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Results 501 - 550 of 2194
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Tian Geng - - 2012
Specificity and versatility in cAMP signalling are governed by the spatial localization and temporal dynamics of the signal. Phosphodiesterases (PDEs) are important for shaping cAMP signals by hydrolyzing the nucleotide. In pancreatic β-cells, glucose triggers sub-plasma membrane cAMP oscillations important for insulin secretion, but the mechanisms underlying the oscillations are ...
Mottolese Carmine - - 2012
The cerebellum is a major motor structure. However, in humans, its efferent topographical organization remains controversial and indirectly inferred from neuroimaging and animal studies. Even central questions such as 'Can we evoke limb movements by stimulating the cerebellar cortex?' have no clear answer. To address this issue, we electrically stimulated ...
Wenge Ulrike - - 2012
Lock it, but not too much: LNA units (locked or bridging nucleic acids) in LNA:DNA hybrids lead to a negative effect on electron transfer (ET), but they also force the nucleic acid structure in the A-type double helix, which allows a better base stacking than the normal B-type and thus ...
Sutrisno Andre - - 2012
Metal-organic frameworks (MOFs) are an extremely important class of porous materials with many applications. The metal centers in many important MOFs are zinc cations. However, their Zn environments have not been characterized directly by (67) Zn solid-state NMR (SSNMR) spectroscopy. This is because (67) Zn (I=5/2) is unreceptive with many ...
Geng Rong-Qing - - 2012
The efficacy of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of mitochondrial 12S rRNA gene in identification of goat cashmere and sheep wool samples was evaluated. The specific fragments of the mitochondrial 12S rRNA gene, which were about 440 bp, were obtained using the PCR. Restriction enzyme digestion of the ...
Marci R - - 2012
The aim of this prospective observational study is to determine the different outcomes of IVF/ICSI treatments after using antagonists or agonists of gonadotrophin-releasing hormone (GnRH) for controlled ovarian hyperstimulation (COH) in normal responder patients. Two hundred forty-seven patients undergoing IVF treatment at the Centre of Reproductive Medicine, Rome (CERMER), from ...
Li Steve Po-Yam - - 2012
A new class of phosphorescent cyclometalated iridium(III)-polyamine complexes [{Ir(N^C)(2) }(n) (bPEI)](PF(6) )(n) (bPEI=branched poly(ethyleneimine), average M(w) =25 kDa, n=15.6-27.4; HN^C=2-phenylpyridine Hppy (1 a), 2-((1,1'-biphenyl)-4-yl)pyridine Hpppy (2 a), 2-phenylquinoline Hpq (3 a), 2-phenylbenzothiazole Hbt (4 a), 2-(1-naphthyl)benzothiazole Hbsn (5 a)) and [Ir(N^C)(2) (en)](PF(6) ) (en=ethylenediamine; HN^C=Hppy (1 b), Hpppy (2 b), Hpq (3 b), Hbt (4 b), Hbsn (5 b)) have been ...
Habara Maoto - - 2012
AIMS: Restenosis of drug-eluting stents (DESs) might be different from that of bare metal stent restenosis in diverse ways including mechanisms and time course; however, these have not been fully examined. To gain insight into the mechanisms and time course of DES restenosis, we evaluated the characteristics of restenotic lesions ...
Barsotti Giovanni - - 2012
Objective  To determine the prevalence and describe ocular abnormalities in healthy Standardbred foals within 48 h of birth. Animals  One hundred and two neonatal foals. Procedures  All foals had an unassisted delivery. On the basis of physical examination and the results of hematological and biochemical parameters, all foals were unaffected by ...
He Li - - 2012
How cells sense and respond to physical forces is an area of intense investigation, which poses significant challenges for in vitro experiments and even greater obstacles for in vivo studies. Analyses of integrin complex dynamics in Drosophila melanogaster now provide evidence that altering mechanical force modulates the stability of integrin ...
Pereira Joilane Alves - - 2012
Objective: To evaluate the nutritional status and lipid profile of young children from an urban Brazilian region.Methods: Cross-sectional study involving a representative sample of 472 children aged 5-8 years from Jundiai city. The nutritional status was assessed by the body mass index for age. Total cholesterol and fractions (low-density lipoprotein ...
