Search Results
Results 351 - 400 of 5546
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Swain Banikalyan - - 2012
Nucleotide binding and oligomerization domain-1 (NOD1) is a cytoplasmic pattern recognition receptor (PRR), and is a member of the NOD-like receptor (NLR) family. It senses a wide range of bacteria and viruses or their products, and plays a key role in inducing innate immunity. In this report, NOD1 gene was ...
Laskowski Tomasz - - 2012
The relative configurations of four stereogenic centers of the C33-C42 fragment of niphimycin A were assigned as 2S*, 3R*, 4S* and 6S*, based upon (1) H NMR analysis with double-quantum filtered COSY and nuclear Overhauser spectroscopy experiments. These data were then correlated with absolute configurations at C36 and C38 of ...
Jack Alexander R - - 2012
Resident Rounds is a section of the JDD dedicated to highlighting various dermatology departments with residency training programs. Resident Rounds includes three sections: (1) a program spotlight, highlighting pertinent information about the department and residency training program; (2) a section presenting study materials used by residents at the program; and ...
Nama Vivek - - 2012
: To estimate if reduced capillary density (ie, capillary rarefaction) precedes the onset of preeclampsia and if it could play a role in its pathogenesis. Capillary rarefaction is a consistent finding in essential hypertension. : In this longitudinal cohort study, we recruited 322 consecutive white women, of whom 305 women ...
Ersoy Hale - - 2012
The purpose of this article is to evaluate the efficiency and reproducibility of a contrast-enhanced 3D MR angiography (MRA) protocol, using the provocative arm position on 1.5- and 3-T MRI scanners, and to determine the frequency and distribution of vascular compression and vascular complications in the thoracic outlet. Seventy-eight consecutive ...
Clegg Ian M - - 2012
The use of in situ mid-infrared spectroscopy to support the development of a pharmaceutical manufacturing process is disclosed. Data on this two-stage telescoped reaction from several reaction scales (<50 mL to 1600 liters) and at multiple manufacturing locations is shown. In addition to providing data on both reactions in the ...
Geissler A - - 2012
DRG systems were introduced across Europe based on expected transparency and efficiency gains. However, European DRG systems have not been systematically analysed so far. As a consequence little is known about the relative strengths and weaknesses of different DRG systems. The EuroDRG project closed this research and knowledge gap by ...
- - 2012
Pipeline Previews brings to you information on the newest drugs and medical products as they become available to the dermatologic community. This department may include additional information from the manufacturers, plus reports from physicians who wish to share their clinical experience with these new products. In addition, we will inform ...
Gordon W Scott - - 2012
Low- and lower-middle-income countries are faced with a large and increasingly complicated portfolio of vaccines to introduce into their national immunization programmes. Countries must also incorporate their vaccine introduction plans into donor-required assessments and multi-year plans. An international workshop and series of key informant interviews were conducted to explore the ...
Flecher X - - 2012
We describe the results of 81 consecutive revision total hip replacements with impaction grafting in 79 patients using a collared polished chrome-cobalt stem, customised in length according to the extent of distal bone loss. Our hypothesis was that the features of this stem would reduce the rate of femoral fracture ...
Park Michael Yong - - 2012
The purpose of this article is to examine the effect of different beam-flow angles on the accuracy of Doppler ultrasound velocity measurements in modern ultrasound systems. A flow phantom was used to create a steady flow of water in a 4.3-mm-diameter tube. Using three different modern university-grade ultrasound systems, flow ...
Yao Lawrence - - 2012
We sought to improve the utility of T2 measurement as a marker of active muscle disease in patients with idiopathic inflammatory myopathy by correcting for T2 prolongations caused by fatty replacement of muscle that accompnaies chronic muscle damage. Twenty-one patients with idiopathic inflammatory myopathy underwent a standardized MRI evaluation of ...
Weakley Andrew T - - 2012
A method of automated baseline correction has been developed and applied to Raman spectra with a low signal-to-noise ratio and surface-enhanced infrared absorption (SEIRA) spectra with bipolar bands. Baseline correction is initiated by dividing the raw spectrum into equally spaced segments in which regional minima are located. Following identification, the ...
