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Results 701 - 750 of 2149
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Kasaras Alexis - - 2012
ABSTRACT: BACKGROUND: Arabidopsis DMP1 was discovered in a genome-wide screen for senescence-associated membrane proteins. DMP1 is a member of a novel plant-specific membrane protein family of unknown function. In rosette leaves DMP1 expression increases from very low background level several 100fold during senescence progression. RESULTS: Expression of AtDMP1 fused to ...
Valenti L - - 2012
BACKGROUND: Homozygosity for the PNPLA3 p.I148M polymorphism influences steatosis and fibrogenesis in chronic hepatitis C (CHC). AIM: To evaluate the effect of p.148M/M on sustained virological response (SVR) and viral kinetics in patients who underwent antiviral therapy with peg-interferon and ribavirin, stratified according to viral genotype and fibrosis severity, and ...
Hasegawa George - - 2012
Macroporous polymer monoliths based on poly(styrene-co-divinylbenzene) with varied styrene/divinylbenzene ratios have been prepared by organotellurium-mediated living radical polymerization. The well-defined co-continuous macroporous structure can be obtained by polymerization-induced spinodal decomposition, and the pore structures are controlled by adjusting the starting composition. The separation efficiency of small molecules (alkylbenzenes) in the ...
Agrawal Vineet - - 2012
Tissue regeneration in response to injury in adult mammals is generally limited to select tissues. Non-mammalian species such as newts and axolotls undergo regeneration of complex tissues such as limbs and digits via recruitment and accumulation of local and circulating multipotent progenitors pre-programmed to recapitulate the missing tissue. Directed recruitment ...
Hamade Eva - - 2012
The anti-inflammatory effect of two new thiazoles derivatives CX-32 (N-[4-(4-hydroxy-3-methoxyphenyl)-1,3-thiazol-2-yl]acetamide ) and CX-35 (4-(2-amino-1,3-thiazol-4-yl)-2-methoxyphenol), was investigated in LPS-stimulated RAW 264.7 cell line. Synthesis, structure analysis and purity of these compounds were evaluated by high performance liquid chromatography, H1 NMR, and C14 NMR. Assessment of CX-32 and CX-35 inhibitory effect on ...
Bostanci Nagihan - - 2012
Porphyromonas gingivalis is a Gram-negative oral anaerobe highly involved in the pathogenesis of periodontitis, an inflammatory disease that destroys the tooth supporting tissues, eventually leading to tooth loss. P. gingivalis has the capacity invade locally periodontal tissues and evade the host defence mechanisms. In doing so, it utilizes a panel ...
Ohto Umeharu - - 2012
Lipopolysaccharide (LPS), also known as endotoxin, activates the innate immune response through toll-like receptor 4 (TLR4) and its coreceptor, MD-2. MD-2 has a unique hydrophobic cavity that directly binds to lipid A, the active center of LPS. Tetraacylated lipid IVa, a synthetic lipid A precursor, acts as a weak agonist ...
Zhang Xinghua - - 2012
Double-stranded DNA is a dynamic molecule whose structure can change depending on conditions. While there is consensus in the literature about many structures DNA can have, the state of highly-stretched DNA is still not clear. Several groups have shown that DNA in the torsion-unconstrained B-form undergoes an "overstretching" transition at ...
Li Guolin - - 2012
Oxidative stress is a key factor linked renal function decline with age. However, there is still no large cohort study exploring the potential role of oxidative stress in mild insufficiency of kidney function (MIKF) and chronic kidney disease (CKD) after adjusting for confounding factors. This study tested the hypothesis that ...
Guizzunti Gianni G Department of Cell Biology and Infection, Membrane Traffic and Pathogenesis Unit, Pasteur Institute, 25, rue du Dr. Roux, 75724 Paris Cedex 15, - - 2012
The natural product gambogic acid (GA) has shown significant potential as an anticancer agent as it is able to induce apoptosis in multiple tumor cell lines, including multidrug-resistant cell lines, as well as displaying antitumor activity in animal models. Despite the fact that GA has entered phase I clinical trials, ...
Megia A - - 2012
Please cite this paper as: Megia A, Näf S, Herranz L, Serrat N, Yañez R, Simón I, Vendrell J. The usefulness of HbA1c in postpartum reclassification of gestational diabetes. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03325.x. To investigate the role of HbA1c in postpartum reclassification of gestational diabetes (GDM) we studied 364 women ...
Wang Yong-Qing - - 2012
Well-defined Li4Ti5O12 nanosheets terminated with rutile-TiO2 at the edges were synthesized by a facile solution-based method, and revealed directly at atomic resolution by an advanced spherical aberration imaging technique. The rutile-TiO2 terminated Li4Ti5O12 nanosheets show much improved rate capability and specific capacity compared with pure Li4Ti5O12 nanosheets when used as ...