Kaleta Katharina - - 2012
The reaction of different metallocene fragments [Cp(2) M] (Cp=η(5) -cyclopentadienyl, M=Ti, Zr) with diferrocenylacetylene and 1,4-diferrocenylbuta-1,3-diyne is described. The titanocene complexes form the highly strained three- and five-membered ring systems [Cp(2) Ti(η(2) -FcC(2) Fc)] (1) and [Cp(2) Ti(η(4) -FcC(4) Fc)] (2) (Fc=[Fe(η(5) -C(5) H(4) )(η(5) -C(5) H(5) )]) by addition ...
Sharma Mani - - 2012
A series of thiazolopyrimidine derivatives were designed, synthesized and screened for in-vitro inhibition of Dipeptidyl Peptidase IV (DPP IV). The SAR study indicated the influence of substituted chemical modifications on thiazolopyrimidine scaffold. Compound 9 (IC(50) = 0.489 μM) and 10 (IC(50) = 0.329 μM) having heterocyclic substituted piperazine with acetamide ...
Mostafavi Ehsan - - 2012
This study aims to introduce the knowledge hub (KH) as an initiative to facilitate transformation of knowledge into practice and to highlight the activity and limitations with this new policy. The study was conducted through a review of articles; expert views in this field were sought for further information. Regional ...
Hobbs Nicola - - 2012
The Theory of Planned Behaviour (TPB) can identify cognitions that predict differences in behaviour between individuals. However, it is not clear whether the TPB can predict the behaviour of an individual person. This study employs a series of n-of-1 studies and time series analyses to examine the ability of the ...
Crisp Michael D - - 2012
CONTENTS: Summary    1 I. Introduction    1 II. What is phylogenetic niche conservatism?    2 III. Pattern or process?    3 IV. What causes a pattern of PNC?    3 V. Tests for PNC    7 VI. Conclusion: is a concept of PNC scientifically useful? 12 Acknowledgements 13 References 13 SUMMARY: Phylogenetic niche conservatism (PNC) ...
Chang Kwok-Chiu - - 2012
Multidrug-resistant (MDR) tuberculosis (TB) denotes bacillary resistance to at least isoniazid and rifampicin. Extensively drug-resistant (XDR) TB is MDR-TB with additional bacillary resistance to any fluoroquinolone and at least one second-line injectable drugs. Rooted in inadequate TB treatment and compounded by a vicious circle of diagnostic delay and improper treatment, ...
Song Sun Choon - - 2012
BACKGROUND: Low resectability rate and poor survival outcomes after surgical resection for hilar cholangiocarcinoma are common in most institutions. We retrospectively reviewed the surgical outcomes of hilar cholangiocarcinoma in a tertiary institution focusing on the surgical procedures, radicalities, survival rates and independent prognostic factors. METHODS: Two hundred thirty patients who ...
Kafizas Andreas - - 2012
It has often been suggested that anatase-rutile mixtures/composites synergistically enhance photocatalysis. However, in the case of dense thin-films containing an intimate mix of both anatase and rutile phases, such an effect has not been observed. In synthesising combinatorial films with graded film thickness and phase, and applying established photocatalytic mapping ...
Sun Shiguo - - 2012
In order to find the ideal carbon chain linkage number n for achieving the highest ECL in bimetallic ruthenium tris-bipyridyl complexes, a series of novel complexes [(bpy)(2)Ru(bpy')(CH(2))(n)(bpy')Ru(bpy)(2)](4+) (, where bpy is 2,2'-bipyridyl, n = 10, 12, 14) for a coreactant electrochemiluminescence (ECL) system have been synthesized. Their ECL properties at ...
Hwang S D - - 2012
RNA aptamers are artificial nucleic acids that specifically bind to a wide variety of targets. They are an effective tool for pharmaceutical research and development of antiviral agents. Here, we describe four Hirame rhabdovirus (HIRRV)-RNA aptamers (H1, H2, H3 and H4) that we obtained from an in vitro process called ...
Lee Eun Jeong - - 2012
BACKGROUND: The role of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography ((18) F-FDG PET/CT) in evaluating pulmonary artery lesions has not yet been established. The purpose of this study is to evaluate the usefulness of (18) F-FDG PET/CT imaging in differentiating malignant from benign pulmonary artery (PA) lesions. METHODS: In this ...
Laas Enora - - 2012
BACKGROUND AND OBJECTIVES:Preterm birth (PTB) and congenital heart defect (CHD) are 2 major causes of mortality and disability of perinatal origin. There are limited data on the relation between CHD and PTB. Our objective was to use population-based data to estimate the risk of PTB in newborns with CHD and ...
