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Hemmrich Karsten - - 2012
Adipose tissue engineering aims to grow fat tissue for soft tissue reconstruction after tumour resection or trauma. However, insufficient progenitor cell differentiation and poor vascularization compromise the generation of clinically applicable adipose tissue. The desired process of neo-adipogenesis seems to be difficult to mimic, even though it takes place in ...
Sandler Netanya G - - 2012
Systemic immune activation is increased in HIV-infected individuals, even in the setting of virus suppression with antiretroviral therapy. Although numerous factors may contribute, microbial products have recently emerged as potential drivers of this immune activation. In this Review, we describe the intestinal damage that occurs in HIV infection, the evidence ...
Godde Kanya - - 2012
A growing body of research is demonstrating increased accuracy in aging from a relatively new method, transition analysis. Although transition analysis was developed for paleodemographic research, a majority of subsequent studies have been in the forensic arena, with very little work in bioarchaeological contexts. Using the Suchey-Brooks pubic symphysis phases, ...
Liu Zhonghua - - 2012
Spider venom is a large pharmacological repertoire containing many biologically active peptides, which may have a potent therapeutic implication. Here we investigated a peptide toxin, named lycosin-I, isolated from the venom of the spider Lycosa Singorensis. In contrast to most spider peptide toxins adopting inhibitor cystine knot (ICK) motif, lycosin-I ...
Bellieni C V - - 2012
Abstract Recent progresses in fetal surgery have raised concern on fetal pain, its long-term consequences and the risks of sudden fetal movements induced by pain. In several studies, surgeons have directly administered opioids to the fetus, while others have considered sufficient the maternally administered analgesics. We performed a review of ...
Moschos Marilita M - - 2012
A 72-year-old woman presented with unexplained, progressive, painless visual loss in the right eye during the past six months. At presentation visual acuity (VA) was 3/60 in the right eye and 6/6 in the left eye. Anterior segment examination and intraocular pressures were normal. Dilated fundoscopy revealed significant macular oedema ...
Lin Wei-Hsiang - - 2012
The telomerase-specific replication-competent oncolytic adenovirus, Telomelysin, was developed for virus-mediated preferential lysis of tumor cells. Its selectivity is derived from a human telomerase reverse transcriptase (hTERT) promoter-driven active viral replication, which occurs in cancer cells with high telomerase activity but not in normal cells lacking such activity. Since the TERT ...
Ioannou C - - 2012
Please cite this paper as: Ioannou C, Talbot K, Ohuma E, Sarris I, Villar J, Conde-Agudelo A, Papageorghiou A. Systematic review of methodology used in ultrasound studies aimed at creating charts of fetal size. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03451.x. Background  Reliable ultrasound charts are necessary for the prenatal assessment of fetal ...
Kameo Hajime - - 2012
Rhodium and iridium complexes bearing a tridentate [PEP] type ligand ([PEP] = {o-(Ph(2)P)C(6)H(4)}(2)E(Me); E = Ge or Sn) were synthesized through the phosphine exchange reaction accompanied by selective E-C bond cleavage. The ligand precursors {o-(Ph(2)P)C(6)H(4)}(2)EMe(2) (E = Ge or Sn) were readily obtained in excellent yields by treating {o-(Ph(2)P)C(6)H(4)}(2)Li with ...
Gupta Subash C - - 2012
Although much has been published about curcumin, which is obtained from turmeric, comparatively little is known about turmeric itself. Turmeric, a golden spice obtained from the rhizome of the plant Curcuma longa, has been used to give color and taste to food preparations since ancient times. Traditionally, this spice has ...
Yassi Annalee - - 2012
Abstract The health service sector has a vital role to play in delivering human immunodeficiency virus (HIV) and tuberculosis (TB) prevention, treatment and care, yet evidence indicates that healthcare workers (HCWs) themselves lack adequate access to HIV and TB services. HCWs are also at increased risk from TB and other ...
Soh Siowling - - 2012
A tomography approach is used to reconstruct 3D cell shapes and, simultaneously, the shapes/positions of the nuclei within these cells. Subjecting the cells to well-defined microconfinements of various diameters allow for relating the steady-state shapes of cells to their static-mechanical properties. The observed shapes show striking regularities between different cell ...
Leiva Marta - - 2012
PURPOSE: To describe the pre-surgical, surgical, and post-surgical considerations for phacoemulsification in non-human primates. METHODS: Records of non-human primates that underwent phacoemulsification by the Ophthalmology Services of FHCV-UAB and HCV-UM, between 2003 and 2009 were reviewed. RESULTS: Five primates were represented: one gorilla, one chimpanzee, one pygmy marmoset, one orangutan, ...
