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Bansal Sandhya S Department of Chemistry, University of Delhi, Delhi 110007, - - 2012
Antibiotic resistance in bacterial pathogens is a serious clinical problem. Novel targets are needed to combat increasing drug resistance in Escherichia coli. Our objective is to demonstrate that 2-(3,4-dimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2yl]-1H-benzimidazole (DMA) inhibits E. coli DNA topoisomerase I more strongly than human topoisomerase I. In addition, DMA is non-toxic to mammalian cells ...
Kim Byeonggwan - - 2012
A solid-state polymerizable monomer, 2,5-dibromo-3,4-propylenedioxythiophene (DBProDOT), was synthesized at 25 °C to produce a conducting polymer, poly(3,4-propylenedioxythiophene) (PProDOT). Crystallographic studies revealed a short interplane distance between DBProDOT molecules, which was responsible for polymerization at low temperature with a lower activation energy and higher exothermic reaction than 2,5-dibromo-3,4-ethylenedioxythiophene (DBEDOT) or its derivatives. ...
Krogh Camilla - - 2012
Bottle-feeding has been suggested to increase the risk of pyloric stenosis (PS). However, large population-based studies are needed. We examined the effect of bottle-feeding during the first 4 months after birth, by using detailed data about the timing of first exposure to bottle-feeding and extensive confounder information. We performed a ...
Hobbs Nicola - - 2012
The Theory of Planned Behaviour (TPB) can identify cognitions that predict differences in behaviour between individuals. However, it is not clear whether the TPB can predict the behaviour of an individual person. This study employs a series of n-of-1 studies and time series analyses to examine the ability of the ...
Crisp Michael D - - 2012
CONTENTS: Summary    1 I. Introduction    1 II. What is phylogenetic niche conservatism?    2 III. Pattern or process?    3 IV. What causes a pattern of PNC?    3 V. Tests for PNC    7 VI. Conclusion: is a concept of PNC scientifically useful? 12 Acknowledgements 13 References 13 SUMMARY: Phylogenetic niche conservatism (PNC) ...
Chang Kwok-Chiu - - 2012
Multidrug-resistant (MDR) tuberculosis (TB) denotes bacillary resistance to at least isoniazid and rifampicin. Extensively drug-resistant (XDR) TB is MDR-TB with additional bacillary resistance to any fluoroquinolone and at least one second-line injectable drugs. Rooted in inadequate TB treatment and compounded by a vicious circle of diagnostic delay and improper treatment, ...
Wang Haitian - - 2012
Epistasis or gene-gene interaction has gained increasing attention in studies of complex diseases. Its presence as an ubiquitous component of genetic architecture of common human diseases has been contemplated. However, the detection of gene-gene interaction is difficult due to combinatorial explosion. We present a novel feature selection method incorporating variable ...
Zhao Jing - - 2013
The aim was to evaluate the repeatability of a new optical low-coherence reflectometric device Lenstar, as well as its agreement with the IOL Master and the Pentacam-HR system in myopes. In a prospective study, 56 eyes of 28 myopes were examined with the Lenstar, the IOL Master and the Pentacam-HR ...
Amano Maho - - 2012
Tumor suppressor p16(INK4a) is known to exert cell-cycle control via cyclin-dependent kinases. An emerging aspect of its functionality is the orchestrated modulation of N/O-glycosylation and galectin expression to induce anoikis in human Capan-1 pancreatic carcinoma cells. Using chemoselective N/O-glycan enrichment technology (glycoblotting) and product characterization, we first verified a substantial ...
Kumeta Masahiro - - 2012
Highly selective nucleocytoplasmic molecular transport is critical to eukaryotic cells, which is illustrated by the size-filtering diffusion and karyopherin-mediated passage mechanisms. However, a considerable number of large proteins without nuclear localization signals are localized to the nucleus. Here, we provide evidence for spontaneous migration of large proteins in a karyopherin-independent ...
Ng Maggie C C - - 2012
The Group XIV tetratolyl series X(C(6) H(4) -CH(3) )(4) (X=C, Si, Ge, Sn, Pb) were studied by using inelastic neutron scattering to measure the low-energy phonon spectra to directly access the methyl-group torsional modes. The effect of increased molecular radius as a function of the size of the central atom was ...
