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Hoppo Toshitaka - - 2012
Patient selection for endoscopic resection is based on meticulous endoscopic examination and histological assessment so as to avoid performing this procedure on patients with a high risk of lymph node involvement or metastatic disease. Currently, endoscopic mucosal resection (EMR) is used for tumors <2 cm, and endoscopic submucosal dissection (ESD) should ...
Gupta Ashutosh - - 2012
The guanine-cytosine (GC) radical anion and its interaction with a single water molecule is studied using <italic>ab initio</italic> and density functional methods. Z-averaged second-order perturbation theory (ZAPT2) was applied to GC radical anion for the first time. Predicted spin densities show that the radical character is localized on cytosine. The ...
Schultz M J - - 2012
BACKGROUND:Three trials of tight glucose control (TGC) found clinical benefit of normalization of blood glucose levels in the intensive care unit (ICU). Implementation of TGC was imperfect in subsequent trials, since attained blood glucose levels (BGLs) never reached the targets as in the original trials of TGC. We investigated whether ...
Lin Harrison W - - 2012
This case report describes the presentation and management of a rare complication of pseudoaneurysm of the superior thyroid artery following tracheostomy. The majority of post-tracheostomy bleeding is managed either with packing or surgical re-exploration. However, angiography can pinpoint an arterial source of bleeding and allow the surgeon to address it ...
Almasi B - - 2012
Stressful situations during development can shape the phenotype for life by provoking a trade-off between development and survival. Stress hormones, mainly glucocorticoids, play an important orchestrating role in this trade-off. Hence, how stress sensitive an animal is critically determines the phenotype and ultimately fitness. In several species, darker eumelanic individuals ...
Holst Jens - - 2012
Yemen is a low-middle-income country where more than half of the population live in rural areas and lack access to the most basic health care. At US$40 per capita, Yemen's annual total health expenditure (THE) is among the lowest worldwide. This study analyses the preconditions and options for implementing basic ...
Khan Khalid Mohammed - - 2012
Benzimidazole derivatives 1-24 have been synthesized and their in vitro β-glucuronidase inhibitory activitiy was evaluated. Compounds 15 (IC50 = 6.33 ± 0.40 µM), 7 (IC50 = 22.0 ± 0.33 µM), 2 (IC50 = 23.1 ± 1.78 µM), 17 (IC50 = 23.9 ± 1.46 µM), and 3 (IC50 = 33.8 ± ...
Shen Qing - - 2012
This study was carried out to investigate the enzymatic hydrolysis condition on the properties of protein hydrolysate from fish muscle of the marine fish species Collichthys niveatus. About 160 fish samples were tested and the analyzed fish species was found to be a lean fish with low fat (1.77 ± ...
Bontadi Agnese - - 2012
Conventional therapy with aspirin and/or heparin is at times incapable of preventing complications in high risk pregnancies of patients with antiphospholipid syndrome (APS). In those cases, a so-called second-line treatment protocol is used in addition to conventional therapy strategies. This manuscript is a report on three APS pregnant patients who ...
Xiang Haifeng - - 2012
A series of new platinum(II) 5,15-bis(pentafluorophenyl)-10,20-bis(phenyl)porphyrin-9,9-dioctylfluorene copolymers, in which the relative intensities of the blue fluorescence and red phosphorescence can be easily tuned by the initial feed ratio of the two monomers or energy transfer between the fluorescent and phosphorescent units, have been designed and prepared for the application in ...
Wang Xu - - 2012
Current estimation schemes as decision support tools for the selection of wastewater treatment alternatives focus primarily on the treatment efficiency, effluent quality and environmental consequences for receiving water bodies. However, these schemes generally do not quantify the potential to convert pollutants in wastewater to recoverable resources. This study proposed a ...
Jensen Thomas - - 2012
OBJECTIVES: The objective was to test the hypotheses: (i) no differences in bone-to-implant contact formation, and (ii) no differences between the use of autogenous mandibular or iliac bone grafts, when autogenous bone, Bio-Oss mixed with autogenous bone, or Bio-Oss is used as graft for the maxillary sinus floor augmentation. MATERIAL ...
Seeboth Julie - - 2012
ABSTRACT: T-2 toxin is known to be one of the most toxic trichothecene mycotoxins. Exposure to T-2 toxin induces many hematologic and immunotoxic disorders and is involved in immuno-modulation of the innate immune response. The objective of this work was to evaluate the effects of T-2 toxin on the activation ...
