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Lin Pengfei - - 2012
Follicular atresia is primarily induced by granulosa cell apoptosis, but description of the apoptotic pathway in granulosa cells is incomplete. In this study, we explored the possibility that endoplasmic reticulum (ER) stress could be involved in granulosa cell apoptosis during goat follicular atresia. Immunohistochemical analysis revealed that DNA damage-inducible transcript ...
Ambe P - - 2012
History and admission findings: A 51-year-old woman presented with right upper abdominal discomfort for three weeks. Her medical history revealed a lower abdominal gynecological laparoscopy and an ileocaecal resection 7 years ago.Investigations: Blood samples including liver enzymes were within normal limits. An upper abdominal ultrasound failed to reveal a gallbladder. ...
Zou Zhi-Hong - - 2012
Multidrug resistance in cancer is a major cause of failure in cancer chemotherapy. In search of new compounds with strong reversal activity and simple molecular structure, we have synthesized a series of compounds in which different substituents were linked to the 2-position of the 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)- tetrahydroisoquinoline system. Compounds were analyzed ...
Varshney Jonish - - 2012
A 2-Dimensional Quantitative Structure-Activity Relationship has been performed on 2 series of hepatitis C virus (HCV) inhibitors, i.e., Isothiazoles and Thiazolones. In each case significant correlations are found between the anti-HCV potencies and some physicochemical, electronic and steric properties of the compounds, indicating that for the first series the activity ...
Sprung Robert W - - 2012
We compared the reproducibility of multiple reaction monitoring (MRM) mass spectrometry-based peptide quantitation in tryptic digests from formalin-fixed, paraffin-embedded (FFPE) and frozen clear cell renal cell carcinoma tissues. The analyses targeted a candidate set of 114 peptides previously identified in shotgun proteomic analyses, of which 104 were detectible in FFPE ...
Frommer Klaus W - - 2012
OBJECTIVES: Several clinical studies have suggested the adipocytokine adiponectin is involved in the progression of rheumatoid arthritis (RA). From this point of view, adiponectin might present a new therapeutic target. However, as adiponectin also exerts beneficial effects in the human organism, a strategy that would allow its detrimental effects to ...
He Chao - - 2012
Hydrogen cyanide is considered as an important precursor to amino acids and nucleic acids and its polymers could have profound implications for prebiotic chemistry. Several structures of HCN polymers are speculated, but these structures are disparate both chemically as well as structurally. Here we employ solution-state NMR spectroscopy to investigate ...
Williams Warren M - - 2012
ABSTRACT: BACKGROUND: White clover (Trifolium repens) is a ubiquitous weed of the temperate world that through use of improved cultivars has also become the most important legume of grazed pastures world-wide. It has long been suspected to be allotetraploid, but the diploid ancestral species have remained elusive. Putative diploid ancestors ...
Xieraili Maimaiti - - 2012
The recurrence and prognostic assessment of patients with hepatocellular carcinoma (HCC) after resection is an important clinical issue. The present study investigated those genes associated with high serum AFP, and their clinical significance including prognosis and recurrence after hepatectomy. Based on gene expression analysis of 110 training HCC cases, twenty ...
Sonmez Fatma Mujgan - - 2012
Pontocerebellar hypoplasia consists of a rare heterogeneous group of congenital neurodevelopmental disorders characterized by hypoplasia and atrophy of the cerebellar cortex, dentate and pontine nuclei, and inferior olives. The very low density lipoprotein receptor protein is an integral part of the reelin signaling pathway, which guides neuroblast migration in the ...
Zimbric Gabrielle - - 2012
OBJECTIVE: To evaluate for adverse outcomes associated with gastroesophageal reflux disease (GERD) following an apparent life-threatening event (ALTE) and potential risk factors of these outcomes. STUDY DESIGN: Retrospective cohort study of well-appearing infants (<12 months) admitted for ALTE. Patients were followed for adverse outcomes associated with GERD (including aspiration pneumonia, ...
Nakatani Masatoshi - - 2012
OBJECTIVES: Garenoxacin, a des-fluoro(6)-quinolone, exhibits potent activity against Mycoplasma pneumoniae, including macrolide-resistant strains. There has been no report on the inhibitory activity of garenoxacin against the target enzyme of M. pneumoniae. METHODS: Subunits of DNA gyrase (GyrA and GyrB) proteins of M. pneumoniae FH were separately expressed as His-tagged proteins ...
