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Results 101 - 150 of 2194
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Yin H - - 2012
Allergic asthma is associated with excessive T helper type 2 (Th2) cells activation and airway hyperreactivity (AHR), implicated in the context of significant morbidity and mortality. Soluble ST2, a member of the interleukin (IL)-1 receptor family, has been shown to play a critical role in modulation of inflammatory disorders, yet ...
Dellalibera-Joviliano R - - 2012
Thromboangiitis obliterans (TAO) is a segmental inflammatory occlusive disorder that affects the arm and leg arteries of young smokers. The immune system seems to play a critical role in the aetiology of TAO; however, knowledge of the aspects involved in the progression of vascular tissue inflammation and, consequently, the evolution ...
Ohlsson S M - - 2012
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). It is not known why ANCA develop, but it has been shown that they participate in pathogenesis by activating polymorphonuclear neutrophils (PMNs). In this study we hypothesize that dysregulation ...
Marques R G - - 2012
When total splenectomy is inevitable, heterotopic splenic autotransplantation seems to be the only alternative to maintain the functions of the spleen. The present study was carried out to analyse the critical mass of splenic autotransplant (SAT) for the development of phagocytic activity in rats. Wistar rats were submitted to total ...
Lee K - - 2012
Forkhead box protein 3 (FoxP3(+)) regulatory T (T(reg)) cells and interleukin (IL)-17-producing T helper 17 (Th17) cells have opposing effects on autoimmunity, as the former are crucial for maintaining self-tolerance while the latter play a key role in precipitating inflammatory autoimmune diseases. Here we report that Bacillus-derived poly-γ-glutamic acid (γ-PGA) ...
Fairman P - - 2012
Dendritic cells (DC) are mediators of the adaptive immune response responsible for antigen presentation to naive T cells in secondary lymph organs. Human immunodeficiency virus (HIV-1) has been reported to inhibit the maturation of DC, but a clear link between maturation and function has not been elucidated. To understand further ...
Giustini Andrew J - - 2012
The success of magnetic nanoparticle (mNP)-based diagnostic and therapeutic techniques is dependent upon how the mNP are distributed in vivo. The potential efficacy and timing of a given magnetic nanoparticle treatment or diagnostic test is largely determined by the number of nanoparticles in each tissue and microscopic compartment: e.g., in ...
Figueiredo Marcondes M Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. - - 2012
Venous ulcers are a frequent complication of venous disease, and a variety of healing methods have been proposed for these lesions. The objective of this study was to provide late follow-up data for a group of patients with venous ulcers who presented with advanced chronic venous insufficiency and were treated ...
Coulthard L R LR NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, - - 2012
Anti-tumour necrosis factor (TNF) biologics have revolutionized therapy of rheumatoid arthritis (RA). We compared the effects of infliximab on numbers of circulating leucocyte subsets in early RA (disease/symptom duration of ≤1 year) and late RA patients (>1 year). A control group consisted of early RA patients treated with a combination ...
Michel Vera V Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, - - 2013
Vacuolar ATPases (V-ATPases) comprise specialized and ubiquitously distributed pumps that acidify intracellular compartments and energize membranes. To gain new insights into the roles of V-ATPases in prostate cancer (PCa), we studied the effects of inhibiting V-ATPase pumps in androgen-dependent (LNCaP) and androgen-independent (C4-2B) cells of a human PCa progression model. ...
Savović Jelena J School of Social and Community Medicine, University of Bristol, Bristol, - - 2012
Published evidence suggests that aspects of trial design lead to biased intervention effect estimates, but findings from different studies are inconsistent. This study combined data from 7 meta-epidemiologic studies and removed overlaps to derive a final data set of 234 unique meta-analyses containing 1973 trials. Outcome measures were classified as ...
Jiang Xue-Feng - - 2012
Ultra-high-Q optical whispering gallery microcavities are promising platforms for fundamental studies and applied photonics. A new type of on-chip microcavity is experimentally realized, which features both highly unidirectional emission and ultra-high-Q factors exceeding 100 million in near infrared. By doping erbium into the microcavity, lasing emission in 1550 nm band ...
