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Chen Lei - - 2012
Checkpoint kinase 1 (Chk1) plays key roles in all currently defined cell cycle checkpoints, but its functions in mouse oocyte meiosis remain unclear. In this study, we report the expression, localization and functions of Chk1 in mouse oocyte meiosis. Chk1 was expressed from germinal vesicle (GV) to metaphase II (MII) ...
Karlgren Maria - - 2012
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. Predicting potential interactions with OATPs is, therefore, of value. Here, we developed in vitro and in silico models for identification and prediction of specific and general inhibitors of ...
Daugherity Erin K - - 2012
Steatoapoptosis is a hallmark of non-alcoholic fatty liver disease (NAFLD) and is an important factor in liver disease progression. We hypothesized that increased reactive oxygen species resulting from excess dietary fat contribute to liver disease by causing DNA damage and apoptotic cell death, and tested this by investigating the effects ...
Goloudina Anastasia R - - 2012
Wip1 is a stress-response phosphatase that negatively regulates several tumor suppressors, including p53. In a sizeable fraction of tumors, overexpression or amplification of Wip1 compromises p53 functions; inhibition of Wip1 activity is an attractive strategy for improving treatment of these tumors. However, over half of human tumors contain mutations in ...
Carlson Scott M - - 2012
Chemical genetics represents an expanding collection of techniques applied to a variety of signaling processes. These techniques use a combination of chemical reporters and protein engineering to identify targets of a signaling enzyme in a global and non-directed manner without resorting to hypothesis-driven candidate approaches. In the last year, chemical ...
Forzati Floriana - - 2012
The generation of knockout mice for the Cbx7 gene validates the tumor suppressor role of CBX7, whose expression is lost in several human malignancies. Indeed, these mice developed liver and lung adenomas and carcinomas. Cyclin E overexpression due to the lack of Cbx7 negative regulation of its expression likely accounts ...
Ricci Francesca - - 2012
Solid tumors appear to contain a subpopulation of cells (tumor-initiating cells, TICs) that not only drives and sustains tumor growth, but is possibly responsible for recurrence. We isolated, after enzymatic digestion of primary ovarian carcinoma samples, a subpopulation of cells propagating as non-adherent spheres in medium suitable for tumor stem ...
McKenna Elizabeth S ES Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA - - 2012
Emerging evidence demonstrates that subunits of the SWI/SNF chromatin remodeling complex are specifically mutated at high frequency in a variety of human cancer types. SNF5 (SMARCB1/INI1/BAF47), a core subunit of the SWI/SNF complex, is inactivated in the vast majority of rhabdoid tumors (RT), an aggressive type of pediatric cancer. SNF5-deficient ...
Selmi Tommaso - - 2012
RNA binding proteins belonging to the TIS11/TTP gene family regulate the stability of multiple targets. Their inactivation or deregulated expression has recently been related to cancer, and it has been suggested that they are capable of displaying tumor suppressor activities. Here we describe three new targets of ZFP36 (PIM-1, PIM-3 ...
Soroka Joanna - - 2012
Comment on: Soroka J, et al. Mol Cell 2012; 45:517-28.
Chuang Linda Shyue Huey - - 2012
RUNX family proteins are critical regulators of lineage differentiation during development. The high prevalence of RUNX mutation/epigenetic inactivation in human cancer indicates a causative role for dysfunctional RUNX in carcinogenesis. This is supported by well-documented evidence of functional interaction of RUNX with components of major oncogenic or tumor suppressive signaling ...
Pabla Navjotsingh - - 2012
Comment on: Pabla N, et al. Proc Natl Acad Sci USA 2012; 109:197-202.
Medjkane Souhila - - 2012
Comment on: Cock-Rada AM, et al. Cancer Res 2011; 72:810-20.
Govan Jeane M - - 2012
Triplex-forming oligonucleotides (TFOs) are efficient tools to regulate gene expression through the inhibition of transcription. Here, nucleobase-caging technology was applied to the temporal regulation of transcription through light-activated TFOs. Through site-specific incorporation of caged thymidine nucleotides, the TFO:DNA triplex formation is blocked, rendering the TFO inactive. However, after a brief ...
