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Results 251 - 300 of 1478
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Kawadkar Jitendra - - 2012
Flurbiprofen is used in the treatment of arthritis. However, its multiple dosing due to short elimination half life is a concern for such treatment. This work aims to develop nanostructured lipid carriers (NLCs) of flurbiprofen and evaluate their potential for transdermal delivery. The NLCs were prepared by the optimized o/w ...
Anderson Richard A - - 2012
The measurement anti-Müllerian hormone (AMH) is leading to new insights into ovarian function. AMH is produced by small growing follicles, thus is distinct from ovulation and is a step closer to being able to assess the true ovarian reserve. AMH is measureable from birth to near the menopause, with a ...
Edimo William's Elong - - 2012
Phosphoinositide (PI) phosphatases such as the SH2 domain-containing inositol 5-phosphatases 1/2 (SHIP1 and 2) are important signalling enzymes in human physiopathology. SHIP1/2 interact with a large number of immune and growth factor receptors. Tyrosine phosphorylation of SHIP1/2 has been considered to be the determining regulatory modification. However, here we present ...
Al-Ghabeesh Suhair Husni - - 2012
Rationale, aims and objectives  Understanding sources of knowledge used in everyday practice is very helpful in improving the quality of health care services. There is a consensus in the literature that nurses mostly relied in their practice on experiential knowledge gained through their interactions with other members of health care ...
Simoni Jane M - - 2013
Knowing at antiretroviral therapy (ART) initiation which patients might be at greatest risk for failure to achieve viral suppression would enable providers to target patients most in need and tailor their care appropriately. This study involved multilevel modeling of data from a randomized controlled trial among outpatients in Seattle, WA, ...
Yao Li Qin - - 2012
Background/Aims: This study aims to compare the clinical outcomes and costs between percutaneous transhepatic biliary stenting (PTBS) and surgical bypass. Methodology: We randomly assigned 142 patients with unresectable malignant biliary obstruction between 2005 and 2010 to receive PTBS or surgical bypass as palliative treatment. PTBS was successfully performed in 70 ...
Murthy Sandhya - - 2012
Double-chambered right ventricle (DCRV) is a rare form of right ventricular outflow tract (RVOT) obstruction accounting for approximately 1% of patients with congenital heart disease. It consists of an anomalous muscle bundle that divides the right ventricle usually between the sinus (inlet) and the infundibulum (outlet). This division creates a ...
Zhou Min - - 2012
Vacuum-assisted closure (VAC) device is widely used to treat infected wounds at clinical work. Although the effect of VAC with different negative pressure values was well established, different negative pressures could result in varying modulation of wound relative cytokines was not clear. We hypothesise that instead of the highest negative ...
Maselli Olivia J - - 2012
Benzene molecules were desorbed from an in vacuo aqueous liquid beam by direct irradiation of the beam with an IR laser tuned to the 2.85 μm absorption band of water. Spectroscopic interrogation of the desorbed benzene molecules was performed via 1 + 1 Resonance-Enhanced Multi-photon Ionisation (REMPI). Rotational contour analyses ...
Cancemi Patrizia - - 2012
PURPOSE: The present study reports for the first time a large-scale proteomic screening of the occurrence, subcellular localization and relative quantification of the S100A7 protein among a group of 100 patients, clinically grouped for the diagnosis of infiltrating ductal carcinoma (IDC). and EXPERIMENTAL DESIGN: To this purpose, the methods of ...
Forsyth M B - - 2012
Investigation was undertaken to assess the occurrence of zoonotic infection among staff at Auckland Zoological Park, New Zealand, in 1991, 2002 and 2010. Serial cross-sectional health surveys in 1991, 2002 and 2010 comprising a health questionnaire, and serological, immunological and microbiological analysis for a range of potential zoonotic infections were ...
Fandakova Yana - - 2012
This study investigated the extent to which older adults' associative memory functioning can be modified through instruction and practice based on individuals' memory status. Here 42 younger adults and 42 older adults performed four tasks that measured strategic and binding aspects of memory. With latent class analysis, two classes of ...
Chu Emily Y - - 2012
Background  Hidradenitis suppurativa (HS) is a relatively common condition marked by abscesses, sinus tracts, and scarring in intertriginous regions of the body. Lymphedema is an under-recognized consequence of chronic inflammation in the setting HS. Methods  We report five cases of patients with lymphedema resulting from long-standing HS; the patients were ...
