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Roy Vivek V *Hematology-Oncology Division, Mayo Clinic Florida, Jacksonville, FL †Mayo Clinic Arizona, Scottsdale, AZ ‡Mayo Clinic, Rochester §Duluth CCOP, Duluth, MN ‚ą•Wichita CCOP, Wichita, - - 2013
We conducted a multicenter phase II trial to assess the efficacy and toxicity of docetaxel and carboplatin combination as neoadjuvant therapy for stage II or III breast cancer (BC). Patients received 75 mg/m of docetaxel and AUC 6 of carboplatin on day 1 followed by pegfilgrastim on day 2, every ...
Frye Victoria V Laboratory of Social and Behavioral Sciences, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA, - - 2013
African Americans are overrepresented among heterosexual cases of HIV/AIDS in the USA. Inconsistent condom use and concurrent partnering are two sexual behaviors driving the heterosexual HIV epidemic in the African American community. To inform the development of an HIV prevention behavioral intervention to decrease concurrent partnering and increase condom use ...
Tritos Nicholas A NA Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Zero Emerson Place # 112, Boston, MA 02114, USA. - - 2013
Patients with thyrotropin-secreting pituitary adenomas may present with mass effect, hypopituitarism, and/or hyperthyroidism. The spectrum of pathologic and clinical features of patients whose tumors demonstrate β-thyrotropin immunoreactivity (β-TSH IR) has not been characterized. To characterize the phenotype of patients with pituitary adenomas with positive β-TSH IR, we conducted a retrospective ...
Momeni Arash A Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, 770Welch Road, Suite 400, Palo Alto, CA 94304-5715, USA. - - 2013
The importance of providing high-quality exposure and training in aesthetic and reconstructive surgery during residency has come to the forefront of plastic surgery education. Adequate training in aesthetic surgery, however, has traditionally been challenging. The authors were interested in how these challenges were met abroad. A 17-item online survey was ...
Ranjbar Mani M Simon Fraser University, 8888 University Dr., Burnaby, BC V5A1S6, Canada. - - 2013
We develop an algorithm for structured prediction with nondecomposable performance measures. The algorithm learns parameters of Markov Random Fields (MRFs) and can be applied to multivariate performance measures. Examples include performance measures such as Fβ score (natural language processing), intersection over union (object category segmentation), Precision/Recall at k (search engines), ...
Liu Hong H Center for Biomedical Imaging and Bioinformatics, School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China. - - 2013
Wireless capsule endoscopy (WCE) is a novel technology aiming for investigating the diseases and abnormalities in small intestine. The major drawback of WCE examination is that it takes a long time to examine the whole WCE video. In this paper, we present a new reduction scheme for WCE video to ...
Wen Quan Q Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, - - 2013
Our recent tissue cross-linking studies have raised the possibility of using aliphatic β-nitroalcohols (BNAs) for pharmacologic, therapeutic corneal cross-linking. The present study was performed to determine the permeability of BNAs and to explore the use of permeability-enhancing agents. Ex vivo rabbit corneas were mounted in a typical Franz diffusion chamber. ...
Donnell Deborah J DJ Department of Global Health, University of Washington, Seattle, USA. - - 2013
Clinic-based pill counts of unused study medication are frequently used to measure adherence in HIV-1 prevention trials. Monthly pill count adherence data from the Partners in Prevention HSV/HIV Transmission Study, a double-blind, placebo controlled trial of twice-daily acyclovir suppression of herpes simplex virus type 2 (HSV-2) in HIV-1 infected persons ...
Alwassia Ahmad A - - 2013
To measure choroidal thickness in patients manifesting an acute change in systemic arterial blood pressure using a portable spectral-domain optical coherence tomography device (iVue). Fifteen patients (15 eyes) undergoing cardiac exercise stress testing were scanned using a portable spectral-domain optical coherence tomography system (iVue). Two scan protocols were used: cross ...
Zhu Lin L Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 140 The Fenway, Boston, MA 02115, - - 2013
Nanopreparations such as liposomes, micelles, polymeric and inorganic nanoparticles, and small molecule/nucleic acid/protein conjugates have demonstrated various advantages over "naked" therapeutic molecules. These nanopreparations can be further engineered with functional moieties to improve their performance in terms of circulation longevity, targetability, enhanced intracellular penetration, carrier-mediated enhanced visualization, and stimuli-sensitivity. The ...
Tsai Alexander C AC Center for Global Health, Massachusetts General Hospital, Room 1529-E3, 100 Cambridge Street, 15th Floor, Boston, MA 02114, USA, - - 2013
HIV infection remains highly stigmatized throughout sub-Saharan Africa despite the increasing availability of treatment. HIV-related stigma is commonly described to be highly prevalent in East Africa, but none of these studies have employed validated scales for measurement. We used data from 456 people living with HIV/AIDS in rural Uganda to ...