Lincoln N B - - 2012
Objective: The purpose was to examine the inter-rater reliability of the Nottingham Neurological Driving Assessment.Participants: Six drivers with dementia (mean age 78 years, 5 men).Interventions: Participants were assessed for their safety to drive on a set route while being observed by two driving assessors, who were experienced in assessing safety ...
Jhaumeer-Laulloo Sabina - - 2012
A series of mono, bis and mixed Schiff bases (1-7) were synthesised and evaluated for potential anti-glycation and anti-oxidant activities using the bovine serum albumin - glucose assay and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay respectively. All compounds showed significant (p < 0.05) antiglycating activities with IC50 values (4.02 ×10-24 ± ...
Bredski Joanna - - 2012
OBJECTIVES: Seizure threshold in electroconvulsive therapy (ECT) is defined as the smallest dose of electrical stimulus that produces a generalized seizure of at least 25 to 30 seconds as recorded by electroencephalography. Seizure thresholds vary considerably, with some patients demonstrating an exceptionally high initial seizure threshold. This case report describes ...
Kambartel K - - 2012
Diagnostic findings of mediastinal metastasis are an important factor for the prognosis of and therapy for lung cancer. In this retrospective study we examined the role of endobronchial ultrasound with transbronchial needle aspiration (EBUS) and mediastinoscopy (MS) in patients with confirmed lung cancer. Between 01 /2009 and 07 /2011 we ...
Marks Angharad - - 2012
BACKGROUND: Applying the Kidney Disease Outcomes Quality Initiative definitions of chronic kidney disease (CKD), it appears that CKD is common. The increased recognition of CKD has brought with it the clinical challenge of translating into practice the implications for the patient and for service planning. To understand the clinical relevance ...
Brugaletta Salvatore - - 2012
Background: Implantation of a metallic prosthesis creates local stiffness with a subsequent mismatch in the compliance of the vessel wall, disturbances in flow and heterogeneous distribution of wall shear stress. Polymeric bioresorbable ABSORB scaffolds have less stiffness than metallic platform stents. We sought to analyze the mismatch in vascular compliance ...
Wardhaugh Carl W - - 2012
1. We tested the hypotheses that feeding guild structure of beetle assemblages changed with different arboreal microhabitats and that these differences were consistent across rainforest tree species. 2. Hand collection and beating techniques were used from the gondola of the Australian Canopy Crane to collect beetles from five microhabitats (mature leaves, flush ...
Kim Sung-Koo - - 2012
Glucose transporter 1 facilitates glucose transport across the blood-brain barrier. By increasing histone acetylation at the SLC2A1 promotor, valproic acid could increase SLC2A1 gene expression. This study was designed to evaluate the effects of valproic acid on glucose transport in astrocyte cultures derived from SLC2A1 heterozygous mice. Primary astrocyte cultures ...
Deng Zhitao - - 2012
Imaging of individual protein molecules at the single amino acid level has so far not been possible due to the incompatibility of proteins with the vacuum environment necessary for high-resolution scanning probe microscopy. Here we demonstrate electrospray ion beam deposition of selectively folded and unfolded cytochrome c protein ions on ...
Burgo Thiago Augusto L - - 2012
Tribocharged polymers display macroscopically patterned positive and negative domains, verifying the fractal geometry of electrostatic mosaics previously detected by electric probe microscopy. Excess charge on contacting polyethylene (PE) and polytetrafluoroethylene (PTFE) follows the triboelectric series but with one caveat: net charge is the arithmetic sum of patterned positive and negative ...
Fleury Blaise - - 2012
The goal of this study is to elaborate few-micron thick optically active coatings based on nanoparticles spray-deposited onto a substrate and to control their scattering properties through a progressive suppression of the coffee-ring effect. The modification of the aggregation state of the nanoparticles to be sprayed induces a change of ...
Magri Flavia - - 2012
Estrogen (ER) and androgen (AR) receptors may be expressed in thyroid tumors, but their prognostic role is controversial. We investigated whether ERs and AR expression could confer a more aggressive phenotype to thyroid tumors. We enrolled 91 patients (13 males and 78 females, mean age 49.3 ± 14.8) bearing small ...
Abdelf-Fattah Mohamed A O - - 2012
Two series of compounds with the general formula of 4,6-diaryl-2-oxo-1,2 dihydropyridine-3-carbonitriles and their isosteric imino derivatives were synthesized through a one pot reaction of acetophenone, aldehyde and ammonium acetate with ethyl cyanoacetate or malononitrile, respectively. The synthesized compounds were evaluated for tumor cell growth inhibitory using the human HT-29 colon ...
