Metal-organic frameworks (MOFs) are an extremely important class of porous materials with many applications. The metal centers in many important MOFs are zinc cations. However, their Zn environments have not been characterized directly by (67) Zn solid-state NMR (SSNMR) spectroscopy. This is because (67) Zn (I=5/2) is unreceptive with many ...

The efficacy of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of mitochondrial 12S rRNA gene in identification of goat cashmere and sheep wool samples was evaluated. The specific fragments of the mitochondrial 12S rRNA gene, which were about 440 bp, were obtained using the PCR. Restriction enzyme digestion of the ...

The aim of this prospective observational study is to determine the different outcomes of IVF/ICSI treatments after using antagonists or agonists of gonadotrophin-releasing hormone (GnRH) for controlled ovarian hyperstimulation (COH) in normal responder patients. Two hundred forty-seven patients undergoing IVF treatment at the Centre of Reproductive Medicine, Rome (CERMER), from ...

A new class of phosphorescent cyclometalated iridium(III)-polyamine complexes [{Ir(N^C)(2) }(n) (bPEI)](PF(6) )(n) (bPEI=branched poly(ethyleneimine), average M(w) =25 kDa, n=15.6-27.4; HN^C=2-phenylpyridine Hppy (1 a), 2-((1,1'-biphenyl)-4-yl)pyridine Hpppy (2 a), 2-phenylquinoline Hpq (3 a), 2-phenylbenzothiazole Hbt (4 a), 2-(1-naphthyl)benzothiazole Hbsn (5 a)) and [Ir(N^C)(2) (en)](PF(6) ) (en=ethylenediamine; HN^C=Hppy (1 b), Hpppy (2 b), Hpq (3 b), Hbt (4 b), Hbsn (5 b)) have been ...

AIMS: Restenosis of drug-eluting stents (DESs) might be different from that of bare metal stent restenosis in diverse ways including mechanisms and time course; however, these have not been fully examined. To gain insight into the mechanisms and time course of DES restenosis, we evaluated the characteristics of restenotic lesions ...

Objective  To determine the prevalence and describe ocular abnormalities in healthy Standardbred foals within 48 h of birth. Animals  One hundred and two neonatal foals. Procedures  All foals had an unassisted delivery. On the basis of physical examination and the results of hematological and biochemical parameters, all foals were unaffected by ...

Understanding the molecular architecture of the flagellum is crucial to elucidate the bending mechanism produced by this complex organelle. The current known structure of the flagellum has not yet been fully correlated with the complex composition and localization of flagellar components. Using cryoelectron tomography and subtomogram averaging while distinguishing each ...

How cells sense and respond to physical forces is an area of intense investigation, which poses significant challenges for in vitro experiments and even greater obstacles for in vivo studies. Analyses of integrin complex dynamics in Drosophila melanogaster now provide evidence that altering mechanical force modulates the stability of integrin ...

Objective: To evaluate the nutritional status and lipid profile of young children from an urban Brazilian region.Methods: Cross-sectional study involving a representative sample of 472 children aged 5-8 years from Jundiai city. The nutritional status was assessed by the body mass index for age. Total cholesterol and fractions (low-density lipoprotein ...

ABSTRACT: BACKGROUND: Adolescents in developing countries face a range of sexual and reproductive health problems. Lack of health care service for reproductive health or difficulty in accessing them are among them. In this study we aimed to examine health care workers' attitudes toward sexual and reproductive health services to unmarried ...

OBJECTIVES: We set out to identify the prognostic factors in adult patients with Candida spp. bloodstream infection, assessing the impact on in-hospital mortality of catheter removal and adequacy of antifungal therapy. METHODS: Patients with positive blood culture for Candida spp. and a central venous catheter in place at the time ...