Farooq Osman - - 2012
Radiation optic neuropathy is a devastating form of vision loss that can occur months to years after radiation therapy for tumors and other lesions located in close proximity to the visual pathways. We present the case of a 24-year-old woman who underwent external beam radiation for treatment of a tectal ...
Nielsen Mette Odegaard - - 2012
CONTEXT Schizophrenic symptoms are linked to a dysfunction of dopamine neurotransmission and the brain reward system. However, it remains unclear whether antipsychotic treatment, which blocks dopamine transmission, improves, alters, or even worsens the reward-related abnormalities. OBJECTIVE To investigate changes in reward-related brain activations in schizophrenia before and after antipsychotic monotherapy ...
Mathews Jose - - 2012
CONTEXT Iatrogenic obesity caused by atypical antipsychotics increases the rate of death from all causes. Olanzapine is a commonly prescribed atypical antipsychotic medication that frequently causes weight gain. To our knowledge, the neural correlates of this weight gain have not been adequately studied in humans. OBJECTIVE To test the hypothesis ...
Olfson Mark - - 2012
CONTEXT Although antipsychotic treatment has recently increased, little is known about how this development has differentially affected the office-based care of adults and young people in the United States. OBJECTIVE To compare national trends and patterns in antipsychotic treatment of adults and youths in office-based medical practice. DESIGN Trends between ...
Roussos Panos - - 2012
CONTEXT Schizophrenia is a common, highly heritable, neurodevelopmental mental illness, characterized by genetic heterogeneity. OBJECTIVE To identify abnormalities in the transcriptome organization among older persons with schizophrenia and controls. DESIGN Weighted gene coexpression network analysis based on microarray transcriptomic profiling. SETTING Research hospital. PATIENTS Postmortem brain tissue samples from 4 ...
Keyes Katherine M - - 2012
CONTEXT The substantial changes in adolescent alcohol use prevalence over time suggest that population-level environmental factors are important determinants of use, yet the potential influence of such environmental factors is inadequately understood. OBJECTIVE To investigate whether adolescents in birth cohorts and/or time periods characterized by restrictive social norms toward alcohol ...
Vaz Josiana A - - 2012
In the present work, methanolic, ethanolic and boiled water extracts of Suillus collinitus were chemically characterised and submitted to an evaluation of their bioactive properties (antioxidant potential and cytotoxic activity in tumor cell lines). Phenolic acids and sugars were identified chromatographically and quantified in the methanolic and boiled water extracts, ...
Gattringer Thomas - - 2012
Increasing availability of neuroimaging has facilitated the diagnosis of cerebral sinus venous thrombosis(CSVT). However, CSVT may also present with unspecific or atypical symptoms, resulting in diagnostic delay.Single reports suggested otologic symptoms as such pitfalls. To screen patients with CSVT for otologic symptoms. Ten-year retrospective case series. Primary and tertiary care ...
Daniels Alan H - - 2012
Biomechanical cadaver investigation. To examine dynamic bending stiffness and energy absorption of the lumbar spine with and without implanted total disc replacement (TDR) under simulated physiological motion. The pendulum testing system is capable of applying physiological compressive loads without constraining motion of functional spinal units (FSUs). The number of cycles ...
Siepmann Timo - - 2012
Cutaneous autonomic function can be quantified by the assessment of sudomotor and vasomotor responses. Although piloerector muscles are innervated by the sympathetic nervous system, there are at present no methods to quantify pilomotor function. To quantify piloerection using phenylephrine hydrochloride in humans. Pilot study. Hospital-based study. Twenty-two healthy volunteers (18 ...
Baker Laura D LD Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, USA. - - 2012
Growth hormone–releasing hormone(GHRH), growth hormone, and insulin like growth factor 1 have potent effects on brain function, their levels decrease with advancing age, and they likely play a role in the pathogenesis of Alzheimer disease. Previously, we reported favorable cognitive effects of short-term GHRH administration in healthy older adults and ...
Davis Nicolynn E - - 2012
Islet cell transplantation has therapeutic potential to cure type 1 diabetes (T1D), which is characterized by autoimmune-mediated destruction of insulin-producing β cells. However, current success rates are limited by long-term decline in islet graft function resulting partially from poor revascularization and immune destruction. Mesenchymal stem cells (MSCs) have the potential ...
Verlinden Marina M The Generation R Study Group, Rotterdam, The - - 2012
To determine whether the amount, type, and patterns of television viewing predict the onset or the persistence of externalizing problems in preschool children. Longitudinal study of a prospective population-based cohort in the Netherlands. Parents reported time of television exposure and type of programs watched by children. Externalizing problems were assessed ...
