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Panjehpour Masoud - - 2012
Differential Normalized Fluorescence (DNF) technique has been used to distinguish high-grade dysplasia from non-dysplastic Barrett's esophagus. This technology may assist gastroenterologists in targeting biopsies, reducing the number of biopsies using the standard protocol. In the presence of reactive atypia/inflammation, it becomes difficult for the pathologist to differentiate non-dysplastic Barrett's esophagus ...
Lake Eileen T ET Center for Health Outcomes and Policy Research, School of Nursing, Department of Sociology, and Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA 19104-6096, USA. - - 2012
Infants born at very low birth weight (VLBW) require high levels of nursing intensity. The role of nursing in outcomes for these infants in the United States is not known. To examine the relationships between hospital recognition for nursing excellence (RNE) and VLBW infant outcomes. Cohort study of 72,235 inborn ...
Wu S-N - - 2012
AIMS: The electrical properties of Na(+) -activated K(+) current (I(K(Na)) ) and its contribution to spike firing has not been characterized in motor neurons. METHODS: We evaluated how activation of voltage-gated K(+) current (I(K) ) at the cellular level could be coupled to Na(+) influx through voltage-gated Na(+) current (I(N) ...
Dantonello Tobias M - - 2012
BACKGROUND: Malignant ectomesenchymoma (MEM) is a soft tissue tumor with heterologous rhabdomyoblastic components believed to arise from pluripotent migratory neural crest cells. To date merely 50 cases have been published and the knowledge about the course of disease and optimal treatment is limited. METHODS: Six patients with MEM were registered ...
Tsiang Manuel - - 2012
tert-Butoxy-(4-phenyl-quinolin-3-yl)-acetic acids (tBPQA) are a new class of HIV-1 integrase (IN) inhibitors that are structurally distinct from IN strand transfer inhibitors but analogous to LEDGINs. LEDGINs are a class of potent antiviral compounds that interacts with the lens epithelium-derived growth factor (LEDGF) binding pocket on IN and were identified through ...
Dargaud Y - - 2012
Summary.  Haemophilic arthropathy (HA) is one of the main complications of recurrent bleeding episodes in patients with severe haemophilia. However, the precise reasons making joints the predilected site of bleeding in patients with haemophilia are not fully understood. The objective of this project was to study the potential effect of ...
Ceponkus Justinas - - 2012
The infrared spectrum of water, isolated in inert matrices has been studied in the interval 60 cm-1 to 4000 cm-1. Experiments with partially deuterated water, combined with DFT (Density Functional Theory) calculations have been used to investigate the structure of matrix isolated water tetramer. A few, strong intermolecular fundamentals of ...
Firth Andrew E - - 2012
Viral protein synthesis is completely dependent upon the translational machinery of the host cell. However, many RNA virus transcripts have marked structural differences from cellular mRNAs that preclude canonical translation initiation, such as the absence of a 5' cap structure or the presence of highly structured 5'UTRs containing replication and/or ...
Brunton Janet A - - 2012
Proline and arginine are each indispensable during parenteral feeding due to limited interconversion by an atrophied gut. Commercial amino acid parenteral products designed for neonates contain proline concentrations that differ by almost 4-fold. To assess the adequacy of the lowest concentration of proline provided in commercial total parenteral nutrition (TPN) ...
Bork Kirsten - - 2012
Several studies have shown an association between an infant and young child feeding index (ICFI) and height-for-age Z-score (HAZ) in Latin America and Africa. A previous study was unable to reproduce these findings in 500 rural Senegalese 12-42-mo-old children. The relationship of ICFI, dietary diversity index (DDI), food variety index ...
Yoshida K - - 2012
Transporter-mediated drug-drug interactions (DDIs) are among the most important of the clinically relevant pharmacokinetic DDIs. We investigated the validity of a static prediction of area under the plasma concentration-time curve (AUC) ratios (AUCRs; AUC(with inhibitor)/AUC(control)) using in vitro inhibition profiles, and selected the types of assumptions that improved the prediction ...
Dang Thu-Thuy T - - 2012
Noscapine is a benzylisoquinoline alkaloid produced in opium poppy (Papaver somniferum) and other members of the Papaveraceae. It has been used as a cough suppressant and more recently was shown to possess anticancer activity. However, the biosynthesis of noscapine in opium poppy has not been established. A proposed pathway leading ...
Deutsch Zvicka - - 2012
Photon antibunching is ubiquitously observed in light emitted from quantum systems, but is usually associated only with the lowest excited state of the emitter. Here we devise a fluorophore which, upon photoexcitation, emits in either one of two distinct colors, but exhibits strong antibunching between the two. This work demonstrates ...
