lao PDR (Peoples Democratic Republic). The results aim to assist decisions on disease control measures that can contribute to increasing cattle and buffalo productivity ...
Hara Yoshiaki - - 2012
Patent ductus venosus (PDV) is a rare condition of a congenital portosystemic shunt from the umbilical vein to the inferior vena cava. This report presents the case of an adult patient with PDV, who was successfully treated with laparoscopic shunt division. A 69-year-old male was referred with hepatic encephalopathy. Contrast-enhanced ...
Allamani Allaman - - 2012
Alcohol-related policies and the prevention of alcohol use-related problems, as well as their creation, are accomplished through planned interventions- laws, social and health programs, community-based initiatives-as well as through complex social movements and efforts implemented by the communities. Among both citizens and alcohol use intervention experts, the following three human ...
Chen Da - - 2012
When paired with high-powered chemometric analysis, spectrometric methods offer great promise for the high-throughput analysis of complex systems. Effective classification or quantification often relies on signal preprocessing to reduce spectral interference and optimize the apparent performance of a calibration model. However, less frequently addressed by systematic research is the affect ...
Briani C - - 2012
BACKGROUND AND PURPOSE: Chemotherapy-induced peripheral neuropathy is a major adverse effect of Oxaliplatin (OXL) treatment. Whereas neurophysiologic study is commonly used to assess the occurrence and severity of polyneuropathies, ultrasound (US) analysis of the peripheral nerves, an emerging technique in the study of peripheral nerve diseases, has never been used ...
Tozzi Alberto E - - 2012
Tozzi AE, Mazzotti E, Di Ciommo VM, Dello Strologo L, Cuttini M. Quality of life in a cohort of patients diagnosed with renal failure in childhood and who received renal transplant. Abstract:  Studies on HRQOL on kidney-transplanted young adults who had a diagnosis of chronic renal failure (CRF) in the ...
Moshaverinia Alireza - - 2012
The objectives of this study were to: (1) develop an injectable and biodegradable scaffold based on oxidized alginate microbeads encapsulating periodontal ligament (PDLSCs) and gingival mesenchymal stem cells (GMSCs); and (2) investigate the stem cell viability, and osteogenic differentiation of the stem cells in vitro. Stem cells were encapsulated using ...
Vila Jorge A - - 2012
Since chemical shifts provide important and relatively accessible information about protein structure in solution, a Web server, CheShift-2, was developed for structure interrogation, based on a quantum mechanics database of (13)C( α ) chemical shifts. We report the application of CheShift-2 to a local inconsistency between two X-ray crystal structures ...
Garganis Kyriakos - - 2012
Of 47 patients with onset of intractable partial seizures and temporal lobe MRI lesions, subjected to presurgical evaluation and temporal lobe surgery, we identified eight (mean age: 24 years; range: 7-52 years) demonstrating surface interictal and/or ictal EEG features suggestive of an extratemporal localisation. All eight patients underwent surgery aiming ...
Dias Camila Arnaldo Olhê - - 2012
The protein eukaryotic initiation factor 5A (eIF5A) is highly conserved among archaea and eukaryotes, but not in bacteria. Bacteria have the elongation factor P (EF-P), which is structurally and functionally related to eIF5A. eIF5A is essential for cell viability and the only protein known to contain the amino acid residue ...
Saha S - - 2012
The untapped potential of the beneficial alleles from Gossypium barbadense L. has not been well utilized in G. hirsutum L. (often referred to as Upland cotton) breeding programs. This is primarily due to genomic incompatibility and technical challenges associated with conventional methods of interspecific introgression. In this study, we used ...
Kuner Ruprecht - - 2012
Loss of cell cycle control is a prerequisite for cancer onset and progression. In prostate cancer, increased activity of cell cycle genes has been associated with prognostic parameters such as biochemical relapse and survival. The identification of novel oncogenic and druggable targets in patient subgroups with poor prognosis may help ...
Nave Rüdiger - - 2012
Background: Intranasal fentanyl spray (INFS, Instanyl®) was developed to treat cancer patients with Breakthrough Pain (BTP). INFS is delivered via a multi-dose delivery system (MDS) that is available in various dose strengths. The aim of this study was to demonstrate the pharmacokinetic bioequivalence of INFS single dose delivery system (SDS) ...
Choi Sang-Ho - - 2012
Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa. The increasing prevalence of antimicrobial resistance and the limited number of antimicrobial agents in development have necessitated a review of the current status of treatments involving ceftazidime. This review focuses on studies examining the in vitro ...