Degidi Marco - - 2012
OBJECTIVES: The aim of this study was to radiographically assess the vertical and horizontal alterations of buccal alveolar bone after the insertion of a post-extractive implant using Bio-Oss(®) Collagen graft. MATERIAL AND METHODS: The study was designed as a prospective study. Adult patients were eligible for the study if they ...
Trotter Timothy N - - 2012
The total synthesis of 7-deoxy-6-O-methylfusarentin (1) and a formal synthesis of 7-deoxy-6,8-O-dimethylfusarentin (2) has been successfully achieved in 10 steps. The described tactic underscores a diastereoselective strategy which incorporates a single acyclic reaction based on the initial stereocenter by means of a 1,3-chelation controlled Reetz-Keck type allylation.
Kim Yong-Jin - - 2012
Position- and morphology-controlled ZnO nanostructures are grown on oxygen plasma-treated, selective area of graphene layers using metal-organic vapor-phase epitaxy. The structural and optical characteristics examined by electron microscopy, cathodoluminescence and photoluminescence techniques indicate that high quality nanostructures are prepared on graphene layers. This approach to selectively grow the controlled ZnO ...
Salles M J C - - 2012
BACKGROUND: The 2009 pandemic influenza A (H1N1) virus spread rapidly throughout Brazil. Non-adjuvanted and the adjuvanted influenza A H1N1/09 monovalent vaccine were recommended as a single dose to persons at risk including renal transplant recipients (RTR). We analyzed the safety and the immune response of 2 influenza A H1N1/09 monovalent ...
Brniak Witold - - 2012
The compendial method of evaluation of orodispersible tablets (ODT) is the same disintegration test as for conventional tablets. Since it does not reflect the disintegration process in the oral cavity, alternative methods are proposed that are more related to in vivo conditions, e.g. modified dissolution paddle apparatus, texture analyzer, rotating ...
Kellosalo Juho - - 2012
Abstract Membrane-bound pyrophosphatases (M-PPases) are enzymes that enhance the survival of plants, protozoans and prokaryotes in energy constraining stress conditions. These proteins use pyrophosphate, a waste product of cellular metabolism, as an energy source for sodium or proton pumping. To study the structure and function of these enzymes we have ...
Dziewulska Anna - - 2012
Abstract Protein kinase C (PKC) activation induced by diacylglycerols (DAGs) is one of the sequels of the dysregulation of intramuscular lipid metabolism and is thought to play an important role in the development of insulin resistance (IR). We tested the hypothesis that DAGs with different acyl chains have different biological ...
Cakmak Bilin Cetinkaya - - 2012
BACKGROUND: The imbalance between pro-inflammatory and anti-inflammatory cytokines may possibly play a role in the development of bronchopulmonary dysplasia (BPD) in preterm infants. Mannose binding lectin (MBL) codon 54 and interleukin 1 receptor antagonist gene (IL1-RN) polymorphisms cause genetic predisposition to increased risk of infection and inflammation, therefore may increase ...
Chesman Anthony S R - - 2012
The isostructural heterometallic complexes [Ln(III)(2)Mn(III)(2)O(2)(ccnm)(6)(dcnm)(2)(H(2)O)(2)] (Ln = Eu (), Gd (), Tb (), Er (); ccnm = carbamoylcyanonitrosomethanide; dcnm = dicyanonitrosomethanide) have been synthesised and structurally characterised. The in situ transition metal promoted nucleophilic addition of water to dcnm, forming the derivative ligand ccnm, plays an essential role in cluster ...
Bagrodia Shubha - - 2012
Cancer drugs that target pivotal signaling molecules required for malignant cell survival and growth have demonstrated striking antitumor activities in appropriately selected patient populations. Unfortunately, however, therapeutic responses are often of limited duration, typically 6-12 months, due to emergence of drug-resistant subclones of tumor cells. In this review, we highlight ...
Figueiredo Rafael L F - - 2012
Objectives: This study aimed to assess the oral health status of the Toronto adult homeless population; to learn how they perceive their own oral health; and to correlate the presence of oral disease with length of homelessness and unemployment. Methods: This cross-sectional descriptive study collected data from 191 homeless adults ...
