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Richey Stephen L SL Departments of *Genitourinary Medical Oncology †Pathology ‡Radiology §Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, - - 2013
To determine the clinical activity and safety of the combination of pemetrexed and gemcitabine in advanced nonclear cell renal cell carcinoma (nccRCC). In this phase II study, patients received pemetrexed 500 mg/m intravenous infusion over 10 minutes on day 1 followed immediately by gemcitabine 1500 mg/m intravenously over 30 minutes ...
Kia Richard R Department of Molecular and Clinical Pharmacology, University of Liverpool, MRC Centre for Drug Safety Science, Liverpool, - - 2013
Amongst the different types of adverse drug reactions, drug-induced liver injury is the most prominent cause of patient morbidity and mortality. However, the current available hepatic model systems developed for evaluating safety have limited utility and relevance as they do not fully recapitulate a fully functional hepatocyte, and do not ...
Reed Daniel M DM Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, London, UK. - - 2013
Stem cell therapy and organ regeneration are therapeutic approaches that will, we suggest, become mainstream for the treatment of human disease. Endothelial cells, which line the luminal surface of every vessel in the body, are essential components in any organ regeneration programme. There are a number of potentially therapeutic endothelial ...
Ando Hitoshi H Division of Clinical Pharmacology, Department of Pharmacology, School of Medicine, Jichi Medical University, Shimotsuke, Tochigi, - - 2013
To investigate whether (i) angiotensin receptor occupying profiles of angiotensin II receptor blockers (ARBs) vary among the drugs and (ii) such differences contribute to the degree of their pleiotropic effects. In a randomized, three phase crossover study, nine hypertensive patients received repeated doses (each recommended starting dose for 7 days ...
Laviolle Bruno B Inserm, CIC-P 0203 Clinical Investigation Centre, Rennes, - - 2013
A single administration of hydrocortisone has been shown to enhance the pressor response to phenylephrine in healthy volunteers and to norepinephrine in septic shock patients. Similar data do not exist for fludrocortisone. Since there continues to be disagreement about the utility of fludrocortisone in septic shock, we assessed the effects ...
Lian Jihong - - 2012
Carboxylesterase 3/triacylglycerol hydrolase (Ces3/TGH) participates in hepatic very low-density lipoprotein (VLDL) assembly and in adipose tissue basal lipolysis. Global ablation of Ces3/Tgh expression decreases serum triacylglycerol (TG) and nonesterified fatty acid levels and improves insulin sensitivity. To understand the tissue-specific role of Ces3/TGH in lipid and glucose homeostasis, we generated ...
Mahady Suzanne E - - 2012
Nonalcoholic steatohepatitis (NASH) is the commonest liver disease in developed countries. However, there are no current data on the cost-effectiveness of therapeutic options such as lifestyle modification, pioglitazone, or vitamin E. We undertook a cost utility analysis to compare these strategies. Using a third-party payer perspective, a deterministic Markov model ...
Yuan Sheng-Xian - - 2012
Survival of patients with hepatocellular carcinoma (HCC) remains poor, which is largely attributed to active angiogenesis. However, the mechanisms underlying angiogenesis in HCC remain to be discovered. In this study, we found that long noncoding RNA associated with microvascular invasion in HCC (lncRNA MVIH) (lncRNA associated with microvascular invasion in ...
King Gavin G Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, - - 2012
Recent trends towards the intensification of urban development to increase urban densities and avoid sprawl should be accompanied by research into the potential for related health impacts from environmental exposure. The objective of the current study was to examine the effect of the built environment and land use on levels ...
Wong Mee-Lian ML Saw Swee Hock School of Public Health (MD 3), National University of Singapore, Singapore, Singapore. - - 2012
Globalization has led to a rapid influx of female workers from Asian countries with high prevalence of HIV to Singapore, with many entering the entertainment industry. We assessed the prevalence of sexual services, condom use, and self-initiated screening for sexually transmitted infections (STIs) and associated variables among foreign female entertainment ...
Park Heiyoung H Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD 20892, - - 2012
Early, vigorous intrahepatic induction of interferon (IFN)-stimulated gene (ISG) induction is a feature of hepatitis C virus (HCV) infection, even though HCV inhibits the induction of type I IFNs in vitro. To identify the cytokines and cells that drive ISG induction and mediate antiviral activity during acute HCV infection, type ...
Zhang Tao - - 2012
Hepatitis B virus X protein (HBx) plays critical roles in the development of hepatocellular carcinogenesis (HCC). Yes-associated protein (YAP), a downstream effector of the Hippo-signaling pathway, is an important human oncogene. In the present article, we report that YAP is involved in the hepatocarcinogenesis mediated by HBx. We demonstrated that ...