Valev V K - - 2012
Circularly polarized light can impart a sense of rotation on the electron density in ring-shaped gold nanostructures. V. K. Valev and co-workers show on p. OP208 that the near-field enhancement becomes more homogeneous on the surface of the nanostructures, thereby increasing the opportunity for interaction with molecules. This type of ...
Zheng Jian Yao - - 2012
A core/sheath structure is fabricated by decorating single-crystal organic nanowires with H(2) O(2) -reactive peroxalate ester, as reported by J. Yao, Y. S. Zhao, and co-workers on page OP194. The shell of the nanocable is highly sensitive and selective to the H(2) O(2) molecules, demonstrated by the generation of chemiluminescence ...
Kim Dong Hyun - - 2012
Smoking has long been associated with osteoporosis, decreased bone mineral density, increased risk of bone fracture, and increased health costs. Nicotine, the main component of cigarette smoke, has major negative effects on bone metabolism and skeletal remodeling in vivo. Although osteoblasts and osteoblast-like cells have been used extensively to study ...
Bhatia S K - - 2012
Alcaligenes sp. MTCC 10674 was isolated as acetone cyanohydrin hydrolyzing bacterium from soil of orchid gardens of Himachal Pradesh. Acetone cyanohydrin hydrolyzing activity of this organism comprised nitrile hydratase and amidase activities. It exhibited higher substrate specificity towards aliphatic hydroxynitrile (acetone cyanohydrin) in comparison to arylaliphatic hydroxynitrile. Isobutyronitrile (40 mM) acted ...
Blank W - - 2012
Ultrasonic examination of the thyroid is essential in any diagnostic process on the thyroid. It helps to meet the challenge of identifying the few malignant among the thousands of benign nodules. Besides tumour infiltration in surrounding tissue and lymph node metastases - which may prove thyroid cancer - there are ...
Gysel W - - 2012
Ultrasound is poorly established in East Africa because of missing finances and medical staff. The Foundation for medical know how transfer SmW installed in the last 3 years an ultrasound departement in all District Hospitals in the South Province Mombasa in Kenya and was teaching the medical staff 2-3 times ...
Gassmann B - - 2012
Digitization is found everywehre in sonography. Printing of ultrasound images using the videoprinter with special paper will be done in single cases. The documentation of sonography procedures is more and more done by saving image sequences instead of still frames. Echocardiography is routinely recorded in between with so called R-R-loops. ...
da Silveira Vanessa Gass - - 2012
A Ketogenic Diet (KD) mimics the anticonvulsant effects of fasting, which are known to suppress seizures. The purinergic system has been investigated in the matter of epilepsy development, especially the nucleoside adenosine, which has been considered a natural brain anticonvulsant. During epileptic seizures, extracellular adenosine concentration rises rapidly to micromolar ...
Wilhelm C - - 2012
To defect incidence of development hip dysplasia by hip ultrasound and to determine efficacy of early treatment: a pilot study in Ulan Bator, Mongolia. Until recently, in Mongolia, early detection and treatment of DDH (developmental dysplasia of the hip) in the first months of life was not possible. A high ...
Rosenberg I - - 2012
The correct setting of the ultrasound equipment is a perequisite for a high quality of the ultrasound examination. Both the B-mode ultrasonography, as well as the Doppler technique offer interesting alternative settings that are often inadequately used. This brief summary of basic settings should help the practicing clinicians in everyday ...
Schwarzenbach H R - - 2012
Based on the prevalence of asymptomatic kidney stones (5% in our general ward, in accordance with the literature) the value of abdominal ultrasonography in the clinical assessment of a suspected kidney-colic is discussed. The eminent importance of the stone-analysis is emphasized. In addition, the most common causes of kidney stone ...
Dietschi A - - 2012
Since the early 1990's, ultrasound through the development of high-resolution probes in the musculoskeletal system has become more and more important. The development of ultrasound technology has gone hand in hand with the development of know-how in different clinical fields, so that diagnostic ultrasound has now become an indispensable diagnostic ...
Risio M - - 2012
Adenomas represent the morphological precursors of the vast majority of colorectal cancers: although every adenoma has the capacity of malignant evolution, most adenomas stabilize their progression or even regress. Pathological factors are predictive of the natural history of adenomas in terms of potential and time interval for becoming malignant. Regression ...
