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Results 601 - 650 of 2149
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Jamnitski Anna A Department of Rheumatology, Jan van Breemen Research Institute/READE, Dr Jan van Breemenstraat 2, 1056 AB Amsterdam, The - - 2013
Data regarding cardiovascular comorbidity and cardiovascular risk factors in patients with psoriatic arthritis (PsA) are limited. To evaluate the cardiovascular risk profile, a systematic literature search was performed to provide an extensive summary of all studies available on cardiovascular risk in PsA. Medline, EMBASE and the Cochrane library were searched ...
Başaran Ebru - - 2012
A major problem in ocular therapeutics with classical formulations is the maintenance of an effective drug concentration at the site of action for a long period of time. Enhancement of ocular bioavailability with increased dose penetration and longer retention time at desired sites can be achieved by recent formulations. Chitosan ...
Rodrigues A D - - 2012
Aim To investigate the association between socioeconomic, demographic, behavioral, and reproductive factors and the metabolic syndrome (MS) in climacteric women. Method This cross-sectional study was carried out in a sample of 527 women aged 40-65 years seen at an outpatient menopause and gynecologic surgery clinic in Southern Brazil. MS was ...
Kaur Manpreet - - 2012
A case of a 3&frac12;-year-old with clinical and correlated electroencephalographic (EEG) features of postictal psychosis is described. The clinical course and sequence of EEG changes parallel the evolution of changes well described in the adult population. Although well established and defined in the adults, postictal psychosis is rarely characterized and ...
Snauwaert Sylvia - - 2012
Background. Criteria for good candidate antigens for immunotherapy of acute myeloid leukemia are high expression on leukemic stem cells in the majority of acute myeloid leukemia patients and low or non-existing expression in vital tissues. It was shown in vaccination trials that Receptor for Hyaluronic Acid Mediated Motility (RHAMM/HMMR) generates ...
Witjes Caroline D M - - 2012
PURPOSE: To explore the potential use of magnetic resonance imaging (MRI) in predicting the outcome for patients with hepatocellular carcinoma (HCC), imaging characteristics were correlated with pathological findings and clinical outcome. MATERIALS AND METHODS: With permission from the Ethical Board, clinical data and tissues of resected HCC patients were collected, ...
Keller Rachel B RB Division of Hematology/Oncology, Stem Cell Program, Children's Hospital Boston, Boston, Massachusetts 02115, - - 2012
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome caused by mutations in seven genes involved in telomere biology, with approximately 50% of cases remaining genetically uncharacterized. We report a patient with classic DC carrying a compound heterozygous mutation in the CTC1 (conserved telomere maintenance component 1) gene, ...
Tsuchikawa Hiroshi - - 2012
Chiral 2-piperidinone compounds with various C-6 substituents were successfully synthesized via a Pd-catalyzed asymmetric 6-endo cyclization of dienamides, which were evidently activated by both N-p-toluenesulfonyl and C-3 ester substituents.
Abdelf-Fattah Mohamed A O - - 2012
Two series of compounds with the general formula of 4,6-diaryl-2-oxo-1,2 dihydropyridine-3-carbonitriles and their isosteric imino derivatives were synthesized through a one pot reaction of acetophenone, aldehyde and ammonium acetate with ethyl cyanoacetate or malononitrile, respectively. The synthesized compounds were evaluated for tumor cell growth inhibitory using the human HT-29 colon ...
Huuhka Kaija - - 2012
OBJECTIVES: Electroconvulsive therapy (ECT) has been established as an effective method in the treatment of severe depressive or psychotic disorders. Its efficacy is greatest in severe major depressive disorder (MDD) with or without psychotic symptoms. However, maintaining remission after a successful course of short-term ECT is often difficult owing to ...
Mayer Gad - - 2012
OBJECTIVE: There is a paucity of information about repetitive transcranial magnetic stimulation (rTMS) as a treatment for adolescent depression, and there are no data about its long-term effectiveness and safety in this age group. The aim of this study was to evaluate symptoms of depression and cognitive functioning in young ...
Holden Deric A - - 2012
The resistive-pulse method was used to monitor the pressure-driven translocation of multilamellar liposomes with radii between 190 and 450 nm through a single conical nanopore embedded in a glass membrane. Liposomes (0% and 5% 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodium salt) (DOPS) in 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), or 0, 5, 9% 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) (DPPG) in ...