Cattani-Scholz Anna - - 2012
Self-assembled monolayers of phosphonates (SAMPs) of 11-hydroxyundecylphosphonic acid, 2,6-diphosphonoanthracene, 9,10-diphenyl-2,6-diphosphonoanthracene and 10,10'-diphosphono-9,9'-bianthracene and a novel self-assembled organophosphonate duplex ensemble were synthesized on nanometer-thick SiO<sub>2</sub>-coated, highly doped silicon electrodes. The duplex ensemble was synthesized by first treating the SAMP prepared from an aromatic diphosphonic acid to form a titanium complex-terminated one; ...
Melo Débora Gusmão - - 2012
Genetic diseases and congenital anomalies are the second most common cause of infant mortality in Brazil. In 2009, the Ministry of Health established the National Policy for Integral Attention in Clinical Genetics in the Brazilian Unified National Health System (UNHS). This policy is not yet regulated, and there is a ...
Drogari-Apiranthitou Maria M Infectious Diseases and Antimicrobial Chemotherapy Research Laboratory, 4th Department of Medicine, 'Attikon' Hospital, National and Kapodistrian University of Athens, Athens, Greece. - - 2012
Mucormycetes (formerly known as zygomycetes of the order Mucorales) and hyaline moulds such as those of the genus Fusarium or Paecilomyces are emerging as significant human pathogens. The aim of the study was to determine the in vitro antifungal susceptibility of these fungi to older and newer antifungals and to ...
Vass David George DG MRC Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, - - 2012
We have previously reported de novo lymphangiogenesis in human renal allograft nephrectomy specimens that exhibited interstitial fibrosis and tubular atrophy (IFTA). This study examined whether a similar pathology developed in an experimental model of renal transplantation in the rat. Renal transplants were carried out in rats comprising both isografts (Lewis ...
Sato Masaaki - - 2012
Caveolins act as scaffold proteins in multiprotein complexes and have been implicated in signaling by G protein-coupled receptors. Studies using knock-out mice suggest that β(3)-adrenoceptor (β(3)-AR) signaling is dependent on caveolin-1; however, it is not known whether caveolin-1 is associated with the β(3)-AR or solely with downstream signaling proteins. We ...
Brimberg Lior - - 2012
Group A streptococcal (GAS) infections and autoimmunity are associated with the onset of a spectrum of neuropsychiatric disorders in children, with the prototypical disorder being Sydenham chorea (SC). Our aim was to develop an animal model that resembled the behavioral, pharmacological, and immunological abnormalities of SC and other streptococcal-related neuropsychiatric ...
Reeser Jonathan C - - 2012
ObjectiveInfraspinatus syndrome (IS) results from injury to the suprascapular nerve. For reasons that are poorly understood, volleyball players are at greater risk of developing IS than are athletes who compete in other overhead sports. Differences between the shoulder kinematics of volleyball-related overhead skills and those skills demanded by other overhead ...
Lambe Andrew Thomas - - 2012
Functionalization (oxygen addition) and fragmentation (carbon loss) reactions governing secondary organic aerosol (SOA) formation from the OH oxidation of alkane precursors were studied in a flow reactor in the absence of NOx. SOA precursors were <italic>n</italic>-decane (<italic>n</italic>-C<sub>10</sub>), <italic>n</italic>-pentadecane (n-C<sub>15</sub>), <italic>n</italic>-heptadecane (<italic>n</italic>-C<sub>17</sub>), tricyclo[5.2.1.0<sup>2,6</sup>]decane (JP-10), and vapors of diesel fuel and Southern ...
Borah Arun Jyoti - - 2012
A catalyst-free protocol has been developed for amidation of alkyl aromatics and aldehydes using TsNBr(2)via a nitrene transfer process in the presence of a base in excellent yield within a short time. The reaction was found to be selective for secondary and tertiary benzylic C-H bonds and C-H bonds of ...
Shan Weiwei W Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, - - 2012
Uterine leiomyosarcoma (ULMS) is a poorly understood cancer with few effective treatments. This study explores the molecular events involved in ULMS with the goal of developing novel therapeutic strategies. Genome-wide transcriptional profiling, Western blotting, and real-time PCR were used to compare specimens of myometrium, leiomyoma, and leiomyosarcoma. Aurora A kinase ...
Karsh Kristen - - 2012
In order to 1) establish the biological systematics necessary to interpret nitrogen (N) and oxygen (O) isotope ratios of nitrate (<sup>15</sup>N/<sup>14</sup>N and <sup>18</sup>O/<sup>16</sup>O) in the environment and 2) investigate the potential for isotopes to elucidate the mechanism of a key N cycle enzyme, we measured the nitrate N and O ...
Sharpp Tara J - - 2012
The purpose of this prospective, ethnographic study was to describe and analyze the care of residents with dementia in an assisted living facility (ALF) providing dementia care. Participant observation and interviews with 20 employees were used to obtain data. Data were collected and analyzed over a period of 6 months. ...
