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Results 401 - 450 of 2880
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Thébaud N B - - 2012
Association of the bone-forming osteoblasts (OBs) and vascular endothelial cells (ECs) into a biomaterial composite provides a live bone graft substitute that can repair the bone defect when implanted. An intimate functional relationship exists between these cell types. This communication is crucial to the coordinated cell behaviour necessary for bone ...
Mittal Anupama - - 2012
PURPOSE: A new, injectable, drug-loaded composite graft was developed to enable infection free wound healing. METHODS: The graft was fabricated using gentamicin and biomimetic microparticulate scaffolds in gelatin gel and characterized for biologically relevant properties like fluid uptake, evaporative water loss (EWL), water vapor transmission rate (WVTR), Young's modulus and ...
Bran Gregor M - - 2012
The objective of the study was to assess the short-term efficacy of radiofrequency volumetric tissue reduction (RFVTR) of the inferior turbinates in patients with nasal obstruction caused by turbinate hypertrophy. The study is a prospective, randomized, single-blinded, placebo-controlled, crossover trial. A total of 22 patients (age range 21-72 years; median age ...
Müller Christine - - 2012
The quorum sensing signalling molecules 2-heptyl-3-hydroxy-4(1H)-quinolone, termed the "Pseudomonas quinolone signal" (PQS), and 2-heptyl-4(1H)-quinolone (HHQ) play an important role in the control of virulence gene expression in Pseudomonas aeruginosa. To construct a bioreporter for the specific and sensitive detection of these compounds, a plasmid with the pqsR gene encoding the ...
Wang Tso-Fu - - 2012
BACKGROUND: The outcome of peripheral blood stem cell (PBSC) harvest depends on mobilization and leukapheresis. Some poor harvests might not be directly related to poor mobilizations. STUDY DESIGN AND METHODS: We retrospectively analyzed the results of 793 consecutive healthy donors who underwent PBSC donation to evaluate the impact of low ...
El-Sharkawy I - - 2012
Auxin-binding protein1 (ABP1) is an active element involved in auxin signaling and plays critical roles in auxin-mediated plant development. Here, we report the isolation and characterization of a putative sequence from Prunus salicina L., designated PslABP1. The expected protein exhibits a similar molecular structure to that of well-characterized maize-ABP1; however, ...
Liu Juewen - - 2012
The interaction between DNA and inorganic surfaces has attracted intense research interest, as a detailed understanding of adsorption and desorption is required for DNA microarray optimization, biosensor development, and nanoparticle functionalization. One of the most commonly studied surfaces is gold due to its unique optical and electric properties. Through various ...
Pan Piin-Ruey - - 2012
Due to the severe self-interaction errors associated with some density functional approximations, conventional density functionals often fail to dissociate the hemibonded structure of the water dimer radical cation (H(2)O)(2)(+) into the correct fragments: H(2)O and H(2)O(+). Consequently, the binding energy of the hemibonded structure (H(2)O)(2)(+) is not well-defined. For a ...
Wang Lan - - 2012
CLEC-2 was first identified by sequence similarity to C-type lectin-like molecules with immune functions and has been reported as a receptor for the platelet-aggregating snake venom toxin rhodocytin and the endogenous sialoglycoprotein podoplanin. Recent researches indicate that CLEC-2-deficient mice were lethal at the embryonic stage associated with disorganized and blood-filled ...
Thanh Quy Nguyen - - 2012
Exact replicas of carbon nanotube devices as fabricated on SiO(2) /Si substrates are prepared on various non-conventional substrates such as nonplanar or soft substrates by a simple, yet versatile, transfer-printing "cut-and-paste" method. In this way, harsh growth and fabrication processes can be minimized on the target substrates. The electrical characteristics ...
Labarta José I - - 2012
CONTEXT: IGF-I is essential for normal human growth and mediates its effects through the IGF1R. IGF1R mutations have been associated with varying degrees of intrauterine and postnatal growth retardation. OBJECTIVE: To identify IGF1R gene mutations in a short-statured family with intrauterine growth retardation and microcephaly. METHODS: Direct DNA sequencing was ...
Miura Yoshinori - - 2012
Melittin, a peptide of 26 amino acid residues, has been used as a model peptide for protein folding and unfolding, and extensive research has been done into its structure and conformational stability. Circular dichroism (CD) studies have demonstrated that melittin in an aqueous solution undergoes a transition from a helical ...