Williams Ursula J - - 2012
Dysprosium complexes of the tmtaa(2-) ligand were synthesized and characterized by X-band EPR and magnetism studies. Both complexes demonstrate magnetoanisotropy and slow paramagnetic relaxation. Comparison of these compounds with the seminal phthalocyanine complex [Dy(Pc)(2)](-) shows the azaannulide complexes are more susceptible to relaxation through non-thermal pathways.
Chen Bin - - 2012
Novel supramolecular hydrogels were formed between pyrene-terminated poly(ethylene glycol) star polymers and γ-cyclodextrin (γ-CD), through the inclusion complexation of dimers of the pyrene terminals with γ-CD, where γ-CD was directly used as a supramolecular cross-linking reagent without any modification.
Pilgrim David - - 2012
It is now over thirty years since Claus Offe theorised the crisis tendencies of the welfare state in late capitalism. As part of that work he explored ongoing and irresolvable forms of crisis management in parliamentary democracies: capitalism cannot live with the welfare state but also cannot live without it. ...
Liu Wei - - 2012
A portion of hemicelluloses and acetic acid can be pre-extracted with dilute sulfuric acid prior to aspen chemi-thermomechanical pulp (CTMP) process. The streams collected from the second press-impregnation stage after acid pre-extraction contain significant amount of acid pre-extracted hemicelluloses. Most of total sugars obtained from the pressate were xylan, in ...
Ambe P - - 2012
History and admission findings: A 51-year-old woman presented with right upper abdominal discomfort for three weeks. Her medical history revealed a lower abdominal gynecological laparoscopy and an ileocaecal resection 7 years ago.Investigations: Blood samples including liver enzymes were within normal limits. An upper abdominal ultrasound failed to reveal a gallbladder. ...
Zou Zhi-Hong - - 2012
Multidrug resistance in cancer is a major cause of failure in cancer chemotherapy. In search of new compounds with strong reversal activity and simple molecular structure, we have synthesized a series of compounds in which different substituents were linked to the 2-position of the 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)- tetrahydroisoquinoline system. Compounds were analyzed ...
Varshney Jonish - - 2012
A 2-Dimensional Quantitative Structure-Activity Relationship has been performed on 2 series of hepatitis C virus (HCV) inhibitors, i.e., Isothiazoles and Thiazolones. In each case significant correlations are found between the anti-HCV potencies and some physicochemical, electronic and steric properties of the compounds, indicating that for the first series the activity ...
Sprung Robert W - - 2012
We compared the reproducibility of multiple reaction monitoring (MRM) mass spectrometry-based peptide quantitation in tryptic digests from formalin-fixed, paraffin-embedded (FFPE) and frozen clear cell renal cell carcinoma tissues. The analyses targeted a candidate set of 114 peptides previously identified in shotgun proteomic analyses, of which 104 were detectible in FFPE ...
Kretschmer Nadine N Department of Pharmacognosy, Institute of Pharmaceutical Sciences, Karl-Franzens University , Graz 8010, - - 2012
Activity-guided fractionation of a petroleum ether-soluble extract of the roots of Onosma paniculata, which has been shown to affect the cell cycle and to induce apoptosis in melanoma cells, led to the isolation of several shikonin derivatives, namely, β-hydroxyisovalerylshikonin (1), acetylshikonin (2), dimethylacrylshikonin (3), and a mixture of α-methylbutyrylshikonin and ...
Skelton J A JA Department of Pediatrics, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27 157, USA. - - 2012
Family-based approaches to pediatric obesity treatment are considered the 'gold-standard,' and are recommended for facilitating behavior change to improve child weight status and health. If family-based approaches are to be truly rooted in the family, clinicians and researchers must consider family process and function in designing effective interventions. To bring ...
Frommer Klaus W - - 2012
OBJECTIVES: Several clinical studies have suggested the adipocytokine adiponectin is involved in the progression of rheumatoid arthritis (RA). From this point of view, adiponectin might present a new therapeutic target. However, as adiponectin also exerts beneficial effects in the human organism, a strategy that would allow its detrimental effects to ...
He Chao - - 2012
Hydrogen cyanide is considered as an important precursor to amino acids and nucleic acids and its polymers could have profound implications for prebiotic chemistry. Several structures of HCN polymers are speculated, but these structures are disparate both chemically as well as structurally. Here we employ solution-state NMR spectroscopy to investigate ...
