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Results 651 - 700 of 2149
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Kumar Praveen - - 2012
A series of 2-(1H-Benzotriazol-1-yl)-N'-[substituted]acetohydrazides were designed & synthesized keeping in view the structural requirement of pharmacophore and evaluated for anticonvulsant activity and neurotoxicity. The new compounds were characterized using FT-IR, 1H NMR, mass spectral data and elemental analysis. The anticonvulsant activity of the titled compounds was assessed using the 6 ...
Koganemaru Satoko - - 2012
Although emotion often primes us for action, its effects on the human motor system are not well understood. The relationship between emotion and motor plasticity also remains unclear, despite the close link between emotion and memory formation. Here, we tested the hypothesis that emotion modulates the plasticity of the human ...
Lee Jhen-Yi - - 2012
A novel cyclometalation pathway to form CC-type palladacycles is reported. Unlike common donor-assisted cyclometalation, the NH(CO) auxiliary group undergoes a deprotonation step to form a palladalactam intermediate. The coordinating nitrogen atom functions as an intramolecular base promoting selective C-H bond cleavage. Without the NH proton, the ortho-N-phenyl C-H is activated ...
Koren Klaus - - 2012
Ir(III)-porphyrins are a relatively new group of phosphorescent dyes that have potential for oxygen sensing and labeling of biomolecules. The requirement of two axial ligands for the Ir(III) ion permits simple linkage of biomolecules by a one-step ligand-exchange reaction, for example, using precursor carbonyl chloride complexes and peptides containing histidine ...
Sällman Almén M - - 2012
Background:The Fat mass and obesity-associated gene (FTO) was the first gene reliably associated with body mass index in genome-wide association studies on a population level. At present, the genetic variations within the FTO gene are still the common variants that have the largest influence on body mass index.Methods:In the current ...
Brown M - - 2012
Although statins do not affect the incidence of prostate cancer (CaP), usage reduces the risk of clinical progression and mortality. Although statins are known to downregulate the mevalonate pathway, the mechanism by which statins reduce CaP progression is unknown. Bone marrow stroma (BMS) was isolated with ethical approval from consenting ...
Liu Kuancan - - 2012
The site-specific recombination mediated by Cre recombinase has been utilized extensively in genetic engineering and gene function studies. Efficient delivery of a Cre enzyme with enzymatic activity and the ability to monitor the enzyme expression are required in applications, and lentiviral constructs with a fluorescent protein (FP) to report the ...
Mir Mohammad Amin - - 2012
The interaction of xanthine oxidase (XO), a key enzyme in purine metabolism, with cetyltrimethylammonium bromide (CTAB) and bis(cetyldimethylammonium)butane dibromide (C16C4C16Br2) has been studied using tensiometry, spectrofluorometry, spectrophotometry and circular dichroism at pH 7.4 and 25oC. The tensiometric profiles of CTAB and C16C4C16Br2 in presence of XO exhibit a single break ...
Khoo Teik-Beng - - 2012
In its 2010 report, the International League Against Epilepsy Commission on Classification and Terminology had made a number of changes to the organization, terminology, and classification of seizures and epilepsies. This study aims to test the usefulness of this revised classification scheme on children with epilepsies aged between 0 and ...
Curnow Paul - - 2012
The synthesis and manipulation of silicon materials on the nanoscale are core themes in nanotechnology research. Inspiration is increasingly being taken from the natural world because the biological mineralization of silicon results in precisely controlled, complex silica structures with dimensions from the millimeter to the nanometer. One fascinating example of ...
Barsalani R - - 2012
Objectives Postmenopausal women are particularly inclined to an increased risk of developing non-alcoholic hepatic steatosis. The purpose of this study was to investigate whether adding isoflavone supplementation to exercise training could reduce the risk. Methods In a 6-month, double-blind, randomized, controlled trial, 54 healthy overweight-to-obese (body mass index 28-40 kg/m2) ...
Chu Jui-Hua - - 2012
ABSTRACT: BACKGROUND: Adaptive divergence driven by environmental heterogeneity has long been a fascinating topic in ecology and evolutionary biology. The study of the genetic basis of adaptive divergence has, however, been greatly hampered by a lack of genomic information. The recent development of transcriptome sequencing provides an unprecedented opportunity to ...
