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Mauri-Llerda J A - - 2012
Epilepsy is one of the most common neurological diseases. In recent years an important number of drugs have been added to the therapeutic options we have available to us. With the aim of offering an optimal clinical effectiveness, the mechanisms of action or chemical structures of the antiepileptic drugs recently ...
Neill James - - 2012
Seven patients underwent 2-stage skin grafting with bovine fetal collagen (BFC) as an initial wound cover. Split-thickness skin grafts were successfully placed on the wounds after completion of interval management. BFC proved to be a resilient acellular dermal matrix that could proceed to assimilation and skin grafting under a variety ...
Roden Katherine S - - 2012
: Despite improvements in automotive safety, motor vehicle collision (MVC)-related facial fractures remain common and represent preventable injuries. This study examines the changing characteristics of facial fractures treated at a regional, level I trauma center, from 2005 to 2010. : We identified all patients with facial fractures admitted to our ...
Balthasar Andrea - - 2012
A critical challenge encountered in interventional pain medicine procedures is to accurately and efficiently identify transitions to peripheral nerve targets. Current methods, which include ultrasound guidance and nerve stimulation, are not perfect. In this pilot study, we investigated the feasibility of identifying tissue transitions encountered during insertions toward peripheral nerve ...
Plapp Bryce V - - 2012
Structures of horse liver alcohol dehydrogenase complexed with NAD(+) and unreactive substrate analogues, 2,2,2-trifluoroethanol or 2,3,4,5,6-pentafluorobenzyl alcohol, were determined at 100 K at 1.12 or 1.14 Å resolution, providing estimates of atomic positions with overall errors of ~0.02 Å, the geometry of ligand binding, descriptions of alternative conformations of amino ...
Young James B - - 2012
In the traditional department-based organizational structure of an academic health center, patients can be neglected as a result of fragmented systems of care. Specialty-driven, provider-oriented, economically influenced organizations dominated by research and education missions might, paradoxically, promote too little concern for the patient. All three components (education, research, and patient ...
Lineaweaver William - - 2012
Between February 2008 and December 2010, the author performed 15 standardized component repairs in patients reinforced with bovine fetal collagen. Of 15 repairs, 14 (93%) were intact at an average follow-up of 18 months. This success rate is a significant improvement from the author's previous success rate with this procedure ...
Henton J - - 2012
Background: Although various solutions have been recommended for cleansing wounds, normal saline is favoured as it is an isotonic solution and does not interfere with the normal healing process. Tap water is commonly used in the community for cleansing wounds because it is easily accessible, efficient and cost effective; however, ...
Maan Sushila - - 2012
Bluetongue virus is the type species of the genus Orbivirus in the family Reoviridae. We report the first complete genome sequence of an isolate (IND2004/01) of bluetongue virus serotype 10 (BTV-10) from Andhra Pradesh, India. This isolate, which is stored in the Orbivirus Reference Collection (ORC) at IAH Pirbright, shows ...
Li Yun - - 2012
More than a third of elderly fall each year in the United States. It has been shown that the longer the lie on the floor, the poorer is the outcome of the medical intervention. To reduce delay of the medical intervention, we have developed an acoustic fall detection system (acoustic-FADE) ...
Woitecki Katrin - - 2012
Objective: This pilot study investigates the effects of habit reversal training in a German-speaking population of children and young adults with chronic tic disorders on comorbid symptoms and subjective interference. Methods: 16 children were treated using a manualized program. Comorbid-symptoms (ADHD, anxiety and OCD, depression) were assessed using parent and ...
Schaudig U - - 2012
Lower lid malposition is common, increases with age and leads to impaired optical function of the ocular surface through chronic irritation of the conjunctiva and cornea. Numerous techniques have been described to reposition the lid margin to the globe and secure this position while maintaining intact motility. Some of these ...
Abecia-Inchaurregui L C - - 2012
INTRODUCTION. Few studies have been conducted on the incidence of migraine in Spain, and those that have been carried out have some shortcomings, such as the lack of a clear population base. AIMS. To examine the evolution of the incidence of migraine over the period 2004-2008 in the province of ...