Abdel Moneim Ahmed E - - 2012
Studies have shown that pomegranate, Punica granatum Linn. (Lythraceae), has remarkable biological and medicinal properties. However, the effects of pomegranate peel methanolic extract (PPME) on the aluminum-induced oxidative stress and histopathological change have not been reported yet. To determine the effect of PPME (200 mg/kg bwt) on the aluminum chloride (AlCl(3); ...
Dietrich C F - - 2012
Recently the «EFSUMB guidelines and recommendations on the clinical practice of contrast enhanced ultrasound (CEUS): Update 2012 on non-hepatic applications» have been published. In the following paper a short summary and comments on the guidelines are given.
Schellhaas S - - 2012
Focused ultrasound is a key methodology of critical care medicine. By referencing few ultrasound differential diagnosis, it is possible to identifying in real-time the reason of the critical state of a patient. Therefore typical focused ultrasound protocols were developed. The well known Focused Assessment with Sonography for trauma (FAST) was ...
Hagara D - - 2012
Ultrasound-based technologies are competing more and more success-fully against computerized tomography and magnetic resonance based imaging procedures. This thanks to technological improvements as well as accumulating evidence, stemming from properly conducted controlled clinical studies. The reduced cost and radiation safety issues are additional arguments in its favor. This article reviews ...
Núñez-Nogueira Gabriel - - 2012
Environmental metal pollution is one of the major problems faced by humankind. This type of pollution affects aquatic systems (estuaries, coastal lagoons, etc.), which are very dynamic systems, therefore making the study of the effects on the organisms that inhabit them an essential issue. In this study, the capacity of ...
Seidel Thorsten - - 2012
ATP-hydrolysis and proton pumping by the vacuolar-type proton translocating ATPase (V-ATPase) are subject to redox regulation in mammals, yeast and plants. Oxidative inhibition of the V-ATPase is ascribed to disulfide-bond formation between conserved cysteine residues at the catalytic site of subunit A. Subunits containing amino acid substitutions of one of ...
Gu Sa-Sa - - 2012
SUMMARY AT A GLANCE: In this study, mice developed hypocalcaemia and hyperparathyroidism following ureteric obstruction. The authors describe subsequent changes in the mRNA expression of target genes and microarchitectrural changes in the proximal tibia, likely to be precursors of renal osteodystrophy. They suggest that in addition to established genetic pathways, ...
Holness Howard K - - 2012
A new mechanism is proposed that describes the gas-phase separation of chiral molecules found in amphetamine-type substances (ATS) by the use of high-resolution ion mobility spectrometry (IMS). Straight-chain achiral alcohols of increasing carbon chain length, from methanol to n-octanol, are used as drift gas modifiers in IMS to highlight the ...
Woźniak Jowita - - 2012
The brachial plexus is an important nervous system structure. It can be injured during the perinatal period and by postnatal damage. The goal of this study was to assess human fetal brachial plexus variability. A total of 220 brachial plexuses were surgically prepared from 110 human fetuses aged 14-32 weeks of ...
Sarici Ahmet M - - 2012
BACKGROUND: This study investigated the use of gamma-knife-based stereotactic radiosurgery (GKRS) for medium- and large-sized posterior uveal melanoma treatment. METHODS: We assessed 50 eyes from 50 consecutive patients with uveal melanoma who were treated with GKRS. All tumors met the criteria for medium- and large-sized uveal melanomas. Patients underwent a ...
Meinersmann R J - - 2012
Waterways should be considered in the migration routes of Campylobacter, and the genus has been isolated from several water sources. Inferences on migration routes can be made from tracking genetic types in populations found in specific habitats and testing how they are linked to other types. Water samples were taken ...
Hussain Ahmed - - 2012
Gelatin scaffolds incorporating or not 50 wt% of magnesium calcium phosphate (MCP) or β-tricalcium phosphate (βTCP) were prepared and the in vitro osteogenic differentiation of rat bone marrow mesenchymal stem cells (MSCs) in the scaffolds was investigated. The pore sizes of the scaffolds were in the range 123.8 ± 47.2-153 ± 60.72 µm in diameter, while ...
