Search Results
Results 401 - 450 of 4185
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Bonk Alison K - - 2012
Nine months prior, S.P., a 64-year-old woman, was diagnosed with stage IV non-small cell lung cancer with distant metastases to the bone. Her large tumor burden had compressed both her trachea and esophagus several months earlier, leading to gastrostomy-tube placement for nutrition and tracheostomy for airway management. Palliative radiation was ...
Phillips Brett T - - 2012
Intraoperative vascular imaging can assist assessment of mastectomy skin flap perfusion to predict areas of necrosis. No head-to-head study has compared modalities such as laser-assisted indocyanine green dye angiography and fluorescein dye angiography with clinical assessment. The authors conducted a prospective clinical trial of tissue expander-implant breast reconstruction with intraoperative ...
Rosenberg Karen - - 2012
A new approach to chronic illness could serve as a national model.
Kasirajan Vigneshwar - - 2012
A web-based registry was used to prospectively study patients after minimally invasive surgery with monitoring to determine freedom from atrial fibrillation (AF) (clinicaltrials.gov/ct2/show/NCT00747838). This is a report showing the utility and feasibility of the registry. All patients had symptomatic AF refractory to medical treatment. Surgical ablation was performed using bipolar ...
Davern Timothy J - - 2012
Drug-induced liver injury (DILI), also known as hepatotoxicity, refers to liver injury caused by drugs or other chemical agents, and represents a special type of adverse drug reaction. It has been estimated that more than 600 drugs and chemicals have been associated with significant liver injury. Many previous reviews have ...
Hadolt Bernhard - - 2012
On the assumption that technical practices and artifacts are fundamental constituents of individual and collective attempts to order lives and bodies in health and sickness, in this introduction, we set out three central propositions. First, medical techniques have to take center stage in research on biomedicine. Second, as medical artifacts ...
Perlman Carrie E - - 2012
A thoracic artificial lung (TAL) provides respiratory support for lung disease. How well a TAL improves blood oxygenation for a specific pathology depends on how the TAL is attached to the pulmonary circulation: in series with the natural lungs (NLs), in parallel, or in a hybrid series/parallel combination. A computational ...
Boening Klaus W - - 2012
Purpose: This study investigated the clinical performance of resin-bonded fixed partial dentures (RBFPDs) using minimally invasive, nonretentive abutment tooth preparation. Materials and Methods: Forty-four patients received 56 porcelain-fused-to-metal RBFPDs (52 three-unit RBFPDs, 4 four-unit RBFPDs). All RBFPDs were inserted between 1995 and 2010 according to a standardized protocol. Thirty-eight RBFPDs ...
Smith Kevin - - 2012
Objective: To determine the absolute bioavailability of naloxone from oral doses ranging from 5 mg to 120 mg. Materials and methods: In this open-label study, 28 healthy subjects received naloxone 1 mg (0.4 mg/ml) as an intravenous infusion (reference treatment), and the following oral doses as prolonged release (PR) naloxone ...
Buijze Geert A - - 2012
The primary risk factor for nonunion of the scaphoid is displacement/instability, but delayed or missed diagnosis, inadequate treatment, fracture location, and blood supply are also risk factors. Untreated nonunion leads to degenerative wrist arthritis-the so-called scaphoid nonunion advanced collapse wrist. However, the correlation of symptoms and disease is poor; the ...
Hammer Marilyn J - - 2012
Purpose/Objectives: To introduce a conceptual model detailing the physiologic contributions of malglycemia to cancer formation and increased morbidity and mortality.Data Sources: A literature search was conducted using the PubMed, CINAHL®, and Cochrane databases, as well as Surveillance, Epidemiology and End Results (SEER) cancer statistics.Data Synthesis: Multiple complex factors are associated ...
Mikasova Lenka - - 2012
Autoimmune synaptic encephalitides are recently described human brain diseases leading to psychiatric and neurological syndromes through inappropriate brain-autoantibody interactions. The most frequent synaptic autoimmune encephalitis is associated with autoantibodies against extracellular domains of the glutamatergic N-methyl-d-aspartate receptor, with patients developing psychotic and neurological symptoms in an autoantibody titre-dependent manner. Although ...
