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Taylor Robert Joseph RJ School of Social Work, Program for Research on Black Americans, Institute for Social Research, University of Michigan, Ann Arbor, MI 48109, USA. - - 2013
This study examines the relationship between religious involvement and 12-month and lifetime DSM-IV major depressive disorder (MDD) within a nationally representative sample of Black Caribbean adults. MDD was assessed using the DSM-IV World Mental Health Composite International Diagnostic Interview (WMH-CIDI). Religious involvement included measures of religious coping, organizational and nonorganizational ...
Teymurazyan A A Department of Physics, University of Alberta, 11322-89 Avenue, Edmonton, AB, T6G 2G7, Canada. - - 2013
Noise levels observed in positron emission tomography (PET) images complicate their geometric interpretation. Post-processing techniques aimed at noise reduction may be employed to overcome this problem. The detailed characteristics of the noise affecting PET images are, however, often not well known. Typically, it is assumed that overall the noise may ...
Whaley Jacquelyn S JS Clinical Applications Research, Carestream Health, Inc., Rochester, NY 14615, USA. - - 2013
A large database of digital chest radiographs was developed over a 14-month period. Ten radiographic technologists and five radiologists independently evaluated a stratified subset of images from the database for quality deficiencies and decided whether each image should be rejected. The evaluation results showed that the radiographic technologists and radiologists ...
Cao Yanna Y Department of Surgery, UTHSC-Houston, Houston, TX 77026, - - 2013
To investigate the role of bone morphogenetic protein (BMP) signaling in acute pancreatitis (AP) by administration of noggin, an endogenous BMP antagonist, in a cerulein-induced AP model. Acute pancreatitis was induced by 9 hourly intraperitoneal injections of cerulein (50 μg/kg). Control mice received phosphate-buffered saline injections. In a separate group, ...
Seidler Norbert W - - 2013
Thus far, two independent laboratories have shown that inhaled anesthetics directly affect GAPDH structure and function. Additionally, it has been demonstrated that GAPDH normally regulates the function of GABA (type A) receptor. In light of these literature observations and some less direct findings, there is a discussion on the putative ...
Seidler Norbert W - - 2013
The concept of the cytosol as a space that contains discrete zones of metabolites is discussed relative to the contribution of GAPDH. GAPDH is directed to very specific cell compartments. This chapter describes the utilization of GAPDH's enzymatic function for focal demands (i.e. ATP/ADP and NAD(+)/NADH), and offers a speculative ...
Seidler Norbert W - - 2013
The GAPDH gene is highly conserved with a promoter that contains several types of regulatory elements, perhaps even in a distal intron. Curiously, the transcription start site shows some ambiguity and there are codon-sharing exons at alternate exon junctions. While there is only one functional gene for GAPDH in humans, ...
Seidler Norbert W - - 2013
There is increasing evidence to support a gene economy model that is fully based on the principles of evolution in which a limited number of proteins does not necessarily reflect a finite number of biochemical processes. The concept of 'gene sharing' proposes that a single protein can have alternate functions ...
Seidler Norbert W - - 2013
GAPDH interacts with a plethora of diverse cellular proteins. The network of interacting partners, or interactome, is presented for GAPDH with the interacting molecules grouped into specific functional and structural categories. By organizing the binding partners in this way, certain common structural features are beginning to surface, such as acidic ...
Seidler Norbert W - - 2013
The chapter begins with an historical perspective of GAPDH isozymes that is juxtaposed to the fact that there is only one somatic functional gene in humans that is virtually identical among the mammalian species. Over the many years of GAPDH research, dozens of labs have reported the existence of multiple ...
Seidler Norbert W - - 2013
This chapter provides a foundation for further research into the relationship between dynamic oligomeric properties and functional diversity. The structural basis that underlies the conformational sub-states of the GAPDH oligomer is discussed. The issue of protein stability is given a thorough analysis, since it is well-established that the primary strategy ...
Seidler Norbert W - - 2013
Pathogens, such as bacteria, viruses, protozoa and fungi, generate molecules that provide them with a selective advantage, often at the expense of the host. These molecules, or virulence factors, enable pathogens to colonize the host through several mechanisms. Some molecules offer the pathogen an advantage through better adhesion to host ...
Seidler Norbert W - - 2013
GAPDH plays a major enzymatic role in the intermediary metabolism of human tissues. In fact, the cells of all organisms require the catalytic capability of GAPDH in order to maintain adequate glycolytic flux. Even the primitive archaea rely on GAPDH in a pivotal step in the Entner-Doudoroff pathway, which is ...