Blecker Nathan - - 2012
The popularity of all-terrain vehicles (ATVs) continues to increase, but this form of recreation is not as well regulated and can impact children disproportionately. This study examines the epidemiology of ATV injuries in Arizona with emphasis on pediatric injuries and compares ATV injuries to those associated with motorcycle (MCC) and ...
Yuan Hang H Department of Pathology, Georgetown University Medical School, Washington, DC, USA. - - 2012
Papillomaviruses are nonenveloped, double-stranded DNA viruses that are associated with both benign and malignant tumors in animals and humans. We report the complete genome sequence of canine papillomavirus type 9 isolated from a solitary pigmented plaque on a mixed-breed bloodhound.
Podrabsky Jason E - - 2012
Embryos of the annual killifish Austrofundulus limnaeus can enter into a state of metabolic dormancy, termed diapause, as a normal part of their development. In addition, these embryos can also survive for prolonged sojourns in the complete absence of oxygen. Dormant embryos support their metabolism using anaerobic metabolic pathways, regardless ...
Tong Winnie M Y - - 2012
: This study evaluates how the transition from pedicled transverse rectus abdominis myocutaneous (pTRAM) to perforator flaps at an academic center has affected outcome and reimbursement. : In 2006, our practice transitioned to almost exclusively perforator flaps for breast reconstruction. This study retrospectively compares pTRAM flaps performed from 2002 to ...
Ma Jie - - 2012
A chemical investigation on the aerial parts of Hypericum scabrum L. resulted in the isolation of three new phloroglucinol derivatives, hyperscabrins A (1), B (2), and C (3), together with one known compound, (2R,3R,4S,6R)-3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)-cyclohexanone (4). The structures were elucidated by means of spectroscopic methods, including MS, IR, 1D NMR, and ...
Yoshimoto Noriko - - 2012
See accompanying article by Seyfried et al. DOI: 10.1002/biot.201100407.
Kreshak Allyson A - - 2012
The goal of this retrospective cohort study of pediatric patients exposed to flumazenil was to identify the frequency of seizures. Included patient were those aged 12 years or younger who received flumazenil, who had evidence of clinical poisoning as defined by an altered mental status, and who were reported to ...
Wen Libin - - 2012
We first report here the genome sequences of 4 rearranged porcine circovirus type 2 strains, JSTZ, ZJQDH1, ZJQDH2, and JSHM, isolated from porcine sera in China. The complete circular genomes of these isolates are 578, 483, 574, and 772 nucleotides in length, respectively. They are predicted to be defective interfering ...
Schmidtendorf Steffen - - 2012
The focus of the present study were performances of N = 433 children and adolescents with AD(H)D on the German version of the Wechsler Intelligence Scale for children (HAWIK-IV). Furthermore, we investigated whether test results depend on comorbid disorders based on subgroups (n = 212, n = 262, n = ...
Freitag Christine M - - 2012
This review article is based on a state-of-the-art lecture given at the 32nd meeting of the German Child Psychiatry Association in March 2011. It summarizes recent findings from epidemiological studies (comorbid disorders, risk factors), early diagnosis, classification, and evidence-based therapeutic interventions (psychopharmacology, early intervention, group-based behavioural interventions). Intensive research over ...
Karpf Michael - - 2012
In the Point-Counterpoint section of this issue, Kastor discusses the pros and cons of a new, institute-based administrative structure that was developed at the Cleveland Clinic in 2008, ostensibly to improve the quality and efficiency of patient care. The real issue underlying this organizational transformation is not whether the institute ...
Sargent Larry A - - 2012
The purpose of this study is to evaluate current treatment of zygomatic fractures presenting at a level I trauma center. Radiology records over a 1-year period were retrospectively reviewed to determine all patients diagnosed with fractures through the zygoma. A total of 1049 computed tomography maxillofacial scans were reviewed which ...
Xie Hai-Hui - - 2012
A new megastigmane glycoside, grasshopper ketone 3-O-primveroside (1), was isolated from the methanolic extract of the whole herbs of Sinocrassula indica (Crassulaceae). Its structure was elucidated on the basis of spectral and chemical evidence.
