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Alfirevic A - - 2012
Genetic predisposition to drug-induced liver injury may be due to variation in both pharmacokinetic and pharmacodynamic pathways. Recent genome-wide association studies have identified, in the human leukocyte antigen (HLA) alleles, strong genetic factors that predispose to liver injury on exposure to any of several drugs. Although the genetic associations have ...
Taka─Ź Iztok - - 2012
Subinvolution of placental bed vessels, a well-recognized cause of postpartum and postabortal hemorrhage, is defined with prolonged or excessive uterine hemorrhage beginning after the delivery or abortion. Although physiological changes in uteroplacental parts of spiral arteries are well known, the sequence of events in involution of these vessels is not ...
Voss S R - - 2012
The transformation of ancestral phenotypes into novel traits is poorly understood for many examples of evolutionary novelty. Ancestrally, salamanders have a biphasic life cycle with an aquatic larval stage, a brief and pronounced metamorphosis, followed by a terrestrial adult stage. Repeatedly during evolution, metamorphic timing has been delayed to exploit ...
André Pascal - - 2012
Uptake1 and uptake2 transporters are involved in the extracellular clearance of biogenic amine neurotransmitters at synaptic clefts. We looked for them at the blood-brain barrier (BBB) and blood-retina barriers (BRB), where they could be involved in regulating the neurotransmitter concentration and modulate/terminate receptor-mediated effects within the neurovascular unit (NVU). Uptake2 ...
Davidsen Jesper Romhild - - 2012
This PhD thesis was performed during my employment at the Research Unit of General Practice in Odense, University of Southern Denmark. It comprises an overview of three papers, all published or submitted for publication in international peer-reviewed scientific journals. Observational studies have revealed inadequate use of inhaled corticosteroids (ICS) among ...
Hu Shu-Chin - - 2012
Ventilator-associated pneumonia (VAP) is a hospital-acquired pneumonia that occurs in patients usually 48 hours or more after mechanical ventilator intubation. VAP is the most common nosocomial infection in critically ill patients. Mechanical ventilators are critical oxygenation and ventilation systems for patients. However, there is a close relationship among self-use efficacy, ...
Holtzman Michael J - - 2012
Research on the pathogenesis of asthma has traditionally concentrated on environmental stimuli, genetic susceptibilities, adaptive immune responses, and end-organ alterations (particularly in airway mucous cells and smooth muscle) as critical steps leading to disease. The focus of this cascade has been the response to allergic stimuli. An alternative scheme suggests ...
Bacchetta Justine - - 2012
Growth retardation, decreased final height and renal osteodystrophy (ROD) are common complications of childhood chronic kidney disease (CKD), resulting from a combination of abnormalities in the growth hormone (GH) axis, vitamin D deficiency, hyperparathyroidism, hypogonadism, inadequate nutrition, cachexia and drug toxicity. The impact of CKD-associated bone and mineral disorders (CKD-MBD) ...
Lima Marco A - - 2012
Brain tuberculomas account for 10-20% of space occupying brain lesions in developing countries. Most lesions are observed at time of tuberculosis diagnosis or soon after starting treatment. We herein describe a 32 year-old patient with a 14-month history of headache and progressive visual loss. Her past medical history revealed pulmonary ...
Venzin C - - 2012
In veterinary medicine, limb-sparing techniques are most implemented when the uninvolved limbs are affected by other orthopaedic or neurological disorders, in large breeds or when the owner declines amputation. This report describes the surgical technique used for implantation of an endoprosthesis following tumour resection in the distal radius in 3 ...
Chalupka Stephanie - - 2012
Calcium supplements have been associated with elevated risk of myocardial infarction, whereas dietary calcium intake has not.
Alomary A - - 2012
The aim of this study was to measure the concentrations of lead (Pb), cadmium (Cd), copper (Cu), iron (Fe), and zinc (Zn) in deciduous teeth from children living in Jordan and to investigate the affecting factors. Deciduous teeth samples (n = 320, without fillings) were collected from 5- to 12-year-old children and ...
Hong Brian W - - 2012
BACKGROUND: Despite lack of evidence-based support, chest X-ray (CXR) prior to thyroid surgery is often used to identify tracheal deviation that may predict difficulty with intubation. The aim of this study is to establish the utility of preoperative CXR to assess tracheal deviation in this group of patients. METHODS: We ...