Whiteoak Christopher J - - 2012
The use of phenolic compounds as organocatalysts is discussed in the context of the atom-efficient cycloaddition of carbon dioxide to epoxides, forming useful cyclic organic carbonate products. The presence and cooperative nature of adjacent phenolic groups in the catalyst structure results in significantly enhanced catalytic efficiencies, allowing these CO(2) fixation ...
Azpeitia Eugenio - - 2012
Recent reports have shown that the molecular mechanisms involved in root stem-cell niche development in Arabidopsis thaliana are complex and contain several feedback loops and non-additive interactions that need to be analyzed using computational and formal approaches. Complex systems cannot be understood in terms of the behavior of their isolated ...
Beamer Edward - - 2012
We investigated the anticonvulsant and neurobiological effects of a highly selective neuronal nitric oxide synthase (nNOS) inhibitor, N (w) -propyl-l-arginine (L-NPA), on kainic acid (KA)-induced status epilepticus (SE) and early epileptogenesis in C57BL/6J mice. SE was induced with 20 mg/kg KA (i.p.) and seizures terminated after 2 h with diazepam (10 mg/kg, i.p). L-NPA ...
Liu Dan - - 2012
One-end-connected short poly(ethylene glycol) (PEG) side chains were facilely introduced into the poly(N-isopropylacrylamide) (PNIPAm) nanocomposite hydrogel (NC gel) via in situ copolymerization of NIPAm monomer and PEG macromonomer in the aqueous suspension of hectorite clay Laponite XLS. The NC gels were characterized with Fourier transform infrared and x-ray photoelectron spectroscopy ...
Vieth Joshua A - - 2012
OBJECTIVE: To determine if receptor localization into lipid rafts, or the lipid rafts themselves, are important for FcγRIIa effector functions. MATERIAL: Wild-type FcγRIIa or mutant FcγRIIa(C208A) that does not translocate to lipid rafts were transfected into Chinese hamster ovary (CHO) cells which have been shown to be reliable cells for ...
Gold C - - 2012
Gold C, Erkkilä J, Crawford MJ. Shifting effects in randomised controlled trials of complex interventions: a new kind of performance bias? Objective:  Randomised controlled trials (RCTs) aim to provide unbiased estimates of treatment effects. However, the process of implementing trial procedures may have an impact on the performance of complex ...
Ramsook Ryan R - - 2012
Low back pain is a common condition that is encountered by both primary care physicians as well as various specialists, which include: orthopedic surgeons, physical medicine and rehabilitation specialists, neurologists, rheumatologists, and pain management specialists. Associated muscular pain is very common and often a reactive response from nociception from other ...
Davis Wendy M - - 2012
Web-based sexual-health promotion efforts often utilise reverse discourse - the acknowledgement and rejection of shame associated with stigmatised terms - both to challenge judgments about 'risky' behaviours (e.g., casual sex) and to appeal to young people. This study examines the use of reverse discourse in Internet-based sexual-health promotion and analyses ...
Murray Michael J - - 2012
The Rho GTP exchange factor, Pebble (Pbl), long recognised as an essential activator of Rho during cytokinesis, also regulates mesoderm migration at gastrulation. Like other cell cycle components, pbl expression patterns broadly correlate with proliferative tissue. Surprisingly, in spite of its role in the early mesoderm, pbl is downregulated in ...
Iijima Kazutoshi - - 2012
We previously identified zinc finger (ZF) protein ZNF385B as a molecule specifically expressed in Burkitt's lymphoma (BL) among hematologic malignancies. Here we investigated ZNF385B expression in healthy B cells in a variety of hematological tissues by RT-PCR and immunohistochemistry. ZNF385B expression was found to be limited to a subset of ...
Mertaniemi Henrikki - - 2012
When water droplets impact each other while traveling on a superhydrophobic surface, we demonstrate that they are able to rebound like billiard balls. We present elementary Boolean logic operations and a flip-flop memory based on these rebounding water droplet collisions. Furthermore, bouncing or coalescence can be easily controlled by process ...
McDowell Matthew T - - 2012
In situ transmission electron microscopy (TEM) is used to study the electrochemical lithiation of high-capacity crystalline Si nanoparticles for use in Li-ion battery anodes. The lithiation reaction slows down as it progresses into the particle interior, and analysis suggests that this behavior is due not to diffusion limitation but instead ...
