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Results 551 - 600 of 2149
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Dallavalle Marco - - 2012
A model is introduced to investigate structure, stability, dynamics and properties of MoS2. The tribological behavior of the material is obtained from the autocorrelation function, ACF, of the forces using the Green-Kubo equation and by the classical Amontons' laws. In the idealized system, i.e. without defects, junctions, vacancies, asperities and ...
Doddrell Robin D S - - 2012
Pax-3 is a paired domain transcription factor that plays many roles during vertebrate development. In the Schwann cell lineage, Pax-3 is expressed at an early stage in Schwann cells precursors of the embryonic nerve, is maintained in the nonmyelinating cells of the adult nerve, and is upregulated in Schwann cells ...
Subramaniam Dharmalingam - - 2012
Despite advances in molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. It is a rapidly invasive, metastatic tumor that is resistant to standard therapies. The phosphatidylinositol-3-kinase/Akt and mTOR signaling pathways are frequently dysregulated in pancreatic cancer. Gemcitabine is the mainstay treatment for metastatic pancreatic cancer. P276 is a ...
Winkler Edith - - 2012
Pathogenic generation of amyloid β-peptide (Aβ) by sequential cleavage of β-amyloid precursor protein (APP) by β- and γ-secretases is widely believed to causally underlie Alzheimer disease (AD). β-Secretase initially cleaves APP thereby generating a membrane-bound APP C-terminal fragment, from which γ-secretase subsequently liberates 37-43-amino acid long Aβ species. Although the ...
Veríssimo Carla - - 2012
Nonketotic hyperglycinemia is a rare metabolic disorder with severe, frequently fatal, neurologic manifestations. Reliable and accurate diagnosis depends on careful interpretation of laboratory findings. The clinical suspicion should lead to determination of glycine in plasma and cerebrospinal fluid. Amino acid analysis presents diagnostic values for classic nonketotic hyperglycinemia, but it ...
Nishie Akihiro - - 2012
PURPOSE: To examine whether the uptake of a liver-specific contrast agent in the liver parenchyma was correlated with the degree of liver fibrosis. MATERIALS AND METHODS: This retrospective study included 54 and 63 patients who underwent superparamagnetic iron oxide (SPIO)- and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI before liver ...
Chiribiri Amedeo A Division of Imaging Sciences, King's College London BHF Centre of Excellence, NIHR Biomedical Research Centre and Wellcome Trust and EPSRC Medical Engineering Centre at Guy's and St Thomas' NHS Foundation Trust, The Rayne Institute, London, United Kingdom. - - 2013
The aim of this article is to describe a novel hardware perfusion phantom that simulates myocardial first-pass perfusion allowing comparisons between different MR techniques and validation of the results against a true gold standard. MR perfusion images were acquired at different myocardial perfusion rates and variable doses of gadolinium and ...
Merryman Reid - - 2012
Although L-asparaginase (ASP) is associated with several toxicities, its myelosuppressive effect has not been well characterized. On DFCI ALL Consortium Protocol 05-01 for children with newly diagnosed acute lymphoblastic leukemia, the Consolidation phase and the initial portion of the Continuation phase were identical for standard risk patients, except ASP was ...
Sajid Muhammad S - - 2012
A systematic review of randomised, controlled trials investigating the effectiveness of fibrin glue (FG) in reducing the postoperative seroma and seroma related morbidities following breast and axillary surgery was conducted. FG failed to influence the incidence of postoperative seroma, average volume of seroma, wound infection, complications and length of hospital ...
Lange Martin - - 2012
ABSTRACT: Classical Swine Fever (CSF) is considered an endemic disease in European wild boar populations. In view of the high economic impact of the introduction of the virus into domestic pig units, huge efforts are invested in the preventive control of CSF in wild boar populations. Recent European Community guidelines ...
Videlock E J - - 2012
BACKGROUND: Diarrhoea is a common occurrence in association with antibiotic administration. Earlier studies and meta-analyses have suggested that probiotic administration reduces the incidence of antibiotic-associated diarrhoea (AAD). AIM: To estimate the reduction in risk of AAD with administration of probiotics in randomised placebo-controlled trials and to identify factors associated with ...
Kroon Féline - - 2012
OBJECTIVES: The aim was to compare continuous and on-demand NSAID treatment with respect to their ability to suppress radiographic progression in subgroups of patients with high/elevated CRP-levels, ESR, ASDAS-levels or BASDAI-levels in comparison to patients with normal levels.METHODS: Post-hoc analyses were performed in a randomized trial comparing continuous and on-demand ...