Rout Smruti R - - 2012
Magnetic mesoporous amorphous calcium phosphate nanoparticles with a size of 62 nm and abundant -COOH groups on the surface have been prepared by a simple method. The particles show excellent aqueous dispersion stability in physiological pH without any deterioration in hydrodynamic size and zetapotential. By virtue of the carboxylate groups ...
Brunamonti Emiliano - - 2012
Number comparison tasks are characterized by distance and size effects. The distance effect reveals that the higher the distance is between two numbers, the easier their magnitude comparison is. Accordingly, people are thought to represent numbers on a spatial dimension, the mental number line, on which any given number corresponds ...
Sommerich Carolyn M - - 2012
Effects of ambulance cot design features (handle design and leg folding mechanism) were evaluated. Experienced ambulance workers performed tasks simulating loading and unloading a cot to and from an ambulance, and a cot raising task. Muscle activity, ratings of perceived exertion, and performance style were significantly affected by cot condition ...
Miller Ronald D - - 2012
BACKGROUND: Blood hemoglobin (Hb) can be continuously monitored utilizing noninvasive spectrophotometric finger sensors (Masimo SpHb). SpHb is not a consistently accurate guide to transfusion decisions when compared with laboratory Co-Oximetry (tHb). We evaluated whether a finger digital nerve block (DNB) would increase perfusion and, thereby, improve the accuracy of SpHb. ...
Pakpour Amir H - - 2012
BACKGROUND: Infertility has a major impact on women's quality of life and emotional well-being. The resulting interpersonal problems extend to women's sexual relationships, with a high proportion of infertile women reporting sexual problems. AIM: To determine the prevalence and identify the potential risk factors of female sexual dysfunction (FSD) among ...
McCuaig Jeanna M - - 2012
It is well known that early-onset breast cancer may be due to an inherited predisposition. When evaluating women diagnosed with breast cancer under age 30, two important syndromes are typically considered: Hereditary Breast and Ovarian Cancer Syndrome and Li-Fraumeni syndrome. Many women are offered genetic testing for mutations in the ...
Lima Mônica Cruvinel de - - 2012
To evaluate the influence of aerobic exercise on oxidative stress in mice. The study included twenty female mice Mus musculus-Swiss divided into two groups: sedentary control (GA) and exercise (GB), each containing ten animals. All animals underwent an adaptation period of seven days isolated in individual boxes. After this period, ...
Tomlins Scott A - - 2012
Fusions of androgen-regulated genes and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) occur in approximately 50% of prostate cancers, encoding a truncated ERG product. In prostatectomy specimens, ERG rearrangements are greater than 99% specific for prostate cancer or high-grade prostatic intraepithelial neoplasia adjacent to ERG-rearranged prostate cancer by fluorescence ...
Yang Yueh-Ying - - 2012
Loss is a phenomenon common to the human experience. Feelings of loss represent an emotional response to separation from subjectively important person(s) or things. Loss often leaves nursing home elderly residents feeling abandoned, insecure, lonely, and hopeless and may affect their perception of the meaning of life. Those who are ...
Beltrame María Ornela - - 2012
The aim of the present study was to examine the parasite fauna present in rodent coprolites collected from Cueva Huenul 1 (CH1), northern Neuquén (Patagonia, Argentina), an archaeological site that provides stratified sequences of archaeological and palaeontological remains dating from the Late Pleistocene/Early Holocene Transition to the Late Holocene period. ...
Balmer Jann T - - 2012
Transforming continuing education (CE) in the health professions requires a focus on competence and performance improvement by all health care professionals to ensure the public's trust. Measures of competence include individual, team, and systems-based performance meeting the growing expectations for quality care by consumers and the government. CE professionals have ...
Chen Zhuo - - 2012
Microalgal lipids are promising alternative feedstocks for biodiesel production. Scenedesmus sp. NJ-1, an oil-rich freshwater microalga isolated from Antarctica, was identified to be a suitable candidate to produce biodiesel in this study. This strain could grow at temperatures ranging from 4 to 35 °C. With regular decrease in nitrate concentration in ...
