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Torsney Evelyn E Division of Clinical Sciences, St. George's Hospital Medical School, London, - - 2013
There is strong epidemiological evidence that patients with diabetes have a lower incidence of abdominal aortic aneurysm. The precise mechanism of this negative association is unknown. Whilst a number of studies have supported the hypothesis that protection is a function of diabetes-mediated changes in the vascular extracellular matrix biology, there ...
Hus Vanessa V Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109, USA. - - 2013
The Autism Diagnostic Interview-Revised (ADI-R) is commonly used to inform diagnoses of autism spectrum disorders (ASD). Considering the time dedicated to using the ADI-R, it is of interest to expand the ways in which information obtained from this interview is used. The current study examines how algorithm totals reflecting past ...
Volak Laurie P LP Program in Pharmacology and Experimental Therapeutics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, - - 2013
Turmeric extract derived curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) are currently being evaluated for the treatment of cancer and Alzheimer's dementia. Previous in vitro studies indicate that curcuminoids and piperine (a black pepper derivative that enhances curcuminoid bioavailability) could inhibit human CYP3A, CYP2C9, UGT and SULT dependent drug metabolism. The aim ...
Kofman Amber E AE Human Molecular Genetics Program, Children's Memorial Research Center, Chicago, IL 60614, - - 2013
The differentiation of adult stem cells involves extensive chromatin remodeling, mediated in part by the gene products of histone deacetylase (HDAC) family members. While the transcriptional downregulation of HDACs can impede stem cell self-renewal in certain contexts, it may also promote stem cell maintenance under other circumstances. In self-renewing, differentiating, ...
Khawaja Muhammed Z MZ Cardiovascular Division, BHF Center of Excellence, King's College London, St Thomas' Hospital, London, United - - 2013
We sought to characterize UK-wide balloon aortic valvuloplasty (BAV) experience in the TAVI era. BAV for acquired calcific aortic stenosis is in a phase of renaissance, largely due to the development of transcatheter aortic valve implantation (TAVI). Data from 423 patients at 14 centers across the UK were analyzed. Patients ...
Gremese Elisa - - 2013
Obesity is a mild, long-lasting inflammatory disease and, as such, could increase the inflammatory burden of rheumatoid arthritis (RA). The study aim was to determine whether obesity represents a risk factor for a poor remission rate in RA patients requiring anti-tumor necrosis factor α (anti-TNFα) therapy for progressive and active ...
Fujiwara Kei - - 2013
Recent studies have found hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells (PBMCs) of the majority of presumed recovered subjects. We investigated this unexpected finding using samples from patients whose HCV RNA and anti-HCV status had been serially confirmed. HCV RNA was detected in PBMCs from 66 of ...
Liu Wangta - - 2012
The mechanisms that mediate the initiation and development of intrahepatic cholangiocarcinoma (ICC) associated with hepatitis B and C virus (HBV and HCV, respectively) infection remain largely unclear. In this study we conditionally coexpressed hepatitis B virus X (HBx) and hepatitis C virus core (HCP) proteins in zebrafish livers, which caused ...
Curtis Jeffrey R JR University of Alabama at Birmingham, Birmingham, AL 35294, USA. - - 2012
Prior observational studies have shown an association between bisphosphonate adherence and fewer fractures. It is unclear if such studies reflect pharmacologic benefits or behavioral attributes, i.e., the healthy adherer effect. Our objective was to examine the association of therapy adherence and fracture risk among patients initiating therapies hypothesized to be ...
Silva Clovis A CA Universidade de Sao Paulo, Sao Paulo, - - 2012
To propose a common nomenclature to refer to individuals who fulfill the American College of Rheumatology classification criteria for systemic lupus erythematosus (SLE) during childhood or adolescence. The medical literature was reviewed for studies conducted in the target population between 1960 and December 2011 to obtain information about the terms ...
Curtis Jeffrey R JR UAB Center for Education and Research on Therapeutics, University of Alabama at Birmingham, FOT 805D, 510 20th Street South, Birmingham, AL 35294, USA. - - 2012
To estimate the incidence and risk factors for gastrointestinal (GI) perforation among patients with rheumatoid arthritis (RA). Claims from employer health insurance plans were used to identify RA patients and those hospitalized for upper or lower GI perforation. GI perforation cases were identified using both a sensitive and a specific ...
Amsel Ben D BD Center for Research in Language, University of California, San Diego, San Diego, CA, USA. - - 2012
To understand how and when object knowledge influences the neural underpinnings of language comprehension and linguistic behavior, it is critical to determine the specific kinds of knowledge that people have. To extend the normative data currently available, we report a relatively more comprehensive set of object attribute rating norms for ...