Hu Jing - - 2012
Although the concept of Janus particles was raised in the early 1990s, the related research has not attracted considerable interest until recently due to the special properties and applications of these colloidal particles as well as the advances in new fabrications. Janus particles can be divided into three categories: polymeric, ...
Jin Zhen - - 2012
Several heavy metal ions (HMIs), such as Cd2+, Pb2+ and Hg2+, are highly toxic even at very low concentrations. Although a large number of fluoroionphores have been synthesized for HMIs, only a few of them show detection limits that are below the maximum contamination levels in drink water (usually in ...
Chen Ruiyong - - 2012
Sol-gel Ru(0.3)Sn(0.7)O(2) electrode coatings with crack-free and mud-crack surface morphology deposited onto a Ti-substrate are prepared for a comparative investigation of the microstructural effect on the electrochemical activity for Cl(2) production and the Cl(2) bubble evolution behaviour. For comparison, a state-of-the-art mud-crack commercial Ru(0.3)Ti(0.7)O(2) coating is used. The compact coating ...
Docobo-Pérez Fernando - - 2012
OBJECTIVES: The British Thoracic Society, American Thoracic Society and Infectious Diseases Society of America guidelines recommend vancomycin for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia, based on evidence suggesting that a vancomycin AUC(0-24)/MIC ratio of 400 predicts clinical success against MRSA pneumonia. The aim of this study was the evaluation of an ...
Lozan Vasile - - 2012
A series of novel mixed ligand dinickel complexes of the type [Ni(II)(2)L(μ-L')](+), where L' is a tetrahedral oxo-alkoxo vanadate (L' = [O(2)V(V)(OR)(2)](-), R = H or alkyl) and L a macrocyclic N(6)S(2) supporting ligand, have been prepared, and their esterification reactivity has been studied. The orthovanadate complex [Ni(2)L(μ-O(2)V(OH)(2))](+) (2), prepared ...
Gallegos Jesus - - 2012
ABSTRACT: Electroconvulsive therapy (ECT) is far and away the most effective treatment for depression and quite effective for a range of other psychiatric conditions that are unresponsive to medication. Electroconvulsive therapy in the developed world has been administered with anesthesia, muscle relaxants, and ventilation since the mid-1950s following 20 years ...
Hinnen Chris - - 2012
Abstract The present study investigated the relationship between adult attachment style and depressive symptomatology in patients with HIV. Moreover, perceived social support was investigated as a potential mediator between adult attachment and depressive symptoms. A sample of 233 HIV-infected patients (90% male) completed questionnaires assessing adult attachment style (Relationship Questionnaire), ...
Pacholarz Kamila J - - 2012
The initial stages of drug discovery are increasingly reliant on development and improvement of analytical methods to investigate protein-protein and protein-ligand interactions. For over 20 years, mass spectrometry (MS) has been recognized as providing a fast, sensitive and high-throughput methodology for analysis of weak non-covalent complexes. Careful control of electrospray ...
Pérez-Losada Marcos - - 2012
The thecostracans include the Facetotecta, Ascothoracida, and Cirripedia and show great diversity in both morphology and biology. This makes them ideal models for studying evolutionary adaptations of the larval and adult body-plan, lifestyle, and reproduction. Surprisingly, despite all the work published since Darwin's seminal monographs, few studies have tested evolutionary ...
Azizi Arash - - 2012
J Oral Pathol Med (2012) Introduction:  Oral lichen planus (OLP) is a chronic, mucocutaneous, inflammatory disease. It has become more evident that the immune system plays a primary role in the development of this disease. The aim of the present study was to evaluate the total antioxidant status (TAS) of ...
Weisleder Pedro - - 2012
Cochlear implant technology has altered the landscape for the Deaf and for those who provide services to the profoundly hearing impaired. As indicated by Teagle in one of the companion articles, cochlear implants afford the profoundly hearing impaired child the ability to circumvent the effects of deafness. Cochlear implants, as ...
Gisbert J P - - 2012
BACKGROUND: The response rate to hepatitis B virus (HBV) vaccination in patients with inflammatory bowel disease (IBD) is low. AIM: To compare two vaccination protocols-the standard dose and the double dose-in IBD patients. METHODS: Patients diagnosed with IBD from three tertiary hospitals were vaccinated against HBV with two different protocols: ...