Moghekar Abhay - - 2012
ABSTRACT: The development of late-onset Alzheimer's disease is believed to be influenced by genetic, socioeconomic, and lifestyle factors. Recently, converging research in animal and human studies has found that beta-amyloid (Aβ) levels in cerebrospinal fluid are modulated by sleep-wake cycles. This raises the possibility that chronic sleep loss causes brain ...
Douglass Kyle M - - 2012
Schwann cell motility was observed on laminin-coated quartz cylinders with different curvatures over an 18 hour period. A new analysis based on difference images helped to determine the minimal radius of curvature, 46 μm, which restricted motility along the cylinder axis. The migration speed, measured by calculating differences between successive ...
López-González Irene - - 2012
Thorn-shaped astrocytes (TsA) are mainly localized in the periventricular white matter of the temporal lobe in a subgroup of aged individuals usually in the context of Alzheimer disease (AD). Immunohistochemistry of TsA shows 4Rtau deposition, tau phosphorylation at different sites recognized with phospho-specific anti-tau antibodies Thr181, Ser202, Ser214, Thr231, Ser396, ...
Kera Kota - - 2012
In eukaryotes, dolichols (C(70-120) ) play indispensable roles as glycosyl carrier lipids in the biosynthesis of glycoproteins on endoplasmic reticulum (ER). In addition to dolichols, seed plants have other types of Z,E-mixed polyisoprenoids termed ficaprenol (tri-trans,poly-cis-polyprenol, C(45-75) ) and betulaprenol (di-trans,poly-cis-polyprenol, C(30-45) and C(≥70) ) in abundance. However, the physiological ...
Sandercock Gavin Rh - - 2012
INTRODUCTION AND AIM: Many physical activity intervention programmes are unable to sustain long-term improvements in activity levels and are often not cost effective. The aim of the study was to determine if a low-cost school- and community-centred sports coaching programme was able to improve health-related fitness in children. METHODS: Children ...
Horling Aline - - 2012
We prepared a number of N-phenethyltetrahydroisoquinolines structurally related to protoberberines. They were tested for activity against bacteria, fungi and human leukaemia HL-60 cells and also for inhibition of biosynthesis: ergosterol in yeasts and cholesterol in human cells. In the latter assay panel, several of the compounds were distinguished by a ...
Bidel Siamak - - 2012
Only few prospective studies have examined the association between coffee consumption and risk of gastric and pancreatic cancer. This study is designed to evaluate this relationship among Finns, whose coffee consumption is the highest in the world. A total of 60,041 Finnish men and women who were 26-74 years of ...
Saa Laura - - 2012
Three innovative assays are developed for the detection of enzymatic activities of glucose oxidase (GOx) and horseradish peroxidase (HRP) by the generation of CdS quantum dots (QDs) in situ using non-conventional enzymatic reactions. In the first assay, GOx catalyzes the oxidation of 1-thio-β-D-glucose to give 1-thio-β-D-gluconic acid. The latter is ...
Kaufman Joan A - - 2012
Abstract There is an urgent need to develop scalable approaches to community-based mental health services for children in rural China and other developing countries involving task shifting from clinicians to trained community workers. Evidence is needed about the effectiveness of interventions for children affected by AIDS in rural areas. This ...
Tan Yan - - 2012
Raman microspectroscopy is a non-destructive, label-free optical technique that offers information-rich molecular analysis of living cells. We report here the first Raman spectral study of human induced pluripotent stem cells (hiPSCs), and compare their Raman features to those of human embryonic stem cells (hESCs) and differentiated progeny of hESCs. Raman ...
Dale Porter W - - 2012
Abstract This study investigated the in vivopulmonary toxicity of inhaled multi-walled carbon nanotubes (MWCNT). Mice inhaled aerosolized MWCNT (10 mg/m(3), 5 hours/day) for 2, 4, 8 or 12 days. MWCNT lung burden was linearly related to exposure duration. MWCNT-induced pulmonary inflammation was assessed by determining whole lung lavage (WLL) polymorphonuclear ...
Sava┼čer Ayhan - - 2012
Metoclopramide HCl (MTC) is commonly used for the management of gastrointestinal disorders. It has a short biological half-life and is usually administered four times daily to maintain effective concentrations throughout the day. The aim of this study is to develop sustained-release hydrophilic matrix tablet formulations of drug to achieve reproducible ...
Chittavong Malavanh - - 2012
The aim of the present study was to investigate feed allowances, body weight (BW), haematocrit, haemoglobin, plasma ionised calcium (iCa), sodium, potassium, pH and glucose concentration and faecal K/Na ratio in local growing pigs, sows and piglets kept by small-holder farmers in Laos. Starting hypotheses were that (1) local pigs ...