Borude Prachi P Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, - - 2012
Farnesoid X receptor (FXR), the primary bile acid-sensing nuclear receptor, also plays a role in the stimulation of liver regeneration. Whole body deletion of FXR results in significant inhibition of liver regeneration after partial hepatectomy (PHX). FXR is expressed in the liver and intestines, and recent reports indicate that FXR ...
Maska Leann B LB University of Nebraska Medical Center, Omaha, NE 68198-3025, - - 2012
Cigarette smoking has emerged as a risk factor for the development of rheumatoid arthritis (RA). Recent studies have suggested that cigarette smoking may lead to lower treatment response rates with methotrexate (MTX) and some biologic agents in RA. Knowledge of whether tobacco exposure reduces treatment efficacy is important, since smoking ...
Jawaheer Damini D Children's Hospital Oakland Research Institute, Oakland, California, - - 2012
To determine whether men with rheumatoid arthritis (RA) are more likely to achieve remission compared to women. RA patients enrolled in the Consortium of Rheumatology Researchers of North America (CORRONA) cohort between October 2001 and January 2010 were selected for the present analyses. Detailed clinical, demographic, and drug utilization data ...
Xia Xuefeng X Methodist Hospital Research Institute, Weill Cornell School of Medicine, Houston, TX 77030, USA. - - 2012
Nuclear receptors (NRs) play crucial roles in the regulation of hepatic cholesterol synthesis, metabolism, and conversion to bile acids, but their actions in cholangiocytes have not been examined. In this study, we investigated the roles of NRs in cholangiocyte physiology and cholesterol metabolism and flux. We examined the expression of ...
Singer Ora O Department of Medicine, Division of Rheumatology, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30907, USA. - - 2012
To define the musculoskeletal syndrome associated with use of aromatase inhibitors (AIs), specifically, to describe its incidence, time to onset, risk factors, and clinical presentation. Postmenopausal women with hormone-sensitive, nonmetastatic breast cancer starting AI therapy were enrolled in this prospective cohort study. They underwent complete rheumatologic evaluation and contrast-enhanced magnetic ...
Vink S - - 2012
Chronic pain affects approximately 20% of people worldwide and places a large economic and social burden on society. Despite the availability of a range of analgesics, this condition is inadequately treated, with complete alleviation of symptoms rarely occurring. In the past 30 years, the voltage-gated calcium channels (VGCCs) have been ...
Charneira C - - 2012
The aim of this study was to obtain evidence for the activation of the nucleoside reverse transcriptase inhibitor abacavir to reactive aldehyde metabolites in vivo. Protein haptenation by these reactive metabolites may be a factor in abacavir-induced toxic events. The formation of N-terminal valine adducts from the abacavir-derived aldehydes was ...
Doll Christian - - 2012
The molecular basis of agonist-selective signalling at the µ-opioid receptor is poorly understood. We have recently shown that full agonists such as [D-Ala(2)-MePhe(4)-Gly-ol]enkephalin (DAMGO) stimulate the phosphorylation of a number of carboxyl-terminal phosphate acceptor sites including threonine 370 (Thr(370)) and serine 375 (Ser(375)), and that is followed by a robust ...
Mahdy Ali K - - 2012
Since the first discovery of an inverse correlation between high-density lipoprotein-cholesterol (HDL-C) levels and coronary heart disease in the 1950s the life cycle of HDL, its role in atherosclerosis and the therapeutic modification of HDL-C levels have been major research topics. The Framingham study and others that followed could show ...
Gaohua Lu - - 2012
Pregnant women are usually not part of the traditional drug development programme. Pregnancy is associated with major biological and physiological changes that alter the pharmacokinetics (PK) of drugs. Prediction of the changes to drug exposure in this group of patients may help to prevent under- or overtreatment. We have used ...
Song Lige - - 2012
Wnt signaling is essential for osteogenesis and also functions as an adipogenic switch, but it is not known if interrupting wnt signaling via knockout of β-catenin from osteoblasts would cause bone marrow adiposity. Here, we determined whether postnatal deletion of β-catenin in preosteoblasts, through conditional cre expression driven by the ...
Bhargava Y - - 2012
In P2X receptors, agonist binding at the interface between neighbouring subunits is efficiently transduced to ion channel gating. However, the relationship between binding and gating is difficult to study because agonists continuously bind and unbind. Here, we covalently incorporated agonists in the binding pocket of P2X receptors and examined how ...