Marusic Maja - - 2012
We herein report on the formation and high-resolution NMR solution-state structure determination of a G-quadruplex adopted by d[G(3)ATG(3)ACACAG(4)ACG(3)] comprised of four G-tracts with the third one consisting of four guanines that are intervened with non-G streches of different lengths. A single intramolecular antiparallel (3+1) G-quadruplex exhibits three stacked G-quartets connected ...
Williams Warren M - - 2012
ABSTRACT: BACKGROUND: White clover (Trifolium repens) is a ubiquitous weed of the temperate world that through use of improved cultivars has also become the most important legume of grazed pastures world-wide. It has long been suspected to be allotetraploid, but the diploid ancestral species have remained elusive. Putative diploid ancestors ...
Xieraili Maimaiti - - 2012
The recurrence and prognostic assessment of patients with hepatocellular carcinoma (HCC) after resection is an important clinical issue. The present study investigated those genes associated with high serum AFP, and their clinical significance including prognosis and recurrence after hepatectomy. Based on gene expression analysis of 110 training HCC cases, twenty ...
Sonmez Fatma Mujgan - - 2012
Pontocerebellar hypoplasia consists of a rare heterogeneous group of congenital neurodevelopmental disorders characterized by hypoplasia and atrophy of the cerebellar cortex, dentate and pontine nuclei, and inferior olives. The very low density lipoprotein receptor protein is an integral part of the reelin signaling pathway, which guides neuroblast migration in the ...
Zimbric Gabrielle - - 2012
OBJECTIVE: To evaluate for adverse outcomes associated with gastroesophageal reflux disease (GERD) following an apparent life-threatening event (ALTE) and potential risk factors of these outcomes. STUDY DESIGN: Retrospective cohort study of well-appearing infants (<12 months) admitted for ALTE. Patients were followed for adverse outcomes associated with GERD (including aspiration pneumonia, ...
Nakatani Masatoshi - - 2012
OBJECTIVES: Garenoxacin, a des-fluoro(6)-quinolone, exhibits potent activity against Mycoplasma pneumoniae, including macrolide-resistant strains. There has been no report on the inhibitory activity of garenoxacin against the target enzyme of M. pneumoniae. METHODS: Subunits of DNA gyrase (GyrA and GyrB) proteins of M. pneumoniae FH were separately expressed as His-tagged proteins ...
Lincoln N B - - 2012
Objective: The purpose was to examine the inter-rater reliability of the Nottingham Neurological Driving Assessment.Participants: Six drivers with dementia (mean age 78 years, 5 men).Interventions: Participants were assessed for their safety to drive on a set route while being observed by two driving assessors, who were experienced in assessing safety ...
Kiritsis Christos - - 2012
A novel series of 3΄-C-ethynyl and 3΄-C-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides has been designed and synthesized. Reaction of 3-keto glucoside 1 with ethynyl magnesium bromide gave the desired precursor 3-C-ethynyl-1,2:5,6-di-O-isopropylidene-α-D-allofuranose (2). Hydrolysis followed by acetylation led to the 1,2,4,6-tetra-O-acetyl-3-C-ethynyl-β-D-allopyranose (3). Compound 3 was condensed with silylated 5-fluorouracil, uracil, thymine, N4-benzoylcytosine and N6-benzoyladenine, ...
Dias Carla - - 2012
The emergence of new diseases and the resurgence of several infections that were controlled in the past, associated with recent increase of bacterial resistance have created the necessity for more studies towards to the development of new antimicrobials and new treatment strategies. The aim of the present study was to ...
Martínez-Amorós Erika - - 2012
OBJECTIVE: To describe a 2-year follow-up in a cohort of patients with major depressive disorder treated with pharmacotherapy plus a short-term course of electroconvulsive therapy (ECT) over the index episode. METHODS: This naturalistic study included 127 patients. After remission, the same pharmacotherapy regimen was maintained in all patients, whereas 44 ...
Pomposelli James J - - 2012
Estimation of standard liver volume (SLV) is an important component in the evaluation of potential live liver donors or for surgical planning for resection of tumor. At least 16 different formulae have been published in the world-wide literature to estimate SLV. More recently, several proprietary Software-Assisted Image Post-processing (SAIP) programs ...
Arshad Muhammad I - - 2012
'Alarmins' are a group of proteins or molecules that are released from cells during cellular demise to alert the host immune system. Two of them, Interleukin-33 (IL-33) and high-mobility group box-1 (HMGB1), share many similarities of cellular localization, functions and involvement in various inflammatory pathologies including hepatitis. The expressions of ...