Sahu Kapendra - - 2012
The aim of this study was to investigate the effect of Morin on the pharmacokinetics of Piracetam in rats, in vitro enzyme kinetics and metabolic stability (high throughput) studies using human liver microsomes in UPLC. For pharmacokinetics studies, male Wistar rats were pretreated with Morin (10 mg/kg) for one week and ...
de Boer Sandra Y - - 2012
The first examples of reactivity at the backbone of a bidentate PN-ligand relevant to N-H activation are described, leading to novel Pd(II) and Cu(I) amido complexes. Activation of the PN-ligand backbone led to selective dearomatization of the pyridyl ring structure. In the case of Pd(II), the intermediate could be efficiently ...
Uysal Bulent - - 2012
PURPOSE: Various studies have been performed to find out novel treatment strategies to prevent postoperative adhesion formation. Ozone therapy (OT) is shown to reduce inflammation in several pathological conditions. Therefore, we aimed to evaluate the efficacy of OT in a rat model of experimental uterine adhesion (EUA). METHODS: Thirty female ...
Ekström M - - 2012
Plasminogen activator inhibitor type-1 (PAI-1) is one of the most important inhibitors of endogenous fibrinolysis. Adipose tissue is a suggested source of the elevated plasma levels of PAI-1 in obesity. The relation between PAI-1 and inflammation is of particular interest, but current knowledge regarding regulation of PAI-1 in adipose tissue ...
Bretterklieber Agnes - - 2012
Background: Numerous studies have confirmed the short-term effectiveness of 8-methoxypsoralen bath PUVA therapy in patients with chronic palmoplantar dermatoses; however, little is known about long-term results. Patients and methods: In this retrospective study we examined the long-term results in 79 patients (mean age: 48 years) with chronic palmoplantar dermatoses who ...
Arnold Maria M - - 2012
Even in the absence of external stimuli there is ongoing activity in the cerebral cortex as a result of recurrent connectivity. This paper attempts to characterize one aspect of this ongoing activity by examining how the information content carried by specific neurons varies as a function of brain state. We ...
Manna Uttam - - 2012
An approach to the modification and post-fabrication chemical patterning of amine-reactive superhydrophobic surfaces is reported. The approach is based on the layer-by-layer fabrication of azlactone-containing polymer multilayers, and permits the direct covalent attachment and subsequent patterning of chemical and biological 'inks' using a variety of pratical and low-cost pattern-transfer methods.
Figueira Etelvina - - 2012
Juncus maritimus is the most abundant macrophyte in Laranjo bay, a Portuguese salt marsh heavily polluted by mercury (Hg). With the aim to elucidate the role of this species in the salt marsh Hg cycling and restoration, plants were harvested between March 2006 and January 2008 from four locations differing ...
Kanthila Jayashree - - 2012
OBJECTIVES: To highlight the varied clinical manifestations and management of idiopathic hypereosinophilic syndrome, a rare disorder in children. METHODS: Retrospective review of case records of 3 patients who were diagnosed to have idiopathic hypereosinophilic syndrome (IHES) in a tertiary referral centre between 1997 and 2010 was performed. These 3 children ...
Patade Vikas Yadav - - 2012
Seed priming is a well known pre-germination strategy that improves seed performance. However, biochemical and molecular mechanisms underlying priming mediated stress tolerance are little understood. Here, we report results of the study on growth, physiological characteristics and expression of stress responsive genes in salt primed sugarcane cv. Co 86032 plants ...
Geng Songmei - - 2012
Increasing evidences have indicated that only a phenotypic subset of cancer cells, termed as the cancer stem cells (CSCs), is capable of initiating tumor growth and provide a reservoir of cells that cause tumor recurrence after therapy. Epithelial-mesenchymal transition (EMT), a cell type change from an epithelial cobblestone phenotype to ...
Ding Yue - - 2012
Prosthetic wear particles are thought to play a central role in the initiation and development of periprosthetic osteolysis, leading to aseptic loosening of prostheses. This study aimed to compare the biological activity of ceramic and titanium particles that are associated with particle-induced, aseptic joint loosening. Different sizes of alumina-ceramic particles ...