Jiang Xiaobing - - 2012
The expression of efflux pump gene lde in ciprofloxacin resistant (Cip(R) ) and susceptible strains of L. monocytogenes collected from retail food samples was investigated. For the two Cip(R) strains the MICs of ciprofloxacin decreased four- to eightfold in the presence of reserpine, however no significant alteration was observed in ...
Brown Michael F - - 2012
Bumblebees were exposed to a discrimination procedure in which reinforcement was contingent on choice of one of two spatial locations. The correct choice depended on whether a stimulus display contained two identical stimuli or two different stimuli. Some bees were trained with color stimuli and tested with line grating stimuli ...
Jonchere Vincent V - - 2012
ABSTRACT: BACKGROUND: In Gallus gallus, eggshell formation takes place daily in the hen uterus and requires large amounts of the ionic precursors for calcium carbonate (CaCO3). Both elements (Ca2+, HCO3-) are supplied by the blood via trans-epithelial transport. Our aims were to identify genes coding for ion transporters that are ...
Kartkaya Kazim - - 2012
Gallic acid, a polyphenyl class natural product from gallnut and green tea, is known to be antioxidant, anti-inflammatory and radical scavenger. In this study, we aimed to investigate the possible protective effects of gallic acid on paraoxonase and arylesterase activities in liver exposed to acute alcohol intoxication. Paraoxonase and arylesterase ...
Ruocco Maria Grazia MG Department of Pathology, New York University School of Medicine, New York, New York 10016, - - 2012
A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance, such as cytotoxic T lymphocyte-associated protein 4 (CTLA-4). However, the determinants of response to anti-CTLA-4 mAb treatment remain incompletely understood. In murine models, anti-CTLA-4 mAbs alone fail to induce effective immune responses to poorly immunogenic tumors ...
El-Hage C M - - 2012
Reasons for performing study: During the 2007 Australian equine influenza (EI) outbreak, an accelerated primary course 14 day intervaccination schedule was proposed, but not widely implemented. Expert opinion was divided as to the efficacy of such a schedule given the lack of published data. This study determined the level and ...
Seidel Thorsten - - 2012
ATP-hydrolysis and proton pumping by the vacuolar-type proton translocating ATPase (V-ATPase) are subject to redox regulation in mammals, yeast and plants. Oxidative inhibition of the V-ATPase is ascribed to disulfide-bond formation between conserved cysteine residues at the catalytic site of subunit A. Subunits containing amino acid substitutions of one of ...
Gu Sa-Sa - - 2012
SUMMARY AT A GLANCE: In this study, mice developed hypocalcaemia and hyperparathyroidism following ureteric obstruction. The authors describe subsequent changes in the mRNA expression of target genes and microarchitectrural changes in the proximal tibia, likely to be precursors of renal osteodystrophy. They suggest that in addition to established genetic pathways, ...
Holness Howard K - - 2012
A new mechanism is proposed that describes the gas-phase separation of chiral molecules found in amphetamine-type substances (ATS) by the use of high-resolution ion mobility spectrometry (IMS). Straight-chain achiral alcohols of increasing carbon chain length, from methanol to n-octanol, are used as drift gas modifiers in IMS to highlight the ...
Curtis J Thomas JT Department of Pharmacology and Physiology, Oklahoma State University-Center for Health Sciences, 1111 West 17th St, Tulsa, OK 74107-1898, - - 2013
Serotonin (5-HT) has been implicated in centrally mediated compensatory responses to volume loss in rats. Accordingly, we hypothesized that slowly developing, non-hypotensive hypovolemia increases serotonin in the hindbrain nucleus of the solitary tract (NTS). We produced volume loss in adult male rats by administering hyperoncotic polyethylene glycol (PEG) and then ...
Owens John - - 2012
BACKGROUND: Personalization - most often understood in terms of granting patients greater opportunity to participate in, and make choices about, the services they receive - has become a key principle guiding reform of the English NHS. OBJECTIVE: This study sets out to explore the relationship between two senses of the ...
Wang Qin - - 2012
Therapy-induced cellular senescence (TCS), characterized by prolonged cell cycle arrest, is an in vivo response of human cancers to chemotherapy and radiation. Unfortunately, TCS is reversible for a subset of senescent cells, leading to cellular re-proliferation and ultimately tumor progression. This invariable consequence of TCS recapitulates the clinical treatment experience ...
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