Xu Jiang - - 2013
AT(2)Rs [AngII (angiotensin II) type 2 receptors] contribute to the cardioprotective effects of angiotensin II receptor blockers, possibly via kinins acting on the B(1)R (B(1) receptor) and B(2)R (B(2) receptor). Recent studies have shown that a lack of B(2)R up-regulates B(1)R and AT(2)R; however, the pathophysiological relevance of such an ...
Benini Ruba - - 2012
Spasticity affects up to 80 % of patients with cerebral palsy (CP) and often plays a significant role in limiting the child's ability to function and participate in daily activities. The treatment of spasticity involves a multifaceted approach that includes pharmacological treatment with antispasmodics, physical therapy to maintain range of motion ...
Russell F A FA Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, - - 2012
The PAR(2) receptors are involved in chronic arthritis by mechanisms that are as yet unclear. Here, we examined PAR(2) activation in the rat knee joint. PAR(2) in rat knee joint dorsal root ganglia (DRG) cells at L3-L5, retrogradely labelled with Fluoro-gold (FG) were demonstrated immunohistochemically. Electrophysiological recordings from knee joint ...
Lo Gin-Ho - - 2012
Carvedilol has been shown to be more effective than propranolol in decreasing portal pressure. Sufficient data from controlled trials remains limited. This trial compared the relative safety and efficacy between carvedilol and nadolol plus isosorbide mononitrate in preventing variceal rebleeding. After successful control of acute esophageal variceal bleeding, eligible patients ...
Nuttall James M - - 2012
NBP (nitrogen-containing bisphosphonate) drugs protect against excessive osteoclast-mediated bone resorption. After binding to bone mineral, they are taken up selectively by the osteoclasts and inhibit the essential enzyme FDPS (farnesyl diphosphate synthase). NBPs inhibit also growth of amoebae of Dictyostelium discoideum in which their target is again FDPS. A fusion ...
Cauley Jane A - - 2012
Bone turnover markers (BTMs) predict fracture in older women, whereas data on younger women are lacking. To test the hypothesis that BTMs measured before and after menopause predict fracture risk, we performed a cohort study of 2,305 women. Women attended up to nine clinic visits for an average of 7.6 ...
Gillies Anne T - - 2012
J proteins are a diverse family of co-chaperones that cooperate with heat shock protein 70 (Hsp70) to coordinate protein quality control, especially in response to cellular stress. Current models suggest that individual J proteins might play roles in recruiting Hsp70s to specific functions, such as maintaining cell wall integrity or ...
Canis Kevin K Division of Molecular Biosciences, Faculty of Natural Sciences, Hammersmith Hospital Campus, Imperial College, London, - - 2012
vWF (von Willebrand factor) is a key component for maintenance of normal haemostasis, acting as the carrier protein of the coagulant Factor VIII and mediating platelet adhesion at sites of vascular injury. There is ample evidence that vWF glycan moieties are crucial determinants of its expression and function. Of particular ...
Dumont Odile O Vascular Sciences Unit, Imperial Centre for Translational & Experimental Medicine, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London, - - 2012
Vascular endothelial injury predisposes to endothelial dysfunction and atherogenesis. We have investigated the hypothesis that PKCε (protein kinase Cε) is an important upstream regulator of cytoprotective pathways in vascular ECs (endothelial cells). Depletion of PKCε in human ECs reduced expression of the cytoprotective genes A1, A20 and Bcl-2. Conversely, constitutively ...
Habib Michel - - 2012
For a given set [Formula: see text] of species and a set [Formula: see text] of triplets on [Formula: see text], we seek to construct a phylogenetic network which is consistent with [Formula: see text] i.e. which represents all triplets of [Formula: see text]. The level of a network is ...
Fung Adrian T - - 2012
The purpose of this study was to describe clinical and multimodal imaging features of patients with Type 1 neovascularization who lack findings of age-related macular degeneration but instead have features consistent with long-standing central serous chorioretinopathy (CSC). Nonconsecutive, retrospective, observational case series. Two groups of patients were identified and analyzed. ...
Lyseng-Williamson Katherine A - - 2012
Ipilimumab (Yervoy™), a recombinant monoclonal antibody targeted at cytotoxic T-lymphocyte-associated antigen 4, is approved for the treatment of advanced melanoma. In a placebo-controlled trial in previously treated patients with advanced melanoma, ipilimumab, without or with an investigational glycoprotein (gp) 100 peptide vaccine, was associated with significantly longer median overall survival ...