The reaction of different metallocene fragments [Cp(2) M] (Cp=η(5) -cyclopentadienyl, M=Ti, Zr) with diferrocenylacetylene and 1,4-diferrocenylbuta-1,3-diyne is described. The titanocene complexes form the highly strained three- and five-membered ring systems [Cp(2) Ti(η(2) -FcC(2) Fc)] (1) and [Cp(2) Ti(η(4) -FcC(4) Fc)] (2) (Fc=[Fe(η(5) -C(5) H(4) )(η(5) -C(5) H(5) )]) by addition ...

A series of thiazolopyrimidine derivatives were designed, synthesized and screened for in-vitro inhibition of Dipeptidyl Peptidase IV (DPP IV). The SAR study indicated the influence of substituted chemical modifications on thiazolopyrimidine scaffold. Compound 9 (IC(50) = 0.489 μM) and 10 (IC(50) = 0.329 μM) having heterocyclic substituted piperazine with acetamide ...

This study aims to introduce the knowledge hub (KH) as an initiative to facilitate transformation of knowledge into practice and to highlight the activity and limitations with this new policy. The study was conducted through a review of articles; expert views in this field were sought for further information. Regional ...

Congenital fibrosarcoma (CFS) is a rare fibrous tissue malignancy that usually presents in the first few years of life. It is unique among human sarcomas in that it has an excellent prognosis. We describe a temporal clustering of a number of cases of CFS and investigate the possible associated prenatal ...

CONTEXT The presence of autistic-like traits in relatives of individuals with autism spectrum disorder (ASD) is well recognized, but, to our knowledge, the emergence of these traits early in development has not been studied. OBJECTIVE To prospectively investigate the emergence of autistic-like traits in unaffected (no ASD diagnosis) infant siblings ...

The Theory of Planned Behaviour (TPB) can identify cognitions that predict differences in behaviour between individuals. However, it is not clear whether the TPB can predict the behaviour of an individual person. This study employs a series of n-of-1 studies and time series analyses to examine the ability of the ...

CONTENTS: Summary    1 I. Introduction    1 II. What is phylogenetic niche conservatism?    2 III. Pattern or process?    3 IV. What causes a pattern of PNC?    3 V. Tests for PNC    7 VI. Conclusion: is a concept of PNC scientifically useful? 12 Acknowledgements 13 References 13 SUMMARY: Phylogenetic niche conservatism (PNC) ...

Multidrug-resistant (MDR) tuberculosis (TB) denotes bacillary resistance to at least isoniazid and rifampicin. Extensively drug-resistant (XDR) TB is MDR-TB with additional bacillary resistance to any fluoroquinolone and at least one second-line injectable drugs. Rooted in inadequate TB treatment and compounded by a vicious circle of diagnostic delay and improper treatment, ...

MOTIVATION: Epistasis or gene-gene interaction has gained increasing attention in studies of c omplex diseases. Its presence as an ubiquitous component of genetic architecture of common human diseases has been contemplated. However, the detection of gene-gene interaction is difficult due to combinatorial explosion. RESULTS: We present a novel feature selection ...

BACKGROUND: The aim was to evaluate the repeatability of a new optical low-coherence reflectometric device Lenstar, as well as its agreement with the IOL Master and the Pentacam-HR system in myopes. METHODS: In a prospective study, 56 eyes of 28 myopes were examined with the Lenstar, the IOL Master and ...

Self-poisoning with pesticides or plants is a major clinical problem in rural Asia, killing several hundred thousand people every year. Over the last 17 years, our clinical toxicology and pharmacology group has carried out clinical studies in the North Central Province of Sri Lanka to improve treatment and reduce deaths. ...

Satellite cells (SCs) are stem cells that mediate skeletal muscle growth and regeneration. Here, we observe that adult quiescent SCs and their activated descendants expressed the homeodomain transcription factor Six1. Genetic disruption of Six1 specifically in adult SCs impaired myogenic cell differentiation, impaired myofiber repair during regeneration, and perturbed homeostasis ...