Bedossa Pierre - - 2012
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and being overweight is a significant risk factor. The aim was to build an algorithm along with a scoring system for histopathologic classification of liver lesions that covers the entire spectrum of lesions in morbidly obese patients. A cohort of 679 obese ...
Rohrmeier C - - 2012
We report on the submucosal injection of bevacizumab (Avastin) at a dose of 0.3 to 3.75 mg per side in a patient with hereditary hemorrhagic telangiectasia. Application of such low doses has not been described in the literature yet. Our case report shows the positive effect of low-dose bevacizumab on ...
Gao Ge - - 2012
Proliferation of pulmonary artery smooth muscle cells (PASMC) is an important contributor to the progress of pulmonary arterial hypertension (PAH). Anti-inflammatory therapies may have therapeutic applicability for PAH. Resveratrol (RES) has prominent anti-inflammatory effects in vitro, but in vivo its beneficial effects are limited by short systemic half life and ...
Sershen Henry - - 2012
It is well known that astrocytic and neuronal transmitter release processes are important for signalling, and that activity-dependent release of adenosine nucleotides and transmitters occurs after stimulation. Neurons and astrocytes can account for the source of ATP efflux. In this issue of the BJP, Heinrich et al. characterized K(+) depolarization-evoked ...
Mason B L BL Institute of Pharmaceutical Science, King's College London, London, UK. - - 2012
The multidrug resistance transporter, P-glycoprotein (P-gp), contributes to highly lipophilic molecules penetrating the brain from the blood at a much lower rate than expected, and has numerous substrates, inhibitors and modulators. The drug-transporting isoform of P-gp is coded by a single human gene, ABCB1, and shares 80% homology with the ...
Akgedik Recep - - 2012
Resveratrol has a preventive potential on bleomycin-induced pulmonary fibrosis in prophylactic use; however, it was not studied in the treatment of the fibrosis. This study investigated the role of resveratrol on the treatment of bleomycin-induced pulmonary fibrosis. Intratracheal bleomycin (2.5 mg/kg) was given in fibrosis groups and saline in controls. First ...
Dunn-Navarra Ann-Margaret - - 2012
Parents who are recent immigrants and/or non-native English speakers are at increased risk for poor health literacy. For example, misconceptions regarding treatment for upper respiratory infections (URIs), including nonjudicious use of antibiotics, have been described among Latinos. We sought to assess the influence of health literacy on knowledge and beliefs ...
Gazit Vered - - 2012
Mice subjected to partial hepatectomy (PH) develop hypoglycemia, followed by increased systemic lipolysis and hepatic fat accumulation, prior to onset of hepatocellular proliferation. Strategies that disrupt these metabolic events inhibit regeneration. These observations suggest that alterations in metabolism in response to hepatic insufficiency promote liver regeneration. Hepatic expression of the ...
Jäger Bernhard - - 2012
Hypoxic hepatitis (HH) is the most frequent cause of acute liver injury in critically ill patients. No clinical data exist about new onset of jaundice in patients with HH. This study aimed to evaluate the incidence and clinical effect of jaundice in critically ill patients with HH. Two hundred and ...
Drewnowska Małgorzata - - 2012
The purpose of this study was to examine the contamination and bioconcentration potential of mercury (Hg) in Yellow-ocher Brittle Gills known also as Yellow-ocher Brittle Gill or Common Russula (Russula ochroleuca) mushroom. Matured fruiting bodies of this fungus and soil samples were collected at ten spatially distant unpolluted sites in ...
Mustapha Adamu - - 2012
The pollution status of the downstream section of the Jakara River was investigated. Dissolved oxygen (DO), 5-day biochemical oxygen demand (BOD(5)), chemical oxygen demand (COD), suspended solids (SS), pH, conductivity, salinity, temperature, nitrogen in the form of ammonia (NH(3)), turbidity, dissolved solids (DS), total solids (TS), nitrates (NO(3)), chloride (Cl) ...
Suzuki Yoshihiro - - 2012
Enterococci such as Enterococcus faecalis and E. faecium are considered as the most suitable indicators of fecal pollution in an aquatic environment, and new methods for Enterococcus determination have been developed, namely, membrane filtration (MF) using membrane-Enterococcus indoxyl-β-D-glucoside agar (mEI) and defined substrate technology (DST) using Enterolert®. This study used ...