Jun Gyungah G Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA, - - 2012
To evaluate the association of risk and age at onset (AAO) of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523). Conditional logistic regression models and survival analysis. Fifteen genome-wide association study data sets assembled ...
Puri Nitin N Department of Pharmacology, New York Medical College, Valhalla, New York, USA. - - 2013
Hydrogen peroxide (H(2)O(2)), a nonradical oxidant, is employed to ascertain the role of redox mechanisms in regulation of vascular tone. Where both dilation and constriction have been reported, we examined the hypothesis that the ability of H(2)O(2) to effect vasoconstriction or dilation is conditioned by redox mechanisms and may be ...
Costine Beth A BA Department of Neurosurgery, The Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA. - - 2012
A peripheral indicator of the presence and magnitude of brain injury has been a sought-after tool by clinicians. We measured neuron-specific enolase (NSE), myelin basic protein (MBP), and S100B, prior to and after scaled cortical impact in immature pigs, to determine if these purported markers increase after injury, correlate with ...
George Christine Marie - - 2012
Exposure to arsenic in groundwater via drinking remains unabated for millions of villagers in Bangladesh. Since a blanket testing campaign using test kits almost a decade ago, millions of new wells have been installed but not tested; thus affordable testing is needed. The performance of the Arsenic Econo-Quick (EQ) kit ...
Grøntved Anders - - 2012
BACKGROUND The role of weight training in the primary prevention of type 2 diabetes mellitus (T2DM) is largely unknown. METHODS To examine the association of weight training with risk of T2DM in US men and to assess the influence of combining weight training and aerobic exercise, we performed a prospective ...
McBrien Kerry - - 2012
BACKGROUND Treatment of hypertension in patients with diabetes mellitus (DM) has been shown to improve cardiovascular outcomes; however, the value of intensive blood pressure (BP) targets remains uncertain. We sought to determine the effectiveness and safety of treating BP to intensive targets (upper limit of 130 mm Hg systolic and ...
Zschauer Tim-Christian TC Molecular Cell and Aging Research, IUF--Leibniz Research Institute for Environmental Medicine, University of Duesseldorf gGmbH, Duesseldorf, - - 2013
Many cardiovascular disorders are accompanied by a deregulated cellular redox balance resulting in elevated levels of intracellular reactive oxygen species (ROS). One major antioxidative cellular molecule is thioredoxin-1 (Trx-1). Its indispensability is demonstrated by the embryonic lethality of Trx-1 deficient mice. Trx-1 is ubiquitously expressed in cells and has numerous, ...
Couturier Jérémy J Unité Mixte de Recherches 1136 INRA-Lorraine Université, Interactions Arbres-Microorganismes, IFR 110, Faculté des Sciences, Vandoeuvre Cedex, - - 2013
Three peroxiredoxins (Prxs) were identified in Thermotoga maritima, which possesses neither glutathione nor typical thioredoxins: one of the Prx6 class; one 2-Cys PrxBCP; and a unique hybrid protein containing an N-terminal 1-Cys PrxBCP domain fused to a flavin mononucleotide-containing nitroreductase (Ntr) domain. No peroxidase activity was detected for Prx6, whereas ...
Bréchard Sabrina S Calcium Signaling and Inflammation Group, Life Sciences Research Unit, University of Luxembourg, Luxembourg, - - 2013
Reactive oxygen species, produced by the phagosomal NADPH oxidase of neutrophils, play a significant physiological role during normal defense. Their role is not only to kill invading pathogens, but also to act as modulators of global physiological functions of phagosomes. Given the importance of NADPH oxidase in the immune system, ...
Burgoyne Joseph R JR Department of Cardiology, King's College London, The Rayne Institute, St. Thomas' Hospital, London, - - 2013
Oxidants were once principally considered perpetrators of injury and disease. However, this has become an antiquated view, with cumulative evidence showing that the oxidant hydrogen peroxide serves as a signaling molecule. Hydrogen peroxide carries vital information about the redox state of the cell and is crucial for homeostatic regulation during ...
Singarayer J S - - 2012
The intention of this review is to place crop albedo biogeoengineering in the wider picture of climate manipulation. Crop biogeoengineering is considered within the context of the long-term modification of the land surface for agriculture over several thousand years. Biogeoengineering is also critiqued in relation to other geoengineering schemes in ...
Goldblatt Colin - - 2012
The ultimate climate emergency is a 'runaway greenhouse': a hot and water-vapour-rich atmosphere limits the emission of thermal radiation to space, causing runaway warming. Warming ceases only after the surface reaches approximately 1400 K and emits radiation in the near-infrared, where water is not a good greenhouse gas. This would ...