Hammami I - - 2012
Many medicinal plants are designed to improve health but their mechanism of action remains not clear. Among these plants, garlic (Allium sativum) has attracted particular attention of modern medicine because of its widespread use for the prevention and treatment of some human diseases such as cardiovascular diseases and cancer. However, ...
Tookman Laura - - 2012
Objective. Metastatic seminoma is a highly curable disease. Standard treatment comprises of combination chemotherapy. The short- and long-term toxicities of this treatment are increasingly recognised and the possibility of over treatment in such a curable disease should be considered. We have therefore assessed the use of single agent carboplatin at ...
Norris A M AM Department of Medicine, Dartmouth Medical School, Hanover, NH, - - 2013
The mechanisms controlling expression of the putative oncogene Anterior gradient 2 (AGR2) in pancreatic ductal adenocarcinoma (PDAC) are not well understood. We now show that AGR2 is a transforming growth factor-β (TGF-β)-responsive gene in human pancreatic cancer cells, whose downregulation is SMAD4 dependent. We also provide evidence supporting a role ...
Chen Fengshi F Department of Thoracic Surgery, Kyoto University, Kyoto, - - 2012
A combination of inspiratory and expiratory three-dimensional computed tomographic volumetry provides useful information on pulmonary function and lung volume. We previously reported an early outcome of a patient undergoing living-donor lobar lung transplantation with sparing of the bilateral native upper lobes. Long-term follow-up on such patients had not been reported, ...
Wang Shengli - - 2012
A new molecularly imprinted polymer (MIP) was synthesized for the selective extraction of mono-substituted sulfonylurea herbicides, with monosulfuron as the template and acrylamide as the functional monomer. The recognition property and affinity of the MIP for monosulfuron and its analog, monosulfuron-ester, were evaluated by equilibrium adsorption and a chromatographic study. ...
Werheit H - - 2012
The isotopic phonon effects in LaB(6) are investigated on the Raman spectra of a series of high-quality single crystals with systematically varied contents of (10)B and (11)B isotopes. A detailed group theoretical analysis enlightens the correlation between distortions of the B(6) octahedra and the splitting or broadening of phonon modes. ...
Yau Po Lai - - 2012
The prevalence of metabolic syndrome (MetS) parallels the rise in childhood obesity. MetS is associated with neurocognitive impairments in adults, but this is thought to be a long-term effect of poor metabolism. It would be important to ascertain whether these brain complications are also present among adolescents with MetS, a ...
Gaines Michelle V - - 2012
Archival data were collected from 98 male inmates at a psychiatric inpatient unit to examine the utility of the Multiscale Feigning Index (MFI) as a proposed feigning index for the Personality Assessment Inventory (PAI). MFI was compared with existing PAI feigning indices, Malingering (MAL), Negative Impression Management (NIM), and Rogers ...
Borrmann Annika - - 2012
Visualizing biomolecules by fluorescent tagging is a powerful method for studying their behaviour and function inside cells. We prepared and genetically encoded an unnatural amino acid (UAA) that features a bicyclononyne moiety. This UAA offered exceptional reactivity in strain-promoted azide-alkyne cycloadditions. Kinetic measurements revealed that the UAA reacted also remarkably ...
Guillemot Laurent - - 2012
Cingulin (CGN) is a M(r) 140 kDa protein, which is localized in the cytoplasmic region of vertebrate tight junctions (TJ), and regulates gene expression and RhoA signalling in cultured cells. To investigate the function of CGN at the organism level, we generated CGN knockout (CGN(-/-)) mice by homologous recombination. CGN(-/-) ...
Komeya Mitsuru - - 2012
An 82-year-old male patient underwent open left lower-pole partial nephrectomy with a microwave tissue coagulator (Microtaze). Pathological findings showed clear cell renal cell carcinoma, pT1a, Fuhrman grade 2 with negative margins. Then 2 years later, he presented with urinary retention. His urine appeared cloudy and milky only after meals, but appeared normal ...
Bergen Anna - - 2012
The solvatochromic emission properties of five naphthoylurea derivatives with different substitution patterns at the naphthoylurea functionality were investigated, with a particular focus on the influence of inter- and intramolecular H-bonding interactions. The bathochromic shifts of the emission maxima correlate well with the acceptor number or Catalán's acidity of the solvent ...