Levy Lauren L - - 2012
Acne scarring is a commonly encountered yet extremely challenging problem to treat for the dermatologist. As acne scarring can lead to significant psychological distress and low self-esteem, it is of utmost importance to have effective and satisfying treatments in the physician's armamentarium. However, many treatments are unsatisfying, leading to patient ...
Beinart Roy - - 2012
The use of magnetic resonance imaging (MRI) as a diagnostic technique is rapidly expanding. The number of patients who undergo implantation of permanent pacemaker, implantable cardioverter defibrillator (ICD), and/or cardiac resynchronization therapy devices is increasing in parallel. Cardiovascular implants are subject to potentially harmful effects from MRI, and the routine ...
Steinhoff B J - - 2012
The aim of the study was an assessment of the tolerability and efficacy of slow release oxcarbazepine (OXC-MR) versus immediate release OXC (OXC-IR) after forced titration in patients with focal epileptic seizures with and without secondary generalization who had previously not become seizure-free under OXC-IR with or without concomitant antiepileptic ...
Koupenova Milka - - 2012
Adenosine is an endogenous metabolite that has an anti-inflammatory effect across the vasculature. Extracellular adenosine activates 4 G-protein coupled receptors (A1, A3, A2A, and A2B) whose expression varies in different cells and tissues, including the vasculature and blood cells. Higher levels of adenosine are generated during stress, inflammation, and upon tissue ...
Naegle Kristen M - - 2012
Cell signaling networks propagate information from extracellular cues via dynamic modulation of protein-protein interactions in a context-dependent manner. Networks based on receptor tyrosine kinases (RTKs), for example, phosphorylate intracellular proteins in response to extracellular ligands, resulting in dynamic protein-protein interactions that drive phenotypic changes. Most commonly used methods for discovering ...
Benzler Jonas - - 2012
GSK3β (glycogen synthase kinase 3β) is a ubiquitous kinase that plays a key role in multiple intracellular signalling pathways, and increased GSK3β activity is implicated in disorders ranging from cancer to Alzheimer's disease. In the present study, we provide the first evidence of increased hypothalamic signalling via GSK3β in leptin-deficient ...
Burrell Earl R - - 2012
Mobile phone social networking applications such as GRINDR are potential tools for recruitment of men who have sex with men (MSM) for HIV prevention research. Demographics and sexual risk behaviors of men recruited through GRINDR and through traditional media were compared. GRINDR participants were younger (mean age 31 vs. 42, ...
Cortese Samuele S Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, Child Study Center of the NYU Langone Medical Center, One Park Avenue, 8th Floor, New York, NY 10016, USA. - - 2012
The neuroimaging literature on attention-deficit/hyperactivity disorder (ADHD) is growing rapidly. Here, we provide a critical overview of neuroimaging studies published recently, highlighting perspectives that may be of relevance for clinicians. After a comprehensive search of PubMed, Ovid, Web of Science, and EMBASE, we located 41 pertinent papers published between January ...
Chen Zhiguo Z Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9069, - - 2012
Peripheral nerves have the potential to regenerate axons and reinnervate end organs. Chronic denervation and disturbed nerve regeneration are thought to contribute to peripheral neuropathy, pain, and pruritus in the skin. The capacity of denervated distal nerves to support axonal regeneration requires proliferation by Schwann cells, which guide regenerating axons ...
Sacco James C JC Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706-1102, - - 2012
To determine whether polymorphisms in the sulfonamide detoxification genes, CYB5A (encoding cytochrome b(5)), CYB5R3 (encoding cytochrome b(5) reductase), or NAT2 (encoding N-acetyltransferase 2) were over-represented in patients with delayed sulfonamide drug hypersensitivity, compared with control patients who tolerated a therapeutic course of trimethoprim-sulfamethoxazole without adverse event. DNA from 99 nonimmunocompromised ...
Pelto Ryan B - - 2012
The α-hydroxydepsipeptide 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (5) is a quite effective substrate of serine β-lactamases and low molecular mass DD-peptidases. The class C P99 and ampC β-lactamases catalyze the hydrolysis of both enantiomers of 5, although they show a strong preference for one of them. The class A TEM-2 and class D ...