Alessi Daniel S DS Environmental Microbiology Laboratory, Ecole Polytechnique Fédérale de Lausanne, CH-1015, - - 2012
The reduction of soluble hexavalent uranium to tetravalent uranium can be catalyzed by bacteria and minerals. The end-product of this reduction is often the mineral uraninite, which was long assumed to be the only product of U(VI) reduction. However, recent studies report the formation of other species including an adsorbed ...
Lowe Nancy K - - 2012
ABSTRACT: Empirical diagnosis and treatment of lower urinary tract infection (UTI) in women is the most common clinical approach due to the urgency of symptoms and cost. This study examines the importance of recognizing common symptoms and accurately diagnosing UTIs in the primary care setting.
McDaniel Jodi C - - 2012
ABSTRACT: An analysis of lifestyle choices of Midwestern young adults suggests that this sector does not heed evidence-based guidelines for reducing risk of chronic diseases, which are the most common, costly, and preventable of all health problems. Nurse practitioners who consistently promote the guidelines may improve long-term health in this ...
Ferrara Lucille R - - 2012
ABSTRACT: An integral part of an advanced practice nursing student's educationis to partner with a clinical preceptor. Developing strategies to balance busy clinical practiceand preceptor responsibilities can foster a positive mentoring experience.
Deshommes Elise - - 2012
High particulate lead (Pb) levels can be measured in tap water, but the hazard linked to particulate Pb ingestion is unknown. An in vitro test was developed to determine the bioaccessibility of Pb particles from tap water, based on the Relative Bioaccessibility Leaching Procedure validated for soils, and applied to ...
Huang Keyang - - 2012
This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display unique advantages over nanoparticles larger than 10 nm in terms of localization to, and penetration of, breast cancer cells, multicellular tumor spheroids, and tumors in mice. Au@tiopronin nanoparticles that have tunable sizes from 2 to 15 nm ...
Bhirde Ashwinkumar A - - 2012
Nanoformulations have shown great promise for delivering chemotherapeutics and hold tremendous clinical relevance. However nuclear mapping of the chemodrugs is important to predict the success of the nanoformulation. In this study fluorescence microscopy and a subcellular tracking algorithm were used to map the diffusion of chemotherapeutic drugs in cancer cells. ...
Yang Likui - - 2012
High-molecular weight heparins promote the protein Z-dependent protease inhibitor (ZPI) inhibition of factors Xa (FXa) and XIa (FXIa) by a template mechanism. To map the heparin-binding site of ZPI, the role of basic residues of the D-helix (residues Lys-113, Lys-116, and Lys-125) in the interaction with heparin was evaluated by ...
Culik Robert M - - 2012
Thioamides are sterically almost identical to their oxoamide counterparts, but they are weaker hydrogen bond acceptors. Therefore, thioamide amino acids are excellent candidates for perturbing the energetics of backbone-backbone H-bonds in proteins and hence should be useful in elucidating protein folding mechanisms in a site-specific manner. Herein, we validate this ...
Walsh Susanna S - - 2012
Materials management personnel at a health care facility in Baltimore, Maryland, were stocking too much suture. They stocked suture requested by surgeons or recommended by suture company representatives, and, because the facility is a teaching institution, they stocked suture requested by residents. No master suture database was available to determine ...
Ryu Kyoung Min - - 2012
A 52-year-old woman presented with bulging of the anterior chest wall. The computed tomographic scan revealed an expansive localized mass based on the sternal manubrium. The patient was successfully treated with en bloc radical resection and reconstruction with clear resection margin. Histopathologic examination of the surgical specimen confirmed the diagnosis ...
Yekeler Erdal - - 2012
Swyer-James Macleod syndrome is a radiologic entity characterized by hyperlucency of one or more lobes or of the entire lung, decreased number and diameter of ipsilateral peripheral pulmonary vessels, and difficult visibility of the arterial network and unobstructed bronchial system. A 21-year-old male was admitted to our clinic on the ...
Dieter Alexis A - - 2012
This is a retrospective cohort study comparing the risk of treatment for postoperative urinary tract infection (UTI) in patients who receive short-term postoperative catheterization versus those who pass a void trial on the day of surgery after midurethral sling with or without concomitant pelvic surgery. We compared two cohorts to ...