Wei Hsin-Yu - - 2012
Magnetic induction tomography (MIT) is a new and emerging type of tomography technique that is able to map the passive electromagnetic properties (in particular conductivity) of an object. Excitation coils are used to induce eddy currents in the medium, and the magnetic field produced by the induced eddy current is ...
Barot Megha - - 2012
Poor bioavailability of topically instilled drug is the major concern in the field of ocular drug delivery. Efflux transporters, static and dynamic ocular barriers often possess rate limiting factors for ocular drug therapy. Different formulation strategies like suspension, ointment, gels, nanoparticles, implants, dendrimers and liposomes have been employed in order ...
Judge Andy A Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Headington, Oxford, UK. - - 2012
To identify pre-operative predictors of patient-reported outcomes of primary total knee replacement (TKR) surgery. The Elective Orthopaedic Centre database is a large prospective cohort of 1991 patients receiving primary TKR in south-west London from 2005 to 2008. The primary outcome is the 6-month post-operative Oxford Knee Score (OKS). To classify ...
Sato Reeko - - 2012
This study reported detailed clinical effects of bovine lactoferrin on two canine littermates (1 female and 1 male) with familial neutrophil dysfunction and an investigation of their genetic background. Clinical signs caused by severe upper respiratory bacterial infections were observed in these dogs. Oral administration of bovine lactoferrin for a ...
Knoop H - - 2012
Incidentally, a lesion in the right upper pulmonary lobe was found in a 74-year-old male patient. The flexible bronchoscopy revealed an endobrochial lipoma in the right lower lobe as the only pathological finding. Due to multiple co-morbidities, no intervention was performed initially. Since the endobronchial lipoma increased in size during ...
Sprague Matthew K - - 2012
The primary products of <italic>n</italic>-butoxy and 2-pentoxy isomerization in the presence and absence of O<sub>2</sub> have been detected using Pulsed Laser Photolysis - Cavity Ringdown Spectroscopy (PLP-CRDS). Alkoxy radicals were generated by photolysis of alkyl nitrite precursors (<italic>n</italic>-butyl nitrite or 2-pentyl nitrite), and the isomerization products were detected by infrared ...
Bull J J - - 2012
Extensive synonymous codon modification of viral genomes appears to be an effective way of attenuating strains for use as live vaccines. An assumption of this method is that codon changes have individually small effects, such that codon-attenuated viruses will be slow to evolve back to high fitness (and thus to ...
Hotzy Jasmin - - 2012
Excitatory amino acid transporters (EAATs) terminate glutamatergic synaptic transmission by removing glutamate from the synaptic cleft into neuronal and glial cells. EAATs are not only secondary active glutamate transporters but also function as anion channels. Gating of EAAT anion channels is tightly coupled to transitions within the glutamate uptake cycle, ...
Watanabe Masahiro - - 2012
We describe a fatal case of mumps virus-associated acute encephalopathy. In terms of the clinical course and cytokine as well as chemokine profiles, the pathogenesis in our case was different from that of mumps meningoencephalitis but was similar to that of influenza virus-associated acute encephalopathy.
Schott Gregory - - 2012
Plant viruses encode RNA silencing suppressors (VSRs) to counteract the antiviral RNA silencing response. Based on in-vitro studies, several VSRs were proposed to suppress silencing through direct binding of short-interfering RNAs (siRNAs). Because their expression also frequently hinders endogenous miRNA-mediated regulation and stabilizes labile miRNA* strands, VSRs have been assumed ...
Tacca Alessandra - - 2012
Anodically grown WO(3) photoelectrodes prepared in an N-methylformamide (NMF) electrolyte have been investigated with the aim of exploring the effects induced by anodization time and water concentration in the electrochemical bath on the properties of the resulting photoanodes. An n-type WO(3) semiconductor is one of the most promising photoanodes for ...
Amonn Kathrin - - 2012
OBJECTIVES: To compare health-related quality of life (QoL) in patients undergoing transcatheter aortic valve implantation via transapical access (TA TAVI) with patients undergoing surgical aortic valve replacement (SAVR). METHODS: One hundred and forty-four high-risk patients referred for aortic valve replacement underwent TAVI screening and were assigned to either TA TAVI ...
Iwahori Kota - - 2012
Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis for which an effective therapy remains to be established. This study investigated the therapeutic potential of gene delivery using suppressor of cytokine signaling 1 (SOCS-1), an endogenous inhibitor of intracellular signaling pathways, for the treatment of MPM. We infected ...