Divine Jon - - 2012
: To investigate the incidence of anterior knee pain among new recruits participating in a targeted exercise intervention, as an addition to army basic training, compared with recruits in an unmodified training program. : Single-blind, cluster (by troop) randomized, controlled trial, during the 14-week period of basic military training. : ...
González-Calle Antonio - - 2012
A patient had a history of a Ross-Konno procedure, stenting of the pulmonary homograft, and an aortic valve replacement. Pressure necrosis developed in the tissues in between the stent and the prosthetic valve. This resulted in a defect between the right and left ventricular outflow tracts that required a complex ...
Suthar V S - - 2012
Three experiments were conducted to determine the effect of endogenous progesterone (P4) on body temperature comparing lactating, pregnant with lactating, nonpregnant cows, and to study the effect of exogenous P4 administered via a controlled internal drug release (CIDR) insert on body temperature in lactating dairy cows. Body temperature was measured ...
Kienzler Hanna - - 2012
This article traces the social life of psychiatric practice in the context of war and postwar societies. It is argued that although psychiatric knowledge and practice is situated and grounded in particular cultural, social, and political contexts, it is important to examine how transnational networks situate local systems of meaning ...
Yuan K - - 2012
The objective of this study was to evaluate the effect of a rumen-protected niacin product (RPN; 65% nicotinic acid; NiaShure, Balchem Corp., New Hampton, NY) on lipid metabolism, oxidative stress, and performance of transition dairy cows. Thirty nonlactating multiparous Holstein cows in late gestation were paired according to expected calving ...
Eller Esben - - 2012
Large studies of individual thresholds and risk profiles for foods are sparse. Previous reports indicate that thresholds adjusted for the protein content in foods would be comparable. To establish and compare clinical threshold values for egg, hazelnut, milk and peanut, and correlating them to severity of symptoms. Seven hundred eighty-one ...
Odell John A - - 2012
The development of antituberculous drugs changed thoracic surgery and also markedly lowered the morbidity and mortality of a disease that had epidemic proportions. This article summarizes aspects from 3 important articles that led to the discovery of these drugs.
Bruschi Giuseppe - - 2012
Transcatheter valve implantation into failing surgical mitral bioprosthetic valves have been reported. This strategy avoids performing high-risk repeat cardiac surgery in elderly patients with multiple comorbidities. All these patients have been treated by a transapical approach. We report a case of failing bioprosthetic mitral valve in an 82-year-old woman successfully ...
Ali Sharif - - 2012
Context.-Patients who undergo hematopoietic stem cell transplant are at an increased risk of developing iron overload. Objectives.-To describe the effect of hepatic iron overload on hematopoietic stem cell transplant recipients and to validate the utility of histologic scoring system of iron granules in the liver. Design.-Records of 154 post allogeneic ...
Lomander H - - 2012
The objective of this field study was to evaluate the effect of supplemental feeding with glycerol or propylene glycol to dairy cows in early lactation on metabolic status, body condition and milk yield. In total, 673 newly calved cows from 12 commercial Swedish dairy herds were randomized to daily supplementation ...
Donahue M - - 2012
This study was conducted on 6 commercial dairy farms in Minnesota and Wisconsin to describe the effect of heat treatment (at 60°C for 60min) on colostrum, on colostrum bacteria counts, and immunoglobulin G concentrations. First-milking colostrum was collected each day, pooled, divided into 2 aliquots, and then 1 aliquot was ...
Wright Sasiporn - - 2012
Linagliptin (BI 1356) is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of Type 2 diabetes which recently gained approval in the US, Europe, and Japan. Linagliptin showed nonlinear pharmacokinetics after intravenous and oral administration, which is due to a concentration-dependent protein binding of linagliptin to its target enzyme DPP-4. The ...
Carter Scott L - - 2012
We describe a computational method that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations. The method, named ABSOLUTE, can detect subclonal heterogeneity and somatic homozygosity, and it can calculate statistical sensitivity for detection of specific aberrations. We used ABSOLUTE to analyze exome sequencing data ...