Khanduja V - - 2012
The FRCS (Tr & Orth) examination has three components: MCQs, Vivas and Clinical Examination. The Vivas are further divided into four sections comprising Basic Science, Adult Pathology, Hands and Children's Orthopaedics and Trauma. The Clinical Examination section is divided into Upper and Lower limb cases. The aim of this section ...
Mescola Andrea - - 2012
Single-cell force spectroscopy is an emerging technique in the field of biomedicine because it has proved to be a unique tool to obtain mechanical and functional information on living cells, with force resolution up to single molecular bonds. This technique was applied to the study of the cytoskeleton organisation of ...
Vander Ley Brian L - - 2012
Bovine viral diarrhea virus is a costly disease of cattle that can be controlled by vaccination, biosecurity, and removal of persistently infected cattle. Development and proficiency testing of assays to identify persistently infected cattle requires substantial quantities of known positive- and negative-sample material. The objective of this study was to ...
Kernberg Paulina F - - 2012
This Practice Parameter describes the principles of psychodynamic psychotherapy with children and is based on clinical consensus and available research evidence. It presents guidelines for the practice of child psychodynamic psychotherapy, including indications and contraindications, the setting, verbal and interactive (play) techniques, work with the parents, and criteria for termination.
Sivasubramanian Premkumar - - 2012
Raman and infrared vibrational spectroscopy were used to confirm the presence of aluminum borohydride dissolved in a commercial polydimethylsiloxane vacuum grease at room temperature. Spectroscopic evidence for an adduct between the aluminum borohydride and polydimethylsiloxane is also presented. Once dissolved in the polydimethylsiloxane grease, the aluminum borohydride was stabilized with ...
Graf von der Schulenburg J-M - - 2012
For decades, economic evaluation studies, or cost-benefit analyses (CBA), have been a tool for decision support in the use of public funds. Despite this, in the last few years, debates on the inclusion of CBAs in the German health care system have paid little attention to the findings and practical ...
Budrys Nicole M - - 2012
: To identify Chlamydia trachomatis antigens associated with tubal factor infertility and acute infection. : A C trachomatis proteome array was used to compare antibody profiles among women with tubal factor infertility, normal fertility, and acute C trachomatis infection. : Thirteen immunodominant antigens reacted with 50% or more sera from ...
Avni Fred E - - 2012
The purpose of this clinical perspective is to describe a decision-tree approach to the finding of hyperechoic kidneys as signs of congenital renal cystic disease in fetuses and children. This approach takes into account the latest classification of inherited renal cystic diseases. The basis of the approach is a detailed ...
Cárdenas Agustín M - - 2012
The objective of this article is to illustrate the imaging features of patients with extrahepatic portal venous obstruction who are evaluated before or after a Rex shunt surgery. The Rex shunt is a potentially curative surgical procedure that reestablishes physiologic hepatopetal portal flow. It is typically accomplished by interposing a ...
Iyer Ramesh S - - 2012
Pediatric elbow trauma is challenging because of the complex nature of the growing skeleton. The objectives of this article are to review the anatomy and radiographic landmarks and to discuss common acute and chronic injuries sustained. Radiographic evaluation of elbow trauma in the acute setting requires a firm understanding of ...
Khorashadi Leila - - 2012
The purpose of this article is to provide a radiologic guide to surgical treatment of first carpometacarpal osteoarthritis, a common problem especially in older women. Knowledge of the indications, surgical technique, component design, normal postoperative imaging assessment, and imaging findings of complications is important to providing a meaningful radiologic evaluation ...
Booth Timothy N - - 2012
This article will review the current literature as it relates to imaging of the child suspected to have cervical spine injury (CSI) and the imaging findings of pediatric CSI, focusing on strategies to minimize radiation dose while maximizing diagnostic yield. Although CSI is uncommon in children, the clinical implications of ...
Anthony Evelyn Y - - 2012
This article reviews the range of adnexal masses that present in pediatric females. The preferred imaging modalities, the appearance of the normal ovaries, and the epidemiology of ovarian diseases and abnormalities are discussed. The illustrated abnormalities include simple and complex ovarian and paraovarian cysts, neoplasms, ovarian torsion, ectopic pregnancy, and ...
Dulhunty Angela F - - 2012
The contractile function of the heart requires the release of Ca(2+) from intracellular Ca(2+) stores in the sarcoplasmic reticulum (SR) of cardiac muscle cells. The efficacy of Ca(2+) release depends on the amount of Ca(2+) loaded into the Ca(2+) store and the way in which this 'Ca(2+) load' influences the ...