Hohnloser S H - - 2012
Dabigatran is a novel direct thrombin inhibitor that has recently been approved for primary and secondary stroke prevention and prevention of systemic embolism in patients with atrial fibrillation. In the pivotal RE-LY study, dabigatran 110 mg BID was demonstrated to be associated with a stroke rate similar to that observed ...
Phillips Catherine M - - 2012
Obesity is a key factor in the development of the metabolic syndrome (MetS), which is associated with increased cardiometabolic risk. We investigated whether obesity classification by body mass index (BMI) and body fat percentage (BF%) influences cardiometabolic profile and dietary responsiveness in 486 MetS subjects (LIPGENE dietary intervention study). Anthropometric ...
Van Yperen-De Deyne A - - 2012
In this paper an overview is presented of several approximations within Density Functional Theory (DFT) to calculate g-tensors in transition metal containing systems and a new accurate description of the spin-other-orbit contribution for high spin systems is suggested. Various implementations in a broad variety of software packages (ORCA, ADF, Gaussian, ...
Abdel-Ghaffar Fathy - - 2012
In the present study, out of 200, 120 (60 %) Plectropomus maculates fish were found to be naturally infected with Kudoa sp. The infection was intensive and appeared as clusters of ovoid to ellipsoidal plasmodia being restricted to the cardiac muscles. More than 100 plasmodia were counted per infected heart and ...
Zhang Jing - - 2012
We have developed a cluster model of a TiO2 nanoparticle in the Dye Sensitized Solar Cell and used first principles quantum chemistry, coupled with a continuum solvation model, to compute structures and energetics of key electronic and structural intermediates and transition states. Our results suggest the existence of shallow surface ...
Kumari Ruma - - 2012
Serine/threonine protein kinases (STPKs) are predominantly involved in growth, development, division, differentiation, and in regulating immune responses in mycobacteria. A wide variety of functions of mycobacterial STPKs persuade mycobacterial growth and further its survival in the hosts. The polymorphic studies have shown that a full length gene of Rv3080c (pknK) ...
Kim J - - 2012
Increased red blood cell distribution width (RDW), which is a marker of anisocytosis, is associated with mortality and cardiovascular events in the general population and in patients with heart failure or coronary heart disease. We investigated whether RDW in acute cerebral infarction is predictive of functional outcome and mortality. A ...
Pepper Ian L - - 2012
AIM: This study evaluates the effect of surface application of dried Class A biosolids on microbial populations within copper mine tailings. METHODS AND RESULTS: Mine tailing sites were established at ASARCO Mission Mine close to Sahuarita Arizona. Site 1 (Dec. 1998) was amended with 248 tons ha(-1) of Class A ...
Tan Guo-Wei - - 2012
Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic xenografts labeled by phycoerythrin fluorescing ...
Szydłowska-Czerniak Aleksandra - - 2012
A novel silver nanoparticle-based (AgNP) method and two modified procedures, ferric reducing antioxidant power (FRAP) and 2,2'-diphenyl-1-picrylhydrazyl (DPPH), were used for determination of antioxidant capacities of the ethanolic, methanolic, methanolic-aqueous (1 : 1 v/v) and aqueous extracts of rapeseed and its products. The AgNP method based on the electron-transfer reaction between silver ...
Baldassarre M - - 2012
Recent data report an important role of testosterone (T) in modulating female sexual responses, but little is known about the expression and distribution of androgen receptor (AR) in the human vagina. Therefore, the aims of our study were to evaluate the expression of AR in the human vagina in premenopausal ...
Cosgarea R - - 2012
Background  Photodynamic therapy (PDT) is an attractive modality for the treatment of BCC, based on its generally favorable efficacy, adverse effect profile and its excellent cosmetic outcome. Objectives  The purpose of the study is to compare the efficacy and cosmetic outcome of photodynamic therapy with topical 5-aminolaevulinic acid (ALA-PDT) vs. ...
van Genderen F R - - 2012
The multifactorial nature of disability makes it difficult to point out a specific cause for limitations in participation. The conceptual framework of the WHO-ICF (International Classification of Function, Disability and Health) was used to study the determinants participation in patients with severe haemophilia. Outcome was assessed in a single-centre cohort ...
Morel O - - 2012
It was the study objective to determine whether glycaemic control affects the extent of platelet inhibition by thienopyridines as assessed by vasodilator-stimulated phosphoprotein flow cytometry (VASP-FCT) in patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI) during acute coronary syndrome (ACS). Although the proportion of high on-treatment residual platelet ...