Je Eun Mi - - 2012
Recurrent somatic mutations in MED12 exon 2 have recently been reported in uterine leiomyomas. The recurrent nature of the mutations strongly suggests that the mutations may play important roles in the pathogenesis of uterine leiomyomas. The aim of this study was to see whether MED12 exon 2 mutations occur in ...
Simons Claudia J P CJ Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht, The Netherlands. - - 2013
Psychotic disorders are associated with neurocognitive alterations that aggregate in unaffected family members, suggesting that genetic vulnerability to psychotic disorder impacts neurocognition. The aim of the present study was to investigate whether selected schizophrenia candidate single nucleotide polymorphisms (SNPs) are associated with (1) neurocognitive functioning across populations at different genetic ...
Lupo Corrado - - 2012
Abstract This study aimed to compare specific technical and tactical indicators of the team and centre forward role of Euro League, and Italian Serie A1, Serie A2, and Serie B men's water polo club competitions. A notational analysis was performed on 21 water polo matches to evaluate the occurrence of ...
Maccann C - - 2012
Objective:The obesity epidemic in industrialized nations has important implications for education, as research demonstrates lower academic achievement among obese students. The current paper compares the test scores and school grades of obese, overweight and normal-weight students in secondary and further education, controlling for demographic variables, personality, ability and well-being confounds.Participants:This ...
Surovy Nusrat Jahan - - 2012
Subcutaneous fat layer thickness in the abdomen is a risk indicator of several diseases and disorders like diabetes and heart problems and could be used as a measure of fitness. Skinfold measurement using mechanical calipers is simple but prone to error. Ultrasound scanning techniques are yet to be established as ...
Hoppo Toshitaka - - 2012
Patient selection for endoscopic resection is based on meticulous endoscopic examination and histological assessment so as to avoid performing this procedure on patients with a high risk of lymph node involvement or metastatic disease. Currently, endoscopic mucosal resection (EMR) is used for tumors <2 cm, and endoscopic submucosal dissection (ESD) should ...
Gupta Ashutosh - - 2012
The guanine-cytosine (GC) radical anion and its interaction with a single water molecule is studied using <italic>ab initio</italic> and density functional methods. Z-averaged second-order perturbation theory (ZAPT2) was applied to GC radical anion for the first time. Predicted spin densities show that the radical character is localized on cytosine. The ...
Schultz M J - - 2012
BACKGROUND:Three trials of tight glucose control (TGC) found clinical benefit of normalization of blood glucose levels in the intensive care unit (ICU). Implementation of TGC was imperfect in subsequent trials, since attained blood glucose levels (BGLs) never reached the targets as in the original trials of TGC. We investigated whether ...
Lin Harrison W - - 2012
This case report describes the presentation and management of a rare complication of pseudoaneurysm of the superior thyroid artery following tracheostomy. The majority of post-tracheostomy bleeding is managed either with packing or surgical re-exploration. However, angiography can pinpoint an arterial source of bleeding and allow the surgeon to address it ...
Almasi B - - 2012
Stressful situations during development can shape the phenotype for life by provoking a trade-off between development and survival. Stress hormones, mainly glucocorticoids, play an important orchestrating role in this trade-off. Hence, how stress sensitive an animal is critically determines the phenotype and ultimately fitness. In several species, darker eumelanic individuals ...
Daniele Michael A - - 2012
The isolation of a single type of protein from a complex mixture is vital for the characterization of the function, structure, and interactions of the protein of interest and is typically the most laborious aspect of the protein purification process. In this work, a model system is utilized to show ...
Holst Jens - - 2012
Yemen is a low-middle-income country where more than half of the population live in rural areas and lack access to the most basic health care. At US$40 per capita, Yemen's annual total health expenditure (THE) is among the lowest worldwide. This study analyses the preconditions and options for implementing basic ...
Emery Andrew C - - 2012
Both cAMP and ERK are necessary for neuroendocrine cell neuritogenesis, and pituitary adenylate cyclase-activating polypeptide (PACAP) activates each. It is important to know whether cAMP and ERK are arranged in a novel, linear pathway or in two parallel pathways using known signaling mechanisms. Native cellular responses [cAMP elevation, ERK phosphorylation, ...