Hammond Dennis C - - 2012
After studying this article, the participant should be able to: 1. Understand the preoperative considerations that must be weighed to appropriately assess operative risk of breast reduction. 2. Have a full understanding of the basic techniques that are available to treat the patient with macromastia. 3. Identify which patients are ...
Baer Ellen Davidson - - 2012
This article identifies some of the major ideas underpinning modern American nursing in its first 100 years, and postulates that distinct periods in nursing's early formal development were dominated by a particular theme or set of ideas. The themes, which were largely determined by social priorities, scientific advances, and national ...
Choi Hye Duck - - 2012
Cilostazol is frequently used to treat and prevent thrombosis in Korean patients. We performed the pharmacokinetic and correlation analysis of cilostazol in Korean healthy subjects. A total of male 78 volunteers was subjected to three separate bioequivalence studies in which 100 mg of cilostazol was administered. AUC, t(1/2), and C(max) ...
Lacey David L - - 2012
Bone is a complex tissue that provides mechanical support for muscles and joints, protection for vital organs, a mineral reservoir that is essential for calcium homeostasis, and the environment and niches required for haematopoiesis. The regulation of bone mass in mammals is governed by a complex interplay between bone-forming cells ...
Franke Heike - - 2012
Astrocytes are fundamental for central nervous system (CNS) physiology and are the fulcrum of neurological diseases. Astroglial cells control development of the nervous system, regulate synaptogenesis, maturation, maintenance and plasticity of synapses and are central for nervous system homeostasis. Astroglial reactions determine progression and outcome of many neuropathologies and are ...
Petersen Bryan C - - 2012
Interleukin-25 (IL-25) is a cytokine associated with allergy and asthma that functions to promote type 2 immune responses at mucosal epithelial surfaces and serves to protect against helminth parasitic infections in the intestinal tract. This study identifies the IL-25 receptor, IL-17RB, as a key mediator of both innate and adaptive ...
Valle-Onate Rafael - - 2012
Physical therapy and orthopedic surgery are important components in the treatment of ankylosing spondylitis (AS). Supervised physical therapy is more effective than individual or unsupervised exercise in improving symptoms, but controlled trials suggest that combined inpatient and outpatient therapy provides the greatest improvement. Recommendations for exercise are universal, but the ...
Tse Shirley M L - - 2012
No specific recommendations for the treatment of juvenile spondyloarthritis have been established. Important differences exist in how spondyloarthritis begins and progresses in children and adults, supporting the need for pediatric-specific recommendations. Recently published recommendations for the treatment of juvenile arthritis consider children with sacroiliitis in a separate group and allow ...
Reveille John D - - 2012
Ankylosing spondylitis (AS) is associated with both significant direct and indirect costs, which vary by country, and have generally increased dramatically since the introduction of anti-tumor necrosis factor therapy. The cost-effectiveness of biologic agents is controversial, although cost-effectiveness studies need to consider the potential impact of anti-tumor necrosis factor treatments ...
Mizner Ryan L - - 2012
To determine the association of 2-dimensional (2D) video-based techniques and 3-dimensional (3D) motion analysis to assess potential knee injury risk factors during jump landing. Observational study. Research laboratory. Thirty-six female athletes in cutting and pivoting sports. : Athletes performed a drop vertical jump during which movement was recorded with a ...
Ng Kee Peng - - 2012
Cladosporium sphaerospermum is one of the most widely distributed allergens causing serious problems in patients with respiratory tract disease. We report the 26,644,473-bp draft genome sequence and gene annotation of C. sphaerospermum UM843. Analysis of the genome sequence led to the finding of genes associated with C. sphaerospermum's melanin biosynthesis, ...
Anand Mallika - - 2012
Urinary tract infections (UTIs), commonly caused by uropathogenic Escherichia coli (UPEC), confer significant morbidity among postmenopausal women. Glycosaminoglycans (GAGs) comprise the first line of defense at the bladder's luminal surface. Our objective was to use a murine model of menopause to determine whether estrogen status affects the GAG layer in ...
Russo Cesare - - 2012
Left atrial (LA) maximum volume (LAV(max)) is an indicator of left ventricular (LV) diastolic function. However, LAV(max) is also influenced by systolic events, whereas the LA minimum volume (LAV(min)) is directly exposed to LV pressure. The authors hypothesised that LAV(min) may be a better correlate of LV diastolic function than ...