Kute Vivek B - - 2012
Kute VB, Trivedi HL, Vanikar AV, Shah PR, Gumber MR, Patel HV, Munjappa BC, Modi PR, Gera DN. Long-term outcome of deceased donor renal transplantation in pediatric recipients: A single-center experience from a developing country Abstract:  RTx is best treatment for children with ESRD. Data scarcity on DDRTx outcome in ...
Nelson Donna J - - 2012
We report the synthesis and characterization of a tamoxifen-tethered single-walled carbon nanotube (SWCNT) conjugate, in which tamoxifen is covalently attached to the single-walled carbon nanotube via oxidation and esterification reactions for the first time. The functionalized SWCNT derivative was characterized by using spectroscopic techniques: IR, UV-vis, Raman, and (1)H NMR ...
Yeritsyan Naira - - 2012
By combining behavioural analyses with intrinsic signal optical imaging, we analysed visual performance and visual cortical activity in the albino mouse strain BALB/c, which is increasingly being used as an animal model of neuropsychological disorders. Visual acuity, as measured by a virtual-reality optomotor system, was 0.12 cycles per degree (cyc/deg) in ...
Geliebter Allan - - 2012
Body Adiposity Index (BAI), a new surrogate measure of body fat (hip circumference/[height(1.5) -18]), has been proposed as an alternative to BMI.We compared BAI with BMI, and each of them with laboratory measures of body fat-derived from bioimpedance analysis (BIA), air displacement (ADP), and dual-energy x-ray absorptiometry (DXA) in clinically ...
VAN Strien Maarten J - - 2012
Landscape genetics aims to assess the effect of the landscape on intraspecific genetic structure. To quantify interdeme landscape structure, landscape genetics primarily uses landscape resistance surfaces (RSs) and least-cost paths or straight-line transects. However, both approaches have drawbacks. Parameterization of RSs is a subjective process, and least-cost paths represent a ...
Paudyal Vibhu - - 2012
Background Simvastatin 10 mg was reclassified in 2004 to over-the-counter (OTC) status in the UK, indicated for the prevention of a first major coronary event in individuals at moderate risk of the event. The primary reason behind the reclassification was to reduce the burden of disease management in general practice. Community ...
Chen Qin - - 2012
Grass carp (Ctenopharyngodon idella), a freshwater species native to China, has been introduced to about 100 countries/regions and poses both biological and environmental challenges to the receiving ecosystems. In this study, we analyzed genetic variation in grass carp from three introduced river systems (Mississippi River Basin in US, Danube River ...
Jain Rishabh M - - 2012
We demonstrate a polymer-free carbon-based photovoltaic device that relies on exciton dissociation at the SWNT/C(60) interface, as shown in the figure. Through the construction of a carbon-based photovoltaic completely free of polymeric active or transport layers, we show both the feasibility of this novel device as well as inform the ...
Kang Edward - - 2012
Alginate microribbons with longitudinally grooved microstructures are continuously fabricated by means of a microfluidic system. The number and dimensions of the microgroovesare successfully controlled by regulation of the slit-shaped channel (yellow in figure). This method opens up the possibility of mass production of scaffolds for tissue engineering purposes, as it ...
He Zhangzhen - - 2012
A new small-pore compound K(4)Fe(4)P(5)O(20) was obtained by conventional solid-state reaction in a closed crucible. The crystal structure is constructed by Fe(4)P(5)O(20) units forming chains along the c axis and elliptical eight-ring channels on the a-b plane in which K cations locate inside. Such structural characteristics seem to be quite ...
Schmitz Matthias - - 2012
Cholesterol is an essential component of eukaryotic plasma membranes and plays an important role in membrane organization and signaling processes. It is the major lipid component of detergent resistant caveolin-1 containing rafts which previously had been reported as a platform for nerve growth factor (NGF) signaling in oligodendrocytes (OL). Surprisingly, ...
Lecchi Michela - - 2012
PURPOSE: In nuclear medicine, radiopharmaceuticals are usually administered in unit doses partitioned from multi-dose vials. The partitioning typically takes place in a radiopharmacy, depending on local practice. Automatic, as opposed to manual, partitioning and administration should reduce radiation exposure of the personnel involved, improve the accuracy of the administration and ...
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