Orseck Michael J - - 2012
Despite many advances in reconstructive techniques, the full-thickness scalp defect remains a difficult problem for the reconstructive surgeon. Patient and disease-specific factors occasionally make reconstruction with a dermal regeneration template (DRT) an attractive option when other methods are less advised. Although the applicability of dermal regeneration templates has been well ...
Yue Xi-Dian - - 2012
Two new C(13)-norisoprenoids, named lyratols E and F (1-2), were isolated from the whole plant of Solanum lyratum Thunb, and their structures were elucidated by extensive spectroscopic analyses. In vitro, two new compounds were found to show significant cytotoxicity against selected cancer cells including P-388 and HT-29.
Elfrink Floor - - 2012
Hepatitis E is endemic in (sub)tropical countries while only sporadic cases have been described in industrialized countries. In a prospective study among 1270 short-term Dutch travelers to (sub)tropical countries we found no seroconversion to anti-hepatitis E virus (HEV) antibodies, indicating a very low risk for travelers to acquire a hepatitis ...
Ghys Christophe - - 2012
We describe a case of atypical loiasis presenting with a chronic pleuroperitoneal effusion in a 50-year-old woman from the Democratic Republic of Congo. Effusions disappeared with conventional treatment and no recurrence was detected after 4 months of follow-up. Such cases of loiasis involving visceral sites have been unusually reported in ...
Capito Anthony E - - 2012
Acellular dermal matrices are used in a variety of reconstructive and cosmetic procedures. There seems to be host tissue integration, revascularization, and recellularization into these products, but the exact timing and differences among these remain unknown. The purpose of this study is to determine and compare these properties of 4 ...
Leung Anthony A Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. - - 2012
Since its discovery in 1963, poly(ADP-ribose) (pADPr) has been shown to play important functions in the nucleus of multicellular eukaryotes. Each of these functions centers upon DNA metabolism, including DNA-damage repair, chromatin remodeling, transcription and telomere functions. We recently described two novel functions for pADPr in the cytoplasm, both of ...
Wang Dandan - - 2012
To compare the anterior chamber area/volume (ACA/ACV) and their relationship with the drainage angle between adult Caucasians and Chinese. Study groups were comprised of four age- and sex-matched cohorts: American Caucasians, American Chinese, southern mainland Chinese, and northern mainland Chinese. All subjects were consecutively recruited from general ophthalmology clinics except ...
Gobbi Federico - - 2012
We report a case of pulmonary coccidioidomycosis imported from the United States to Italy. This disease should enter in the differential diagnosis of any febrile patient (especially if presenting with pulmonary symptoms, with or without hypereosinophilia) coming from Coccidioides immitis endemic areas.
Farner Kelley - - 2012
In 2009, the JMS Burn Centers network opened as the only organized inpatient burn unit in Mississippi. Initial predictions of total annual state burn admissions (431 patients) and total annual state burn center admissions (239 patients) were made by extrapolating from national burn and census data. Actual JMS admissions for ...
- - 2012
Focus: Imaging technology. This issue of Biotechnology Journal features a collection of articles on the latest in imaging technologies, such as CARS microscopy to show lipid synthesis pathways, ApoTome imaging in immunohistochemistry, and functional imaging of microbial physiology. Image: © SSilver - Fotolia.com.
Molinuevo J L - - 2012
INTRODUCTION. Studies with cerebrospinal fluid (CSF) biomarkers in patients with confirmed Alzheimer's disease (AD) pathology have shown that decreased levels of Abeta1-42 and increased levels of tau and p-tau, are a specific feature of the AD type pathology. AIM. To describe a new method for determining the AD-CSF-Index, through the ...
Haus-Cheymol Rachel - - 2012
A cluster of 21 cases of watery diarrhea suspected to be cholera that involved French military policemen and young volunteers occurring in the context of the Haiti cholera outbreak is described. The attack rate (AR) was higher among young volunteers (71.4%) than among policemen (15.3%) (p < 0.0001). There was ...