Sivapatham Paramasivam - - 2012
Wastewater treatment by-products (WTBP), such as sewage sludge (SS) may be used to enhance soil chemical, physical, and biological properties. These enhanced soil properties, in turn, could from its source of production to its site of application. These concerns may be mitigated by incineration of the SS to produce ash ...
Chang Juhua - - 2012
Butachlor has adverse effects on fecundity and disrupts sex hormone homeostasis in adult zebrafish, but the underlying molecular mechanisms are still unclear. In the present study, zebrafish (Danio rerio) embryos were exposed to various concentrations of butachlor from 2 h post-fertilization (hpf) to 30 days post-fertilization (dpf). The transcription of genes involved ...
Kačániová Miroslava - - 2012
The objective of this investigation was to contribute towards the knowledge of microbiology of honey, more than 50 samples of honey from Slovakia and other countries were mycologically investigated in terms of the overall fungal diversity and toxicological potential of isolated fungi from Penicillium genera. The study revealed that out ...
Brown Jenell - - 2012
Triclosan (TCS) is among the top 10 most persistent contaminants found in U.S. rivers, streams, lakes, and aquifers. Although TCS has not been found to be hazardous to humans, it can be toxic to aquatic environments and animals. The effects of TCS on growth rates and the locomotive behavior of ...
Falandysz Jerzy - - 2012
This communication reports data on the mercury contents of Red Aspen Boletes (Leccinum aurantiacum) mushrooms and the forest soils substrate layer (0-10 cm) underneath the fruit bodies collected from nine spatially distant sites across Poland. Total Hg concentration in soil substrate in seven of the nine sites studied varied from 0.0078 ...
Saarinen Tuomas S - - 2012
Drainage of acid sulphate soils (ASS) increases oxidation, leading to extensive leaching of acidity and metals to rivers (Al, Cd, Cr, Fe, Ni and Zn). This is often apparent during high runoff periods in spring and autumn after long dry periods with low groundwater levels and associated ASS oxidation. Regression ...
Sarkar Dhruba Jyoti - - 2012
Amphiphilic copolymers, synthesized from poly(ethylene glycols) and various aliphatic and aromatic diacids, which self-assemble into nanomicellar aggregates in aqueous media, were used to develop controlled release (CR) formulations of thiamethoxam (3-(2-chloro-1,3-thiazol-5-ylmethyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene(nitro)amine) using encapsulation technique Formulations were characterised by Infrared (IR) spectroscopy, Dynamic Light Scattering (DLS) and Transmission Electron Microscope (TEM). ...
Doganlar Zeynep B - - 2012
In this study, the effects of the herbicide, quizalofop-p-ethyl, on pigment contents (total chlorophyll, chlorophyll a/b, carotenoid), antioxidant enzyme [superoxide dismutase (SOD) and guaiacol peroxidase (POD)] activities, lipid peroxidation product (malondialdehyde: MDA) and DNA profiles were investigated in Lemna gibba and Lemna minor. Laboratory-acclimatized plants were treated with quizalofop-p-ethyl at ...
Ratasuk Nopawan - - 2012
Tetracyclines such as oxytetracycline (OTC) are widely used veterinary chemicals. They are often poorly absorbed with a significant fraction being excreted in manure that can subsequently result in environmental contamination. In many countries throughout South East Asia swine manure is not composted, but sun-dried. Using sunlight to heat manure has ...
Sawczyn Tomasz - - 2012
This study was undertaken to test the hypothesis that following exposure to insecticides, changes take place in the metabolism of carbohydrates and absorption in the midgut of insects. The Madagascar hissing cockroach (Gromphadorhina portentosa) was chosen for the experiment as a model organism, due to it being easy to breed ...
Chao Keh-Ping - - 2012
A cold, electrodeless method was used to prepare bimetals (Fe/Cu, Fe/Ni) and trimetals (Fe/Cu/Ni) for the treatment of trichloroethylene (TCE). With Fe/Cu, the degradation of TCE was observed to increase with increasing copper content up to 9.26 % (w/w) with a first-order degradation rate constant approximately 10 times faster than ...
Longest P Worth - - 2012
Submicrometer and nanoparticle aerosols may significantly improve the delivery efficiency, dissolution characteristics, and bioavailability of inhaled pharmaceuticals. The objective of this study was to explore the formation of submicrometer and nanometer aerosols from mesh nebulizers suitable for respiratory drug delivery using experiments and computational fluid dynamics (CFD) modeling. Mesh nebulizers ...