Kammes K L - - 2012
Effects of legume particle length on dry matter intake (DMI), milk production, ruminal fermentation and pool sizes, and digestion and passage kinetics, and the relationship of these effects with preliminary DMI (pDMI) were evaluated using 13 ruminally and duodenally cannulated Holstein cows in a crossover design with a 14-d preliminary ...
Paraskevas Kosmas I - - 2012
In 2011, five independent, international guideline committees reported their recommendations for the management of symptomatic and asymptomatic carotid artery stenosis. These included the American College of Cardiology/American Heart Association, the Society for Vascular Surgery, the European Society of Cardiology, the Australasian, and the UK National Institute of Health and Clinical ...
Nayyer Leila L Center for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London, London, United - - 2012
External ear reconstruction for congenital deformity such as microtia or following trauma remains one of the greatest challenges for reconstructive plastic surgeons. The problems faced in reconstructing the intricate ear framework are highly complex. A durable, inert material that is resistant to scar contracture is required. To date, no material, ...
Hammond Dennis C DC Partners in Plastic Surgery, Suite 202, 4070 Lake Drive, SE, Grand Rapids, MI 49546, USA. - - 2012
After studying this article, the participant should be able to: 1. Understand the preoperative considerations that must be weighed to appropriately assess operative risk of breast reduction. 2. Have a full understanding of the basic techniques that are available to treat the patient with macromastia. 3. Identify which patients are ...
Tse Shirley M L - - 2012
No specific recommendations for the treatment of juvenile spondyloarthritis have been established. Important differences exist in how spondyloarthritis begins and progresses in children and adults, supporting the need for pediatric-specific recommendations. Recently published recommendations for the treatment of juvenile arthritis consider children with sacroiliitis in a separate group and allow ...
Hombergen Susan P - - 2012
Hombergen SP, Huisstede BM, Streur MF, Stam HJ, Slaman J, Bussmann JB, van den Berg-Emons RJ. Impact of cerebral palsy on health-related physical fitness in adults: systematic review. To conduct a systematic review of the impact of cerebral palsy (CP) on the level of health-related physical fitness (body composition, cardiorespiratory ...
Ng Kee Peng - - 2012
Cladosporium sphaerospermum is one of the most widely distributed allergens causing serious problems in patients with respiratory tract disease. We report the 26,644,473-bp draft genome sequence and gene annotation of C. sphaerospermum UM843. Analysis of the genome sequence led to the finding of genes associated with C. sphaerospermum's melanin biosynthesis, ...
Tarr Megan E - - 2012
To describe perioperative bowel habits of women undergoing gynecologic surgery. This prospective cohort study included women undergoing gynecologic surgery. Before surgery, participants completed the Bristol Stool Form Scale (BSFS), a validated instrument describing stool characteristics consistent with transit categories: slow (BSFS 1-2), normal (BSFS 3-5), and fast (BSFS 6-7). For ...
Wolleb Karin K University of Zurich, Zurich, Switzerland. - - 2012
The aim of this research was to assess survival and complication rates of tooth- and implant-supported fixed dental prostheses (FDPs) and single crowns (SCs) after 5 years of function in a specific patient population group who underwent comprehensive prosthetic treatment. This retrospective study included a convenience sample of 52 patients ...
Lupiáñez Darío G - - 2012
According to the classical paradigm, the vasculature of the embryonic testis is more dense and complex than that of the ovary, but recent studies based on whole-mount detection of Caveolin-1 (CAV1) as an endothelial cell marker, have suggested that the level of ovarian vascularization is higher than previously assumed. However, ...
Choi Hye Duck - - 2012
Cilostazol is frequently used to treat and prevent thrombosis in Korean patients. We performed the pharmacokinetic and correlation analysis of cilostazol in Korean healthy subjects. A total of male 78 volunteers was subjected to three separate bioequivalence studies in which 100 mg of cilostazol was administered. AUC, t(1/2), and C(max) ...