Davidson Peter - - 2012
The Royal Society report 'Geoengineering the Climate' identified solar radiation management using albedo-enhancing aerosols injected into the stratosphere as the most affordable and effective option for geoengineering, but did not consider in any detail the options for delivery. This paper provides outline engineering analyses of the options, both for batch-delivery ...
Williamson Phillip - - 2012
Fundamental changes to marine chemistry are occurring because of increasing carbon dioxide (CO(2)) in the atmosphere. Ocean acidity (H(+) concentration) and bicarbonate ion concentrations are increasing, whereas carbonate ion concentrations are decreasing. There has already been an average pH decrease of 0.1 in the upper ocean, and continued unconstrained carbon ...
Matthews H Damon - - 2012
The primary objective of the United Nations Framework Convention on Climate Change is to stabilize greenhouse gas concentrations at a level that will avoid dangerous climate impacts. However, greenhouse gas concentration stabilization is an awkward framework within which to assess dangerous climate change on account of the significant lag between ...
Latham John - - 2012
The idea behind the marine cloud-brightening (MCB) geoengineering technique is that seeding marine stratocumulus clouds with copious quantities of roughly monodisperse sub-micrometre sea water particles might significantly enhance the cloud droplet number concentration, and thereby the cloud albedo and possibly longevity. This would produce a cooling, which general circulation model ...
Shepherd J G - - 2012
The climate change that we are experiencing now is caused by an increase in greenhouse gases due to human activities, including burning fossil fuels, agriculture and deforestation. There is now widespread belief that a global warming of greater than 2(°)C above pre-industrial levels would be dangerous and should therefore be ...
Holmes Geoffrey - - 2012
We present a conceptually simple method for optimizing the design of a gas-liquid contactor for capture of carbon dioxide from ambient air, or 'air capture'. We apply the method to a slab geometry contactor that uses components, design and fabrication methods derived from cooling towers. We use mass transfer data ...
Pidgeon Nick - - 2012
Proposals for geoengineering the Earth's climate are prime examples of emerging or 'upstream' technologies, because many aspects of their effectiveness, cost and risks are yet to be researched, and in many cases are highly uncertain. This paper contributes to the emerging debate about the social acceptability of geoengineering technologies by ...
Freeman Christopher - - 2012
Terrestrial and oceanic ecosystems contribute almost equally to the sequestration of ca 50 per cent of anthropogenic CO(2) emissions, and already play a role in minimizing our impact on Earth's climate. On land, the majority of the sequestered carbon enters soil carbon stores. Almost one-third of that soil carbon can ...
Vaughan Naomi E - - 2012
We use a simple carbon cycle-climate model to investigate the interactions between a selection of idealized scenarios of mitigated carbon dioxide emissions, carbon dioxide removal (CDR) and solar radiation management (SRM). Two CO(2) emissions trajectories differ by a 15-year delay in the start of mitigation activity. SRM is modelled as ...
Friedman Gary D - - 2012
In screening pharmaceuticals for possible carcinogenic effects we noted an association between lip cancer risk and the photosensitizing antihypertensive drugs hydrochlorothiazide and nifedipine. In this study, we further characterized the risk of lip cancer associated with these and other commonly used antihypertensive drugs. In a comprehensive medical care program, we ...
Shao Yang - - 2012
We review non-conformal domain decomposition methods (DDMs) and their applications in solving electrically large and multi-scale electromagnetic (EM) radiation and scattering problems. In particular, a finite-element DDM, together with a finite-element tearing and interconnecting (FETI)-like algorithm, incorporating Robin transmission conditions and an edge corner penalty term, are discussed in detail. ...
Turitsyna E G - - 2012
We study numerically optical turbulence using the particular example of a recently created, ultra-long fibre laser. For normal fibre dispersion, we observed an intermediate state with an extremely narrow spectrum (condensate), which experiences instability and a sharp transition to a fluctuating regime with a wider spectrum. We demonstrate that the ...
Ghosh Sudakshina S Department of Pathobiology, Lerner Research Institute, Cleveland, OH 44195, - - 2013
Loss of superoxide dismutase (SOD) activity is a defining biochemical feature of asthma. However, mechanisms for the reduced activity are unknown. We hypothesized that loss of asthmatic SOD activity is due to greater susceptibility to oxidative inactivation. Activity assays of blood samples from asthmatics and healthy controls revealed impaired dismutase ...
Barton Kirston K Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7042, - - 2013
Quiescent HIV-1 infection of resting CD4(+) T cells is an obstacle to eradication of HIV-1 infection. These reservoirs are maintained, in part, by repressive complexes that bind to the HIV-1 long terminal repeat (LTR) and recruit histone deacetylases (HDACs). cMyc and YY1 are two transcription factors that are recruited as ...
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