Claeys Hannes - - 2012
Drought is responsible for considerable yield losses in agriculture due to its detrimental effects on growth. Drought responses have been extensively studied, but mostly on the level of complete plants or mature tissues. However, stress responses were shown to be highly tissue and developmental stage specific, and dividing tissues have ...
Prokop Katharine A - - 2012
The direct conversion of a Mn<sup>III</sup> complex ((TBP<sub>8</sub>Cz)Mn<sup>III</sup>, <bold>1</bold>) to an Mn<sup>V</sup>-oxo complex ((TBP<sub>8</sub>Cz)Mn<sup>V</sup>(O), <bold>2</bold>) with O<sub>2</sub> and visible light is reported. Complex <bold>1</bold> is also shown to function as an active photocatalyst for the oxidation of PPh<sub>3</sub> to OPPh<sub>3</sub>. Mechanistic studies indicate that the photogeneration of <bold>2</bold> does not ...
Born Philipp - - 2012
A 47-year-old female underwent interventional patent foramen ovale (PFO) closure with an Amplatzer septal occluder (AGA Medical Corporation, USA). After 48 hours of implantation, she experienced intermittent pulse synchronous retrosternal pain. Subsequently, device-associated compression of the aortic root was diagnosed. Occluder retrieval and surgical PFO-closure was accomplished successfully via minimal ...
Lee Jung Uee - - 2012
Objective: The genetic mutations causing the constitutive activation of MEK/ERK have been regarded as an initiating factor in papillary thyroid carcinoma (PTC). The ERK-specific dual specificity phosphatase 6 (DUSP6) is part of the ERK-dependent transcriptional output. Therefore, the coordinated regulation of the activities of ERK kinases and DUSP6 may need ...
Busse Michelle - - 2012
Many cognitive measures have been studied for their ability to detect suboptimal cognitive effort; however, attention measures have not been extensively researched. The current study evaluated the classification accuracy of commonly used attention/concentration measures, the Brief Test of Attention (BTA), Trail Making Test (TMT), and the Conners' Continuous Performance Test ...
Rydze Robert T - - 2012
Human immunodeficiency virus (HIV) disease progression is associated with a helper T cell 1 (Th1) to helper T cell 2 (Th2) cytokine profile switch. Persistent GB virus type C (GBV-C) infection is associated with survival and a serum Th1 cytokine profile in HIV-infected individuals. We found that GBV-C infection increased ...
Sainz-Gonzalo F J - - 2012
A novel europium(iii) membrane luminescence sensor based on a tridentate bis(phosphinic amide)-phosphine oxide, PhPO(C(6)H(4)POPhN(CH(CH(3))(2))(2))(2) (), is described. The new luminescent complex, [Eu()(2)]Cl(3), which is formed between europium(iii) and ligand and has a 1 : 2 stoichiometry, has been evaluated in solution. It has the excellent spectroscopic and chemical characteristics that make it ...
Song Kyoung Doo - - 2012
BackgroundAs diffusion-weighted imaging (DWI) is routinely incorporated into the standard clinical protocol, it is clinically relevant to determine whether DWI after gadoxetic acid is comparable to pre-contrast DWI, with regard to the detection and characterization of focal liver lesions.PurposeTo compare DWI before and after administration of gadoxetic acid in the ...
Wiebe Sandra A SA Department of Psychology, University of Alberta, Biological Sciences Building, Edmonton, AB, Canada. - - 2012
The development of response inhibition was investigated using a computerized go/no-go task, in a lagged sequential design where 376 preschool children were assessed repeatedly between 3.0 and 5.25 years of age. Growth curve modeling was used to examine change in performance and predictors of individual differences. The most pronounced change was ...
O'Connor Christopher M - - 2012
AIMS: In patients with acute heart failure (AHF), early worsening heart failure (WHF) predicts a significant proportion of post-discharge readmissions and mortality. We aimed to identify the predictors of 7-day heart failure events or death in patients hospitalized with AHF. METHODS AND RESULTS: A predictive model and risk score for ...
Greenblum Catherine A - - 2012
Sleep disturbances may occur in more than 50% of individuals with dementia, and nighttime activity can lead to unsafe situations and serious consequences for both the person and his or her caregivers. Nighttime awakenings expose individuals with dementia to two major dangers: falls and unattended home exits. This article is ...
Smith V E VE School of Clinical and Experimental Medicine, Institute for Biomedical Research, University of Birmingham, Birmingham, B15 2TT, United - - 2012
Within the basolateral membrane of thyroid follicular epithelial cells, two transporter proteins are central to thyroid hormone (TH) biosynthesis and secretion. The sodium iodide symporter (NIS) delivers iodide from the bloodstream into the thyroid, and after TH biosynthesis, monocarboxylate transporter 8 (MCT8) mediates TH secretion from the thyroid gland. Pituitary ...