Wang Shengli - - 2012
A new molecularly imprinted polymer (MIP) was synthesized for the selective extraction of mono-substituted sulfonylurea herbicides, with monosulfuron as the template and acrylamide as the functional monomer. The recognition property and affinity of the MIP for monosulfuron and its analog, monosulfuron-ester, were evaluated by equilibrium adsorption and a chromatographic study. ...
Werheit H - - 2012
The isotopic phonon effects in LaB(6) are investigated on the Raman spectra of a series of high-quality single crystals with systematically varied contents of (10)B and (11)B isotopes. A detailed group theoretical analysis enlightens the correlation between distortions of the B(6) octahedra and the splitting or broadening of phonon modes. ...
Błachowski A - - 2012
(57)Fe Mössbauer spectroscopy was applied to investigate the superconductor parent compound Fe(1+x)Te for x = 0.06, 0.10, 0.14, 0.18 within the temperature range 4.2-300 K. A spin density wave (SDW) within the iron atoms occupying regular tetrahedral sites was observed, with the square root of the mean square amplitude at 4.2 K varying between ...
van Wunnik Bart Pw - - 2012
Aim:  Sacral neuromodulation(SMN) plays a major part in the algorithm of managment of faecal incontinence, but there are limited data on its cost-effectiveness. The study aimed to analyse this and quality adjusted life-years associated with two different treatment algorithms. The first (SNM-) included useof an artificial sphincter (dynamic graciloplastya [DGP] ...
Kim Jun Ho - - 2012
The purpose of this study was to evaluate whether conjugated linoleic acid (CLA) exposure during the developmental period increases voluntary activity, which would influence obesity outcome later in life. The effects of dietary supplementation of 0.5% CLA in a high fat diet were evaluated in nescient basic helix-loop-helix 2 (Nhlh2) ...
Alvarenga César Augusto - - 2012
Histological special types (HST) account for about 25% of breast cancers, and correspond to at least 17 pathological entities. However, their molecular characteristics remain to be determined. The purpose of the present study is to apply the recently used immunohistochemical profiling of HST breast carcinomas (BC), as a surrogate for ...
da Silva-Diz V - - 2012
Epidermal keratinocytes and hair follicle (HF) stem cells (SCs) expressing oncogenes are competent at developing squamous cell carcinomas (SCCs) in epidermis and HFs, respectively. To determine whether bulge and hair germ (HG) SCs from HF contribute to SCC generation at distant epidermis, the most frequent epidermal region where these lesions ...
Hamberg Anders - - 2012
The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.
Rezaei-Adaryani Morteza - - 2012
Abstract A long-term challenge to the nursing profession is the concept of image. In this study, we used the Rodgers' evolutionary concept analysis approach to analyze the concept of the nursing image. The aim of this concept analysis was to clarify the attributes, antecedents, consequences, and implications associated with the ...
Logemann Jeri A - - 2012
This manuscript reviews the current state of research on treatment efficacy for swallowing disorders in relation to the use of large-scale randomized multi institutional trials. Dose response trials, i.e., how much treatment is needed to achieve the desired result, are not yet available in dysphagia. The financial and medical pressures ...
Mullins Larry L - - 2012
OBJECTIVE: To determine the feasibility and acceptability of an interdisciplinary intervention for mothers of children newly diagnosed with cancer and to estimate effect sizes for the intervention in reducing distress. Management of illness uncertainty was a key framework for the intervention. METHODS: Mothers (N = 52) were randomly assigned to ...
Jacobson Therese - - 2012
Several metals and metalloids profoundly affect biological systems, but their impact on the proteome and mechanisms of toxicity are not fully understood. Here, we demonstrate that arsenite causes protein aggregation in Saccharomyces cerevisiae. Various molecular chaperones were found to be associated with arsenite-induced aggregates indicating that this metalloid promotes protein ...
Cichoń Tomasz - - 2012
One of the preconditions of effective anticancer therapy is efficient transfer of the therapeutic agent (chemotherapeutic) to tumor cells. Fundamental barriers making drug delivery and action difficult include underoxygenation, elevated interstitial pressure, poor and abnormal tumor blood vascular network and acidic tumor milieu. In this study we aimed at developing ...
Li Chun Hua - - 2012
The interaction of HIV-1 trans-activator protein Tat with its cognate trans-activation response element (TAR) RNA is critical for viral transcription and replication. Therefore, it has long been considered as an attractive target for the development of antiviral compounds. Recently, the conformationally constrained cyclic peptide mimetics of Tat have been tested ...