Park Eunae - - 2012
Phytochromes are red and far-red light receptors in plants that mediate critical responses to light throughout the lifecycle. They achieve this in part by targeting negatively acting bHLH transcription factors called phytochrome-interacting factors (PIFs) for degradation within the nucleus. However, it is not known whether protein degradation is the primary ...
Hieu Trinh Trung - - 2012
Radioiodine-131 ((131)I) is widely used for diagnosis and treatment of benign thyroid diseases. Observational studies have not been conclusive about the carcinogenic potential of (131)I and we therefore conducted a meta-analysis. We performed a literature search till September 2011 which included (131)I as a diagnostic or treatment modality ((131)I for ...
Poling Deborah - - 2012
Case management (CM) is a growing and evolving profession. Outcomes-based research that identifies the role of CM is needed in health care today. Case management has been recognized as a way to help patients experience high-quality and cost-effective care. The purpose of this nonexperimental, retrospective research study was to examine ...
Ozkan Bugra - - 2012
In this study, we examined the relationship between PAI-1 4G/5G polymorphism and patency of the infarct-related artery after thrombolysis in patients with ST-elevation myocardial infarction (STEMI). Acute STEMI patients who received thrombolytic therapy within first 12 h were included in our study. The PAI-1 4G/5G promoter region insertion/deletion polymorphism was ...
Wasoontarajaroen Siriwat - - 2012
This paper presents the development of an in vivo exposure system for exposing small rodents. The system consists of four identical cylindrical waveguide chambers, each with a plastic cage for housing the animal. The chamber is fed by circularly polarized radiofrequency power in the 1.9 GHz cellular frequency band and ...
Weber Shane N - - 2012
ABSTRACT: Skin penetration by radionuclide contaminants serves as a route of entry into the body and may pose a serious health risk to humans depending on the magnitude of intake. The United States Transuranium and Uranium Registry whole body Case 0262 was involved in a wound intake of plutonium at ...
Mooney James F - - 2012
Femur fractures are common long bone injuries in children. Open femur fractures; however, are uncommon. Traditionally, long-term external fixation has been recommended for treatment of these fractures. Damage control orthopedics is a well-recognized concept in adult orthopedic trauma management. Little or no literature exists demonstrating the use of damage control ...
Askren-Gonzalez Angela - - 2012
This article examines the recent hospital emphasis on preventing hospital readmission. This article also identifies hospital programs that help prevent such readmissions by using a systematic approach to transitions of care. Hospital case management departments. A coordinated, patient-focused transition of care plan is a key element in preventing hospital readmissions. ...
Manjunatha H C - - 2012
ABSTRACT: The effective atomic numbers (Zeff) and electron densities (Nel) of cortical and compact bone have been computed for total and partial photon interactions (photoelectric absorption, coherent scattering, incoherent scattering, pair production in a nuclear field, pair production in an electronic field, and sum of non-coherent scattering) by computing the ...
Samara Eleni Theano - - 2012
ABSTRACT: The aim of this study was to investigate the radiation exposure of the Swiss population to interventional procedures. A nationwide survey was conducted in Switzerland. The annual effective dose per capita due to interventional procedures was found to be 0.14 mSv, corresponding to 12% of the total dose. Coronary ...
Daka Joseph N - - 2012
ABSTRACT: Urine is the most popular matrix used in performance testing programs (PTP) and inter-comparison programs (ICP) for bioassay. Because it comes from humans, there are concerns regarding its biosafety. For large programs, its collection can take several hours or days to complete. In addition, natural urine has an unpleasant ...
Shaw Stephen B - - 2012
ABSTRACT: A set of 317 samples collected from wells throughout New York State (excluding Long Island) from 2003 through 2008 was used to assess the distribution of radon gas in drinking water. Previous studies have documented high concentrations of radon in groundwater from granitic and metamorphic bedrock, but there have ...
Steck Daniel J - - 2012
ABSTRACT: Increased lung cancer incidence has been linked with long-term exposure to elevated residential radon. Experimental studies have shown that soil ventilation can be effective in reducing radon concentrations in single-family homes. Most radon mitigation systems in the U.S. are installed by private contractors. The long-term effectiveness of these systems ...
Lobaugh Megan L - - 2012
ABSTRACT: The detection efficiency and interference susceptibility of four different types of low energy photon detectors, each with a unique geometric arrangement, were compared for direct measurement of Am deposited in the axillary lymph nodes. Although the most efficient detector was a single large 23,226 mm square phoswich detector, it ...
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