Frühe Barbara - - 2012
Objective: We compared the concurrent validity of several tests for screening depression in pediatric care with respect to ICD-10 depression diagnoses in medically ill children: the German version of the Children's Depression Inventory (Depressionsinventar für Kinder und Jugendliche, DIKJ), the scale Dysphoria of the Depression Test for Children (Depressionstest für ...
Reichert Janice M - - 2012
The Summer 2012 conference season provides ample opportunities to attend meetings that feature topics relevant to antibody research and development (R&D). Meetings such as these serve critical informational and educational functions and are key networking opportunities. Locations are spread throughout the world, reflecting the global nature of antibody R&D.
Tong Winnie Mao Yiu - - 2012
: Because of the anatomic variability of the deep inferior epigastric artery, preoperative CT angiography (pCTA) has gained popularity for planning abdominal perforator flap breast reconstruction. This study evaluates how pCTA has affected preoperative planning, operative time, and outcome. : We performed a retrospective study of abdominal free flap breast ...
Blanco-Lago R - - 2012
INTRODUCTION. Tumours of the central nervous system (CNS) are one of the most common causes of child mortality, second only to accidents. In the last few decades we have witnessed an increase in the incidence of these tumours, which now stands at 2.5-3.2 cases/100,000 children/year in the population under 15 ...
Marrs Joel C - - 2012
The prevalence of type 2 diabetes mellitus is high among the elderly population. Treatment of elderly patients with type 2 diabetes presents challenges because of co-morbidities and the potential increase in the risk of adverse effects. Hyperlipidaemia is also common in the elderly population. Glucose- and lipid-lowering treatment in elderly ...
Weymouth Anne E - - 2012
To compare the effects of aging on two shape-discrimination tasks: a closed shape task (radial frequency [RF] patterns) and a Glass pattern coherence task (discrimination of global shape signal from textured noise). We hypothesized that aging would impair the extraction of shape from texture more than the discrimination of closed ...
Ogunyankin Maria O - - 2012
This work describes a technique for forming nanometer-scale pixilated lipid domains that are self-organized into geometric patterns residing on a square lattice. In this process, a lipid multibilayer stack is deposited onto a silica substrate patterned with a square lattice array of bumps, hemispherical on their sides, formed by electron ...
Jenkins Ronald J - - 2012
UDP-3-O-(R-3-hydroxyacyl)GlcN N-acyltransferase (LpxD) has been shown to be essential to survival of lipid A producing Gram-negative bacteria. In this study, LpxD-binding peptides 12 amino acids in length were identified from a phage-bound random peptide library screen. Three peptides displayed antibacterial activity when expressed intracellularly, one of which (RJPXD33) represented 15% ...
Wiśniewska Katarzyna - - 2012
The emergence of spa types and spa-clonal complexes (CC) among clinical methicillin-resistant Staphylococcus aureus isolates collected from the University Clinical Center in Gdańsk between 2008 and 2009 were investigated. Phage typing was used as the initial screening in the study. The basic set of phages and the additional set of ...
Marks Lara - - 2012
This paper examines the development and termination of nebacumab (Centoxin®), a human IgM monoclonal antibody (mAb) drug frequently cited as one of the notable failures of the early biopharmaceutical industry. The non-approval of Centoxin in the United States in 1992 generated major concerns at the time about the future viability ...
Chung Shan - - 2012
The presence or absence of core fucose in the Fc region N-linked glycans of antibodies affects their binding affinity toward FcγRIIIa as well as their antibody-dependent cell-mediated cytotoxicity (ADCC) activity. However, the quantitative nature of this structure-function relationship remains unclear. In this study, the in vitro biological activity of an ...
Raju T Shantha - - 2012
There are currently ~25 recombinant full-length IgGs (rIgGs) in the market that have been approved by regulatory agencies as biotherapeutics to treat various human diseases. Most of these are based on IgG1k framework and are either chimeric, humanized or human antibodies manufactured using either Chinese hamster ovary (CHO) cells or ...
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