Sutcu Recep - - 2012
Hypertension is major risk factor leading to cerebrovascular pathologies. N-methyl d-aspartate receptors (NMDARs) and renin-angiotensin system are involved in neuronal plasticity, as well as cognitive functions in the hippocampus. In this study, we examined the effects of lisinopril, an ACE inhibitor, on the levels of hippocampal NMDAR subunits; NR2A and ...
Amano Maho - - 2012
Tumor suppressor p16(INK4a) is known to exert cell-cycle control via cyclin-dependent kinases. An emerging aspect of its functionality is the orchestrated modulation of N/O-glycosylation and galectin expression to induce anoikis in human Capan-1 pancreatic carcinoma cells. Using chemoselective N/O-glycan enrichment technology (glycoblotting) and product characterization, we first verified a substantial ...
Kumeta Masahiro - - 2012
Highly selective nucleocytoplasmic molecular transport is critical to eukaryotic cells, which is illustrated by the size-filtering diffusion and karyopherin-mediated passage mechanisms. However, a considerable number of large proteins without nuclear localization signals are localized to the nucleus. Here, we provide evidence for spontaneous migration of large proteins in a karyopherin-independent ...
Ng Maggie C C - - 2012
The Group XIV tetratolyl series X(C(6) H(4) -CH(3) )(4) (X=C, Si, Ge, Sn, Pb) were studied by using inelastic neutron scattering to measure the low-energy phonon spectra to directly access the methyl-group torsional modes. The effect of increased molecular radius as a function of the size of the central atom was ...
Hammami I - - 2012
Many medicinal plants are designed to improve health but their mechanism of action remains not clear. Among these plants, garlic (Allium sativum) has attracted particular attention of modern medicine because of its widespread use for the prevention and treatment of some human diseases such as cardiovascular diseases and cancer. However, ...
Tookman Laura - - 2012
Objective. Metastatic seminoma is a highly curable disease. Standard treatment comprises of combination chemotherapy. The short- and long-term toxicities of this treatment are increasingly recognised and the possibility of over treatment in such a curable disease should be considered. We have therefore assessed the use of single agent carboplatin at ...
Zeng Zhen - - 2012
In this study, the complete mitochondrial genome of the endangered roughskin sculpin, Trachidermus fasciatus, was first determined. The mitogenome (16,536 bp) consisted of 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and 1 control region. Except for the eight tRNA and ND6 genes, all other mitochondrial genes were encoded on ...
Anglada Josep M - - 2012
The role of the HO(4) (-) anion in atmospheric chemistry and biology is a matter of debate, because it can be formed from, or be in equilibrium with, key species such as O(3) + HO(-) or HO(2) + O(2) (-) . The determination of the stability of HO(4) (-) in ...
Eilertsen Grethe - - 2012
AIM: To interpret and synthesize stroke survivors' experiences of poststroke fatigue. BACKGROUND: Several studies have found fatigue to be a common and distressing difficulty experienced after stroke. This review has synthesized qualitative findings of stroke survivors' experiences of poststroke fatigue with the aim of guiding practice and further research. DATA ...
Steudel Bastian - - 2012
Positive relationship between biodiversity and ecosystem functioning has been observed in many studies, but how this relationship is affected by environmental stress is largely unknown. To explore this influence, we measured the biomass of microalgae grown in microcosms along two stress gradients, heat and salinity, and compared our results with ...
Davis Jennifer C - - 2012
ABSTRACT: BACKGROUND: The appropriateness of cataract surgery procedures has been questioned, the suggestion being that the surgery is sometimes undertaken too early in the disease progression. Our three study questions were: What is the level of visual impairment in patients scheduled for cataract surgery? What is the improvement following surgery? ...
Schiopu Irina - - 2012
Herein we explored the role of topological distribution of aromatic amino acids in peptide-membrane interfacial interactions. The membrane activity of closely related peptides and their binding energy is sensitive to the positioning of minimum two tryptophans, and by the degree of flanking at the membrane interface mediated by aromatic amino ...
Pagny Gaëlle - - 2012
Sharka is a devastating viral disease caused by the Plum pox virus (PPV) in stone fruit trees and few sources of resistance are known in its natural hosts. Since any knowledge gained from Arabidopsis on plant virus susceptibility factors is likely to be transferable to crop species, Arabidopsis's natural variation ...
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