Adwan Hussamuddin H University Department of Surgery, University College London, Royal Free Hospital, London, UK. - - 2013
Although hepatocytes have a remarkable regenerative power, the rapidity of acute liver failure makes liver transplantation the only definitive treatment. Attempts to incorporate engineered three-dimensional liver tissue in bioartificial liver devices or in implantable tissue constructs, to treat or bridge patients to self-recovery, were met with many challenges, amongst which ...
Shinjo Keiko - - 2012
DNA methylation affects the aggressiveness of human malignancies. Cancers with CpG island methylator phenotype (CIMP), a distinct group with extensive DNA methylation, show characteristic features in several types of tumors. In this study, we initially defined the existence of CIMP in 41 lung adenocarcinomas (AdCas) through genome-wide DNA methylation microarray ...
Chiang Chia-Hung - - 2012
The association between use of oral bisphosphonate and cancer development in elder women is still uncertain, and previous studies showed controversial results. We used a nationwide, population-based database to explore the relationship between the use of alendronate, an oral bisphosphonate agent used for the treatment of osteoporosis, and the risk ...
Mindemark Jonas - - 2012
A series of end-functionalized poly(trimethylene carbonate) DNA carriers, characterized by low cationic charge density and pronounced hydrophobicity, is used to study structural effects on in vitro gene delivery. As the DNA-binding moieties are identical in all polymer structures, the differences observed between the different polymers are directly related to the ...
Luu Nghe S - - 2012
Abstract Objective: To perform a systematic review of the literature to assess the reliability and validity of linear measurements using virtual vs plaster study models. Materials and Methods: A search strategy was developed for four online databases, and references were further hand searched for studies additional papers. Three researchers determined ...
Fowler Drew A - - 2012
We report on a cocrystal between C-propyl pyrogallol[4]arene and the ionic liquid 1-ethyl-3-methylimidazolium ethylsulfate exhibiting a remarkable bilayer topology comprising two unique host-guest complexes resulting from the ionic liquid cation binding in two distinctive orientations relative to the macrocycle.
Dutertre Fabien - - 2012
The self-assembly in water of an amphiphilic P(nBMA(50%) -stat-DMAEMA(50%) )(100) -b-PDMAEMA(235) diblock copolymer based on hydrophilic dimethylaminoethylmethacrylate (DMAEMA) units and hydrophobic n-butylmethacrylate (nBMA) ones is reported. DMAEMA units have been incorporated into the hydrophobic block of this copolymer to moderate its hydrophobic character. Light scattering experiments revealed the formation of ...
O'Brien K S - - 2012
Objective:Self-report measures of anti-fat prejudice are regularly used by the field, however, there is no research showing a relationship between explicit measures of anti-fat prejudice and the behavioral manifestation of them; obesity discrimination. The present study examined whether a recently developed measure of anti-fat prejudice, the universal measure of bias ...
Dickmann Leslie J - - 2012
Carnosic acid is a phenolic diterpene isolated from rosemary (Rsomarinus officinalis) which may have anticancer, antiadipogenic, and anti-inflammatory properties. Recently, carnosic acid was shown to prevent weight gain and hepatic steatosis in a mouse model of obesity and type II diabetes. Based on these results, carnosic acid has been suggested ...
Dewdney A - - 2012
Bevacizumab is commonly used in combination with chemotherapy in the treatment of metastatic colorectal cancer, but to date, despite extensive research, no predictive or prognostic biomarkers for bevacizumab have been identified. The development of bevacizumab-induced arterial hypertension has recently been suggested as a potential predictive biomarker. Blood pressure was recorded ...
Andersen S B - - 2012
Wolbachia are renowned as reproductive parasites, but their phenotypic effects in eusocial insects are not well understood. We used a combination of qrt-PCR, fluorescence in situ hybridization and laser scanning confocal microscopy to evaluate the dynamics of Wolbachia infections in the leaf-cutting ant Acromyrmex octospinosus across developmental stages of sterile ...
Jazirehi Ali R - - 2012
Adoptive cell transfer (ACT) of ex vivo engineered autologous lymphocytes encoding high-affinity MART-1/ HLA-A*0201-specific T-cell receptor (TCR α/β chains (F5 CTL), densely infiltrate into sites of metastatic disease, mediating dramatic but partial clinical responses in melanoma patients. We hypothesized that MART-1 down-modulation in addition to aberrant apoptotic/survival signaling could confer ...
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