Sauerbier M - - 2012
This article gives an overview about arthroplasties at the wrist joint, the distal radioulnar joint, and the hand with special emphasis on joint replacement.
Baums Iliana B - - 2012
The expanse of deep water between the central Pacific islands and the continental shelf of the Eastern Tropical Pacific is regarded as the world's most potent marine biogeographic barrier. During recurrent climatic fluctuations (ENSO, El Niño Southern Oscillation), however, changes in water temperature and the speed and direction of currents ...
Taban F - - 2012
BackgroundStudies have reported that breast cancer (BC) units could increase the quality of care but none has evaluated the efficacy of alternative options such as private BC networks, which is our study objective.Patients and methodsWe included all 1404 BC patients operated in the public unit or the private network and ...
Eamer Gwendolen G - - 2012
The vertical transmission of HIV occurs when an HIV-positive woman passes the virus to her baby during pregnancy, delivery or breastfeeding. The World Health Organization's (WHO) Guidelines on HIV and infant feeding 2010 recommends exclusive breastfeeding for HIV-positive mothers in resource-limited settings. Although evidence shows that following this strategy will ...
Ye Shengqing - - 2012
Aryl N-aminosulfonamides could be easily produced via a palladium-catalyzed coupling of aryl halides, potassium metabisulfite, and hydrazines. Potassium metabisulfite is an excellent equivalent of sulfur dioxide in the reaction of palladium-catalyzed aminosulfonylation.
Qureshi Moosa Rashid - - 2012
AIMS: To investigate the experience of clinicians in the management of patients with myelofibrosis, current treatment options and their utility. METHODS: We used an internet-based survey RESULTS: Of 105 respondents (mostly consultants), 79% identified bothersome symptoms as the most common issue to be addressed, while for 19%, lack of efficacy ...
Gil Girol Christian - - 2012
Piecing it together: Aspergillus niger produces kotanin by dimerization of the monomeric, polyketide-synthase-derived (PKS) 7-demethylsiderin. A combined approach, comprising bioinformatics and gene-deletion experiments, identified the biosynthetic cluster responsible for kotanin production. Homology modeling and substrate docking provide a rationale for the regio- and stereoselective phenol coupling reaction.
Asoh Taka-Aki - - 2012
Hydrogel constructs were rapidly fabricated via the electrophoretic adhesion of oppositely charged microbeads. The reversible preparation of hydrogel constructs was achieved by the reconstruction of microbead networks.
Li Qing-Zhong - - 2012
The NCX-NCI-HMY (X=H, Cl, Br, I, Li; M=Be, Mg; Y=H, Li, Na) trimers are investigated to find ways to enhance the iodine-hydride interaction. The interaction energy in the NCI-HMH dimer is -2.87 and -5.87 kcal mol(-1) for M=Be and Mg, respectively. When the free H atom in the NCI-HMH dimer is replaced ...
Fruscio R - - 2012
BackgroundTo assess the long-term oncological outcome and the fertility of young women with early-stage epithelial ovarian cancer (ES/EOC) treated with fertility-sparing surgery (FSS).Patients and methodsAll patients treated with FSS for ES/EOC in two Italian centers were considered for this analysis. Univariate and multivariate analyses were used to test demographic characteristics ...
Barner Caroline - - 2012
OBJECTIVE: The aim of this trial was to evaluate the effect on insulin sensitivity and body composition of combination therapy with GH and insulin-like growth factor I (IGF-I) in adults with GHD and diabetes. DESIGN, PATIENTS AND METHODS: 6 months randomised placebo controlled pilot study. 14 adults with GHD and ...
Suarez Lucina - - 2012
We reviewed the published findings from the Texas Neural Tube Defect Project, a 6-year case-control study (1995-2000) of neural tube defects (NTDs) on the Texas-Mexico border. In this review, we highlight what was learned about environmental, genetic, and nutritional factors (i.e., those related to the folate and other metabolic pathways) ...
Sobolevsky Tim - - 2012
The metabolism of two anabolic steroids - oxymetholone and desoxymethyltestosterone - was reinvestigated to identify new targets potentially valuable for the antidoping analysis. Excretion urine samples from the laboratory reference collection were used in this study. Following fractionation of the urinary extract by means of high performance liquid chromatography (HPLC), ...