Huuhka Kaija - - 2012
OBJECTIVES: Electroconvulsive therapy (ECT) has been established as an effective method in the treatment of severe depressive or psychotic disorders. Its efficacy is greatest in severe major depressive disorder (MDD) with or without psychotic symptoms. However, maintaining remission after a successful course of short-term ECT is often difficult owing to ...
Mayer Gad - - 2012
OBJECTIVE: There is a paucity of information about repetitive transcranial magnetic stimulation (rTMS) as a treatment for adolescent depression, and there are no data about its long-term effectiveness and safety in this age group. The aim of this study was to evaluate symptoms of depression and cognitive functioning in young ...
Holden Deric A - - 2012
The resistive-pulse method was used to monitor the pressure-driven translocation of multilamellar liposomes with radii between 190 and 450 nm through a single conical nanopore embedded in a glass membrane. Liposomes (0% and 5% 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodium salt) (DOPS) in 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), or 0, 5, 9% 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) (DPPG) in ...
Chiang C-H - - 2012
Objective:This study aimed to investigate the metabolic risk factors of high hepatitis B viral load.Design:Large-scale, community-based cross-sectional study.Subjects:A total of 3587 hepatitis B virus (HBV)-infected participants without liver cirrhosis at study entry were investigated. High HBV viral load was defined as a serum level 10(4) copies per ml for hepatitis ...
de Sousa Vanessa Emille Carvalho - - 2012
BACKGROUND: The accuracy of an indicator determines the direct relationship between a defining characteristic and the presence or absence of a specific nursing diagnosis. AIMS: To analyse the accuracy of the clinical indicators of ineffective airway clearance in patients during the postoperative period of cardiac surgery. METHODS: A total of ...
Ou C Y - - 2012
BACKGROUND: Although a sensitive flow triggering (FT) level is supposed to be associated with reduced breathing effort, the incidence of autotriggering (AT) is likely to be increased. The actual effects of various FT levels on the work of breathing and occurrence of AT in mechanically ventilated patients are unknown. We ...
Obeyesekere Manoj N - - 2012
BACKGROUND: The incidence of sudden cardiac death (SCD) and the management of this risk in patients with asymptomatic pre-excitation remains controversial. The purpose of this meta-analysis was to define the incidence of SCD and supraventricular tachycardia (SVT) in patients with asymptomatic Wolff-Parkinson-White ECG pattern. METHODS AND RESULTS: We performed a ...
Kim Kyeongtae - - 2012
Understanding energy dissipation at the nanoscale requires the ability to probe temperature fields with nanometer resolution. Here, we describe an ultra-high vacuum (UHV)-based scanning thermal microscope (SThM) technique that is capable of quantitatively mapping temperature fields with ~15 mK temperature resolution and ~10 nm spatial resolution. In this technique, a ...
Ghosh Partha S - - 2012
Cerebral vasculopathy is an important but underrecognized complication of neurofibromatosis type 1. Over a 10-year period, we retrospectively assessed the prevalence, clinical manifestations, management, and outcome of cerebral vasculopathy in children with neurofibromatosis type 1. Magnetic resonance imaging (MRI) of the brain was performed on 78% of the patients (312/398) ...
Liu Lei - - 2012
The reaction of m-fluorophenylsulfone anions with dialkylboranes, followed by alkaline hydroperoxide oxidation, yields alcohols in high yields. Optimization of the process, scope and limitation, and application to the synthesis of one of the C14-C35 building blocks of E7389, a right half analogue of halichondrin B, are reported.
Moore Ek - - 2012
Please cite this paper as: Moore EK, Roylance R, Rosenthal AN. Breast cancer metastasising to the pelvis and abdomen: what the gynaecologist needs to know. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03314.x. A small proportion of breast cancers metastasise within the peritoneal cavity. With increasing breast cancer incidence rates, gynaecologists and oncologists will ...
Nguyen Dinh Cat1 Aurelie - - 2012
Significance: Ang II influences the function of many cell types and regulates many organ systems through redox-sensitive processes. In the vascular system, Ang II is a potent vasoconstrictor and also promotes inflammation, hypertrophy, and fibrosis, which are important in vascular damage and remodeling in cardiovascular diseases. The diverse actions of ...
Aronhalt Kimberly - - 2012
More healthcare institutions are using bleach products which are sporicidal to reduce Clostridium difficile infection (CDI). There may be patient and employee concerns about the appearance of bleach residue left on surfaces, odors, and respiratory tract irritation. The intervention used bleach wipes for daily and terminal patient room cleaning to ...