Chiang C-H CH Department of Community and Family Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, - - 2013
This study aimed to investigate the metabolic risk factors of high hepatitis B viral load. Large-scale, community-based cross-sectional study. A total of 3587 hepatitis B virus (HBV)-infected participants without liver cirrhosis at study entry were investigated. High HBV viral load was defined as a serum level 10(4) copies per ml ...
de Sousa Vanessa Emille Carvalho - - 2012
BACKGROUND: The accuracy of an indicator determines the direct relationship between a defining characteristic and the presence or absence of a specific nursing diagnosis. AIMS: To analyse the accuracy of the clinical indicators of ineffective airway clearance in patients during the postoperative period of cardiac surgery. METHODS: A total of ...
Ribi K - - 2012
In the BIG 1-98 trial objective cognitive function improved in postmenopausal women 1 year after cessation of adjuvant endocrine therapy for breast cancer. This report evaluates changes in subjective cognitive function (SCF). One hundred postmenopausal women, randomised to receive 5 years of adjuvant tamoxifen, letrozole, or a sequence of the ...
MacDonald Norman J - - 2012
Determining the taxonomic lineage of DNA sequences is an important step in metagenomic analysis. Short DNA fragments from next-generation sequencing projects and microbes that lack close relatives in reference sequenced genome databases pose significant problems to taxonomic attribution methods. Our new classification algorithm, RITA (Rapid Identification of Taxonomic Assignments), uses ...
Ou C Y - - 2012
BACKGROUND: Although a sensitive flow triggering (FT) level is supposed to be associated with reduced breathing effort, the incidence of autotriggering (AT) is likely to be increased. The actual effects of various FT levels on the work of breathing and occurrence of AT in mechanically ventilated patients are unknown. We ...
Obeyesekere Manoj N - - 2012
BACKGROUND: The incidence of sudden cardiac death (SCD) and the management of this risk in patients with asymptomatic pre-excitation remains controversial. The purpose of this meta-analysis was to define the incidence of SCD and supraventricular tachycardia (SVT) in patients with asymptomatic Wolff-Parkinson-White ECG pattern. METHODS AND RESULTS: We performed a ...
Kim Kyeongtae - - 2012
Understanding energy dissipation at the nanoscale requires the ability to probe temperature fields with nanometer resolution. Here, we describe an ultra-high vacuum (UHV)-based scanning thermal microscope (SThM) technique that is capable of quantitatively mapping temperature fields with ~15 mK temperature resolution and ~10 nm spatial resolution. In this technique, a ...
Ghosh Partha S - - 2012
Cerebral vasculopathy is an important but underrecognized complication of neurofibromatosis type 1. Over a 10-year period, we retrospectively assessed the prevalence, clinical manifestations, management, and outcome of cerebral vasculopathy in children with neurofibromatosis type 1. Magnetic resonance imaging (MRI) of the brain was performed on 78% of the patients (312/398) ...
Liu Lei - - 2012
The reaction of m-fluorophenylsulfone anions with dialkylboranes, followed by alkaline hydroperoxide oxidation, yields alcohols in high yields. Optimization of the process, scope and limitation, and application to the synthesis of one of the C14-C35 building blocks of E7389, a right half analogue of halichondrin B, are reported.
Moore Ek - - 2012
Please cite this paper as: Moore EK, Roylance R, Rosenthal AN. Breast cancer metastasising to the pelvis and abdomen: what the gynaecologist needs to know. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03314.x. A small proportion of breast cancers metastasise within the peritoneal cavity. With increasing breast cancer incidence rates, gynaecologists and oncologists will ...
Aronhalt Kimberly - - 2012
More healthcare institutions are using bleach products which are sporicidal to reduce Clostridium difficile infection (CDI). There may be patient and employee concerns about the appearance of bleach residue left on surfaces, odors, and respiratory tract irritation. The intervention used bleach wipes for daily and terminal patient room cleaning to ...
Koba Marcin - - 2012
Artificial neural networks (ANNs) have been applied for the quantitative structure-activity relationships (QSAR) studies of antitumor activity of acridinone derivatives. Molecular modeling studies were performed with the use of HyperChem and Dragon computer programs and molecular geometry optimization using MM+ molecular mechanics and semi-empirical AM1 method, and several molecular descriptors ...
Salama Ismail - - 2012
Taking advantage of our in-house experimental data on 3-cyano-2-imino-1, 2-dihydropyridine and 3-cyano-2-oxo-1,2-dihydropyridine derivatives as inhibitors of the growth of the human HT-29 colon adenocarcinoma tumor cell line, we have established a highly significant CoMFA and CoMSIA models (q2 cv =0.70/0.639). The models were investigated to assure their stability and predictivity ...