Khedri Zahra - - 2012
Sialidases or neuraminidases catalyze the hydrolysis of terminal sialic acid residues from sialyl oligosaccharides and glycoconjugates. Despite successes in developing potent inhibitors specifically against influenza virus neuraminidases, the progress in designing and synthesizing selective inhibitors against bacterial and human sialidases has been slow. Guided by sialidase substrate specificity studies and ...
Kusuma Damar Yoga - - 2012
Conductance bistability in Pt/Si-Vinylidene Fluoride (VDF) oligomer-Au ferroelectric tunnel junction devices is demonstrated. I-V and C-V measurements reveal bistable conductance switching within biasing voltage of ±0.5V with stable memory retention up to 1 × 10(4) cycles. The memory element exhibits a low switching voltage of ±1.0 V, coincides with the ...
Huang Jie - - 2012
The last few years have witnessed rapid development of biological and medical applications of graphene oxide (GO), such as drug/gene delivery, biosensing, and bioimaging. However, little is known about the cellular uptake mechanism and pathway of GO. In this work, surface-enhanced Raman scattering (SERS) spectroscopy is employed to investigate the ...
Holmberg Leif - - 2012
Rationale, aims and objectives  Evidence-based medicine and clinical guidelines have been found difficult to implement in the clinical practice - mainly because lack of evidence quality and guidelines that, generally, do not account for variations in the medical cases. Variation in the medical cases enhances task uncertainty and uncertainty seems ...
Almazi Juhura G - - 2012
PURPOSE: Human Raji cells treated with fludarabine nucleoside (2-FaraA, 3 μM) undergo apoptosis with accumulation of p53 in the nuclei as multiple phosphorylated isoforms and C-terminal truncated derivatives. Changes induced by 2-FaraA in the levels of p53, p63 and p73 in the nuclear, cytosolic and mitochondrial fractions have been determined ...
Leheta Tahra M - - 2012
Abstract Background: There have been no well-controlled studies evaluating the efficacy of combining 1,540nm nonablative fractional laser with percutaneous collagen induction (PCI) and trichloroacetic acid (TCA) 20% in the treatment of atrophic acne scars. Objective: We hypothesized that combined alternating sessions of both modalities would show better results than each ...
Harkness Kellen M KM Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN37235, - - 2012
Gold nanoparticles (AuNPs) protected by self-assembled monolayers (SAMs) are capable of presenting precisely engineered surfaces at the nanoscale, allowing the mimicry of biomacromolecules on an artificial platform. Here we review the generation, characterization, and applications of monolayer-protected AuNPs that have been designed for immunorecognition by the integration of an oligopeptide ...
Kelly Andrew J AJ School of Psychology, Georgia Institute of Technology, Atlanta, GA 30332-0170, USA. - - 2013
In everyday prospective remembering, individuals must often delay the execution of a retrieved intention until they are in the appropriate setting. These so-called 'delay-execute' tasks are particularly troublesome for older adults, who consistently demonstrate impaired performance in this kind of laboratory task. To better understand this effect, we investigated delay-execute ...
Espino Daniel M - - 2012
A transient multi-physics model of the mitral heart valve has been developed, which allows simultaneous calculation of fluid flow and structural deformation. A recently developed contact method has been applied to enable simulation of systole (the stage when blood pressure is elevated within the heart to pump blood to the ...
Zhao Lin - - 2012
Background/Aims: To investigate the feasibility and mechanism of liver damage repair using BMSCs, we investigated the potential for BMSCs in recovery from liver damage, using the CCl4-induced rat model for liver damage. Methodology: Phenotypings of BMSCs of the third generation were analyzed by flow cytometry. BMSCs labelled by BrdU were ...
Liang Desheng - - 2012
BACKGROUND: Wolf-Hirschhorn syndrome (WHS) is caused by a deletion involving the 4p16.3 region. Approximately 70% of WHS patients have a de novo isolated deletion and 22% involve unbalanced translocations. However, WHS with unbalanced rearrangements involving the short arm of an acrocentric chromosome are infrequently reported. METHODS: Cytogenetic and molecular analyses ...