Green Uri - - 2012
Once coal is excavated it comes into contact with atmospheric oxygen and begins to undergo low temperature oxidation. The mechanism by which the molecular oxygen interacts with the coal macromolecule is suggested to occur in several steps. These steps primarily involve O(2) diffusion to the surface where physical adsorption followed ...
Park Jisung - - 2012
Objectives: This study examined the associations of daily spiritual experiences (DSE) and social support with depression to find viable coping resources and enhance the quality of life among elderly Korean immigrants. Method: We used Smith's (2003) theory of religious effects and Baron and Kenny's (1986) approach for mediation analysis to ...
Liu Hui - - 2012
Abstract Phase ratio is a measure of effort distribution in the triple jump. Hop-dominant, balanced, and jump-dominant techniques were three triple jump techniques defined based on phase ratio. The purpose of this study was to determine the effect of the phase ratio on the performance of the triple jump. Three-dimensional ...
Avila Thiago C - - 2012
This work presents the use of Raman spectroscopy and chemometrics for on-line control of the fermentation process of glucose by Saccharomyces cerevisiae. In a first approach, an on-line determination of glucose, ethanol, glycerol and cells was accomplished using multivariate calibration based on partial least squares (PLS). The PLS models presented ...
Palem Chinna Reddy - - 2012
The objective of the study was to prepare and characterize the domperidone (DOM) hot-melt extruded (HME) buccal films by both in vitro and in vivo techniques. The HME film formulations contained PEO N10 and/or its combination with HPMC E5 LV or Eudragit RL100 as polymeric carriers, and PEG3350 as a ...
Hall Jean P - - 2012
Objectives: To inform policy with better information about the oral health-care needs of a Medicaid population that engages in employment, that is, people ages 16 to 64 with Social Security-determined disabilities enrolled in a Medicaid Buy-In program. Methods: Statistically test for significant differences among responses to a Medicaid Buy-In program ...
Sachar Ashneet - - 2012
An in-depth understanding of the interactions between cells and three-dimensional (3D) matrices (scaffolds) is pivotal to the development of novel biomaterials for tissue regeneration. However, it remains a challenge to find suitable biomimetic substrates and tools to observe cell-material and cell-cell interactions on 3D matrices. In the present study, we ...
Dumay Anne - - 2012
TP53 is mutated in approximately 30% of breast cancers, but this frequency fluctuates widely between subclasses. We investigated the p53 mutation status in 572 breast tumors, classified into luminal, basal and molecular apocrine subgroups. As expected, the lowest mutation frequency was observed in luminal (26%), and the highest in basal ...
Krüger Eduardo - - 2012
To understand thermal preferences and to define a preliminary outdoor comfort range for the local population of Glasgow, UK, an extensive series of measurements and surveys was carried out during 19 monitoring campaigns from winter through summer 2011 at six different monitoring points in pedestrian areas of downtown Glasgow. For ...
Goetsch Liliane - - 2012
In order to identify new potential targets in oncology, functional approaches were developed using tumour cells as immunogens to select monoclonal antibodies targeting membrane receptors involved in cell proliferation. For that purpose cancer cells were injected into mice and resulting hybridomas were screened for their ability to inhibit cell proliferation ...
Nandy Suman Kumar - - 2012
Cystatins are extensively studied cysteine protease inhibitors, found in wide range of organisms with highly conserved structural folds. S-type of cystatins is well known for their abundance in saliva, high selectivity and poorer activity towards host cysteine proteases in comparison to their immediate ancestor cystatin C. Despite more than 90% ...
Erlandsson Martin - - 2012
Ultraviolet/visible (UV/Vis) absorbance spectroscopy is a commonly used technique for characterizing dissolved organic matter (DOM). We present an analysis of UV/Vis absorbance spectra from 983 lakes throughout Sweden, sampled during autumn 2009. Metrics included both specific absorbances (i.e. absorbance per mass unit of organic carbon), and descriptions of spectral shape. ...
Xing Lidan - - 2012
The oxidation induced reactions of the common lithium battery electrolyte solvent ethylene carbonate (EC) have been investigated for EC(2) using density functional theory and for selected reaction paths using Møller-Plesset perturbation theory (MP4). The importance of explicitly treating at least one solvent molecule interacting with EC during oxidation (removal of ...
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