Urpi-Sarda Mireia - - 2012
Adherence to a Mediterranean diet (MD) is associated with a reduced risk of coronary heart disease. However, the molecular mechanisms involved are not fully understood. The aim of this study was to compare the effects of 2 MD with those of a low-fat-diet (LFD) on circulating inflammatory biomarkers related to ...
Lazzeri Valerio - - 2012
Although light is recognised as one of the main factors influencing fruit carotenogenesis, the specific role of UV-B radiation has been poorly investigated. The present work is addressed to assess the molecular events underlying carotenoid accumulation in presence or absence of ultraviolet-B (UV-B) light in tomato fruits of wild-type and ...
Ko Hyunsun - - 2012
This was a prospective, cohort study in Korean pregnant and postpartum women, to estimate the prevalence and patterns of sleep disturbances. The survey was composed of the following validated sleep questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Women's Health Initiative Insomnia Rating Scale, Berlin Questionnaire for ...
Rasmussen Jeffrey P JP Fred Hutchinson Cancer Research Center, Seattle, WA 98109, - - 2012
The development of many animal organs involves a mesenchymal to epithelial transition, in which cells develop and coordinate polarity through largely unknown mechanisms. The C. elegans pharynx, which is an epithelial tube in which cells polarize around a central lumen, provides a simple system with which to understand the coordination ...
Arnaout Christina L - - 2012
Silver nanoparticles (AgNPs) are increasingly used as bacteriostatic agents to prevent microbial growth. AgNPs are manufactured with a variety of coatings and their potential impacts on wastewater treatment in general are poorly understood. In the present study, <italic>Nitrosomonas europaea</italic>, a model ammonia oxidizing bacterium, was exposed to AgNPs with citrate, ...
Maat Barbara - - 2012
BACKGROUND: Prescribing glucose requires complex calculations because glucose is present in parenteral and enteral nutrition and drug vehicles, making it error prone and contributing to the burden of prescribing errors. OBJECTIVE: Evaluation of the impact of a computerized physician order entry (CPOE) system with clinical decision support (CDS) for glucose ...
Lauritzen Fredrik - - 2012
Emerging evidence points to monocarboxylates as key players in the pathophysiology of temporal lobe epilepsy (TLE) with hippocampal sclerosis (mesial temporal lobe epilepsy, MTLE). Monocarboxylate transporters (MCTs) 1 and 2, which are abundantly present on brain endothelial cells and perivascular astrocyte endfeet, respectively, facilitate the transport of monocarboxylates and protons ...
Sirim Demet - - 2012
ABSTRACT: In our article (Sirim et al. BMC Struct Biol 2010, 10: 34) the cytochrome P450 monooxygenase P450cam was referred to as CYP101D. In the latest release 3.0 of our cytochrome P450 database CYPED (www.CYPED.uni-stuttgart.de) P450cam was reassigned to family CYP101A and referred to as CYP101A1.
Agarwal Hitesh K - - 2012
A number of fatty acyl derivatives of (-)-2',3'-dideoxy-3'-thiacytidine (lamivudine, 3TC, 1) were synthesized and evaluated for their anti-HIV activity. The monosubstituted 5'-O-fatty acyl derivatives of 1 (EC50 = 0.2-2.3 μM) were more potent than the corresponding monosubstituted N4-fatty acyl (EC50 = 0.4-29.4 μM) and 5'-O-N4-disubstituted (EC50 = 72.6 to 〉154.0 ...
Kleffner Tim - - 2012
Intralobar sequestration (ILS) is a rare anomaly that is usually diagnosed with symptoms of cough, expectoration, or recurrent pneumonia in children. We experienced a case of an 11-year-old boy with massive hemoptysis after judo sports. He was admitted to hospital and intubated due to respiratory failure. His chest computed tomography ...
Schmitt Bryan H - - 2012
We report an unusual case of a foreign body removed from the urinary bladder of a 63-year-old male which mimicked a parasitic worm. The foreign body was identified as an artificial fishing worm by morphological comparison to a similar commercially produced product and by infrared spectrum analysis.
Pérez-Labrada Karell - - 2012
Unique types of ceramide and glycolipid architectures were obtained by means of Ugi reactions incorporating lipidic isocyanides as surrogates of sphingolipids. The multicomponent nature of this process allowed for a highly efficient assembly process, wherein two of the components provided the lipidic tails while a third one incorporated either the ...
Tsinberg Michael - - 2012
Subclinical Cushing's syndrome (SCS) refers to subtle autonomous cortisol hypersecretion that is insufficient to generate the typical, clinically recognizable overt syndrome. Diagnosis of SCS is challenging. The combination of 1 mg overnight dexamethasone suppression test, serum ACTH level, and urinary cortisol level are used to diagnose SCS. Laparoscopic adrenalectomy is the ...
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