Yang Lang L NIHR Biomedical Research Unit for Musculoskeletal Disease, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK. - - 2012
This prospective case-cohort study aimed to map the distribution of bone density in the proximal femur and examine its association with hip fracture. We analyzed baseline quantitative computed tomography (QCT) scans in 250 men aged 65 years or older, which comprised a randomly-selected subcohort of 210 men and 40 cases ...
Salo Eeva E Hospital for Children and Adolescents, University of Helsinki, Helsinki, - - 2012
The aim of the present study was to compare the epidemiologic features of Kawasaki disease (KD) in three northern European countries and Japan. Data were obtained from discharge databases for hospitals in Finland, Norway, and Sweden for 1999-2009 and from nationwide epidemiologic surveys in Japan for 1998-2008. Annual incidence for ...
- - 2012
Cover: Ingenuity network analysis showing up-(red) and down-regulation (green) of miRNAs as analyzed by miRNA profiling that are involved in pancreatic cancer and their target genes. See article by Ali et al., pages 3373-338 0this issue.
Wu You-Lin - - 2012
A mold-cast polydimethylsiloxane (PDMS) confined window was integrated with a poly-silicon wire (PSW) ion sensor. The PSW sensor surface inside the confined window was coated with a 3-aminopropyltriethoxysilane (γ-APTES) sensitive layer which allowed a single living cell to be cultivated. The change in the microenvironment due to the extracellular acidification ...
Pineda Miguel A - - 2012
Among many survival strategies, parasitic worms secrete molecules that modulate host immune responses. One such product, ES-62, is protective against collagen-induced arthritis (CIA), a model of rheumatoid arthritis (RA). Since interleukin-17 (IL-17) has been reported to play a pathogenic role in the development of RA, this study was undertaken to ...
Kim Ju Hee - - 2012
RNase H (retroviral ribonuclease H) cleaves the phosphate backbone of the RNA template within an RNA/DNA hybrid to complete the synthesis of double-stranded viral DNA. In the present study we have determined the complete structure of the RNase H domain from XMRV (xenotropic murine leukaemia virus-related virus) RT (reverse transcriptase). ...
Sierra-Vargas Martha Patricia - - 2012
Air pollution is becoming a major health problem that affects millions of people worldwide. In support of this observation, the World Health Organization estimates that every year, 2.4 million people die because of the effects of air pollution on health. Mitigation strategies such as changes in diesel engine technology could ...
Sun Xiuzhu - - 2012
VDJ and VJ rearrangements, expression of RAG-1, Tdt and VpreB, and the presence of signal joint circles (SJC) were used to identify sites of B-cell lymphogenesis. VDJ, VλJλ but not VκJκ rearrangements or SJC were recovered from yolk sac (YS) at 20 days of gestation (DG) along with strong expression ...
Yim Robert P - - 2012
Steroid-resistant asthma (SRA) refers to patients with symptoms consistent with asthma who show very poor or no response at all to high doses of inhaled or even of systemic corticosteroids. The current article reviews the SRA related literature focusing on the problems associated with the definition of SRA (especially its ...
Semeere Aggrey S - - 2012
Given the recent availability of antiretroviral therapy (ART) in resource-limited settings and the significant burden exacted by Kaposi's sarcoma in these areas, we reviewed data regarding the impact of ART on Kaposi's sarcoma incidence. We summarized the sizeable literature in resource-rich settings as well as emerging data from resource-limited regions. ...
Goedert James J - - 2012
To estimate the impact of highly effective antiretroviral therapy (ART) on the incidence and prognosis of Hodgkin lymphoma among people with human immunodeficiency virus infection or AIDS (PWHA). Age-adjusted incidence of Hodgkin lymphoma in PWHA is unchanged and is still five-fold to fifteen-fold higher than in the general population. Aging ...
Bhatia Kishor - - 2012
In immunodeficiency, an increased sarcoma risk is confirmed for Kaposi's sarcoma. Whether rates of other sarcoma subtypes are elevated in the setting of immunodeficiency is not known. We therefore reviewed published case reports on HIV and AIDS patients and organ transplant recipients with sarcomas. For comparison, we assessed sarcomas in ...
Boldrin Luisa L The Dubowitz Neuromuscular Centre, UCL Institute of Child Health, London, United Kingdom. - - 2012
Stem cell transplantation is already in clinical practice for certain genetic diseases and is a promising therapy for dystrophic muscle. We used the mdx mouse model of Duchenne muscular dystrophy to investigate the effect of the host satellite cell niche on the contribution of donor muscle stem cells (satellite cells) ...