Goske Marilyn J - - 2012
The objective of this article is to highlight strategies that can be used to implement changes locally for improved safety of pediatric patients. Specific examples of international organizations engaged with quality improvement are discussed. Large-scale quality improvement to promote radiation protection for children is being aggressively pursued by numerous international ...
Sung Edward K - - 2012
The purpose of this article is to review the different scrotal disease entities in the pediatric population, focusing on acute scrotum, traumatic injuries, and testicular tumors. Many pediatric scrotal disorders can be well characterized on sonography. An understanding of the various disease entities, their clinical presentations, and the typical sonographic ...
Iyer Ramesh S - - 2012
Osteoid osteomas are benign painful skeletal neoplasms that preferentially afflict young male patients and are readily treatable. This article focuses on the various imaging manifestations of the tumor, while also discussing its clinical presentation, pathogenesis, and treatment. Knowledge of the common imaging features of osteoid osteomas will improve our diagnosis ...
Lee Elaine Yuen Phin - - 2012
Myeloid sarcoma (MS) is a rare extramedullary manifestation of acute myeloid leukemia that often presents during remission or disease relapse. With awareness of this clinical entity and the appropriate clinical history, MS can be detected despite its nonspecific radiologic features. This article highlights the utility of (18)F-FDG PET/CT, which has ...
Verschuuren Sylvia - - 2012
The purpose of this article is to present and discuss the susceptibility-weighted imaging signal characteristics of the normal pediatric brain and those of a variety of pediatric brain pathologic abnormalities. Its high susceptibility for blood products, iron depositions, and calcifications makes susceptibility-weighted imaging an important additional sequence for the diagnostic ...
Thapa Mahesh M - - 2012
Cartilage development has a profound impact on musculoskeletal growth. The objective of this article is to offer insights about the maturation of hyaline cartilage through MRI. We begin by briefly describing the molecular make up of hyaline cartilage. We will then follow with a discussion of the basic principles to ...
Thapa Mahesh M - - 2012
The purpose of this article is to discuss MRI of the pediatric knee and familiarize the reader with conditions encountered in the pediatric population. Clinical scenarios are included to convey important concepts and to orient the learner to normal variants and abnormalities of the pediatric knee. The conditions discussed include, ...
Ramos-Duran Luis - - 2012
The purpose of this article is to review the normal anatomy of the aortic arch and the most common variations of congenital aortic arch anomalies using low-radiation-dose, defined as a dose-length product of 7-15 mGy × cm, MDCT angiography. Radiologists should be prepared to fully describe congenital aortic arch anomalies; ...
Nigam Rishi - - 2012
We propose rituximab as a first-line therapy for pemphigus vulgaris and steroid-dependent bullous pemphigoid with or without systemic steroids. A brief review of the literature substantiates the significant risk associated with the use of long term, high-dose prednisone, mycophenolate mofetil (MMF), and azathioprine. No head-to-head studies are available with respect ...
Franchina Tindara - - 2012
Breast carcinoma (BC) is a heterogeneous disease in terms of histology, therapeutic response, dissemination patterns to distant sites and patient outcomes. Triple-negative breast cancer (TNBC), defined by the lack of protein expression of estrogen and progesterone receptors and the absence of HER2 protein overexpression (ER-/PR-/HER2-) has significant clinical implications due ...
Harb Elise - - 2012
To determine whether macular thickness is associated with ethnicity, gender, axial length (AL), and severity of myopia in a cohort of young adults from the Correction of Myopia Evaluation Trial (COMET). Eleven years after their baseline visit, 387/469 (83%) subjects returned for their annual visit. In addition to the protocol-specific ...
Lin Hong-Yu - - 2012
Reaction of a substituted indole-3-acetyl chloride with N-5-azidopentyl-N'-hydroxyguanidine generated a substituted 3-(5-azidopentylamino)-5-((indol-3-yl)methyl)-1,2,4-oxadiazole. Reduction of the azide with zinc and ammonium formate afforded the amine, which was elaborated to the guanidine, completing short and efficient syntheses of the cytotoxic natural products phidianidines A and B in 19% overall yield by a ...