Pérez Pintor Luis - - 2012
INTRODUCTION: Mental dysfunction and especially gait disorders, such as freezing and postural instability in "on phase," are partially unresponsive to dopaminergic therapy late in the course of Parkinson disease (PD). Some of them have been related to decreased sensitivity of postsynaptic dopaminergic receptors, and it is known that electroconvulsive therapy ...
Rawashdeh Y F - - 2012
PURPOSE: We present a consensus view of members of the International Children's Continence Society on the therapeutic intervention in congenital neuropatic bladder and bowel dysfunction in children. MATERIAL AND METHODS: Discussions were held by a group of pediatric urologists and gastroenterologists appointed by the board. The following draft review document ...
Lynn Helena - - 2012
Egress of wrapped virus (WV) to the cell periphery following vaccinia virus (VACV) replication is dependent on interactions with the microtubule motor complex kinesin-1 and is mediated by the viral envelope protein A36. Here we report that ectromelia virus (ECTV), a related orthopoxvirus and the causative agent of mousepox, encodes ...
Pjetursson Bjarni E - - 2012
OBJECTIVE: To assess the long-term survival of implants inserted in periodontally susceptible patients and to investigate the influence of residual pockets on the incidence of peri-implantitis and implant loss. MATERIALS AND METHODS: For 70 patients, comprehensive periodontal treatment was followed by installation of 165 Straumann(®) Dental implants. Subsequently, 58 patients ...
Patel A - - 2012
The commencing age of cervical screening in England was raised from 20 to 25 years in 2004. Cervical cancer incidence in young women of England is increasing. It is not clear if this is due to either greater exposure to population risk factors or reduced cervical screening. We measured if ...
Shinar Y - - 2012
The objective of this study was to assess the prevalence of the Mediterranean FeVer (MEFV) gene mutations in systemic lupus erythematosus (SLE) patients and their effect on organ involvement, as well as disease activity and severity. The frequencies of three familial Mediterranean fever-related MEFV gene mutations (M694V, V726A and E148Q) ...
Vater Y - - 2012
BACKGROUND: Preoperative body mass index (pre-BMI) affecting patients' recovery from orthotropic liver transplantation (OLT) is controversial. Pre-BMI measurements may be exaggerated by ascites. AIMS: Assessment of early outcome associated with pre-BMI and ascites. METHODS: Postoperative BMI values and ascites volumes of 206 patients undergoing OLT (2006-2007) were reviewed. RESULTS:There were ...
Sultan Pervez - - 2012
This retrospective, descriptive study aimed to assess hematologic testing practices in 100 patients with preeclampsia undergoing neuraxial blockade (NB). Prior to NB, platelet (PLT) count was performed in 61 (98%) of 62 women in labor and in 37 (97%) of 38 women undergoing cesarean delivery (CD). No patients had a ...
Lach Boleslaw - - 2012
The brain of a 5-year-old boy with Schinzel-Giedion syndrome displayed a cobblestone appearance of orbital and lateral aspects of frontal lobes due to widespread glioneuronal meningeal heterotopia. Meningeal heterotopia consisted of scattered neurons, neurofilament positive axons, and myelinated fibers accompanied by striking astrocytic gliosis. The underlying cortex showed gaps in ...
Lim Shuhui - - 2012
During neurogenesis, cell cycle regulators play a pivotal role in ensuring proper proliferation, cell cycle exit, and differentiation of neural precursors. However, the precise role of cyclin-dependent kinases (Cdks) in these processes is not well understood. We generated Cdk2 and Cdk4 double knockout (DKO) mice and found a striking ablation ...
Lee Jae In - - 2012
Human adenoviruses (HAdVs) are an important cause of acute gastroenteritis in children. However, few studies on the epidemiology or types of HAdVs associated with acute gastroenteritis have been conducted in Korea. Therefore, we aimed to examine the incidence of HAdV in 2,064 stool samples from Korean children hospitalized with acute ...
Zhang Huanjun - - 2012
The rational design of composite nanoparticles with desired optical and electronic properties requires the detailed analysis of surface and bulk contributions to the respective overall function. We use flame spray pyrolysis (FSP) to generate nanoparticles of the ternary Zn-Mg-O system the compositions of which range from solid solutions of Zn2+ ...
Duman Selin - - 2012
S0, S1, and T1 states of various orthogonal 8,8' and 8,2'-bis-boradiaza-s-indacene (BODIPY) dyes, recently (Angew. Chem. Int. Ed. 2011, 50, 11937) proposed as heavy atom free photosensitizers for O2(1Deltag) generation, were studied by multi-reference quantum chemical approaches. S0→S1 excitation characteristics of certain bis-BODIPYs are shown to be drastically different than ...