Mason W Alex WA Boys Town National Research Institute for Child and Family Studies, Boys Town, NE 68010, USA. - - 2012
This study tests risk factors for four dimensions of alcohol use in the sequence from (i) early onset prior to age 13 to (ii) adolescent alcohol use and (iii) alcohol problems to (iv) young adult alcohol abuse. It also examines whether family-focused preventive interventions buffer predictive relationships. Data were from ...
Brady Joanne E JE Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, - - 2013
This study aims to examine the prevalence of alcohol and/or other drugs (AOD) in a large sample of fatally injured drivers. Using data from the Fatality Analysis Reporting System for 2005-09, the authors examined the prevalence of AOD detected in fatally injured drivers in the United States. Fatal motor vehicle ...
Soneji Samir S Cancer Control Research Program, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, NH 03756, - - 2012
This study assesses how race/ethnicity and socio-economic status modify the relationship between exposure to movie smoking and having tried smoking in adolescents. Data come from a cross-sectional telephone survey and were analyzed using logistic regression models. A respondent reporting ever having tried smoking was regressed on exposure to movie smoking, ...
Liu Chih-Wei - - 2012
Ubiquitination of proteins plays an important role in regulating a myriad of physiological functions in plants such as xylogenesis, senescence, cell cycle control, and stress response. However, only a limited number of proteins in plants have been identified as being ubiquitinated in response to salt stress. The relationships between ubiquitination ...
Calza P - - 2012
A comprehensive study of the environmental fate of pollutants is more and more required, above all on new contaminants, i.e. pharmaceuticals. As high-resolution mass spectrometry (HRMS(n) ) may be a suitable analytical approach for characterization of unknown compounds, its performance was evaluated in this study. The analyses were carried out ...
Kania Magdalena - - 2012
The aim of this study was to determine whether Atmospheric Pressure Photoionization (APPI) was better suited for the mass spectrometric (MS) analysis of polyisoprenoid alcohols than the commonly used Electrospray Ionization (ESI) method. The APPI method should make possible the use of non-polar solvents without any of the additives required ...
Madeira Paulo J Amorim - - 2012
The gas-phase behaviour of six Ru(II) cyclopentadienyl-derived complexes with N-coordinated ligands, compounds with antitumor activities against several cancer lines, was studied. This was performed with the intent of establishing fragmentation pathways and to determine the Ru-L(N) and Ru-L(P) ligand bond dissociation energies. Such knowledge can be an important tool for ...
Gorshkov Mikhail V - - 2012
Similar to other mass spectrometric technologies based on ion trapping in a spatially restricted area, the performance of Orbitrap Fourier transform mass spectrometry (FTMS) is affected by the interaction between the trapped ion clouds. One of the effects associated with Coulombic interaction inside the ion trap is the ion cloud ...
Jeong Eun-Kyung - - 2012
Alkaloids with significant therapeutic effects are the main active constituents of Corydalis (C.) species. There are several kinds of alkaloids in C. species associated with diverse alkaloid metabolism in plants, but they are rarely identified. This study aimed to identify diverse alkaloids in C. species by liquid chromatography/electrospray ionization tandem ...
Wassenaar L I - - 2012
The interpretation of stable hydrogen and oxygen isotope data in isotope hydrology relies on accurate, high-precision analytical measurements of the (2) H:(1) H and (18) O:(16) O ratios in liquid H(2) O samples. A synthesis of the International Atomic Energy Agency (IAEA) worldwide proficiency test for analytical laboratories conducting routine ...
Unterman Shimon A SA Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, - - 2012
Hyaluronic acid (HA) is an extracellular matrix molecule with multiple physical and biological functions found in many tissues, including cartilage. HA has been incorporated in a number of biomaterial and scaffold systems. However, HA in the material may be difficult to control if it is not chemically modified and chemical ...
Hultquist Judd F JF Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, - - 2012
Human immunodeficiency virus type 1 (HIV-1) requires the cellular transcription factor core binding factor subunit β (CBFβ) to stabilize its viral infectivity factor (Vif) protein and neutralize the APOBEC3 restriction factors. CBFβ normally heterodimerizes with the RUNX family of transcription factors, enhancing their stability and DNA-binding affinity. To test the ...
Kim Hye-Lee - - 2012
(1,3)-(1,6)-β-D-glucan (BG), a natural product of glucose polymers, has immune stimulatory activity that is especially effective in wound healing. In this study, poly(lactic-co-glycolic acid) (PLGA) membranes containing BGs (BG/PLGA membranes) were investigated for their wound-healing effects. The growth rate of human dermal fibroblasts was enhanced in BG/PLGA membranes. Their growth ...
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