Stekhoven Daniel J - - 2012
Genotypic causes of a phenotypic trait are typically determined via randomized controlled intervention experiments. Such experiments are often prohibitive with respect to durations and costs, and informative prioritization of experiments is desirable. We therefore consider predicting stable rankings of genes (covariates), according to their total causal effects on a phenotype ...
Janovská Michaela - - 2012
The full elastic tensor of orthorhombic dysprosium scandate (DyScO(3)) at room temperature was determined by resonant ultrasound spectroscopy (RUS). Measurements were performed on three 500 μm thick substrates with orientations (110), (100) and (001) in the Pbnm (a < b < c) setting. For this purpose, a modification of the RUS method was developed, enabling ...
Tu Yunqiu - - 2012
We report a new strategy for microRNA analysis based on the fluorescence quenching of gold nanoparticles (AuNPs) integrating with a conformation-switched hairpin-structured oligonucleotide probe for improving selectivity.
Lupo Philip J - - 2012
BACKGROUND:There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs ...
Wu Xiao-Feng - - 2012
(C), its (O)K! An efficient palladium-catalyzed carbonylative synthesis of 2-alkylbenzoxazinones has been developed. By starting from 2-bromoanilines and acid anhydrides, the corresponding products were isolated in good yields.
Hahn Yoon-Bong - - 2012
Unique and fascinating features of metal oxide nanostructures (MONs) have attracted considerable attention in recent years because without much effort, the MONs can be grown in many different nanoscale forms, thus allowing various novel devices of chemical and biological sensing to be fabricated. To improve the sensors performance by tailoring ...
García-Martínez Javier - - 2012
A mesostructured Y zeolite was prepared by a surfactant-templated process at the commercial scale and tested in a refinery, showing superior hydrothermal stability and catalytic cracking selectivity, which demonstrates, for the first time, the promising future of mesoporous zeolites in large scale industrial applications.
Uraloğlu Muhammet - - 2012
This study was intended to investigate the healing effect of five different products on split-thickness skin graft (STSG) donor sites and full-thickness cutaneous wounds (FTCWs) using an occlusive dressing model. Six groups were planned, 1 control and 5 experimental groups, with a total of 24 rats, using an occlusive dressing ...
Guo Peng - - 2012
Aim: The aim of the present study was to develop a simple and straightforward method for formulating hydrophobic drugs into nanoparticulate form in a scalable and inexpensive manner. Materials & methods: The nanoporous membrane extrusion (NME) method was used to prepare hydrophobic drug nanoparticles. NME is based on the induced ...
Tian Yuemin - - 2012
Anoctamin 1 (Ano1; TMEM16A) and anoctamin 2 (Ano2; TMEM16B) are novel Cl(-) channels transiently activated by increase in intracellular Ca(2+). These channels are essential for epithelial Cl(-) secretion, smooth muscle peristalsis and olfactory signal transduction. They are central to inherited diseases and cancer and can act as heat sensors. Surprisingly, ...
Eadie Mervyn J - - 2012
William Gowers' classic single-authored two-volume A manual of diseases of the nervous system appeared in a first edition in 1886 and 1888, and in a second edition in 1892 and 1893, with a third edition of Volume 1 in 1899. No third edition of Volume 2 ever appeared. However, in ...
Khoshravesh Roxana - - 2012
C(4) photosynthesis independently evolved >62 times, with the majority of origins within 16 dicot families. One origin occurs in the poorly studied genus Anticharis Endl. (Scrophulariaceae), which consists of ~10 species from arid regions of Africa and southwest Asia. Here, the photosynthetic pathway of 10 Anticharis species and one species ...
Larroque-Lombard Anne-Laure - - 2012
In breast cancer cells expressing c-Src and EGFR, a control of one of the two oncogenes over proliferation and invasion is observed whereas in others, the synergistic interaction between them is required for tumour progression. With the purpose of developing molecules with the highest probability for blocking the adverse effects ...
Hetzer Roland - - 2012
A straightforward tricuspid valve repair technique is illustrated here, which may be employed either for functional (normal valve with dilated annulus) or for primary or organic (Ebstein's anomaly, leaflet retraction/tethering and chordal malposition/tethering, with annular dilatation) tricuspid valve incompetence and for moderate and severe degrees of incompetence, without any residual ...
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