Gringeri A - - 2012
There is lack of evidence-based recommendations or clear-cut consensus regarding the clinical and economic utility of regular prophylaxis started in adulthood, with the aim of keeping the clinical situation from getting worse by prevention of further bleeds contributing to increasing musculo-skeletal or other morbidity in haemophilia. Such a prophylaxis program ...
Kobayashi Zen - - 2012
A 30-year-old Japanese woman without relevant family history presented with a behavioral abnormality followed by motor weakness about 14 years later. The patient died at age 45. Post mortem examination revealed degeneration of the frontal and temporal lobes, as well as lower motor neurons in the brainstem and spinal cord. ...
Hill Anita - - 2012
Pulmonary hypertension is becoming a recognized complication of the hereditary and acquired haemolytic anaemias, associated with a poor prognosis. Recently we reported that patients with paroxysmal nocturnal haemoglobinuria (PNH) have high levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), a biomarker associated with both right and left ventricular dysfunction and cardiac ...
Brick Katherine - - 2012
  A defect in type VII collagen causes dystrophic epidermolysis bullosa (DEB). The pruriginosa variant (DEB-Pr) is unique because its initial presentation may be delayed until adolescence or adulthood, and its predominant feature is scarring and pruritus without the characteristic skin fragility of DEB. We describe three families with multiple ...
Li Jian-Hao - - 2012
We systematically investigate the possible complex transition origin of electronic excitations of giant molecular systems by using the recently proposed QNTO analysis [J.-H. Li, J.-D. Chai, G. Y. Guo and M. Hayashi, Chem. Phys. Lett., 2011, 514, 362.] combined with long-range corrected TDDFT calculations. Thymine (Thy) related excitations of a ...
Schwappach David L B - - 2012
Background  Various authorities recommend the participation of patients in promoting patient safety, but little is known about health care professionals' (HCPs') attitudes towards patients' involvement in safety-related behaviours. Objective  To investigate how HCPs evaluate patients' behaviours and HCP responses to patient involvement in the behaviour, relative to different aspects of ...
Alfaro-Castellón Patricia - - 2012
  Eruptive vellus hair cysts are benign lesions that can be difficult to distinguish from other skin conditions, including molluscum contagiosum and acne vulgaris. Diagnosis can be corroborated with histopathology. We emphasize differing dermoscopy features to help distinguish eruptive vellus hair cysts from molluscum contagiosum or acne.
Chaudhuri Debangshu - - 2012
Dual singlet-triplet fluorescence-phosphorescence emitting compounds demonstrate that plasmonic surface enhancement is controlled solely by the underlying oscillator strength of a transition: metal-free compounds with weak spin-orbit coupling show no enhancement in phosphorescence efficiency even though fluorescence is amplified.
Haetge Jan - - 2012
Nanocrystalline nickel molybdate (NiMoO(4)) thin film electrodes with a 3D honeycomb structure of uniform 17 nm diameter pores were successfully produced through facile polymer templating strategies. These novel sol-gel type materials exhibit enhanced lithium ion storage capabilities, and thus show promise for battery applications.
Funatogawa Ikuko - - 2012
In some clinical trials or clinical practice, the therapeutic agent is administered repeatedly, and doses are adjusted in each patient based on repeatedly measured continuous responses, to maintain the response levels in a target range. Because a lower dose tends to be selected for patients with a better outcome, simple ...
Cohen J T JT Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA. - - 2012
Retrospective cohort. To estimate the association between the Functional Independence Measure (FIM) for spinal cord injury (SCI) patients at time of discharge from rehabilitation and long-term resource utilization, residential status and employment. The intention was to assess the value of FIM for projecting economic burden in SCI. Federally designated spinal ...
Sandoval-García F - - 2012
Background: The ACTN3 gene encodes the fast muscle protein α-actinin-3. The ACTN3 R577X polymorphism is a premature stop codon and results in absence of α-actinin-3 in 577XX homozygotes. The aim of this study was to determine the ACTN3 genotype in idiopathic inflammatory myopathies (IIMs). Methods: We performed ACTN3 genotyping on ...
Kirby S - - 2012
Sample size planning is an important design consideration for a phase 3 trial. In this paper, we consider how to improve this planning when using data from phase 2 trials. We use an approach based on the concept of assurance. We consider adjusting phase 2 results because of two possible sources of bias. ...