Patel Imran I - - 2012
Normal function and physiology of the epidermis is maintained by the regenerative capacity of this tissue via adult stem cells (SCs). However, definitive identifying markers for SCs remain elusive. Infrared (IR) spectroscopy exploits the ability of cellular biomolecules to absorb in the mid-IR region (λ = 2.5-25 μm), detecting vibrational transitions of chemical ...
Peng Liang - - 2012
Patched homolog 1 (PTCH1) is a known tumor suppressor that regulates the Hedgehog (Hh) pathway and has been implicated in tumorigenesis. The role of PTCH1 in colon carcinogenesis, however, is controversial. The aim of the present study was to investigate epigenetic modifications of PTCH1 in aberrant crypt foci (ACF), the ...
Greenhoot Andrea Follmer - - 2012
This study explored the connections between multiple measures of meaning making and psychological adjustment in people with and without histories of abuse. Young adults (n = 177), recollected their three most stressful memories and rated them on importance and emotional and sensory qualities. We analysed the narratives for lexical markers ...
González-Renteria Siblie Marbey - - 2012
BACKGROUND: The SLC38A4 gene is related with system "A" activity, which seems to be related with impaired gluconeogenesis. The objective of this study was to determine if the 292 C > T and 1304 G > A polymorphisms of SLC38A4 gene are associated with hyperglycemia, in humans. METHODS: A total of 227 individuals were enrolled ...
Schurman Jennifer Verrill - - 2012
The objective of the current study was to assess the factor structure of the Illness Behavior Encouragement Scale (IBES) by Walker and Zeman (1992) among children with functional gastrointestinal disorders (FGIDs). Two hundred seventy nine children (63 % female), and 135 primary caregivers (90.8 % mothers), recruited from a large Midwestern children's ...
Desroches M - - 2012
A technique is presented, based on the differential geometry of planar curves, to evaluate the excitability threshold of neuronal models. The aim is to determine regions of the phase plane where solutions to the model equations have zero local curvature, thereby defining a zero-curvature (inflection) set that discerns between sub-threshold ...
Owens John - - 2012
BACKGROUND: Personalization - most often understood in terms of granting patients greater opportunity to participate in, and make choices about, the services they receive - has become a key principle guiding reform of the English NHS. OBJECTIVE: This study sets out to explore the relationship between two senses of the ...
Wang Qin - - 2012
Therapy-induced cellular senescence (TCS), characterized by prolonged cell cycle arrest, is an in vivo response of human cancers to chemotherapy and radiation. Unfortunately, TCS is reversible for a subset of senescent cells, leading to cellular re-proliferation and ultimately tumor progression. This invariable consequence of TCS recapitulates the clinical treatment experience ...
McNicholas F - - 2012
Two factors predict treatment outcome, how effective the treatment is and whether the patient takes or follows the treatment plan. As clinicians or scientists, we strive to develop newer and more effective treatments, both pharmacological and non-pharmacological to improve treatment outcome in our patient population. Adherence is the single most ...
Zhu Tracy Y - - 2012
We assessed the relationship of bone density and microarchitecture between hand, peripheral, and axial skeletal sites using high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual-energy X-ray absorptiometry (DXA) in patients with rheumatoid arthritis (RA) and which factors influence these parameters. This was a cross-sectional study of 100 female patients (53.4 ± 9.3 years) ...
Felton Sarah - - 2012
This article reviews recent data on the expression, regulation and activation of antimicrobial peptides (AMP) in human skin, and considers their potential protective and pro-inflammatory roles following upregulation by ultraviolet radiation (UVR). Antimicrobial peptides are small peptides that are key components of the innate immune system, originally identified by their ...
Moore Ann M - - 2012
Unwanted sexual experiences are most frequently examined from the woman's perspective, yet these experiences happen to men as well. Part of the reason for the paucity of studies on coerced sexual experiences among men is the difficulty in gathering information about such experiences. This study examines the prevalence of unwanted ...
Blockley Nicholas P - - 2012
The dynamics of the blood oxygenation level-dependent (BOLD) response are dependent on changes in cerebral blood flow, cerebral blood volume and the cerebral metabolic rate of oxygen consumption. Furthermore, the amplitude of the response is dependent on the baseline physiological state, defined by the haematocrit, oxygen extraction fraction and cerebral ...
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