Ornbjerg Lykke Midtbøll - - 2012
OBJECTIVES: To compare radiographic progression during treatment with disease-modifying antirheumatic drugs (DMARD) and subsequent treatment with tumour necrosis factor α inhibitors (TNF-I) in rheumatoid arthritis (RA) patients in clinical practice.METHODS: Conventional radiographs (x-rays) of hands and wrists were obtained ∼2 years before start (prebaseline), at baseline and ∼2 years after ...
Wang Yan-Hong - - 2012
In natural product chemistry, it is often crucial to determine sugar composition as well as the absolute configuration of each monosaccharide in glycosides. An ultra-performance liquid chromatography method using both photodiode array (PDA) and mass spectrometry detectors (UPLC-UV/MS) was developed for qualitative analysis of the absolute configuration of monosaccharide enantiomers. ...
Makhov Peter B - - 2012
Tyrosine kinase inhibitors exhibit impressive activity against advanced renal cell carcinoma. However, recent clinical studies have shown an equivocal response to sunitinib in patients with castration-resistant prostate cancer. The tumor suppressor PTEN acts as a gatekeeper of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR cell-survival pathway. Our experiments showed that PTEN expression inversely ...
Kawakami Kohsaku - - 2012
Amorphous solid dispersions have great potential for enhancing oral absorption of poorly soluble drugs. Crystallization behavior during storage and after exposure to aqueous media must be examined in detail for designing stable and effective amorphous formulations, and it is significantly affected by the intrinsic properties of an amorphous drug. Many ...
Kramer Ms - - 2012
Please cite this paper as: Kramer M, Rouleau J, Liu S, Bartholomew S, Joseph K for the Maternal Health Study Group of the Canadian Perinatal Surveillance System. Amniotic fluid embolism: incidence, risk factors, and impact on perinatal outcome. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03323.x. Objective  To extend our previous work on AFE ...
Bal Gaëlle - - 2012
The objective was to evaluate the analysis of adverse events and the decisions for quality improvement decided during morbidity and mortality conferences (MMCs). We conducted a prospective observational study of MMCs conducted in a teaching hospital between November 2007 and May 2008. Two observers attended the conferences and collected data ...
Sakoda Yoshihiro - - 2012
Affinity chromatography using sulfated, spherical cellulose beads (Cellufine(®) Sulfate) was assessed for the purification of influenza A and influenza B viruses. Recovery rates of viruses eluted from the beads were high for all tested virus strains. This method was also useful to remove chicken egg-derived impurities from allantoic fluids containing ...
Guerrero-Martínez Andrés - - 2012
The development of nanoplasmonics has been tremendous during the past two decades, driven in part by the improvements in colloidal synthesis of nanocrystals and manipulation of nanoparticle surface functionalities. This has granted access not only to exquisite control over the morphology of nanoparticles but also to novel multiparticle nanostructures with ...
Yoshimura Koji - - 2012
AIMS: To investigate whether objective cardiovascular parameters have an independent association with nocturnal voiding in women. METHODS: Thirty-two parameters derived from questionnaires, and anthropometric, physiological and biochemical measures of 5,980 women were applied for analysis. Nocturnal voiding was assessed by the International Prostate Symptom Score and the Overactive Bladder Symptom ...
Windell Deborah - - 2012
BACKGROUND: Understanding perceived influences on recovery following a first episode of psychosis could help improve services. MATERIAL: Thematic analysis was used to examine important influences on early recovery identified by 30 individuals receiving services in an early intervention programme. DISCUSSION: Social support, medication, meaningful activities and lifestyle modification were identified ...
Karatzanis Alexander D - - 2012
BACKGROUND AND OBJECTIVE: Base-of-tongue carcinoma is a relatively rare disease with aggressive behavior and poor prognosis. Up to date no consensus exists regarding the ideal management strategy for each stage of the disease. This study aims to evaluate the experience of a single head and neck oncology center in the ...
Golubic R R Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, - - 2013
To investigate the relationship of body weight and its changes over time with physical activity (PA). Population-based prospective cohort study (Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition, EPIC-Norfolk, United Kingdom). A total of 25 639 men and women aged 39-79 years at baseline. PA was self-reported. Weight ...
Lowe Elisabeth C - - 2012
Signaling across the membrane in response to extracellular stimuli is essential for survival of all cells. In bacteria, responses to environmental changes are predominantly mediated by two-component systems, which are typically composed of a membrane-spanning sensor histidine kinase and a cytoplasmic response regulator. In the human gut symbiont Bacteroides thetaiotaomicron, ...