BACKGROUND: Low resectability rate and poor survival outcomes after surgical resection for hilar cholangiocarcinoma are common in most institutions. We retrospectively reviewed the surgical outcomes of hilar cholangiocarcinoma in a tertiary institution focusing on the surgical procedures, radicalities, survival rates and independent prognostic factors. METHODS: Two hundred thirty patients who ...

It has often been suggested that anatase-rutile mixtures/composites synergistically enhance photocatalysis. However, in the case of dense thin-films containing an intimate mix of both anatase and rutile phases, such an effect has not been observed. In synthesising combinatorial films with graded film thickness and phase, and applying established photocatalytic mapping ...

In order to find the ideal carbon chain linkage number n for achieving the highest ECL in bimetallic ruthenium tris-bipyridyl complexes, a series of novel complexes [(bpy)(2)Ru(bpy')(CH(2))(n)(bpy')Ru(bpy)(2)](4+) (, where bpy is 2,2'-bipyridyl, n = 10, 12, 14) for a coreactant electrochemiluminescence (ECL) system have been synthesized. Their ECL properties at ...

RNA aptamers are artificial nucleic acids that specifically bind to a wide variety of targets. They are an effective tool for pharmaceutical research and development of antiviral agents. Here, we describe four Hirame rhabdovirus (HIRRV)-RNA aptamers (H1, H2, H3 and H4) that we obtained from an in vitro process called ...

BACKGROUND: The metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS. METHODS: The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed ...

BACKGROUND: The role of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography ((18) F-FDG PET/CT) in evaluating pulmonary artery lesions has not yet been established. The purpose of this study is to evaluate the usefulness of (18) F-FDG PET/CT imaging in differentiating malignant from benign pulmonary artery (PA) lesions. METHODS: In this ...

BACKGROUND AND OBJECTIVES:Preterm birth (PTB) and congenital heart defect (CHD) are 2 major causes of mortality and disability of perinatal origin. There are limited data on the relation between CHD and PTB. Our objective was to use population-based data to estimate the risk of PTB in newborns with CHD and ...

Insufficient sleep over long durations of the lifespan is believed to adversely affect proper development and healthful aging, although how this might become manifested is unknown. In the present study, rats were repeatedly sleep-restricted during 72 days to permit maladaptations to evolve, thereby permitting study. Densitometric and histomorphometric analyses were ...

A combination of inspiratory and expiratory three-dimensional computed tomographic volumetry provides useful information on pulmonary function and lung volume. We previously reported an early outcome of a patient undergoing living-donor lobar lung transplantation with sparing of the bilateral native upper lobes. Long-term follow-up on such patients had not been reported, ...

A new molecularly imprinted polymer (MIP) was synthesized for the selective extraction of mono-substituted sulfonylurea herbicides, with monosulfuron as the template and acrylamide as the functional monomer. The recognition property and affinity of the MIP for monosulfuron and its analog, monosulfuron-ester, were evaluated by equilibrium adsorption and a chromatographic study. ...

The isotopic phonon effects in LaB(6) are investigated on the Raman spectra of a series of high-quality single crystals with systematically varied contents of (10)B and (11)B isotopes. A detailed group theoretical analysis enlightens the correlation between distortions of the B(6) octahedra and the splitting or broadening of phonon modes. ...

ABSTRACT: BACKGROUND: The discovery of the autotransporter family has provided a mechanism for surface expression of proteins in laboratory strains of Escherichia coli. We have previously reported the use of the AIDA-I autotransport system to express the Salmonella enterica serovar Enteritidis proteins SefA and H:gm. The SefA protein was successfully ...

The prevalence of metabolic syndrome (MetS) parallels the rise in childhood obesity. MetS is associated with neurocognitive impairments in adults, but this is thought to be a long-term effect of poor metabolism. It would be important to ascertain whether these brain complications are also present among adolescents with MetS, a ...

(57)Fe Mössbauer spectroscopy was applied to investigate the superconductor parent compound Fe(1+x)Te for x = 0.06, 0.10, 0.14, 0.18 within the temperature range 4.2-300 K. A spin density wave (SDW) within the iron atoms occupying regular tetrahedral sites was observed, with the square root of the mean square amplitude at 4.2 K varying between ...