Miaskowski Christine - - 2012
To review the evidence on a number of biomarkers that show potential clinical utility in the prediction of and treatment responsiveness for the four most common symptoms associated with cancer and its treatment (ie, pain, fatigue, sleep disturbance, depression). Review and synthesis of review articles and data-based publications. A growing ...
Documet Patricia I - - 2012
To explore (a) how women who were diagnosed with breast cancer (BC) defined themselves as survivors and when this occurred, and (b) the types of benefits they derived from their experiences. An exploratory, qualitative approach. 112 women who had BC (response rate = 70%). Participants were recruited from two cancer ...
Jain Manu - - 2012
Multiphoton microscopy (MPM) is a nonlinear imaging approach, providing cellular and subcellular details from fresh (unprocessed) tissue by exciting intrinsic tissue emissions. With miniaturization and substantially decreased cost on the horizon, MPM is an emerging imaging technique with many potential clinical applications. To assess the imaging ability and diagnostic accuracy ...
Baker-Lepain Julie C - - 2012
To test whether single-nucleotide polymorphisms (SNPs) of the FRZB gene are associated with hip shape, and to determine whether FRZB variant alleles affect the relationship between hip shape and radiographic osteoarthritis (OA) of the hip. A nested case-control study of Caucasian women, age ≥65 years, from the Study of Osteoporotic ...
Ng Kee Peng - - 2012
Daldinia eschscholzii is an invasive endophyte that is most commonly found in plant tissues rich in secondary metabolites. We report the draft genome sequence of D. eschscholzii isolated from blood culture. The draft genome is 35,494,957 bp in length, with 42,898,665 reads, 61,449 contigs, and a G+C content of 46.8%. ...
Wenzel Jennifer - - 2012
To obtain experiential data regarding African American older adult survivors' perceptions of and recommendations on the role of community health workers (CHWs) in providing a cancer navigation intervention. Focus groups. Rural Virginia and urban Maryland. 48 African American solid-tumor cancer survivors, aged 65 years or older, with Medicare insurance. Analysis ...
Kiyosaki Krista - - 2012
To assess the effect of initial visit with a specialist on disease understanding in women with pelvic floor disorders. Women with referrals or chief complaints suggestive of urinary incontinence or pelvic organ prolapse were recruited from an academic urology clinic. The patients completed a Test of Functional Health Literacy in ...
Kodumuri Preetham - - 2012
Septic arthritis is a life-threatening emergency with high mortality of up to 11 %. We investigated if delay of arthroscopic lavage of infected major joints would have a bearing on the mortality and morbidity such as admission to an intensive care unit (ICU). We retrospectively reviewed patients presenting with septic ...
Piantoni P - - 2012
Bovine mammary parenchyma (PAR) and fat pad (MFP) development are responsive to preweaning level of nutrient intake. We studied transcriptome alterations in PAR and MFP from Holstein heifer calves (n=6/treatment) fed different nutrient intakes from birth to ca. 65 d age. Conventional nutrient intake received 441 g of dry matter ...
- - 2012
We sought to provide evidence-based guidelines for using progestogens for the prevention of preterm birth (PTB). Relevant documents, in particular randomized trials, were identified using PubMed (US National Library of Medicine, 1983 through February 2012) publications, written in English, which evaluate the effectiveness of progestogens for prevention of PTB. Progestogens ...
Dunn Barbara K - - 2012
To define and discuss surrogate endpoint biomarkers, which are used in therapeutic trials as a substitute for the clinically meaningful "true" endpoint; and hence, may be used in answering cancer prevention questions in clinical trials evaluating drug/nutrient interventions for a number of common cancer sites. Literature, research articles. Surrogate endpoint ...
Deqin Ma - - 2012
Epidermal growth factor receptor (EGFR) is overexpressed in up to 80% of colorectal and endometrial carcinomas. Deletions of the polyA tract in the 3' untranslated region (3' UTR) have been reported in microsatellite instability-high (MSI-H) colonic carcinomas, but their impacts on EGFR expression and downstream pathways are unclear. This phenomenon ...
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