Tam Johnny - - 2012
To establish adaptive optics scanning laser ophthalmoscopy as a method to detect and characterize microscopic signs of diabetic retinopathy in capillaries and cone photoreceptors in the parafovea. Recently, adaptive optics scanning laser ophthalmoscope (AOSLO) has enabled noninvasive assessment of photoreceptors, capillaries, and leukocytes in the retinas of live human subjects. ...
Brooks Alan - - 2012
Traditionally it has taken years or decades for new public health interventions targeting diseases found in developing countries to be accessible to those most in need. One reason for the delay has been insufficient anticipation of the eventual processes and evidence required for decision making by countries. This paper describes ...
Angold Adrian - - 2012
To compare examples of three styles of psychiatric interviews for youth: the Diagnostic Interview Schedule for Children (DISC) ("respondent-based"), the Child and Adolescent Psychiatric Assessment (CAPA) ("interviewer-based"), and the Development and Well-Being Assessment (DAWBA) ("expert judgment"). Roughly equal numbers of males and females of white and African American ethnicity, aged ...
Townsend Mary K - - 2012
To estimate the association between long-term caffeine intake and risk of urinary incontinence (UI) progression over 2 years among women with moderate UI. We conducted a prospective cohort study in 21,564 women with moderate UI enrolled in the Nurses' Health Study and Nurses' Health Study II. Incontinence progression was identified ...
Hadizadeh Dariusch R - - 2012
The purpose of this study was to investigate the prevalence of incidental deep venous thrombosis (DVT) in patients with clinically suspected peripheral arterial occlusive disease (PAOD) using contrast-enhanced MR angiography (MRA) with a blood pool contrast agent. Two hundred fifty-nine MRA examinations with blood pool contrast agent in 245 consecutive ...
Henry Travis S TS Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. - - 2012
The purpose of this study was to characterize the chest CT findings of North American paragonimiasis due to Paragonimus kellicotti in the largest (to our knowledge) case series reported to date and to compare the findings with those reported for paragonimiasis infections in other regions. A retrospective review was performed ...
Rudolf M C J MC Department of Child Health, Leeds Community Health Care Trust and University of Leeds, Leeds, - - 2012
Body mass index (BMI) is the pragmatic measure to assess children's obesity clinically and BMI charts are widely used for counselling families about children's weight management over time. To explore the variability in clinicians' interpretation of BMI patterns and to ascertain the diagnostic accuracy of their judgement by relating it ...
Liu David X DX Divisions of Comparative Pathology, Tulane National Primate Research Center, 18733 Three Rivers Road, Covington, LA 70433, USA. - - 2012
An 8-year-old male rhesus macaque (Macaca mulatta) presented with unilateral enlargement of the left mandible. Radiographs revealed a marked expansion of the left mandible with a multilocular radiolucent mass with abundant osteolysis. The mass was grossly firm, fleshy, and gelatinous on the cut surface. Histologically, the mass was locally infiltrative ...
Kaza Ravi K RK Department of Radiology, University of Michigan Hospitals, Ann Arbor, 48109-5030, USA. - - 2012
The objective of our study was to evaluate the image quality and diagnostic adequacy of the following two CT enterography protocols in patients weighing less than 160 lb (72 kg): 80-kVp imaging with the adaptive statistical iterative reconstruction (ASIR) in comparison with 120-kVp imaging with the filtered back projection reconstruction. ...
Kamath-Rayne Beena D BD Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Maternal-Fetal Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45229, USA. - - 2012
To estimate whether antenatal corticosteroids given after fetal lung immaturity in pregnancies at 34 weeks of gestation or more would improve neonatal outcomes and, in particular, respiratory outcomes. We compared outcomes of 362 neonates born at 34 weeks of gestation or more after fetal lung maturity testing: 102 with immature ...
Luff Jennifer A JA Department of Pathology, Microbiology, and Immunology, One Shields Avenue, Room 4206, Building VM3A, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA. - - 2012
In dogs, papillomaviruses are thought to cause oral and cutaneous papillomas and pigmented plaques. Eight canine papillomaviruses have been fully sequenced to date. Four of these canine papillomaviruses, including Canis familiaris papillomavirus (CPV)-3, CPV-4, CPV-5, and CPV-8, were amplified from pigmented plaques. Given the identification of several different canine papillomaviruses ...
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