To assess when vestibulosympathetic projections become functional postnatally, and to establish a preparation in which vestibulosympathetic circuitry can be characterized more precisely, we used an optical approach to record VIIIth nerve-evoked synaptic inputs to thoracic sympathetic preganglionic neurons (SPNs) in newborn mice. Stimulation of the VIIIth nerve was performed in ...

Aim:  Sacral neuromodulation(SMN) plays a major part in the algorithm of managment of faecal incontinence, but there are limited data on its cost-effectiveness. The study aimed to analyse this and quality adjusted life-years associated with two different treatment algorithms. The first (SNM-) included useof an artificial sphincter (dynamic graciloplastya [DGP] ...

Although tumor surveillance by T and B lymphocytes is well studied, the role of innate immune cells, in particular macrophages, is less clear. Moreover, the existence of subclonal genetic and functional diversity in some human cancers such as leukemia underscores the importance of defining tumor surveillance mechanisms that effectively target ...

BACKGROUND Acute heart failure (AHF) in sub-Saharan Africa has not been well characterized. Therefore, we sought to describe the characteristics, treatment, and outcomes of patients admitted with AHF in sub-Saharan Africa. METHODS The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF) was a prospective, multicenter, observational survey of patients with AHF ...

The purpose of this study was to evaluate whether conjugated linoleic acid (CLA) exposure during the developmental period increases voluntary activity, which would influence obesity outcome later in life. The effects of dietary supplementation of 0.5% CLA in a high fat diet were evaluated in nescient basic helix-loop-helix 2 (Nhlh2) ...

Histological special types (HST) account for about 25% of breast cancers, and correspond to at least 17 pathological entities. However, their molecular characteristics remain to be determined. The purpose of the present study is to apply the recently used immunohistochemical profiling of HST breast carcinomas (BC), as a surrogate for ...

Epidermal keratinocytes and hair follicle (HF) stem cells (SCs) expressing oncogenes are competent at developing squamous cell carcinomas (SCCs) in epidermis and HFs, respectively. To determine whether bulge and hair germ (HG) SCs from HF contribute to SCC generation at distant epidermis, the most frequent epidermal region where these lesions ...

The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.

The preparation of tetrakis((+)-hfbc) lanthanide(III) complexes with an encapsulated alkali metal and ammonium ions M[Ln((+)-hfbc)(4) ] (hereafter abbreviated as M-Ln : (+)-hfbc, (+)-heptafluorobutyrylcamphorate; M, ammonium or benzyl ammonium ions as well as alkali metal ions) was reported and discussed. The electronic circular dichroism (CD) spectra in the intraligand π-π* transition of M-Ln ...

Abstract A long-term challenge to the nursing profession is the concept of image. In this study, we used the Rodgers' evolutionary concept analysis approach to analyze the concept of the nursing image. The aim of this concept analysis was to clarify the attributes, antecedents, consequences, and implications associated with the ...

This manuscript reviews the current state of research on treatment efficacy for swallowing disorders in relation to the use of large-scale randomized multi institutional trials. Dose response trials, i.e., how much treatment is needed to achieve the desired result, are not yet available in dysphagia. The financial and medical pressures ...

OBJECTIVE: To determine the feasibility and acceptability of an interdisciplinary intervention for mothers of children newly diagnosed with cancer and to estimate effect sizes for the intervention in reducing distress. Management of illness uncertainty was a key framework for the intervention. METHODS: Mothers (N = 52) were randomly assigned to ...

Several metals and metalloids profoundly affect biological systems, but their impact on the proteome and mechanisms of toxicity are not fully understood. Here, we demonstrate that arsenite causes protein aggregation in Saccharomyces cerevisiae. Various molecular chaperones were found to be associated with arsenite-induced aggregates indicating that this metalloid promotes protein ...