Lee Sung-Chan - - 2012
We report the first fluorescent diamino-chalcone library and its application in the discovery of a mouse embryonic stem cell (mESC) probe. CDg4, a novel green fluorescent mESC probe was discovered through a high-content image based screening of 160 members of the chalcone library. Interestingly, the molecular binding target of CDg4 ...
Zhou Lin - - 2012
Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs) in surface sediment samples from Taihu Lake-an important water supply of the Yangtze River Delta, China-were investigated in the present study. Concentrations of PCDD/Fs ranged from 0.91 to 4.8 pg TEQ g(-1) dw (mean: 2.9 pg TEQ g(-1) dw, ...
Kendler K S KS Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0126, USA. - - 2013
In an effort to understand how environmental experiences contribute to risk for major depression (MD), we conducted joint autobiographical interviews with 14 pairs of monozygotic twins (mean age 51.2) rigorously discordant for a lifetime history of MD. Twelve of the pairs could be sorted into four broad categories. In two ...
Harrington Jay T - - 2012
Objective  To determine the clinical and histologic effects of diode endoscopic cyclophotocoagulation (ECP) in the phakic equine eye. Animals studied  Phase I: 10 equine cadaver eyes. Phase II: four normal adult horses. Procedures  Phase I: ECP probe angle of reach (AR) was determined. Multiple ECP energy levels: 0.75, 0.90, 1.05, ...
Malyguine Anatoli - - 2012
The immune system is a critical element involved in the control of tumor development and progression. While professionals have learned how to manipulate the immune system to generate tumor-specific immune responses, cancer immunotherapy has not yet delivered substantial clinical benefits. It has become increasingly clear that tumor-induced abnormalities in the ...
Marsh Elizabeth J - - 2012
A key educational challenge is how to correct students' errors and misconceptions so that they do not persist. Simply labelling an answer as correct or incorrect on a short-answer test (verification feedback) does not improve performance on later tests; error correction requires receiving answer feedback. We explored the generality of ...
Zhu Mengmeng - - 2012
Stomata on leaf epidermis formed by pairs of guard cells control CO(2) intake and water transpiration, and respond to different environmental conditions. Stress induced stomatal closure is mediated via an intricate hormone network in guard cells. Although methyl jasmonate (MeJA) has been intensively studied for its function in plant defense, ...
Satgé Daniel - - 2012
  Melanoma has rarely been reported in people with Down syndrome, and its frequency in this condition has not been clearly established. We report a 19-year-old woman with Down syndrome and lumbar melanoma. This possible association must be kept in mind.
Dobler Ina M - - 2012
Research in the past four decades has repeatedly shown that selective retrieval of some (non-target) memories can impair subsequent retrieval of other (target) information, a finding known as retrieval-induced forgetting. More recently, however, there is evidence that selective retrieval can both impair and enhance recall of related memories (K-H. T. ...
McGeachie M J MJ Partners Healthcare Center for Personalized Genetic Medicine, Boston, MA, - - 2013
Inhaled corticosteroids (ICS) are the most commonly used controller medications prescribed for asthma. Two single-nucleotide polymorphisms (SNPs), rs1876828 in corticotrophin releasing hormone receptor 1 and rs37973 in GLCCI1, have previously been associated with corticosteroid efficacy. We studied data from four existing clinical trials of asthmatics, who received ICS and had ...
Jemel Sara - - 2012
Aortic graft infection, one of the most common fatal complications of aortovascular surgery, is managed mainly by the removal of infected graft material and re-establishment of vascular continuity using an extra-anatomical bypass or in situ graft replacement. Despite significant progress in perioperative, surgical, and medical treatments, the mortality and morbidity ...
Leahy Siobhan - - 2012
Anthropometric data indicate that the human phenotype is changing. Today's adult is greater in stature, body mass and fat mass. Accurate measurement of body composition is necessary to maintain surveillance of obesity within the population and to evaluate associated interventions. The aim of the present study was to construct and ...
Novoa-Candia Mónica P MP Pediatric Dermatology Unit, Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, SpainClinica DermikDepartment of Pathology, USP Dexeus, Barcelona, - - 2013
Congenital melanocytic nevi (CMN) are benign skin lesions present in some newborns. We describe a newborn boy with a giant CMN on the scalp. It appeared as an atrophic patch with a central nodule that was suggestive of a rapidly involuting congenital hemangioma or some other vascular tumor. Histopathology confirmed ...
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