Khan Nasim Ahmed NA Division of Rheumatology, University of Arkansas for Medical Sciences, 4301 West Markham Street, # 509, Little Rock, AR 72205, USA. - - 2012
To assess (A) determinants of patient's global assessment of disease activity (PTGL) and patient's assessment of general health (GH) scores of rheumatoid arthritis (RA) patients; (B) whether they are equivalent as individual variables; and (C) whether they may be used interchangeably in calculating common RA activity assessment composite indices. Data ...
Takahashi Mitsuhiko M Orthopaedic Surgery, University of California and Research Service, VA San Diego Healthcare System, San Diego, CA, - - 2012
Chronic skeletal muscle stretch typically increases serial muscle fiber sarcomere number. Since serial sarcomere number correlates with functional excursion in normal muscle, observed changes in sarcomere number are often extrapolated to their new assumed function. However, this has not been well demonstrated experimentally. Thus, we measured the functional properties of ...
Xu Zhichuan - - 2012
The oxidation of AuCu nanoparticles was studied as a function of composition and temperature. Oxidation rates at 110 °C were higher for NPs with higher Cu content, showing that Au stabilized the Cu. Electrochemistry measurements show that AuCu could be a promising catalyst for lowering the over potential of CO(2) ...
Mhanna Maroun J MJ Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA. - - 2013
We sought to investigate the risk factors and outcome of Ventilator Associated Tracheitis (VAT) according to the Center for Disease Control (CDC) definition in pediatric trauma patients who were ventilated for ≥48 hr. In a retrospective cohort study, medical records of all pediatric trauma patients admitted to our Pediatric Intensive Care ...
Au-Yeung Ho Yu - - 2012
A reaction-based strategy exploiting cobalt-mediated oxidative C-O bond cleavage affords a selective turn-on fluorescent probe for paramagnetic Co(2+) in water and in living cells.
Madsen Charlotte S - - 2012
We have designed and synthesised a double-headed nucleotide that presents two nucleobases in the interior of a dsDNA duplex. This nucleotide recognises and forms Watson-Crick base pairs with two complementary adenosines in a Watson-Crick framework. Furthermore, with judicious positioning in complementary strands, the nucleotide recognises itself through the formation of ...
Silva Pedro Jorge - - 2012
Substituted pyrroles may be synthesized from selected 1,2-pyridazines through a reductive ring contraction involving the addition of four electrons and four protons. Our density functional theory computations of this reaction mechanism show that the first reduction event must be preceded by the uptake of one proton by 1,2-pyridazine, and that ...
Thor Maria - - 2012
Background and purpose. The purpose of this study was to evaluate the performance of gantry angle optimisation (GAO) compared to equidistant beam geometry for two inverse treatment planning systems (TPSs) by utilising the information obtained from a range of treatment plans. Material and methods. The comparison was based on treatment ...
Chaudhry Aqif A - - 2012
A rapid and continuous hydrothermal route for the synthesis of nano-sized hydroxyapatite rods co-precipitated with calcium-doped zirconia nanoparticles using a superheated water flow at 450°C and 24.1 MPa as a crystallizing medium is described. Hydroxyapatite and calcium-doped zirconia phases in the powder mixtures could be clearly identified based on particle ...
Giorgioni Gianfabio - - 2012
Dopamine (DA) agonists, bearing catechol or phenol rings, are endowed with low oral bioavailability and short effect duration. In this report, the synthesis of novel differently substituted 4-(3-pyridyl)-1,2,3,4-tetrahydroisoquinolines and (1,2,3,4-tetrahydroisoquinolin-4-yl)phenylmethanols as potential non phenolic and non catecholic DA receptor ligands is reported. The new compounds, evaluated by binding tests on ...
Scrima Nathalie - - 2012
The hepatitis C virus (HCV) NS5B protein is an RNA-dependent RNA polymerase essential for replication of the viral RNA genome. In vitro and presumably in vivo, NS5B initiates RNA synthesis by a de novo mechanism and then processively copies the whole RNA template. Dissections of de novo RNA synthesis by ...
Sitasuwan Pongkwan - - 2012
Many nanoscale materials have been developed to investigate the effects on stem cell differentiations via topographical and chemical cues for applications in tissue engineering and regenerative medicine. The use of plant viruses as cell supporting substrates has been of particular interest due to the rapid induction of bone marrow derived ...
Elsner Rebecca A - - 2012
Influenza virus infection results in strong, mainly T-dependent, extrafollicular and germinal center B cell responses, which provide lifelong humoral immunity against the homotypic virus strain. Follicular T helper cells (T(FH)) are key regulators of humoral immunity. Questions remain regarding the presence, identity, and function of T(FH) subsets regulating early extrafollicular ...