Hamade Eva - - 2012
The anti-inflammatory effect of two new thiazoles derivatives CX-32 (N-[4-(4-hydroxy-3-methoxyphenyl)-1,3-thiazol-2-yl]acetamide ) and CX-35 (4-(2-amino-1,3-thiazol-4-yl)-2-methoxyphenol), was investigated in LPS-stimulated RAW 264.7 cell line. Synthesis, structure analysis and purity of these compounds were evaluated by high performance liquid chromatography, H1 NMR, and C14 NMR. Assessment of CX-32 and CX-35 inhibitory effect on ...
Krämer Benjamin - - 2012
BACKGROUND: Natural killer (NK) cells play a role in the early control and natural course of hepatitis C virus (HCV) infection. NK cell function is regulated by a multitude of receptors, including activating NKp46 receptor. However, reports on NKp46 in hepatitis C are controversial. Therefore, we investigated hepatic recruitment and ...
Bostanci Nagihan - - 2012
Porphyromonas gingivalis is a Gram-negative oral anaerobe highly involved in the pathogenesis of periodontitis, an inflammatory disease that destroys the tooth supporting tissues, eventually leading to tooth loss. P. gingivalis has the capacity invade locally periodontal tissues and evade the host defence mechanisms. In doing so, it utilizes a panel ...
Megia A - - 2012
Please cite this paper as: Megia A, Näf S, Herranz L, Serrat N, Yañez R, Simón I, Vendrell J. The usefulness of HbA1c in postpartum reclassification of gestational diabetes. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03325.x. To investigate the role of HbA1c in postpartum reclassification of gestational diabetes (GDM) we studied 364 women ...
Wang Yong-Qing - - 2012
Well-defined Li4Ti5O12 nanosheets terminated with rutile-TiO2 at the edges were synthesized by a facile solution-based method, and revealed directly at atomic resolution by an advanced spherical aberration imaging technique. The rutile-TiO2 terminated Li4Ti5O12 nanosheets show much improved rate capability and specific capacity compared with pure Li4Ti5O12 nanosheets when used as ...
Williams Ursula J - - 2012
Dysprosium complexes of the tmtaa(2-) ligand were synthesized and characterized by X-band EPR and magnetism studies. Both complexes demonstrate magnetoanisotropy and slow paramagnetic relaxation. Comparison of these compounds with the seminal phthalocyanine complex [Dy(Pc)(2)](-) shows the azaannulide complexes are more susceptible to relaxation through non-thermal pathways.
Chen Bin - - 2012
Novel supramolecular hydrogels were formed between pyrene-terminated poly(ethylene glycol) star polymers and γ-cyclodextrin (γ-CD), through the inclusion complexation of dimers of the pyrene terminals with γ-CD, where γ-CD was directly used as a supramolecular cross-linking reagent without any modification.
Pilgrim David - - 2012
It is now over thirty years since Claus Offe theorised the crisis tendencies of the welfare state in late capitalism. As part of that work he explored ongoing and irresolvable forms of crisis management in parliamentary democracies: capitalism cannot live with the welfare state but also cannot live without it. ...
Liu Wei - - 2012
A portion of hemicelluloses and acetic acid can be pre-extracted with dilute sulfuric acid prior to aspen chemi-thermomechanical pulp (CTMP) process. The streams collected from the second press-impregnation stage after acid pre-extraction contain significant amount of acid pre-extracted hemicelluloses. Most of total sugars obtained from the pressate were xylan, in ...
Wei Hsin-Yu - - 2012
Magnetic induction tomography (MIT) is a new and emerging type of tomography technique that is able to map the passive electromagnetic properties (in particular conductivity) of an object. Excitation coils are used to induce eddy currents in the medium, and the magnetic field produced by the induced eddy current is ...
Barot Megha - - 2012
Poor bioavailability of topically instilled drug is the major concern in the field of ocular drug delivery. Efflux transporters, static and dynamic ocular barriers often possess rate limiting factors for ocular drug therapy. Different formulation strategies like suspension, ointment, gels, nanoparticles, implants, dendrimers and liposomes have been employed in order ...
Sato Reeko - - 2012
This study reported detailed clinical effects of bovine lactoferrin on two canine littermates (1 female and 1 male) with familial neutrophil dysfunction and an investigation of their genetic background. Clinical signs caused by severe upper respiratory bacterial infections were observed in these dogs. Oral administration of bovine lactoferrin for a ...
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