Chen Wei-Yu - - 2012
The impact of environmentally pulsed metal exposure on population dynamics of aquatic organisms remains poorly understood and highly unpredictable. The purpose of our study was to link a dynamic energy budget model to a toxicokinetic/toxicodynamic (TK/TD). We used the model to investigate tilapia population dynamics in response to pulsed waterborne ...
Kandori Ikuo I Laboratory of Entomology, Faculty of Agriculture, Kinki University, Naka-machi, Nara, 631-8505, Japan. - - 2012
Learning plays an important role in food acquisition for a wide range of insects. To increase their foraging efficiency, flower-visiting insects may learn to associate floral cues with the presence (so-called reward learning) or the absence (so-called non-reward learning) of a reward. Reward learning whilst foraging for flowers has been ...
Kim Chanhong - - 2012
Recently the porA-1 null mutant of Arabidopsis thaliana has been identified, which contains an insertion of the Dissociation (Ds) element in the PORA gene (Paddock et al. in Plant Mol Biol 78:447-460, 2012). Light-grown porA-1 seedlings suffer from a drastically reduced chlorophyll content and a developmental arrest beyond the cotyledon ...
Zano Stephen - - 2012
Canavan disease (CD) is a fatal neurological disorder caused by defects in the gene that encodes for a critical metabolic enzyme. The enzyme aspartoacylase catalyzes the deacetylation of N-acetylaspartate to produce acetate required for fatty acid biosynthesis in the brain. The loss of aspartoacylase activity leads to the demyelination and ...
Calza P - - 2012
The aqueous environmental fate of two antibiotics, lincomycin and clarithromycin, and an antiepileptic drug, carbamazepine, was investigated by monitoring drugs decomposition and identifying intermediates in Po river water (North Italy). Initially, control experiments in the dark and under illumination were performed on river water spiked with drugs to simulate all ...
Dornelas Conceição Aparecida - - 2012
To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN). Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From the 32nd to the 40th ...
Camelo-Piragua Sandra - - 2012
Clear cell tumors of the central nervous system (CNS) encompass a variety of tumor subtypes that are challenging to diagnose given their similar morphologic features. Here, I use a case-based approach to review the clinicopathologic and radiologic features to help guide the general pathologist in the diagnosis of clear cell ...
Huang Ya-Hsuan - - 2012
Intra-aortic balloon pump (IABP) is one of the most important treatment strategies for patients with heart failure in the intensive care unit (ICU). To ensure quality of treatment, clinical preceptors must employ effective teaching strategies to acquaint nurses with the proper use of IABPs. Many nurses are hesitant to use ...
Walters-Brown Bobbie - - 2012
The aim of this concept analysis is to define women's body image in the context of mental health and to describe its antecedents and consequences. The analysis is grounded in a selective review delimited to literature about women's self-perceived body image. The psychological, social, and spiritual effects of a negative ...
Akerstedt Maria - - 2012
Streptococcus (Str.) agalactiae is a contagious mastitis bacterium, often associated with cases of subclinical mastitis. Different mastitis bacteria have been evaluated previously from a diagnostic point of view, but there is a lack of knowledge concerning their effect on milk composition. Protein composition is important in achieving optimal yield and ...
Souza Samaly Dos Santos Sdos - - 2012
In molluscs, internal defence against microorganisms is performed by a single cell type, i.e., the haemocyte or amoebocyte. The origin of these cells in Biomphalaria glabrata was initially thought to be localised within the vasculo-connective tissue. More recently, origin from a single organ, termed the amoebocyte-producing organ (APO), has been ...
Kastantin Mark - - 2012
Although imperfect spatial localization in single-molecule object tracking experiments has long been recognized to induce apparent motion in an immobile population of molecules, this effect is often ignored or incorrectly analyzed for mobile molecules. In particular, apparent motion due to positional uncertainty is often incorrectly assigned as a distinct diffusive ...
Scherr Kyle C - - 2012
Miranda v. Arizona (384 U.S. 436, 1966) required that suspects be explicitly warned of the right to avoid self-incrimination and the right to legal representation. This research was designed to examine whether stress, induced via an accusation of wrong-doing, undermined or enhanced suspects' ability to comprehend their Miranda rights. Participants ...