King John T - - 2012
The thermodynamic driving forces for protein folding, association and function are often determined by protein-water interactions. Using a novel covalently bound labeling approach, we have used sensitive vibrational probes, site-selectively conjugated to two lysozyme variants, in conjunction with ultrafast two-dimensional infrared spectroscopy, to investigate directly the protein-water interface. By probing ...
Megiatto Jackson D JD - - 2012
A series of random copoly(styrene)s has been synthesized via radical polymerization of functionalized anthraquinone (AQ) and β-O-4 lignin model monomers. The copolymers were designed to have a different number of styrene spacer groups between the AQ and β-O-4 lignin side chains aiming at investigating the distance effects on AQ/β-O-4 electron ...
Cheng Xiaofei - - 2012
• The CUP-SHAPED COTYLEDON (CUC)/NO APICAL MERISTEM (NAM) family of genes control boundary formation and lateral organ separation, which is critical for proper leaf and flower patterning. However, most downstream targets of CUC/NAM genes remain unclear. • In a forward screen of the tobacco retrotransposon1 (Tnt1) insertion population in Medicago ...
Luo H - - 2012
Background and study aims: The use of natural orifice transluminal endoscopic surgery (NOTES) for gastroenterostomy has been previously reported, but it remains technically challenging and additional assistance is often needed. The aim of this study was to develop and evaluate a novel method for the creation of a gastroenterostomy using ...
Gaggero Pascal Olivier - - 2012
Electrical impedance tomography (EIT) can image the distribution of ventilated lung tissue, and is thus a promising technology to help monitor patient breathing to help selection of mechanical ventilation parameters. Two key difficulties in EIT instrumentation make such monitoring difficult: (1) EIT data quality depends on good electrode contact and ...
Noolvi Malleshappa N - - 2012
A set of thirty one substituted 2-phenoxy-N-phenylacetamide derivatives with HIF-1 inhibitory activities was subjected to 2D and 3D Quantitative Structure Activity Relationship (QSAR) studies using various combinations of descriptors. 2D-QSAR was performed using Multiple Linear Regression (MLR), Principal Component Regression (PCR) and Partial Least Squares Regression (PLS) methods. Among these ...
Riganas Stefanos - - 2012
The synthesis of 4-(1-adamantyl)-4,4-diarylbutylamines 1, 5-(1-adamantyl)-5,5-diarylpentylamines 2 and 6-(1-adamantyl)-6,6-diarylhexylamines 3 is described and the σ1, σ2-receptors and sodium channels binding affinity of compounds 1 were investigated. The in vitro activity of compounds 1, 2 and 3 against main cancer cell lines is significant. One of the most active analogs, 1a, ...
Rezaej Farzin - - 2012
OBJECTIVES: To investigate the effect of adding remifentanil to propofol used in the induction of anesthesia in efficacy, and to investigate the cognitive adverse effects of electroconvulsive therapy (ECT) in the treatment of patients with severe mania. METHODS: Thirty-eight patients' condition was diagnosed as manic episode by the Diagnostic and ...
van den Broek M - - 2012
OBJECTIVE: Several prediction models for rapid radiological progression (RRP) in the first year of rheumatoid arthritis have been designed to aid rheumatologists in their choice of initial treatment. The association was assessed between RRP and disability and joint damage progression in 8 years.METHODS: Patients from the BeSt cohort were used. ...
Saxena Anil K - - 2012
The present study describes application of computational approaches to identify a validated and reliable 3D QSAR pharmacophore model for the CCK-2R antagonism through integrated ligand and structure based studies using anthranilic sulphonamide and 1,3,4-benzotriazepine based CCK-2R antagonists. The best hypothesis consisted five features viz. two aliphatic hydrophobic, one aromatic hydrophobic, ...
Suzuki Norihiro - - 2012
The colloidal mesoporous silica nanoparticles with small particle sizes (namely, CMS) are used as inorganic fillers of polymers (i.e. epoxy and silicone). From simple calculation, almost all polymers are estimated to be confined in the mesopores. To clarify the superiority of CMS over nonporous silica particles and mesoporous silica particles ...
Lin Shangchao - - 2012
Functionalization of single-walled carbon nanotubes (SWCNTs) using diazonium salts allows modification of their optical and electronic properties for a variety of applications, ranging from drug-delivery vehicles to molecular sensors. However, control of the functionalization process remains a challenge, requiring molecular-level understanding of the adsorption of diazonium ions onto heterogeneous, charge-mobile ...