Butler Matthew A - - 2012
Anterior transolecranon fracture dislocation of the elbow is relatively uncommon in children. We reviewed the experience over the past 5 years at our institution in treating this injury to identify pediatric variants and outline a rational treatment strategy. We found 2 pediatric variants to the injury pattern and determined that ...
Butt Clare M - - 2012
Purpose/Objectives: To describe the Mid-Life Directions workshop as an intervention to support hope and quality of life in midlife cancer survivors.Data Sources: Published articles and books.Data Synthesis: The Mid-Life Directions workshop assists survivors to integrate the cancer experience through conscious awareness and choice, and transistion to survivorship with an increased ...
Bittar Sami M SM Department of Plastic and Reconstructive Surgery and Surgery, Rush University Medical Center, Chicago, IL, USA. - - 2012
Traditional latissimus dorsi myocutaneous flap breast reconstruction results in a large wound on the back, difficult inset of flap, and skin color disparity. An anterior approach to harvesting the latissimus dorsi muscle flap reduces morbidity, and with skin-sparing mastectomy, immediate single-stage reconstruction with a permanent implant is provided. A retrospective ...
Kline-Krammes Sarah - - 2012
Upper airway obstruction is responsive to the reduction in airflow turbulence provided by helium/oxygen (heliox) admixture. Our pediatric critical care transport team (PCCTT) has used heliox for children with upper airway obstruction from croup. We sought to describe our experience with heliox on transport and hypothesized that heliox-treated children with ...
Peterson Mark D - - 2012
Peterson MD, Haapala HJ, Hurvitz EA. Predictors of cardiometabolic risk among adults with cerebral palsy. To examine the independent association between various anthropometric indicators and standard clinical markers of cardiometabolic health risk among adults with cerebral palsy (CP). Cross-sectional study. Clinical center for CP treatment and rehabilitation. Adults with CP ...
Hullfish Kathie L - - 2012
Our null hypothesis was that the introduction of preoperative hysterectomy checklists for fibroids, dysfunctional uterine bleeding (DUB), and chronic pelvic pain (CPP) would not affect the rate of hysterectomy or the proportion of cases with nonconfirmable final pathology. Using a prospective 6-month cohort, we compared the rate of hysterectomy (using ...
Sananes Renée - - 2012
The purpose of this study was to monitor developmental progress and identify predictors of developmental outcomes at 2 years after operation in infants who underwent a surgical procedure with cardiopulmonary bypass (CPB) at less than 3 months of age. Patients (N = 131 enrolled; N = 106 assessed) less than ...
Flamm Steven L - - 2012
Hepatic granulomata are not infrequently encountered in liver biopsy and often are associated with systemic disease. The clinical presentation varies with the particular systemic process. From a biochemical standpoint, the most common abnormalities are elevated serum alkaline phosphatase and γ-glutamyltransferase. The observation of granulomata in a liver biopsy specimen warrants ...
Vanneste Sven - - 2012
Objective: Tinnitus is defined as an intrinsic sound sensation that cannot be attributed to an external sound source. Currently there are no standardized drug therapies for the treatment of tinnitus. Based on the analogy between pain and tinnitus it is suggested that among all antidepressant families that have been used ...
Soberon M A - - 2012
A calf milk replacer (CMR) is designed to replace whole, saleable milk as a lower cost nutrient source for calves while striving to nourish a newborn calf, reduce calf mortality, strengthen immunity, and increase animal life span and productivity. Antioxidants (AO) can enhance immune defense by reducing oxidative damage, but ...
Mills-Wisneski Sharon M - - 2012
While I did enjoy the article by White and Boehmer (2012) in the March issue, I did have a hard time accepting the author's definition of sexual minority women. When I first saw the title, I immediately thought of minority women, thinking race or ethnicity. I just don't think that ...
Fàbrega Anna - - 2012
The sperm surface is covered with a dense coating of carbohydrate-rich molecules. Many of these molecules are involved in the acquisition of fertilising ability. In the present study, eight lectins (i.e. Arachis hypogae (peanut) agglutinin (PNA), Lens culimaris (lentil) agglutinin-A (LCA), Pisum sativum (pea) agglutin (PSA), Triticum vulgari (wheat) germ ...
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