Zang Dejin - - 2012
Novel fenvalerate double-sided hollow molecularly imprinted microspheres (fenvalerate-DHMIMs) were fabricated by in situ polymerization with the help of mesoporous silica microspheres (MSMs) in this paper for the very first time. Scanning electron microscope was employed to characterize the surface morphology of the fenvalerate-DHMIMs. Taking advantage of the quenching effect of ...
Tang Yuefeng Y Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, - - 2013
Hematopoietic stem cells (HSC) are found in several independent sites embryonically. Loss-of-function studies indicated that Notch1, but not Notch2 signaling was required for HSC emergence from the aortic-gonado-mesonephros (AGM) region. We previously showed that constitutive Notch1 activation impaired primitive erythroid differentiation, but its effects on HSC emergence from the AGM ...
Errico Francesco - - 2012
Free D: -aspartate (D: -Asp) occurs in substantial amounts in the brain at the embryonic phase and in the first few postnatal days, and strongly decreases in adulthood. Temporal reduction of D: -Asp levels depends on the postnatal onset of D: -aspartate oxidase (DDO) activity, the only enzyme able to ...
Soler Fernando - - 2012
The use of a microsomal preparation from skeletal muscle revealed that both Ca(2+) transport and Ca(2+)-dependent ATP hydrolysis linked to Sarco-Endoplasmic Reticulum Ca(2+)-ATPase are inhibited by epigallocatechin-3-gallate (EGCG). A half-maximal effect was achieved at approx. 12 μM. The presence of the galloyl group was essential for the inhibitory effect of the ...
Caulfield Timothy - - 2012
Stem cell research remains a tremendously promising yet controversial field of study. It continues to attract considerable public interest and generate discussion and debate. However, while the high profile of this field has endured, the tone and nature of the discourse that drives this profile appears to be changing. In ...
Rungta Shilpa S Department of Pathology and the Comprehensive Cancer Center, University of Michigan Hospital and Health Systems, Ann Arbor, MI 48109, USA. - - 2012
Comprising less than 1% of invasive carcinomas of the breast, metaplastic carcinomas are a heterogeneous group of malignant tumors in which part or all of the carcinomatous epithelium is transformed into a nonglandular (metaplastic) growth process. Metaplastic carcinomas with a low-grade spindle cell component resembling fibromatosis, as in our present ...
Tseng Chiu-Jung - - 2012
Background: Quality of life (QOL) is a critical issue in mental health care. The associations between quality of life and schizophrenia patients' stigma perception and stigma coping behavior are not well understood. Purpose: This study investigated quality of life in schizophrenia patients. Methods: We used a cross-sectional, correlational research design; ...
Adams Priscilla - - 2012
Inpatient psychiatric settings anticipate changes in reimbursement that will link payment rates to objective quality measures. Readmission rates are expected to be one of the quality measures. Inpatient areas are undertaking initiatives to decrease readmission rates in preparation for this change. The emphasis on avoiding readmission could cause an increase ...
Ullah Ghanim - - 2012
The inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) channel is crucial for the generation and modulation of intracellular Ca(2+) signals in animal cells. To gain insight into the complicated ligand regulation of this ubiquitous channel, we constructed a simple quantitative continuous-time Markov-chain model from the data. Our model accounts for most experimentally ...
Sawada Hidetaka - - 2012
A method for measurement of the aberration status from high-resolution dark-field images is developed using scanning transmission electron microscopy (STEM), called the Segmented Image Autocorrelation function Matrix (SIAM). The method employs an autocorrelation function from the segmented area in the defocused STEM images from an aligned crystalline specimen to measure ...
Oeberst Aileen - - 2012
Inconsistencies in eyewitness accounts are perceived as indicative of inaccuracy and reduce the witnesses' credibility. Reminiscence, the delayed recall of previously not recalled information, is generally interpreted as a type of inconsistency. Even though it does not necessarily involve the falsity of the statements, reminiscence presents a counterintuitive instance with ...
Schultz Nicolai A - - 2012
BACKGROUND: The aim of the present study was to identify a panel of microRNAs (miRNAs) that can predict overall survival (OS) in non micro-dissected cancer tissues from patients operated for pancreatic cancer (PC). METHODS: MiRNAs were purified from formalin-fixed paraffin embedded (FFPE) cancer tissue from 225 patients operated for PC. ...
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