Choi Yong Jun - - 2012
For the prevention of osteoporotic fracture, adequate screening and treatment are important. However, there are few published data on diagnosis and treatment rates of osteoporosis in Asia. We used data from the fourth Korea National Health and Nutrition Examination Survey 2008-2009 to estimate the nationwide prevalence, physician diagnosis rate and ...
Ntokou Eleni - - 2012
Outbreaks caused by linezolid-resistant (LR) enterococci remain rare. We report the epidemiological and molecular characteristics of the multiclonal dissemination of LR enterococci in the intensive care unit (ICU) of a Greek hospital. All LR enterococcal isolates recovered from patients hospitalized in the ICU of the University Hospital of Larissa, Greece, ...
Wu Shuxing - - 2012
In this paper, Bi(2) O(3) and rare earth (La, Ce) doped Bi(2) O(3) visible-light-driven photocatalysts were prepared in a Triton X-100/n-hexanol/cyclohexane/water reverse microemulsion. The resulting materials were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) surface area, photoluminescence spectra (PLS) and UV-vis diffuse reflectance spectroscopy. The ...
Wiegand J - - 2012
BACKGROUND: The histological pattern of fibrosis in liver cirrhosis varies in different chronic liver diseases, and hepatic decompensation may be differentiated in consequences of fibrosis (i.e. ascites, variceal bleeding) or in lack of function (i.e. jaundice) resulting in aetiology-specific variable morbidity and mortality. AIM: To evaluate patterns of hepatic decompensation ...
Cardu Roberto - - 2012
Electrode contact impedance is a crucial factor in physiological measurements and can be an accuracy-limiting factor when performing electroencephalography and electrical impedance tomography. In this work, standard flat electrodes and micromachined multipoint spiked electrodes are characterized with a finite-element method electromagnetic solver and the dependence of the contact impedance on ...
Patil Vaishali M - - 2012
Hepatitis C virus (HCV) NS5B polymerase is the key replicating protein of the virus and thus an attractive target for drug development. Here we report on the synthesis and biological evaluation of a new series of benzimidazole derivatives as HCV NS5B inhibitors. This yielded compound 6b and 6d bearing 2-(2-benzyloxy)phenyl ...
Soustiel Jean F - - 2012
For years, therapeutic approach to brain injury has been mostly physiological in essence, either based on revascularization of ischemic tissue in stroke or decompression of the swollen brain in neurotrauma. Despite tremendous efforts for the development of new strategies, translational research targeting specific cellular pathophysiological processes triggered by the injury ...
Jewell April D - - 2012
Surface molecular self-assembly is a fast advancing field with broad applications in sensing, patterning, device assembly, and biochemical applications. A vast number of practical systems utilize alkane thiols supported on gold surfaces. Whereas a strong AuS bond facilitates robust self-assembly, the interaction is so strong that the surface is reconstructed, ...
Bauer Stuart B - - 2012
PURPOSE: The objective of this ICCS standardization document is to report the initial diagnostic evaluation and subsequent work-up of children with neuropathic bladder dysfunction. MATERIALS AND METHODS: Due to a paucity of level I or level II, "levels of evidence" publications, these recommendations are actually a compilation of best practices ...
Larsen Stine Rosenkilde - - 2012
J Oral Pathol Med (2012) Background:  Salivary gland carcinomas are a heterogeneous group of tumors with varying malignant potential. In this study, we evaluated the proliferative marker Ki-67 in salivary gland carcinomas and related the Ki-67 index to clinical data. Methods:  A total of 176 salivary gland carcinomas of 13 ...
Kohsaka Shinji - - 2012
Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with a poor prognosis. Current standard treatment includes chemotherapy with the DNA alkylating agent temozolomide (TMZ) concomitant with surgical resection and/or irradiation. However, a number of cases are resistant to TMZ-induced DNA damage due to elevated expression of the ...
Fitzpatrick J L - - 2012
The size of the vertebrate brain is shaped by a variety of selective forces. Although larger brains (correcting for body size) are thought to confer fitness advantages, energetic limitations of this costly organ may lead to trade-offs, for example as recently suggested between sexual traits and neural tissue. Here, we ...
Shintani Ryo - - 2012
A palladium-catalyzed decarboxylative cyclopropanation of γ-methylidene-δ-valerolactones with aromatic aldehydes has been developed to give 4-oxaspiro[2.4]heptanes with high selectivity. The site of nucleophilic attack to a π-allylpalladium intermediate has been controlled with a sterically demanding phosphine ligand. The course of the reaction is highly dependent on ligands and solvents, and selective ...
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