Shimakami Tetsuro - - 2012
MicroRNA 122 (miR-122) facilitates hepatitis C virus (HCV) replication by recruiting an RNA-induced silencing complex (RISC)-like complex containing argonaute 2 (Ago2) to the 5' end of the HCV genome, thereby stabilizing the viral RNA. This requires base pairing between the miR-122 "seed sequence" (nucleotides [nt] 2 to 8) and two ...
Spencer Patrick S - - 2012
Implantation is a major landmark in life. It involves the correct apposition of the embryo in the maternal endometrium. The cellular environment influences placenta development, and direct contact of the fetus with maternal tissues is achieved through decidual cells. At the decidua, and at systemic level, the correct balance of ...
Kaye S - - 2012
As a prelude to combination studies aimed at resistance reversal, this dose-escalation/dose-expansion study investigated the selective Src kinase inhibitor saracatinib (AZD0530) in combination with carboplatin and/or paclitaxel. Patients with advanced solid tumours received saracatinib once-daily oral tablets in combination with either carboplatin AUC 5 every 3 weeks (q3w), paclitaxel 175 ...
Michimae H - - 2012
Phenotypic plasticity has long been a focus of research, but the mechanisms of its evolution remain controversial. Many amphibian species exhibit a similar plastic response in metamorphic timing in response to multiple environmental factors; therefore, more than one environmental factor has likely influenced the evolution of plasticity. However, it is ...
Ma Fang - - 2012
Objective.The aim of this study was to investigate the clinical significance of real-time gray-scale contrast-enhanced ultrasound (CEUS) through evaluating renal microvascular perfusion in diabetic kidney damage.METHODS: Diabetic patients (aged: 62.5 ± 7.2, n = 33) were divided into Group A with chronic kidney disease (CKD) Stages I and II (n ...
Tan Jiali - - 2012
Upregulation of miR-34a by p53 is recently believed to be a key mediator in the pro-apoptotic effects of this tumor suppressor. We sought to determine whether restoration of miR-34a levels in p53 deficient cells could rescue the response to DNA damage. Compared with the p53 wildtype U2OS cells, miR-34a expression ...
Lee Dayong - - 2012
Defining cannabinoid stability in authentic oral fluid (OF) is critically important for result interpretation. There are few published OF stability data, and of those available, all employed fortified synthetic OF solutions or elution buffers; none included authentic OF following controlled cannabis smoking. An expectorated OF pool and a pool of ...
Dulícek Petr - - 2012
Purple toe syndrome is a rare complication of warfarin therapy. It occurs usually after 3 to 8 weeks of therapy and it is caused by cholesterol emboli from atheromatous plaque. Sudden onset of pain in affected area, typically in toes and feet, is the main characteristic of the syndrome. We ...
Ishikawa Toshio - - 2012
Background: The AhR (aryl hydrocarbon receptor) is a transcription factor that is activated by xenobiotic substances such as dioxin. After activation, it binds to dioxin response elements of DNA, thereby inducing transcription of a variety of xenobiotic metabolizing enzymes. In order to investigate whether AhR-activating substances accumulate in patients with ...
Sánchez Fernández Iván - - 2012
The study objective was to compare qualitatively the clinical features of patients with electrical status epilepticus in sleep with focal versus generalized sleep potentiated epileptiform activity. We enrolled patients 2 to 20 years of age, studied between 2001 and 2009, and with sleep potentiated epileptiform activity defined as an increase ...
Escalante Gómez C - - 2012
Background Postmenopausal women have increased oxidative stress and decreased antioxidant status. Estrogen has great antioxidant capacity both in vitro and in vivo. Few authors have studied the effect that hormone replacement therapy (HRT) has on the oxidant and antioxidant status and none have studied the effect on DNA oxidation as ...
Yun Seokho - - 2012
Metamaterials have dramatically expanded the range of available optical properties, enabling an array of new devices such as superlenses, perfect absorbers, and ultrafast switches. Most research has focused on demonstrating negative- and high-index metamaterials at terahertz and optical wavelengths. However, far less emphasis has been placed on low-loss near-zero-index metamaterials ...
Sun Linlin - - 2012
Inspired from biological systems, small synthetic organic molecules expressing the hydrogen bonding arrays of the DNA bases guanine and cytosine were prepared and their self-assembly into rosette nanotubes (RNTs) was investigated. Due to their unique biological, physicochemical, and mechanical properties, RNTs could serve as the next generation of injectable orthopedic ...
Bernad Sophie - - 2012
Nitric Oxide Synthases (NOSs) are hemoproteins responsible for the biosynthesis of NO in mammals. They catalyze two successive oxidation reactions. The mechanism of oxygen activation is based on the transfer of two electrons and two protons. Despite structural analogies with cytochromes P450, the molecular mechanism of NOS remains yet to ...
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