Verendel J Johan - - 2012
Several types of chiral hetero- and carbocyclic compounds have been synthesized by using the asymmetric hydrogenation of cyclic alkenes. N,P-Ligated iridium catalysts reduced six-membered cyclic alkenes with various substituents and heterofunctionality in good to excellent enantioselectivity, whereas the reduction of five-membered cyclic alkenes was generally less selective, giving modest enantiomeric ...
Brunner G - - 2012
To date, the safety and tolerability of proton pump inhibitors (PPIs) have been demonstrated in studies of up to 10 years. To report on the tolerability, safety and efficacy of up to 15 years' continuous treatment with pantoprazole in patients with severe acid-peptic disease. Following healing of endoscopically confirmed peptic ...
Liao Hong-Jun - - 2012
Following the addition of EGF or ionomycin to A431 cells, protease activity mediates the cleavage of the EGF receptor producing a 60 kDa fragment that includes the intracellular domain (ICD). This fragment is located in both membrane and nuclear fractions. Based on sensitivity to chemical inhibitors and overexpression of cDNAs, ...
Lönnroos Eija - - 2012
Background: Medications with anticholinergic and sedative effects carry significant risks in older people. Adverse events arising from the use of these medications may also lead to hospitalization and contribute to length of stay. The Drug Burden Index (DBI) is a tool that measures a person's total exposure to medications with ...
Wang W - - 2012
Divalproex sodium is an antiepileptic drug. Hepatotoxicity is one of the most common side effects induced by divalproex sodium. Impaired fatty acid metabolism is considered to play an important role in the drug-induced hepatotoxicity. The sterol regulatory element-binding protein 1c (SREBP-1c) and peroxisome proliferator-activated receptor α (PPARα) are two key ...
Hayrabedyan Soren - - 2012
It is currently accepted that the Sertoli cells are proliferatively active only during the embryogenesis and early fetal development, seizing to divide after puberty, when the spermatogenic niche is prepared, and they become terminally differentiated. So far, only seasonal breeders from mammals have been reported as having season-dependent variations in ...
Mahar Kelly M - - 2012
To further characterize the time course of gastric pH with respect to meals and gastric residence times (GRTs) in dogs, continuous pH measurements were recorded with Bravo® capsules, which were attached to the dogs' stomach mucosa or administered as free capsules, respectively. Experiments took place in home or study cages, ...
Ding Caifeng - - 2012
Herein we report a polymerase chain reaction (PCR)-free electrochemiluminescence (ECL) approach that uses ECL nanoprobes for the determination of cancer cells with high sensitivity. The ECL nanoprobe consists of gold nanoparticles (AuNPs), linker DNA, and tris(2,2'-bipyridyl)ruthenium (TBR)-labeled signal DNA. The linker DNA and signal DNA were modified on the surface ...
Coulter Cynthia - - 2012
This paper describes the determination of tetrahydrocannabinol (THC) and its metabolite, 11-nor-Δ(9)-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in oral fluid using solid-phase extraction and liquid chromatography with tandem mass spectral detection (LC-MS-MS) and its application to proficiency specimens. The method employs collection of oral fluid with the Quantisal™ device, base hydrolysis, solid-phase extraction ...
Wu Kuan-Lin - - 2012
Panchromatic Os(II) sensitizers for dye-sensitized solar cells (DSCs) were prepared. A DSC based on TF-52 showed promising performance characteristics: short-circuit photocurrent density J(SC) =23.3 mA cm(-2) , open-circuit photovoltage V(OC) =600 mV, fill factor (FF)=0.633 and power conversion efficiency η=8.85 % under AM 1.5G simulated one-sun irradiation.
Liao Kristine - - 2012
The coverage dependent heats of adsorption and sticking probabilities for oxygen on fcc Co{110} have been measured at 300 K using single crystal adsorption calorimetry (SCAC). Initial adsorption is consistent with dissociative chemisorption at low coverage followed by oxide formation above 0.6 ML coverage. The initial heat of adsorption of ...
Neilson James Richmond - - 2012
Here, we study the nature of metal--metal bonding in the ThCr<sub>2</sub>Si<sub>2</sub> structure type by probing the rate-limiting steps in the oxidative deintercalation of KNi<sub>2</sub>Se<sub>2</sub>. For low extents of oxidation, alkali ions are removed exclusively to form K<sub>1-<italic>x</italic></sub>Ni<sub>2</sub>Se<sub>2</sub>. For greater extents of oxidation, the rate of the reaction decreases dramatically, concomitant ...
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