Poulopoulos Stavros G - - 2012
In the present work, the catalytic decomposition or oxidation of ethanol over CuO/CeO(2)/γ-alumina catalysts is presented. Ethanol was oxidized in a tubular flow reactor under both oxygen excess and deficit conditions. Various amounts of ceria (0-14 % w/w) were added by wet impregnation to catalysts containing 1 % and 10 ...
Jiamjitrpanich Waraporn - - 2012
This study was designed to compare the initial method for phytoremediation involving germination and transplantation. The study was also to determine the tolerance efficiency of Panicum maximum (Purple guinea grass) and Helianthus annuus (Sunflower) in TNT-contaminated soil and nZVI-contaminated soil. It was found that the transplantation of Panicum maximum and ...
Thanyacharoen Uthumporn - - 2012
Worldwide contamination by acrylamide, a neurotoxicant and carcinogen in animals, is becoming a significant problem. We isolated three novel acrylamide-degrading bacteria from domestic wastewater in Chonburi, Thailand. Using biochemical characteristics and 16S rRNA gene sequencing, the strains were identified as Klebsiella pneumoniae, Kluyvera georgiana and Enterococcus faecalis. K. georgiana strain ...
Gondal Mohammed A - - 2012
CO(2) was converted into value-added hydrocarbons (methanol) by laser-induced photocatalytic reduction of CO(2) over commercially available silicon-carbide (SiC) granules as catalyst. The conversion of CO(2) was carried out in a glass reactor having quartz window and equipped with stirring system and was provided with continuous CO(2) flow at ambient conditions. ...
Somensi Cleder A - - 2012
Cytostatics are a major class of chemotherapy drugs with great potential to cause genotoxic and/or mutagenic effects in all organisms. Currently, hospital wastewater treatment systems (HWTS) are not able to remove these compounds and they are discharged to the environment. Thus, the objective of this study was to investigate the ...
Salvo Lígia M - - 2012
This study is aimed at evaluating the sublethal effects of endosulfan (EDS) in juvenile common carp (Cyprinus carpio). For this purpose, fish were exposed for 15 days to the technical EDS (95% pure) diluted in dimethyl sulfoxide (DMSO) 0.1% of the total volume in water solution in a semi-static system at ...
Bakhmet Igor N - - 2012
The heart rate and calpain activity of blue mussels Mytilus edulis from the sublittoral zone, exposed to different levels of water-borne copper and cadmium, was investigated in a long-term experiment. The content of cadmium and copper in the blue mussel was determined using flame and graphite Atomic absorption spectroscopy. The ...
Oreščanin Višnja - - 2012
The subject of this study was chemical and radiological characterization of the fly and bottom ash, by-product of the combustion of coal used as an energy source in the former sulfate pulp factory in Plaški. The research involves determination of the concentration of macro, micro and trace elements and activities ...
Kačániová Miroslava - - 2012
The aim of this study was to examine the effect of propolis extracts on the microbial colonization of chicken gastrointestinal tract in vivo. The propolis was administered to both feed mixtures in various amounts except of the control group. The addition of 150 mg propolis to 1 kg of feed was included ...
Falandysz Jerzy - - 2012
In this study a two simple and one-step extraction methods were compared for the evaluation of Ag, Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, P, Pb, Rb, Sr and Zn accessibility in the soils to Larch Boletes (Suillus grevillei) mushrooms. Determination of chemical elements ...
Guha Mazumder Debendra - - 2012
Various systemic manifestations are reported to be caused by chronic arsenic exposure in the population living in the Indo-Bangladesh subcontinent. This study from West Bengal assesses the likelihood of occurrence of hypertension (HTN) in individuals resident in an area of high groundwater contamination with arsenic (Nadia district) compared to those ...
Gerić Marko - - 2012
The present study aimed to characterize chemical properties of clay bricks containing 20 % of sewage sludge. After detection of potentially hazardous metals, we simulated precipitation exposure of such material to determine the amount of heavy metals that could leach out of the bricks. Metals, such as copper, zinc, nickel, ...
Stiaccini Giulia - - 2012
The cardioprotective and anti-aging effects of red wine phenols, especially resveratrol (RSV), are well known. One of the most interesting biological properties of RSV and other naturally occurring phenols is the regulation of the expression and activity of SIRT1 (silent mating type information regulation 2 homolog). In view of the ...
Fontana Robert J - - 2012
A recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) can lead to accelerated allograft injury and fibrosis. The aim of this article is to report the first ever use of daclatasvir (DCV; also known as BMS-790052), a potent orally administered nonstructural 5A replication complex inhibitor, in combination with ...
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