Pfannkuchen Martin Andreas - - 2012
Mass appearances of the toxic dinoflagellate genus Ostreopsis are known to cause dangerous respiratory symptoms in humans exposed to aerosols. The outbreaks can appear in shallow marine waters of temperate regions around the globe. We followed a massive bloom event on a public beach on the northern Adriatic coast near ...
Hot Arnaud - - 2012
OBJECTIVES: To examine the effect of interleukin-17 (IL-17) on rheumatoid arthritis (RA) synoviocyte migration and invasiveness.METHODS: IL-17A and tumour necrosis factor α (TNFα)-induced messenger RNA expression in RA synoviocytes was analysed using Affymetrix U133A microarrays. The capacity of IL-17 alone or in combination with TNFα to induce synoviocyte migration and ...
Michels Martina E J - - 2012
Background: Everybody seems to know what a clinical skill (CS) is but closer consideration shows that the concept of a CS is not as clear as might be assumed. Some seem to use "CSs" when just referring to physical examination skills, whereas others use the term to also include diagnostic, ...
Caballero-Velazquez Teresa - - 2012
Background. We have previously shown that Bortezomib induces a depletion of alloreactive T-cells and allows the expansion of T-cells with suppressive properties. In the current study we analyzed the potential synergistic effect of bortezomib in conjunction with sirolimus in order to reduce-graft-versus host disease without hampering graft versus leukemia in ...
Sakiyama Norifumi - - 2012
Put a ring on it: A cationic rhodium(I)/binap complex catalyzes the intramolecular cyclization reactions of naphthol- or phenol-linked 1,6-enynes to produce vinylnaphtho- or vinylbenzofurans and vinylnaphtho- or vinylbenzopyrans through the cleavage and formation of sp(2) CO bonds. Mechanistic studies imply that the present cyclization reactions proceed through β-oxygen elimination from ...
Linley Ezra - - 2012
Hydrogen peroxide is extensively used as a biocide, particularly in applications where its decomposition into non-toxic by-products is important. Although increasing information on the biocidal efficacy of hydrogen peroxide is available, there is still little understanding of its biocidal mechanisms of action. This review aims to combine past and novel ...
Kontou E - - 2012
Objective: To assess the internal consistency, validity and factor structure of a revised version of the Visual Analog Mood Scales (VAMS-R) in healthy older adults and aphasic stroke patients. DESIGN: Cross-sectional study. PARTICIPANTS: Fifty healthy older people and 71 aphasic stroke patients.Setting: Community and hospital.Measures: The healthy participants were asked ...
Liu Wei - - 2012
Nanostructures as catalysts: Pd aerogels modified with α-, β-, and γ-cyclodextrins can be obtained by the spontaneous self-assembly of in situ generated Pd nanoparticles. The Pd aerogels show excellent electrocatalytic activity for the oxidation of ethanol. The catalytic activity is believed to arise from the nonsupported nanometer-scale structure of the ...
Talungchit Pattarawalai - - 2012
Severe preeclampsia/eclampsia and postpartum hemorrhage (PPH) are serious obstetric problems worldwide. Quality improvement of care measured by evidence-based indicators is recommended as a recent important strategy; however, the indicators for quality of care of these two conditions have not been established. This study aimed to develop such indicators and assess ...
Jahangard Leila - - 2012
OBJECTIVES: There is mixed evidence as to the merits of continuing versus discontinuing medication with anticonvulsants before starting electroconvulsive therapy (ECT) in patients with manic episodes. The aim of the present study was therefore to compare, in a controlled double-blind randomized clinical trial, treatment improvements and treatment outcome in patients ...
Donders Jacobus - - 2012
The performance of 54 patients with complicated mild-severe traumatic brain injury (TBI) was evaluated on the Attention, Executive Functions, and Memory modules of the Neuropsychological Assessment Battery (NAB) and compared with that of 54 demographically matched healthy controls. All three NAB indices demonstrated statistically significant group differences and negative covariances ...
Hilton C C OXLIP group, OCDEM, University of Oxford, Churchill Hospital, Oxford, UK. - - 2013
MicroRNAs (miRNAs) are endogenous small RNAs that posttranscriptionally regulate gene expression and that have been shown to have important roles in numerous disease processes. There is growing evidence for an important role of miRNAs in regulating the pathways in adipose tissue that control a range of processes including adipogenesis, insulin ...
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